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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27GTPUniRule annotation1
Binding sitei77GTPUniRule annotation1
Metal bindingi107MagnesiumUniRule annotation1
Binding sitei107GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 16GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:Bcen2424_1108
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191091 – 205Molybdenum cofactor guanylyltransferaseAdd BLAST205

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0K5T4
SMRiA0K5T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280423
KOiK03752
OMAiFVPCDVP

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.101 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR02665 molyb_mobA, 1 hit

Sequencei

Sequence statusi: Complete.

A0K5T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPAFPSIA GLLLAGGRAT RMDGVDKGLQ LLDGTPLALH VLRRLTPQVD
60 70 80 90 100
ETLISANRHA DRYAELSAPF DARIIADETP DFPGPLAGLL AGMRAARAPL
110 120 130 140 150
VACSPCDTPY LPVDLVARLR AALDAQQADI AMAVTVDAQQ VRSPQPTFAL
160 170 180 190 200
LRTSLADDLA ARLAAGDRKV RAWYARHKTV EVEFRDERAF YNANSWQELA

ALARR
Length:205
Mass (Da):22,191
Last modified:December 12, 2006 - v1
Checksum:i8774AE550B3BCC60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000458 Genomic DNA Translation: ABK07861.1
RefSeqiWP_011544927.1, NC_008542.1

Genome annotation databases

EnsemblBacteriaiABK07861; ABK07861; Bcen2424_1108
KEGGibch:Bcen2424_1108

Similar proteinsi

Entry informationi

Entry nameiMOBA_BURCH
AccessioniPrimary (citable) accession number: A0K5T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program