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Entry version 62 (12 Aug 2020)
Sequence version 1 (12 Dec 2006)
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Protein

CCR4-NOT transcription complex subunit 1

Gene

cnot1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-429947, Deadenylation of mRNA
R-XTR-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 1
Alternative name(s):
CCR4-associated factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cnot1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1032888, cnot1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003155441 – 2388CCR4-NOT transcription complex subunit 1Add BLAST2388

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0JP85

PRoteomics IDEntifications database

More...
PRIDEi
A0JP85

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CCR4-NOT complex.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000034721

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0JP85

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1076 – 1617Interaction with CCR4-NOT complex catalytic subunitsBy similarityAdd BLAST542

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi153 – 157LXXLL5
Motifi181 – 185LXXLL5
Motifi223 – 227LXXLL5
Motifi570 – 574LXXLL5
Motifi1651 – 1655LXXLL5
Motifi1954 – 1958LXXLL5
Motifi2108 – 2112LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1027 – 1033Poly-Thr7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNOT1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1831, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0JP85

KEGG Orthology (KO)

More...
KOi
K12604

Database of Orthologous Groups

More...
OrthoDBi
42530at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 1 hit
1.25.40.840, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007196, CCR4-Not_Not1_C
IPR024557, CCR4-Not_Not1su_DUF3819
IPR040398, CNOT1
IPR032191, CNOT1_CAF1_bind
IPR032194, CNOT1_HEAT
IPR032193, CNOT1_TTP_bind
IPR038535, CNOT1_TTP_bind_sf
IPR016021, MIF4-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13162, PTHR13162, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16415, CNOT1_CAF1_bind, 1 hit
PF16418, CNOT1_HEAT, 1 hit
PF16417, CNOT1_TTP_bind, 1 hit
PF12842, DUF3819, 1 hit
PF04054, Not1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

A0JP85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLDSLSLAL SQISYLVDNL TKKNYRASQL EIQHIVNRHG PEADRHLLRC
60 70 80 90 100
LFSHVDFSGD GKSSGKDFHQ TQFLIQECAS LITKPNFIST LSYAIDNPLH
110 120 130 140 150
YQKSLKPSPH LFAQLSKVLK LSKVQEVIFG LALLNSSSCE LRGFAAQFVK
160 170 180 190 200
QKLPDLLRSY VDVDVSGSQE GGFQDIAIEV LHLLLSNLLF GQKGAFGVGQ
210 220 230 240 250
EQIVAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL ADSGGITKTM
260 270 280 290 300
MDSSLADFMQ EVGYSFCASV EECRNVIVQF GVREVTAVQV ARVLGMMART
310 320 330 340 350
HSGLTDGIPL QSITSPGSGI WSDGKDKNDA VQPHTWNVEV LIDVVKELNP
360 370 380 390 400
TLNFKEVTYE LDNPSFQIRD SKGLQTVVYG IQRGLGIEAF PVDLVYRPWK
410 420 430 440 450
NAEGQLSFIQ HSLVNPDVFC FADYACHAVA TDILKAPPED DNREIATWKS
460 470 480 490 500
LDLIESLLRL AELGQYEQVK QLFAYPIKHC PDMLVLALLQ INTTWHTLRH
510 520 530 540 550
ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH AMAEWYMRGE
560 570 580 590 600
QYDQARLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW
610 620 630 640 650
LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT
660 670 680 690 700
MLACLQACAG SVSQELSETI LTMVANCSNV VNKARQPPPG VMPKGRPPST
710 720 730 740 750
SSLDAISPVQ IDPIAAMASL SIGGSAAPHT QSMPVFPPNL GSAFSTPQSP
760 770 780 790 800
AKAFPPLTAP NQSTAFSGLG GLTSQLPGGL GTGSLTGMGT GGLSLPTVNS
810 820 830 840 850
DPFGQRKLST SGLNQPTFQQ TDLSQVWPEA NQHFSKEIDD EANSYFQRIY
860 870 880 890 900
NQPPHPTMSV DEVLEMLQRF KDSNIKRERE VFNCMLRNLF EEYRFFPQYP
910 920 930 940 950
DKELHITACL FGGIIEKGLV TYMALGLALR YVLEALRKPY QSKMYFFGIA
960 970 980 990 1000
ALDRFKNRLK DYPQYCQHLA SISHFMQFPH HLQEYIEYGQ QSRDPPVKMQ
1010 1020 1030 1040 1050
GSITTPGSIA LSQAQTPAKP ASSSAVTTPT TTTPAKTITI TRPTGVSFKK
1060 1070 1080 1090 1100
DVPPSINTTN IDTLLVATDL AGQIVEPPEN VQEKIAFIFN NLSQSNMTQK
1110 1120 1130 1140 1150
VEELKETVKD DYMPWVSQYL VMKRVSIELN FHSLYSNFLD ALKHLEFNKM
1160 1170 1180 1190 1200
VLAETYRNIK VLLTSDKAAA NFSDRSLLKN LGHWLGMITL AKNKPILHTD
1210 1220 1230 1240 1250
LDLKSLLLEA YVKGQQELLY VVPFVAKVLE SSVRSVVFRP PNPWTMAIMN
1260 1270 1280 1290 1300
VLAELHQEHD LKLNLKFEIE VLCKNLVLDI NDLKPGTLLK DKDRLKSLDE
1310 1320 1330 1340 1350
QLSAPKKDVK QPEELPPMTS ASEYAIRTAG KLWASVEKQE SDAVFTATAT
1360 1370 1380 1390 1400
APPPSTTCTT TVPPQPQYSY HDIHVYSLAG LAPHITLNPT IPLFQAHPQL
1410 1420 1430 1440 1450
KQCVRQAIER AVQELVHPVV DRSIKIAMTT CEQIVRKDFA LDSEESRMRI
1460 1470 1480 1490 1500
AAHHMMRNLT AGMAMITCRE PLLMSIATNL KNSFATAMRA ASPQQREMME
1510 1520 1530 1540 1550
QAAAQLAQDN CELACCFIQK TAVEKAGPEM DKRPATEFEL RKHARQEGRR
1560 1570 1580 1590 1600
YCDPVVLTYQ AERMPEQIRL KVGGVDPKQL AVYEEFARNV PGFLPTNDLT
1610 1620 1630 1640 1650
QPTGFLAQPM KQQAWATDDV AQIYDKCITE LEQHLHAIPP ALSMNPQSQA
1660 1670 1680 1690 1700
LRSLLEAVAV ARNSRDAIAA LGLLQKAVEG LLDATSGADA DLLLRYRECH
1710 1720 1730 1740 1750
LLVLKALQDG RAYGSPWCNK QITRCLIECR DEYKYNVEAV ELLIRNHLVN
1760 1770 1780 1790 1800
MQQYDLHLAQ SMENGLNYMA VAFAMQLVKI LLVDERSVSH VTEAEFFHTI
1810 1820 1830 1840 1850
ETLMRINAHS RGNAPEGLPQ LMDVLRSNFD AMMERAHGGP NFMMHSGISQ
1860 1870 1880 1890 1900
ASEYDDPPGL REKAEYLLRE WVNLYHSAAA GRDSTKAFSA FVGQMHQQGI
1910 1920 1930 1940 1950
LKTDDLITRF FRLCTEMCVE ISYRAQAEQQ HNPAANPTMI RAKCYHNLDA
1960 1970 1980 1990 2000
FVRLIALLVK HSGEATNTVT KINLLNKVLG IVVGVLLQDH EVRQSEFQQL
2010 2020 2030 2040 2050
PYHRIFIMLL LELNAPEHVL ETINFQTLTA FCNTFHILRP TKAPGFVYAW
2060 2070 2080 2090 2100
LELISHRIFI ARMLAHTPQQ KGWPMYAQLL IDLFKYLAPF LRNVELTKPM
2110 2120 2130 2140 2150
QILYKGTLRV LLVLLHDFPE FLCDYHYGFC DVIPPNCIQL RNLILSAFPR
2160 2170 2180 2190 2200
NMRLPDPFTP NLKVDMLSEI NIAPRILTNF TGVMPPQFKK DLDSYLKTRS
2210 2220 2230 2240 2250
PVTFLSELRS NLQVSNEPGN RYNIQLINAL VLYVGTQAIA HIHNKGSTPS
2260 2270 2280 2290 2300
MSTITHSAHM DIFQNLAVDL DTEGRYLFLN AIANQLRYPN SHTHYFSCTM
2310 2320 2330 2340 2350
LYLFAEANTE AIQEQITRVL LERLIVNRPH PWGLLITFIE LIKNPAFKFW
2360 2370 2380
NHEFVHCAPE IEKLFQSVAQ CCMGQKQAQQ VMEGTGAS
Length:2,388
Mass (Da):268,153
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80A2D43D6BED5FF9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RAX8F6RAX8_XENTR
Alpha-T4 globin, Putative ortholog ...
hba4 LOC100486033
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TMQ7F6TMQ7_XENTR
Mitogen-activated protein kinase 2-...
cnot1 mapkap1
522Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q38IW0Q38IW0_XENTR
Alpha globin larval-6
hba2 HBA-L6, hba4
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7EHU9F7EHU9_XENTR
Target of rapamycin complex 2 subun...
mapkap1
446Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7AAE2F7AAE2_XENTR
CCR4-NOT transcription complex subu...
cnot1 hspb2
2,318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZND7F6ZND7_XENTR
CCR4-NOT transcription complex subu...
pih1d2 cnot1
2,371Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YMR9F6YMR9_XENTR
Alpha-T4 globin, Putative ortholog ...
hba4 cnot1
2,388Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ABD0F7ABD0_XENTR
CCR4-NOT transcription complex subu...
cnot1
2,304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TND7F6TND7_XENTR
CCR4-NOT transcription complex subu...
cnot1 LOC100490911
381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8QUU6A0A6I8QUU6_XENTR
CCR4-NOT transcription complex subu...
cnot1
2,306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC127296 mRNA Translation: AAI27297.1

NCBI Reference Sequences

More...
RefSeqi
NP_001090658.1, NM_001097189.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100036630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100036630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127296 mRNA Translation: AAI27297.1
RefSeqiNP_001090658.1, NM_001097189.1

3D structure databases

SMRiA0JP85
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000034721

Proteomic databases

PaxDbiA0JP85
PRIDEiA0JP85

Genome annotation databases

GeneIDi100036630
KEGGixtr:100036630

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23019
XenbaseiXB-GENE-1032888, cnot1

Phylogenomic databases

eggNOGiKOG1831, Eukaryota
InParanoidiA0JP85
KOiK12604
OrthoDBi42530at2759

Enzyme and pathway databases

ReactomeiR-XTR-429947, Deadenylation of mRNA
R-XTR-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Family and domain databases

Gene3Di1.25.40.180, 1 hit
1.25.40.840, 1 hit
InterProiView protein in InterPro
IPR007196, CCR4-Not_Not1_C
IPR024557, CCR4-Not_Not1su_DUF3819
IPR040398, CNOT1
IPR032191, CNOT1_CAF1_bind
IPR032194, CNOT1_HEAT
IPR032193, CNOT1_TTP_bind
IPR038535, CNOT1_TTP_bind_sf
IPR016021, MIF4-like_sf
PANTHERiPTHR13162, PTHR13162, 1 hit
PfamiView protein in Pfam
PF16415, CNOT1_CAF1_bind, 1 hit
PF16418, CNOT1_HEAT, 1 hit
PF16417, CNOT1_TTP_bind, 1 hit
PF12842, DUF3819, 1 hit
PF04054, Not1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNOT1_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JP85
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: August 12, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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