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Protein

Alkylglycerol monooxygenase

Gene

Agmo

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (By similarity).By similarity

Catalytic activityi

1-alkyl-sn-glycerol + tetrahydrobiopterin + O2 = 1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O.

Cofactori

Fe cationBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandIron

Enzyme and pathway databases

ReactomeiR-RNO-75109 Triglyceride biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Alkylglycerol monooxygenase (EC:1.14.16.5)
Alternative name(s):
Transmembrane protein 195
Gene namesi
Name:Agmo
Synonyms:Tmem195
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1312038 Agmo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993021 – 447Alkylglycerol monooxygenaseAdd BLAST447

Proteomic databases

PaxDbiA0JPQ8
PeptideAtlasiA0JPQ8
PRIDEiA0JPQ8

PTM databases

PhosphoSitePlusiA0JPQ8

Expressioni

Gene expression databases

BgeeiENSRNOG00000023116
GenevisibleiA0JPQ8 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029816

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 136Histidine box-15
Motifi145 – 149Histidine box-25
Motifi221 – 225Histidine box-35

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0872 Eukaryota
COG3000 LUCA
GeneTreeiENSGT00440000033807
HOVERGENiHBG097659
InParanoidiA0JPQ8
KOiK15537
OMAiFMPTGWR
OrthoDBiEOG091G0P9T
PhylomeDBiA0JPQ8
TreeFamiTF314881

Family and domain databases

InterProiView protein in InterPro
IPR006694 Fatty_acid_hydroxylase
PfamiView protein in Pfam
PF04116 FA_hydroxylase, 1 hit

Sequencei

Sequence statusi: Complete.

A0JPQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNPGAQDNV SVSQGMRAMF YMMKPSETAF QTVEEVPDYV KKATPFFIFL
60 70 80 90 100
ILLELVVSWI LKGKPSGRLD DILTSMSAGV VSRLPNLFFR SLEVTSYIYI
110 120 130 140 150
WENYRVCELP WDSPWTWYLT FLGVDFGYYW FHRMAHEINI IWAAHQAHHS
160 170 180 190 200
SEDYNLSTAL RQSVLQQYSS WVFYCPLALF VPPSVFAVHI QFNLLYQFWI
210 220 230 240 250
HTEVIRTLGP LELVLNTPSH HRVHHGRNRY CIDKNYAGTL IIWDRIFGTF
260 270 280 290 300
EAENEQVIYG LTHPIGTFEP FKVQFHHLLY IWTTFWATPG FCHKFSVLFK
310 320 330 340 350
GPGWGPGKPR LGLSEEIPEV TGQEVPFTSS ASQFLKIYAV LQFAVMLVFY
360 370 380 390 400
EETFANTAVL SQVTILLRIC FIILTLTSIG FLLDQRPKAA IVETLRCLLF
410 420 430 440
LTLYRFGHLK PLIESLSFAF EIFFSVCIAF WGVRSITHLA SGSWKKP
Length:447
Mass (Da):51,698
Last modified:December 12, 2006 - v1
Checksum:i5920D097F0D99EB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127545 mRNA Translation: AAI27546.1
RefSeqiNP_001129371.1, NM_001135899.1
UniGeneiRn.152690

Genome annotation databases

EnsembliENSRNOT00000032108; ENSRNOP00000029816; ENSRNOG00000023116
GeneIDi362732
KEGGirno:362732
UCSCiRGD:1312038 rat

Similar proteinsi

Entry informationi

Entry nameiALKMO_RAT
AccessioniPrimary (citable) accession number: A0JPQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: June 7, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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