UniProtKB - A0JPE9 (GLPK5_DANRE)
Protein
Putative glycerol kinase 5
Gene
gk5
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:2.7.1.30
: glycerol degradation via glycerol kinase pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.Proteins known to be involved in this subpathway in this organism are:
- Glycerol kinase (zgc:172295), Putative glycerol kinase 5 (gk5), ATP:glycerol 3-phosphotransferase 5 (gk5), Glycerol kinase (zgc:172295)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 3 | SubstrateBy similarity | 1 | |
Binding sitei | 73 | SubstrateBy similarity | 1 | |
Binding sitei | 250 | SubstrateBy similarity | 1 | |
Binding sitei | 272 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 414 – 419 | ATPBy similarity | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glycerol kinase activity Source: GO_Central
- phosphotransferase activity, alcohol group as acceptor Source: GO_Central
GO - Biological processi
- glycerol-3-phosphate biosynthetic process Source: GO_Central
- glycerol catabolic process Source: UniProtKB-UniPathway
- glycerol metabolic process Source: GO_Central
- phosphorylation Source: GO_Central
- triglyceride metabolic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Glycerol metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00672 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative glycerol kinase 5 (EC:2.7.1.30)Short name: GK 5 Short name: Glycerokinase 5 Alternative name(s): ATP:glycerol 3-phosphotransferase 5 |
Gene namesi | Name:gk5 ORF Names:zgc:152983 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-061110-49, gk5 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000323757 | 1 – 510 | Putative glycerol kinase 5Add BLAST | 510 |
Proteomic databases
PaxDbi | A0JPE9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FGGY kinase family.Curated
Phylogenomic databases
eggNOGi | KOG2517, Eukaryota |
InParanoidi | A0JPE9 |
PhylomeDBi | A0JPE9 |
Family and domain databases
CDDi | cd07793, FGGY_GK5_metazoa, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR000577, Carb_kinase_FGGY IPR018485, Carb_kinase_FGGY_C IPR018483, Carb_kinase_FGGY_CS IPR018484, Carb_kinase_FGGY_N IPR037444, GK5_FGGY |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit PF00370, FGGY_N, 1 hit |
PIRSFi | PIRSF000538, GlpK, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00445, FGGY_KINASES_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0JPE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTTSIRCHV YDKSASIRGS CSAKVSLLYP QPGWVEIDPD ELWDGFVTVV
60 70 80 90 100
KGAVQDSGLQ MCQMESLGIS TQRATFMTWD RNTGKPFHKF ITWQDMRAAE
110 120 130 140 150
LVRSWNGSCA MKTVHGVMKM LHFLSRQKRF LAASLVVFTT QHVSLRLVWA
160 170 180 190 200
LNNIPQLRQA VEDGSCYFGT IDTWLLYKLT KGLVHATDYS NASATAIFDS
210 220 230 240 250
YQMCWSGFLC SLLSIPLSIL PKVQDTSHKF GLCDSSIFGV PIPIMCVMAD
260 270 280 290 300
QQTAMFGECC FDTGDVKITM GTGTFMDINT GSKPHTSVAG LYPLVGWKIG
310 320 330 340 350
ADVVYLAEGN AAGTGAAIKW AQDLELFSDV KETEAIATSV EDSDGVFFVP
360 370 380 390 400
SFSGLQAPLN DPKACASFMG LKPSTTKRHL VRAILESIAF RNKQLFDVML
410 420 430 440 450
RETRIPITKI RADGGVCTND FIMQLTADLL GRKIARPSHF DMSCLGAAFV
460 470 480 490 500
AGLGTGYWRN QEELKKLLST DQHFLPRRSK SEGEKGGLYR GVLQSWEKAL
510
QRSMHWYNQP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1QS50 | F1QS50_DANRE | ATP:glycerol 3-phosphotransferase 5 | gk5 | 529 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC127390 mRNA Translation: AAI27391.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC127390 mRNA Translation: AAI27391.1 |
3D structure databases
SMRi | A0JPE9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000085784 |
Proteomic databases
PaxDbi | A0JPE9 |
Organism-specific databases
ZFINi | ZDB-GENE-061110-49, gk5 |
Phylogenomic databases
eggNOGi | KOG2517, Eukaryota |
InParanoidi | A0JPE9 |
PhylomeDBi | A0JPE9 |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00672 |
Miscellaneous databases
PROi | PR:A0JPE9 |
Family and domain databases
CDDi | cd07793, FGGY_GK5_metazoa, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR000577, Carb_kinase_FGGY IPR018485, Carb_kinase_FGGY_C IPR018483, Carb_kinase_FGGY_CS IPR018484, Carb_kinase_FGGY_N IPR037444, GK5_FGGY |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit PF00370, FGGY_N, 1 hit |
PIRSFi | PIRSF000538, GlpK, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00445, FGGY_KINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLPK5_DANRE | |
Accessioni | A0JPE9Primary (citable) accession number: A0JPE9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | December 12, 2006 | |
Last modified: | October 7, 2020 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families