UniProtKB - A0KK26 (END4_AERHH)
Protein
Probable endonuclease 4
Gene
nfo
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Functioni
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.UniRule annotation
Catalytic activityi
- Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.UniRule annotation EC:3.1.21.2
Cofactori
Zn2+UniRule annotationNote: Binds 3 Zn2+ ions.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 69 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 109 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 145 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 145 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 179 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 182 | Zinc 3UniRule annotation | 1 | |
Metal bindingi | 216 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 229 | Zinc 3UniRule annotation | 1 | |
Metal bindingi | 231 | Zinc 3UniRule annotation | 1 | |
Metal bindingi | 261 | Zinc 2UniRule annotation | 1 |
GO - Molecular functioni
- deoxyribonuclease IV (phage-T4-induced) activity Source: UniProtKB-UniRule
- DNA binding Source: InterPro
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease |
Biological process | DNA damage, DNA repair |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | AHYD380703:G1G7B-2096-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable endonuclease 4UniRule annotation (EC:3.1.21.2UniRule annotation)Alternative name(s): Endodeoxyribonuclease IVUniRule annotation Endonuclease IVUniRule annotation |
Gene namesi | Name:nfoUniRule annotation Ordered Locus Names:AHA_2097 |
Organismi | Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240) |
Taxonomic identifieri | 380703 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000011285 | 1 – 281 | Probable endonuclease 4Add BLAST | 281 |
Family & Domainsi
Sequence similaritiesi
Belongs to the AP endonuclease 2 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0648, Bacteria |
HOGENOMi | CLU_025885_0_4_6 |
OMAi | HPGSHLK |
Family and domain databases
CDDi | cd00019, AP2Ec, 1 hit |
HAMAPi | MF_00152, Nfo, 1 hit |
InterProi | View protein in InterPro IPR001719, AP_endonuc_2 IPR018246, AP_endonuc_F2_Zn_BS IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
PANTHERi | PTHR21445, PTHR21445, 1 hit |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
SMARTi | View protein in SMART SM00518, AP2Ec, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
TIGRFAMsi | TIGR00587, nfo, 1 hit |
PROSITEi | View protein in PROSITE PS00729, AP_NUCLEASE_F2_1, 1 hit PS00730, AP_NUCLEASE_F2_2, 1 hit PS00731, AP_NUCLEASE_F2_3, 1 hit PS51432, AP_NUCLEASE_F2_4, 1 hit |
i Sequence
Sequence statusi: Complete.
A0KK26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFIGAHVSA AGGVENTIAR AQAIGANAFA LFTKNQRQWQ AAPLSEASIH
60 70 80 90 100
AFKLACEKGG FRPEQILPHD SYLINLGHPD PDGLAKSRDA FLDEMKRCEQ
110 120 130 140 150
LGLCYLNFHP GSHLKQIPEA ASLKLVSESI NWALERSQGV TAVIENTAGQ
160 170 180 190 200
GTNLGWSFEH LATIIDGVED KSRVGICFDT CHAFAAGYDL RTADACAAVF
210 220 230 240 250
AEFEQTVGFQ YLKGMHINGA KCTFGSRVDR HHSLREGNLG EAVFHHIMND
260 270 280
DRFDGIPLIL ETIDESIWGD EIRWLRSLAK A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000462 Genomic DNA Translation: ABK37567.1 |
RefSeqi | WP_011705964.1, NC_008570.1 YP_856627.1, NC_008570.1 |
Genome annotation databases
EnsemblBacteriai | ABK37567; ABK37567; AHA_2097 |
KEGGi | aha:AHA_2097 |
PATRICi | fig|380703.7.peg.2105 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000462 Genomic DNA Translation: ABK37567.1 |
RefSeqi | WP_011705964.1, NC_008570.1 YP_856627.1, NC_008570.1 |
3D structure databases
SMRi | A0KK26 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 380703.AHA_2097 |
Genome annotation databases
EnsemblBacteriai | ABK37567; ABK37567; AHA_2097 |
KEGGi | aha:AHA_2097 |
PATRICi | fig|380703.7.peg.2105 |
Phylogenomic databases
eggNOGi | COG0648, Bacteria |
HOGENOMi | CLU_025885_0_4_6 |
OMAi | HPGSHLK |
Enzyme and pathway databases
BioCyci | AHYD380703:G1G7B-2096-MONOMER |
Family and domain databases
CDDi | cd00019, AP2Ec, 1 hit |
HAMAPi | MF_00152, Nfo, 1 hit |
InterProi | View protein in InterPro IPR001719, AP_endonuc_2 IPR018246, AP_endonuc_F2_Zn_BS IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
PANTHERi | PTHR21445, PTHR21445, 1 hit |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
SMARTi | View protein in SMART SM00518, AP2Ec, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
TIGRFAMsi | TIGR00587, nfo, 1 hit |
PROSITEi | View protein in PROSITE PS00729, AP_NUCLEASE_F2_1, 1 hit PS00730, AP_NUCLEASE_F2_2, 1 hit PS00731, AP_NUCLEASE_F2_3, 1 hit PS51432, AP_NUCLEASE_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | END4_AERHH | |
Accessioni | A0KK26Primary (citable) accession number: A0KK26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 10, 2021 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families