UniProtKB - A0K4B3 (RPPH_BURCH)
Protein
RNA pyrophosphohydrolase
Gene
rppH
Organism
Burkholderia cenocepacia (strain HI2424)
Status
Functioni
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation
Cofactori
a divalent metal cationUniRule annotation
GO - Molecular functioni
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BioCyci | BCEN331272:G1GW2-622-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)Alternative name(s): (Di)nucleoside polyphosphate hydrolaseUniRule annotation |
Gene namesi | Name:rppHUniRule annotation Synonyms:nudHUniRule annotation Ordered Locus Names:Bcen2424_0586 |
Organismi | Burkholderia cenocepacia (strain HI2424) |
Taxonomic identifieri | 331272 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000021932 | 1 – 214 | RNA pyrophosphohydrolaseAdd BLAST | 214 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 149 | Nudix hydrolaseUniRule annotationAdd BLAST | 144 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 38 – 59 | Nudix boxAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | HOG000066723 |
KOi | K08311 |
OMAi | PCVGIML |
OrthoDBi | 1345242at2 |
Family and domain databases
CDDi | cd03671 Ap4A_hydrolase_plant_like, 1 hit |
HAMAPi | MF_00298 Nudix_RppH, 1 hit |
InterProi | View protein in InterPro IPR020476 Nudix_hydrolase IPR015797 NUDIX_hydrolase-like_dom_sf IPR020084 NUDIX_hydrolase_CS IPR000086 NUDIX_hydrolase_dom IPR022927 RppH |
Pfami | View protein in Pfam PF00293 NUDIX, 1 hit |
PRINTSi | PR00502 NUDIXFAMILY |
SUPFAMi | SSF55811 SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462 NUDIX, 1 hit PS00893 NUDIX_BOX, 1 hit |
i Sequence
Sequence statusi: Complete.
A0K4B3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDREGFRPN VGIILLNARN EVFWGKRLRE HSWQFPQGGI KYGETPMQAM
60 70 80 90 100
YRELHEETGL HPEHVKIIGR TRDWLRYEVP DKFIKREVRG HYRGQKQIWF
110 120 130 140 150
LLRMVGRDCD ICLRATDHPE FDAWRWNEYW VPLDAVIEFK RDVYQLALTE
160 170 180 190 200
LSRFLRRPAQ RAEKPRGPRV SRYPRVIGAQ AQTLTIVDTS VVCSEIEVEA
210
STLDEMPPHV IVGK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000458 Genomic DNA Translation: ABK07340.1 |
RefSeqi | WP_006476994.1, NC_008542.1 |
Genome annotation databases
EnsemblBacteriai | ABK07340; ABK07340; Bcen2424_0586 |
KEGGi | bch:Bcen2424_0586 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000458 Genomic DNA Translation: ABK07340.1 |
RefSeqi | WP_006476994.1, NC_008542.1 |
3D structure databases
SMRi | A0K4B3 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ABK07340; ABK07340; Bcen2424_0586 |
KEGGi | bch:Bcen2424_0586 |
Phylogenomic databases
HOGENOMi | HOG000066723 |
KOi | K08311 |
OMAi | PCVGIML |
OrthoDBi | 1345242at2 |
Enzyme and pathway databases
BioCyci | BCEN331272:G1GW2-622-MONOMER |
Family and domain databases
CDDi | cd03671 Ap4A_hydrolase_plant_like, 1 hit |
HAMAPi | MF_00298 Nudix_RppH, 1 hit |
InterProi | View protein in InterPro IPR020476 Nudix_hydrolase IPR015797 NUDIX_hydrolase-like_dom_sf IPR020084 NUDIX_hydrolase_CS IPR000086 NUDIX_hydrolase_dom IPR022927 RppH |
Pfami | View protein in Pfam PF00293 NUDIX, 1 hit |
PRINTSi | PR00502 NUDIXFAMILY |
SUPFAMi | SSF55811 SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462 NUDIX, 1 hit PS00893 NUDIX_BOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPPH_BURCH | |
Accessioni | A0K4B3Primary (citable) accession number: A0K4B3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | December 12, 2006 | |
Last modified: | October 16, 2019 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |