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Protein
Submitted name:

PLEKHA5 protein

Gene

PLEKHA5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
PLEKHA5 proteinImported
Submitted name:
Pleckstrin homology domain-containing family A member 5Imported
Gene namesi
Name:PLEKHA5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000052126.14
HGNCiHGNC:30036 PLEKHA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000052126

Expressioni

Gene expression databases

BgeeiENSG00000052126 Expressed in 227 organ(s), highest expression level in female reproductive system

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 26PHInterPro annotationAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili64 – 84Sequence analysisAdd BLAST21
Coiled coili407 – 427Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000063012
HOVERGENiHBG053615

Family and domain databases

InterProiView protein in InterPro
IPR001849 PH_domain
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0JP02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTYYFCTDT GKEMELWMKA MLDAALVQTE PVKRVDKITS ENAPTKETNN
60 70 80 90 100
IPNHRVLIKP EIQNNQKNKE MSKIEEKKAL EAEKYGFQKD GQDRPLTKIN
110 120 130 140 150
SVKLNSLPSE YESGSACPAQ TVHYRPINLS SSENKIVNVS LADLRGGNRP
160 170 180 190 200
NTGPLYTEAD RVIQRTNSMQ QLEQWIKIQK GRGHEEETRG VISYQTLPRN
210 220 230 240 250
MPSHRAQIMA RYPEGYRTLP RNSKTRPESI CSVTPSTHDK TLGPGAEEKR
260 270 280 290 300
RSMRDDTMWQ LYEWQQRQFY NKQSTLPRHS TLSSPKTMVN ISDQTMHSIP
310 320 330 340 350
TSPSHGSIAA YQGYSPQRTY RSEVSSPIQR GDVTIDRRHR AHHPKHVYVP
360 370 380 390 400
DRRSVPAGLT LQSVSPQSLQ GKTLSQDEGR GTLYKYRPEE VDIDAKLSRL
410 420 430 440 450
CEQDKVVHAL EEKLQQLHKE KYTLEQALLS ASQEIEMHAD NPAAIQTVVL
460 470 480 490 500
QRDDLQNGLL STCRELSRAT AELERAWREY DKLEYDVTVT RNQMQEQLDH
510 520 530 540 550
LGEVQTESAG IQRAQIQKEL WRIQDVMEGL SKHKQQRGTT EIGMIGSKPF
560 570 580 590 600
STVKYKNEGP DYRLYKSEPE LTTVAEVDES NGEEKSEPVS EIETSVVKGS
610 620 630 640 650
HFPVGVVPPR AKSPTPESST IASYVTLRKT KKMMDLRTER PRSAVEQLCL
660 670 680 690 700
AESTRPRMTV EEQMERIRRH QQACLREKKK GLNVIGASDQ SPLQSPSNLR
710 720 730 740 750
DNPFRTTQTR RRDDKELDTA IRENDVKPDH ETPATEIVQL KETEPQNVDF
760 770 780 790 800
SKELKKTENI SYEMLFEPEP NGVNSVEMMD KERNKDKMPE DVTFSPQDET
810 820 830 840 850
QTANHKPEEH PEENTKNSVD EQEETVISYE STPEVSRGNQ TMAVKSLSPS
860 870
PESSASPVPS TQPQLTEGSH FMCV
Length:874
Mass (Da):99,694
Last modified:December 12, 2006 - v1
Checksum:i560BB9EACB2EDBE9
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9HAU0PKHA5_HUMAN
Pleckstrin homology domain-containi...
PLEKHA5 KIAA1686, PEPP2
1,116Annotation score:
B4DJX4B4DJX4_HUMAN
cDNA FLJ59284, highly similar to Pl...
PLEKHA5
977Annotation score:
F5H1X3F5H1X3_HUMAN
Pleckstrin homology domain-containi...
PLEKHA5
118Annotation score:
H0YG48H0YG48_HUMAN
Pleckstrin homology domain-containi...
PLEKHA5
135Annotation score:
H0YGJ6H0YGJ6_HUMAN
Pleckstrin homology domain-containi...
PLEKHA5
397Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024902 Genomic DNA No translation available.
AC087314 Genomic DNA No translation available.
AC091805 Genomic DNA No translation available.
AC092828 Genomic DNA No translation available.
BC127091 mRNA Translation: AAI27092.1
UniGeneiHs.188614

Genome annotation databases

EnsembliENST00000539256; ENSP00000440611; ENSG00000052126
UCSCiuc009zin.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024902 Genomic DNA No translation available.
AC087314 Genomic DNA No translation available.
AC091805 Genomic DNA No translation available.
AC092828 Genomic DNA No translation available.
BC127091 mRNA Translation: AAI27092.1
UniGeneiHs.188614

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539256; ENSP00000440611; ENSG00000052126
UCSCiuc009zin.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000052126.14
HGNCiHGNC:30036 PLEKHA5
OpenTargetsiENSG00000052126
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063012
HOVERGENiHBG053615

Miscellaneous databases

ChiTaRSiPLEKHA5 human

Gene expression databases

BgeeiENSG00000052126 Expressed in 227 organ(s), highest expression level in female reproductive system

Family and domain databases

InterProiView protein in InterPro
IPR001849 PH_domain
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0JP02_HUMAN
AccessioniPrimary (citable) accession number: A0JP02
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: October 10, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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