UniProtKB - A0JPL0 (ZN382_RAT)
Protein
Zinc finger protein 382
Gene
Znf382
Organism
Rattus norvegicus (Rat)
Status
Functioni
Functions as a sequence-specific transcriptional repressor.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 211 – 233 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 513 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 519 – 541 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of cell growth Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 382Alternative name(s): KRAB/zinc finger suppressor protein 1 Short name: KS1 Multiple zinc finger and krueppel-associated box protein KS1 |
Gene namesi | Name:Znf382 Synonyms:Zfp382 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708385, Zfp382 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 16 – 17 | DV → AA: Loss of transcriptional repressor activity. Loss of interaction with TRIM28. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000361568 | 1 – 549 | Zinc finger protein 382Add BLAST | 549 |
Proteomic databases
PaxDbi | A0JPL0 |
Expressioni
Tissue specificityi
Ubiquitously expressed with higher expression in lung, kidney and testis.1 Publication
Inductioni
Up-regulated by EGF; delayed early response target for EGF (at protein level).1 Publication
Gene expression databases
Bgeei | ENSRNOG00000020777, Expressed in brain and 22 other tissues |
ExpressionAtlasi | A0JPL0, baseline and differential |
Interactioni
Subunit structurei
Interacts with TRIM28; enhances the transcriptional repressor activity.
1 PublicationProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028187 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 83 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 105 | Mediates interaction with TRIM281 PublicationAdd BLAST | 105 | |
Regioni | 10 – 51 | Represses transcriptionAdd BLAST | 42 | |
Regioni | 75 – 210 | Represses transcriptionAdd BLAST | 136 | |
Regioni | 295 – 549 | Required for transcriptional repression activity; probably mediates sequence-specific DNA-bindingAdd BLAST | 255 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 211 – 233 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 513 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 519 – 541 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162338 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | A0JPL0 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A0JPL0 |
TreeFami | TF337898 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0JPL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNCHSVPLQG PVSFKDVTVD FTQEEWQRLD PAQKALYRDV MLENYCHFIS
60 70 80 90 100
VGFHITKPDM IRKLEQGEEL WTERMFPSQS YLEDEEVLVK FRDYQDKPPT
110 120 130 140 150
SIVIINHKKL IKERNNVYEK TLGNNHIISK TLFEYKSDGK VLKNISDFIS
160 170 180 190 200
RDINPVMGTL GDSSEWEESV LTSEQEKTHP VPTLYKQIGR NLSSSLELAQ
210 220 230 240 250
HQKTQIPEQR FECDECDSSF LMTEVAFPHD RAHRGVRDFN CSKDEIAFFE
260 270 280 290 300
KSDLGIHPHN LMEKKCSTYN KYGKLLCRKS VFVMHPRSQV DERPFQCPYC
310 320 330 340 350
GNSFRRKSYL IEHQRIHTGE KPYICSQCGK AFRQKTALTL HEKTHTDGKP
360 370 380 390 400
YLCVDCGKSF RQKATLTRHH KTHTGEKAYE CTQCGSAFGK KSYLIDHQRT
410 420 430 440 450
HTGEKPYQCA ECGKAFIQKT TLTVHQRTHT GEKPYMCSEC GKSFCQKTTL
460 470 480 490 500
TLHQRIHTGE KPYVCSDCGK SFRQKAILTV HYRIHTGEKS NGCPQCGKAF
510 520 530 540
SRKSNLIRHQ KTHTGEKPYE CHECGKFFSC KSNLVAHQKT HKAETVRFQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JSS4 | A0A0G2JSS4_RAT | Zinc finger protein 382 | Zfp382 | 566 | Annotation score: | ||
A0A0G2JYS5 | A0A0G2JYS5_RAT | Zinc finger protein 382 | Zfp382 | 507 | Annotation score: |
Sequence cautioni
The sequence AAD05020 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56732 mRNA Translation: AAD05020.1 Sequence problems. BC127483 mRNA Translation: AAI27484.1 |
RefSeqi | NP_653350.1, NM_144749.1 |
Genome annotation databases
Ensembli | ENSRNOT00000087931; ENSRNOP00000069192; ENSRNOG00000020777 |
GeneIDi | 246264 |
KEGGi | rno:246264 |
UCSCi | RGD:708385, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56732 mRNA Translation: AAD05020.1 Sequence problems. BC127483 mRNA Translation: AAI27484.1 |
RefSeqi | NP_653350.1, NM_144749.1 |
3D structure databases
SMRi | A0JPL0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028187 |
Proteomic databases
PaxDbi | A0JPL0 |
Genome annotation databases
Ensembli | ENSRNOT00000087931; ENSRNOP00000069192; ENSRNOG00000020777 |
GeneIDi | 246264 |
KEGGi | rno:246264 |
UCSCi | RGD:708385, rat |
Organism-specific databases
CTDi | 233060 |
RGDi | 708385, Zfp382 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162338 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | A0JPL0 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A0JPL0 |
TreeFami | TF337898 |
Enzyme and pathway databases
Reactomei | R-RNO-212436, Generic Transcription Pathway |
Miscellaneous databases
PROi | PR:A0JPL0 |
Gene expression databases
Bgeei | ENSRNOG00000020777, Expressed in brain and 22 other tissues |
ExpressionAtlasi | A0JPL0, baseline and differential |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN382_RAT | |
Accessioni | A0JPL0Primary (citable) accession number: A0JPL0 Secondary accession number(s): Q62977 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | December 12, 2006 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families