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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciAHYD380703:G1G7B-826-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:AHA_0825
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000756 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000847281 – 352tRNA pseudouridine synthase DAdd BLAST352

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_0825

Structurei

3D structure databases

ProteinModelPortaliA0KGH7
SMRiA0KGH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 299TRUDUniRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
KOiK06176
OMAiLWLWVEK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

A0KGH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEQLAYLHG APTARGILKA QAADFVVNED LGFEPCGEGE HIFVRVRKTG
60 70 80 90 100
ENTAWVAGLL ADAAGVNRSA VTWAGLKDRH AVTEQWFGIH LPGKAEPDLS
110 120 130 140 150
VIESDSIQIL QVKRHNKKLR VGYLKGNHFI LRLTGLEQAD GLESRLQAIA
160 170 180 190 200
EQGVPNYYGE QRFGRGGNNL EAAKAMFAGK RIKDRNKRSL YLSAARSMLF
210 220 230 240 250
NAIVSARIEQ GLAHQLLAGD CVMLKGSHSI FSEEGVTPEL AARLASGDVQ
260 270 280 290 300
LTAPQWGRGR LASQGAAAEF EQSVLAPYHD WCDGLEKAGL DQDRRPLLLK
310 320 330 340 350
PQAMSWQLEG TVLILSFFLP AGAFATSVVR ELMQAEEADH GFRNQSDENS

GQ
Length:352
Mass (Da):38,455
Last modified:December 12, 2006 - v1
Checksum:iFDDC4BC6B40CCA72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA Translation: ABK38160.1
RefSeqiWP_011704773.1, NC_008570.1
YP_855368.1, NC_008570.1

Genome annotation databases

EnsemblBacteriaiABK38160; ABK38160; AHA_0825
GeneIDi4489305
KEGGiaha:AHA_0825
PATRICifig|380703.7.peg.825

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA Translation: ABK38160.1
RefSeqiWP_011704773.1, NC_008570.1
YP_855368.1, NC_008570.1

3D structure databases

ProteinModelPortaliA0KGH7
SMRiA0KGH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi380703.AHA_0825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK38160; ABK38160; AHA_0825
GeneIDi4489305
KEGGiaha:AHA_0825
PATRICifig|380703.7.peg.825

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
KOiK06176
OMAiLWLWVEK

Enzyme and pathway databases

BioCyciAHYD380703:G1G7B-826-MONOMER

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_AERHH
AccessioniPrimary (citable) accession number: A0KGH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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