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Entry version 72 (07 Apr 2021)
Sequence version 1 (12 Dec 2006)
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Protein

Laminin subunit gamma-1

Gene

lamc1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-3000157, Laminin interactions
R-XTR-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-XTR-8874081, MET activates PTK2 signaling
R-XTR-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lamc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-478553, lamc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000036420220 – 1592Laminin subunit gamma-1Add BLAST1573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi269 ↔ 278PROSITE-ProRule annotation
Disulfide bondi271 ↔ 288PROSITE-ProRule annotation
Disulfide bondi290 ↔ 299PROSITE-ProRule annotation
Disulfide bondi302 ↔ 322PROSITE-ProRule annotation
Disulfide bondi325 ↔ 334PROSITE-ProRule annotation
Disulfide bondi327 ↔ 350PROSITE-ProRule annotation
Disulfide bondi353 ↔ 362PROSITE-ProRule annotation
Disulfide bondi365 ↔ 378PROSITE-ProRule annotation
Disulfide bondi381 ↔ 393PROSITE-ProRule annotation
Disulfide bondi383 ↔ 399PROSITE-ProRule annotation
Disulfide bondi401 ↔ 410PROSITE-ProRule annotation
Disulfide bondi413 ↔ 425PROSITE-ProRule annotation
Disulfide bondi428 ↔ 439PROSITE-ProRule annotation
Disulfide bondi430 ↔ 446PROSITE-ProRule annotation
Disulfide bondi448 ↔ 457PROSITE-ProRule annotation
Disulfide bondi460 ↔ 475PROSITE-ProRule annotation
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi707 ↔ 716PROSITE-ProRule annotation
Disulfide bondi709 ↔ 723PROSITE-ProRule annotation
Disulfide bondi725 ↔ 734PROSITE-ProRule annotation
Disulfide bondi737 ↔ 753PROSITE-ProRule annotation
Disulfide bondi756 ↔ 764PROSITE-ProRule annotation
Disulfide bondi758 ↔ 775PROSITE-ProRule annotation
Disulfide bondi778 ↔ 787PROSITE-ProRule annotation
Disulfide bondi790 ↔ 808PROSITE-ProRule annotation
Disulfide bondi811 ↔ 825PROSITE-ProRule annotation
Disulfide bondi813 ↔ 832PROSITE-ProRule annotation
Disulfide bondi835 ↔ 844PROSITE-ProRule annotation
Disulfide bondi847 ↔ 864PROSITE-ProRule annotation
Disulfide bondi867 ↔ 881PROSITE-ProRule annotation
Disulfide bondi869 ↔ 888PROSITE-ProRule annotation
Disulfide bondi890 ↔ 899PROSITE-ProRule annotation
Disulfide bondi902 ↔ 915PROSITE-ProRule annotation
Disulfide bondi918 ↔ 930PROSITE-ProRule annotation
Disulfide bondi920 ↔ 937PROSITE-ProRule annotation
Disulfide bondi939 ↔ 948PROSITE-ProRule annotation
Disulfide bondi951 ↔ 963PROSITE-ProRule annotation
Disulfide bondi966 ↔ 978PROSITE-ProRule annotation
Disulfide bondi968 ↔ 984PROSITE-ProRule annotation
Disulfide bondi986 ↔ 995PROSITE-ProRule annotation
Disulfide bondi998 ↔ 1011PROSITE-ProRule annotation
Glycosylationi1005N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1041N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1090N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1487N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0JP86

PRoteomics IDEntifications database

More...
PRIDEi
A0JP86

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000027398

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0JP86

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 268Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini269 – 324Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini325 – 380Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini381 – 427Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini428 – 477Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST50
Domaini504 – 672Laminin IV type APROSITE-ProRule annotationAdd BLAST169
Domaini707 – 755Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST49
Domaini756 – 810Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST55
Domaini811 – 866Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST56
Domaini867 – 917Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST51
Domaini918 – 965Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST48
Domaini966 – 1013Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1013 – 1592Domain II and IBy similarityAdd BLAST580

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1018 – 1477Sequence analysisAdd BLAST460
Coiled coili1515 – 1579Sequence analysisAdd BLAST65

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0JP86

Database of Orthologous Groups

More...
OrthoDBi
156553at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 11 hits
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 11 hits
SM00281, LamB, 1 hit
SM00136, LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 10 hits
PS50027, EGF_LAM_2, 10 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

A0JP86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPVLAVLA VLLLGTVRAA MDECYEEGSP QRCMPEFVNA AFNATVVATN
60 70 80 90 100
TCGTPPEEYC VQTGVTGVTK SCHICDSGQF HLQHGAEYLT DYNNQAEITW
110 120 130 140 150
WQSQTMLAGI QYPSTINLTL HLGKAFDITY VRLKFHTSRP ESFALYKRTH
160 170 180 190 200
EDGPWIPYQY YSGSCEKTYQ KFNRGFIRTG EDEQQALCTD EFSDISPLTG
210 220 230 240 250
GNVAFSTLEG RPSAYNFDNS PVLQEWVTAT DIRVTLNRLN TFGDEVFSDP
260 270 280 290 300
KVLKSYYYAI SDFAVGGRCK CNGHASECVR NEFEKIVCNC KHNTFGSDCE
310 320 330 340 350
KCLPFYNDRP WRRSTADSPN ECLPCNCNGR SQECYFDPEL YRSTGHGGHC
360 370 380 390 400
TGCADNTDGP NCERCRENYY RQDNNEPCHA CQCNPVGSLS TQCDNYGRCS
410 420 430 440 450
CKPGVMGEKC DRCQPGFHSL TEAGCRPCAC NPAGSTDECN VETGRCSCKD
460 470 480 490 500
NVEGFNCERC KPGFFHLDEA NPRGCTPCFC YGHSSVCSSA EGYRVSSIVS
510 520 530 540 550
TFESGVEGWT AQQRDGSEYS LSWVSDSSAV SVISESYFPI YFIAPAKFLG
560 570 580 590 600
NQGASYGQNL TFSFRVERRD TRLSAEDLVL EGAGLRVSVP LIAQGNSYPS
610 620 630 640 650
ETTQRYIFRM HEATDYPWRP SVSPFEFQKM LQNLTAIKIR GSYSERSAGF
660 670 680 690 700
LEEVSLVTAV AGAGPSAPWV EICSCPTGYI GQFCERCAPG YRRENPSQGP
710 720 730 740 750
YSPCVLCTCN GHSDTCDPES GVCDCQHNTA GPHCERCSEG YYGDSTTGSA
760 770 780 790 800
SDCQPCPCPG GSSCAVVPRT KEVVCTNCPL GTTGKRCELC DDGYFGDPLG
810 820 830 840 850
ENGAPRPCRI CECSNNIDPN AVGNCDRLTG ECLKCIYNTG GFYCDRCRDG
860 870 880 890 900
FYGNPLAQNP DLKCRACSCN PYGTVKGQSG CNQVTGQCEC LPHVTERDCS
910 920 930 940 950
ACEPGFYNLL SGRGCERCDC HSLGSTSGQC DVRTGQCECH PGISGQQCQQ
960 970 980 990 1000
CEPNHFGFGP EGCKPCDCDP EGSGSLQCKE DGRCECKSGF VGTRCDQCEE
1010 1020 1030 1040 1050
NYFYNRSGPG CQECPACYRL VKDKVNEQRG KLQELEDLLK NLSTGEENIT
1060 1070 1080 1090 1100
DQAFEERLRE AEKAVNDLLL DAQSSKDVDQ GMLDRLAEIN TTLSFQLERL
1110 1120 1130 1140 1150
QNIRDMIRDT DKQAQEARDR VENTEFIIDS ARVQLEKAKM AIANVSITPP
1160 1170 1180 1190 1200
ESTGDPNNMT LLAEEARKLA ERHMQEARDI EKAAKEANDT ANEALRLLQK
1210 1220 1230 1240 1250
TLASENQTAL DIEELNRKYA QAKDIARELE KQASKVHAEA EEAGNRALQI
1260 1270 1280 1290 1300
YANLTSVPSI DTTALQNEAD KIQKEAEELD SLIDRKLRDY EDLREDMRGR
1310 1320 1330 1340 1350
EMEVKNLLDK GKTEQQTADQ LLARADAAKA QAEEAAKKGR ETLQEANDIL
1360 1370 1380 1390 1400
NKLRDFDKRV NDNKTAAEAA LRKIPMIAQT IAEANNKTRQ AESALGNANA
1410 1420 1430 1440 1450
DARGAKSKAE EAEALANTVQ KKAATARAEA DNTFKEVTDL DGELQDMLQQ
1460 1470 1480 1490 1500
LQEAENQLKK KQAEAESDEK MAEMASNATK DAESNANNSK KSVNGVLATI
1510 1520 1530 1540 1550
DELLSRLGQL DSVDVGQLTV LEKTLDDAKN QLRDSDLDRK LAELQESSNL
1560 1570 1580 1590
QRVALDSYSR DIDQILRDIA NLEDIKNTLP AGCYNTPIIE KP
Length:1,592
Mass (Da):175,580
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i458E53775436C3CA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QKD9F6QKD9_XENTR
HECT-type E3 ubiquitin transferase
hectd1
2,531Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PRC4A0A6I8PRC4_XENTR
HECT-type E3 ubiquitin transferase
hectd1
2,580Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8QWK1A0A6I8QWK1_XENTR
HECT-type E3 ubiquitin transferase
hectd1
2,517Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8RQZ9A0A6I8RQZ9_XENTR
HECT-type E3 ubiquitin transferase
hectd1
2,526Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8SFW5A0A6I8SFW5_XENTR
HECT-type E3 ubiquitin transferase
hectd1
2,562Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8SL25A0A6I8SL25_XENTR
HECT-type E3 ubiquitin transferase
hectd1
2,529Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8SLK1A0A6I8SLK1_XENTR
HECT-type E3 ubiquitin transferase
hectd1
2,470Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V9U9F6V9U9_XENTR
Laminin subunit gamma-1
rfwd3 lamc1
1,580Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZRJ1F6ZRJ1_XENTR
Laminin subunit gamma-1
hectd1 lamc1
1,578Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8R0X1A0A6I8R0X1_XENTR
Laminin subunit gamma-1
lamc1
1,598Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC127297 mRNA Translation: AAI27298.1

NCBI Reference Sequences

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RefSeqi
NP_001090659.1, NM_001097190.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100036631

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
xtr:100036631

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127297 mRNA Translation: AAI27298.1
RefSeqiNP_001090659.1, NM_001097190.1

3D structure databases

SMRiA0JP86
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027398

Proteomic databases

PaxDbiA0JP86
PRIDEiA0JP86

Genome annotation databases

GeneIDi100036631
KEGGixtr:100036631

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3915
XenbaseiXB-GENE-478553, lamc1

Phylogenomic databases

eggNOGiKOG1836, Eukaryota
InParanoidiA0JP86
OrthoDBi156553at2759

Enzyme and pathway databases

ReactomeiR-XTR-3000157, Laminin interactions
R-XTR-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-XTR-8874081, MET activates PTK2 signaling
R-XTR-8957275, Post-translational protein phosphorylation

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
PfamiView protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 11 hits
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 11 hits
SM00281, LamB, 1 hit
SM00136, LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 10 hits
PS50027, EGF_LAM_2, 10 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC1_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JP86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 12, 2006
Last modified: April 7, 2021
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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