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UniProtKB - A0JPB1 (IGSF3_XENTR)

Entry version 53 (02 Dec 2020)
Sequence version 1 (12 Dec 2006)
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Protein

Immunoglobulin superfamily member 3

Gene

igsf3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily member 3
Short name:
IgSF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:igsf3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-18006038, igsf3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 1091ExtracellularSequence analysisAdd BLAST1075
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1092 – 1112HelicalSequence analysisAdd BLAST21
Topological domaini1113 – 1161CytoplasmicSequence analysisAdd BLAST49

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032013717 – 1161Immunoglobulin superfamily member 3Add BLAST1145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 117PROSITE-ProRule annotation
Disulfide bondi164 ↔ 242PROSITE-ProRule annotation
Disulfide bondi298 ↔ 372PROSITE-ProRule annotation
Disulfide bondi428 ↔ 507PROSITE-ProRule annotation
Disulfide bondi562 ↔ 641PROSITE-ProRule annotation
Disulfide bondi697 ↔ 775PROSITE-ProRule annotation
Disulfide bondi831 ↔ 914PROSITE-ProRule annotation
Disulfide bondi970 ↔ 1047PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A0JPB1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 135Ig-like C2-type 1Add BLAST118
Domaini140 – 258Ig-like C2-type 2Add BLAST119
Domaini272 – 382Ig-like C2-type 3Add BLAST111
Domaini402 – 523Ig-like C2-type 4Add BLAST122
Domaini541 – 651Ig-like C2-type 5Add BLAST111
Domaini674 – 796Ig-like C2-type 6Add BLAST123
Domaini806 – 930Ig-like C2-type 7Add BLAST125
Domaini947 – 1063Ig-like C2-type 8Add BLAST117

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi246 – 248EWI motif3

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A0JPB1

Database of Orthologous Groups

More...OrthoDBi		180654at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07686, V-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 8 hits
SM00408, IGc2, 5 hits
SM00406, IGv, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0JPB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTAALLILL AGVSWAQREV AIQPGPLYRA EGSQISIWCN VRGYQGPSEQ 
        60         70         80         90        100
NFLWSIYLPT APEKEIQIVG TNDPSFSYAI YSQRVRSGGI YVERVSGDRA 
       110        120        130        140        150
LLHIRQLQDQ DTGEYECHTP NTDPSYHGSY SAKVNLQVIP DTLTVSSPAQ 
       160        170        180        190        200
TIQKVEGGSL QVTCEVSQNS SRHTHLSVSW LRLSEGEATE IISVTQNFSV 
       210        220        230        240        250
RPGPSYAQKH SVGDVRLDKV GDSTFRLTLY NLHPSDQGDI YCEGTEWIQD 
       260        270        280        290        300
PDGTWFPLTQ KRSEGTSVTV LPTDKEFNVR LETERRTYNG GDTATLRCII 
       310        320        330        340        350
EAQNPGDRLF AVSWAFNSSL IASQSPGGVP SLTGEYARRE DGGELRVGKD 
       360        370        380        390        400
SDSVFSLKIF RLRPEDSGKY NCRVTERERG PSGELIDRES KRPKNIPISV 
       410        420        430        440        450
LPLRTSLTVT VTANSSSVLE GVRLSLSCSV ASLAGPQSRV SASWHLQDKQ 
       460        470        480        490        500
GRQRDVVRQD RDGVTWAGEQ YRERLGTGGL RLLRSGSDTF SLELEGSQRT 
       510        520        530        540        550
DAGSYECRVA EWVPAPDGEW QLLGERSAQA NVDILALETG FAVTAITRTP 
       560        570        580        590        600
GVTYFDSFDL QCILKPHYPP WVGVSVTWRF QPAGGGDTHD LVTFSRSGGV 
       610        620        630        640        650
QWGERAGSFR GRSIVEKGDS THTVRLSVSR ASDSEAGKYQ CVAELWRRET 
       660        670        680        690        700
SGMWARLAER ASNLLEIRVQ RPVPRLQVTK VTRTLSVVEG SPVTLSCSIR 
       710        720        730        740        750
SQSGPDSRFA VLWLVQQPSG AEGKLIGRSD AGTEFGTYPE GALLKGRLQL 
       760        770        780        790        800
GVTAPGQYAL TLQGARTDDS GSYYCQVEEW AMDPNQAWYR LAEETSGLTE 
       810        820        830        840        850
IRVRPPDANL QLDQLPRNVS ALEGQSVTVT CHVLNRTLPD SRLSLEWLCW 
       860        870        880        890        900
RAGHMERRGL ARLTVDGVLG SVEEEPGDVA PGLPSRVQVS QPSLGLYALT 
       910        920        930        940        950
LRGTEVRDSG TYSCLVQEWL RDPRGQWYRR TEERSGATYV SVRQPDPQLQ 
       960        970        980        990       1000
LDPSLLNVSV MEGGHFDLDC MVSSRSRPDS QLAISWSLQG TSRGAEPETL 
      1010       1020       1030       1040       1050
LNVDRSGVWA PLAPRWEGRL QQLQLSPTLF RLHVPRVGPG DSGNYTCLVQ 
      1060       1070       1080       1090       1100
EWLLGPRGDW YLLAQDEAVI GWIRVQRKES NLQSTICAND ALFYLVFFYP 
      1110       1120       1130       1140       1150
FPIFGILIIT ILLVRFRHRP TGKPGEGKNG VPLLWIKEPH LNYSPTCLEP 
      1160 
PVLSIHPGTI D
Length:1,161
Mass (Da):128,475
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i997BCBB9C72875B0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC127336 mRNA Translation: AAI27337.1

NCBI Reference Sequences

More...RefSeqi		NP_001090681.1, NM_001097212.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100036654

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xtr:100036654

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127336 mRNA Translation: AAI27337.1
RefSeqiNP_001090681.1, NM_001097212.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiA0JPB1

Genome annotation databases

GeneIDi100036654
KEGGixtr:100036654

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3321
XenbaseiXB-GENE-18006038, igsf3

Phylogenomic databases

InParanoidiA0JPB1
OrthoDBi180654at2759

Family and domain databases

Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF07686, V-set, 4 hits
SMARTiView protein in SMART
SM00409, IG, 8 hits
SM00408, IGc2, 5 hits
SM00406, IGv, 7 hits
SUPFAMiSSF48726, SSF48726, 8 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGSF3_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JPB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 12, 2006
Last modified: December 2, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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