Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

EF-hand calcium-binding domain-containing protein 5

Gene

Efcab5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi786 – 797PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 5
Gene namesi
Name:Efcab5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442440 Efcab5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158371 – 1406EF-hand calcium-binding domain-containing protein 5Add BLAST1406

Proteomic databases

PaxDbiA0JP43
PRIDEiA0JP43

PTM databases

iPTMnetiA0JP43
PhosphoSitePlusiA0JP43

Expressioni

Gene expression databases

BgeeiENSMUSG00000050944
CleanExiMM_EFCAB5
ExpressionAtlasiA0JP43 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini773 – 808EF-handPROSITE-ProRule annotationAdd BLAST36

Phylogenomic databases

eggNOGiENOG410IECF Eukaryota
ENOG410YZ07 LUCA
GeneTreeiENSGT00390000009150
HOGENOMiHOG000112338
HOVERGENiHBG107836
InParanoidiA0JP43
OMAiQDAEAHG
OrthoDBiEOG091G047D
PhylomeDBiA0JP43
TreeFamiTF329659

Family and domain databases

Gene3Di3.30.450.40, 1 hit
InterProiView protein in InterPro
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR029016 GAF-like_dom_sf
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0JP43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLMQVEKKKL LSQADIPTKF DPINYLGEYL MRHNTHYIKD PGVSGYQRVM
60 70 80 90 100
KEITEELKTH VPDTINNRIS KMKEKVKEKR EQREYISTVK VKVAGMRKQA
110 120 130 140 150
LEEQFNEWVL NPKGMIPIVV YISSYITDLK SEVFEEFLKH LCHSAEEFRE
160 170 180 190 200
IILTDMRRQM FAELFLQCDS GKVMALDRQR TLALLEAFYD QCSSTTRSLL
210 220 230 240 250
RNPRQWPFVE FEEIELIEFW GDMDIKKHIY EDFDALLLKM NMLVAEKLAG
260 270 280 290 300
KLAENKDLPQ QQRDQELSSD STTEPETATQ LTSQQRSRRV SLTGQGQGKG
310 320 330 340 350
PRKTSASKQG ASRGSVAEQG SRRSSGVNQT QQRGSVAEQG SRRSSAVEQT
360 370 380 390 400
QQRGSVAEQG SRRSSTVEQT RQRGSVAEQG SRRSSTVEQT QRRGSVAEQG
410 420 430 440 450
SRRSSGVNQT QQRGSVAEQG SRRSSAVEQT QQRGSVAEQG SRRSSAMEQE
460 470 480 490 500
PQTAQDPNSD SLPEQESHRG SITEGSHRGS ISEPGQRRAS VTGQRRKSSV
510 520 530 540 550
DDSGSAGSRR GSGTDQGQHR GSVGQRKGSG ERKMSASEYG PHQESITEEP
560 570 580 590 600
LTASEPGPQI DTIQELDEDS TPQLEDDSAL KESKTSELTK IETQEEKPLL
610 620 630 640 650
LINEEQVPRD SKQPEVPTSS KKERPSGSPK KGRLSGTSKR DSQKDKACEP
660 670 680 690 700
KPQHVEGKKW SGEFLICDWK IKHVKSEEEE QAKLICDDTR FTDLHATIRN
710 720 730 740 750
FQTYKGIKGR SAFNGVSLDL LQFVQLLETF VGEDTSFSLS KDLASFFQKN
760 770 780 790 800
YSETKQEKIK ALEQARQNSS RIRRRILLQA IFEKWDNDGS GFLDLNEVDD
810 820 830 840 850
LLYTYKEGME RESMKKAKLH INFPEPSPGH EVKLSSKQFQ RYIELVVSEL
860 870 880 890 900
RGNEDEVLES VVEFLMGSLE RSHVEGLRNC ARRKWLHQIQ YAAETSGVSL
910 920 930 940 950
EPVYTETFRV LTQDAEAHGN KKISAHISLL EENVFLPERG HVLLRNVACT
960 970 980 990 1000
LDDAPFVLNK VLYRDMKGIS FTVVDEGKPI HVPQVQHHGN IFFWNSFRSK
1010 1020 1030 1040 1050
NEYNGSFLAL PLQDAYMRIF GVLAVDTLRD PHEINIFLPH EIKFYQGVAN
1060 1070 1080 1090 1100
AFSTAYHHVH SREHVLHSVM TGIRWLFSVT SGITTITTCF IEPSSEQEDY
1110 1120 1130 1140 1150
VLRNMMVTDC LGLAEIHTDP PTITRNACIF RDFLFKCTDT SEVILASSGG
1160 1170 1180 1190 1200
ETHIAIPLRQ RTKEAMGILD VNIGRSRMLL YQEYKDLQKM VKMIQNVSYE
1210 1220 1230 1240 1250
ILGEFSGEIE KTMVIEMESA GEVKRAGILF FRTMLQELQE CLCLLDSMDF
1260 1270 1280 1290 1300
VSLLLYEHKY HVDSILQDIT LQEVEANVAL VHDVLKGVIL FSQREKDSLS
1310 1320 1330 1340 1350
DLEEWEKWKF HINKYLVEEI CVLDPTASNV EVNVELVTSY IQAHSRTEVW
1360 1370 1380 1390 1400
NFRNIVIELL YHWINICLTL IELNMRQDVS IIPPLPKKSA TSIYAISSER

SIREKL
Length:1,406
Mass (Da):159,935
Last modified:January 15, 2008 - v2
Checksum:i65D68CDFAB564246
GO
Isoform 2 (identifier: A0JP43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1098-1118: EDYVLRNMMVTDCLGLAEIHT → LILGLKSGISGTLSLNSCITG
     1119-1406: Missing.

Note: No experimental confirmation available.
Show »
Length:1,118
Mass (Da):126,282
Checksum:i36C59698EAF11A47
GO
Isoform 3 (identifier: A0JP43-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1311-1406: HINKYLVEEI...SSERSIREKL → VSLGVISSGQ...DLPVWGCVCW

Note: No experimental confirmation available.
Show »
Length:1,402
Mass (Da):158,881
Checksum:i69E57A35A2E3A2AB
GO

Sequence cautioni

The sequence BAC26618 differs from that shown. Reason: Frameshift at position 1384.Curated
The sequence BAC29157 differs from that shown. Reason: Frameshift at position 439.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0307361098 – 1118EDYVL…AEIHT → LILGLKSGISGTLSLNSCIT G in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0307371119 – 1406Missing in isoform 2. 1 PublicationAdd BLAST288
Alternative sequenceiVSP_0307381311 – 1406HINKY…IREKL → VSLGVISSGQILTVELAGVR MQESAASKEHPRNPHPSSQV CMRINILKAHLLSFLMTPSD PKPYSPKLSVIPTSDPRDMT VEDLPVWGCVCW in isoform 3. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603842, AL663066, BX321897 Genomic DNA Translation: CAI35066.3
BX321897, AL603842, AL663066 Genomic DNA Translation: CAI35095.3
AL603842, AL663066 Genomic DNA Translation: CAQ12685.1
AL663066, AL603842, BX321897 Genomic DNA Translation: CAI35938.3
AL663066, AL603842 Genomic DNA Translation: CAQ11539.1
DT929470 mRNA No translation available.
AK029790 mRNA Translation: BAC26618.1 Frameshift.
AK035698 mRNA Translation: BAC29157.1 Frameshift.
BC127154 mRNA No translation available.
CCDSiCCDS36232.1 [A0JP43-1]
RefSeqiNP_795939.2, NM_176965.3 [A0JP43-1]
UniGeneiMm.108786

Genome annotation databases

EnsembliENSMUST00000108400; ENSMUSP00000104037; ENSMUSG00000050944 [A0JP43-1]
GeneIDi319634
KEGGimmu:319634
UCSCiuc007kgj.1 mouse [A0JP43-1]
uc007kgk.1 mouse [A0JP43-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEFCB5_MOUSE
AccessioniPrimary (citable) accession number: A0JP43
Secondary accession number(s): B0QZJ9
, Q5NC53, Q8CBN1, Q8CDP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health