UniProtKB - A0JNU3 (LPP60_MOUSE)
Protein
60 kDa lysophospholipase
Gene
Aspg
Organism
Mus musculus (Mouse)
Status
Functioni
Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.
Catalytic activityi
- EC:3.1.1.5
- EC:3.5.1.1
- 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+EC:3.1.1.47
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 19 | Acyl-ester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: MGI
- asparaginase activity Source: MGI
- lysophospholipase activity Source: MGI
GO - Biological processi
- asparagine metabolic process Source: MGI
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: MGI
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 3.1.1.47 3474 |
Reactomei | R-MMU-70614 Amino acid synthesis and interconversion (transamination) |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Aspg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2144822 Aspg |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324164 | 1 – 564 | 60 kDa lysophospholipaseAdd BLAST | 564 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 478 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | A0JNU3 |
MaxQBi | A0JNU3 |
PaxDbi | A0JNU3 |
PRIDEi | A0JNU3 |
PTM databases
iPTMneti | A0JNU3 |
PhosphoSitePlusi | A0JNU3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037686 Expressed in 93 organ(s), highest expression level in liver |
ExpressionAtlasi | A0JNU3 baseline and differential |
Genevisiblei | A0JNU3 MM |
Interactioni
Subunit structurei
Monomer.By similarity
Protein-protein interaction databases
BioGridi | 222710, 1 interactor |
STRINGi | 10090.ENSMUSP00000078369 |
Structurei
3D structure databases
ProteinModelPortali | A0JNU3 |
SMRi | A0JNU3 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 355 | Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST | 347 | |
Repeati | 141 – 170 | ANK 1Add BLAST | 30 | |
Repeati | 396 – 426 | ANK 2Add BLAST | 31 | |
Repeati | 430 – 459 | ANK 3Add BLAST | 30 | |
Repeati | 463 – 492 | ANK 4Add BLAST | 30 | |
Repeati | 530 – 559 | ANK 5Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 350 | AsparaginaseAdd BLAST | 310 | |
Regioni | 84 – 86 | Substrate bindingBy similarity | 3 | |
Regioni | 116 – 117 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
In the N-terminal section; belongs to the asparaginase 1 family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0503 Eukaryota COG0252 LUCA |
GeneTreei | ENSGT00390000001610 |
HOGENOMi | HOG000227974 |
HOVERGENi | HBG079531 |
InParanoidi | A0JNU3 |
KOi | K13278 |
OMAi | LAKQDPC |
OrthoDBi | 886725at2759 |
PhylomeDBi | A0JNU3 |
TreeFami | TF315247 |
Family and domain databases
CDDi | cd00204 ANK, 1 hit |
Gene3Di | 1.25.40.20, 2 hits 3.40.50.1170, 1 hit 3.40.50.40, 1 hit |
InterProi | View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR006033 AsnASEI IPR036152 Asp/glu_Ase-like_sf IPR006034 Asparaginase/glutaminase-like IPR027475 Asparaginase/glutaminase_AS2 IPR027473 L-asparaginase_C IPR027474 L-asparaginase_N IPR037152 L-asparaginase_N_sf |
Pfami | View protein in Pfam PF00710 Asparaginase, 1 hit |
PRINTSi | PR00139 ASNGLNASE |
SMARTi | View protein in SMART SM00248 ANK, 4 hits SM00870 Asparaginase, 1 hit |
SUPFAMi | SSF48403 SSF48403, 1 hit SSF53774 SSF53774, 1 hit |
TIGRFAMsi | TIGR00519 asnASE_I, 1 hit |
PROSITEi | View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS00917 ASN_GLN_ASE_2, 1 hit PS51732 ASN_GLN_ASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A0JNU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARAMGPERR LLAIYTGGTI GMRSEGGVLV PGRGLAAVLK TLHMFHDEEY
60 70 80 90 100
AQAHSLPEDT LVLPPASPDQ RIIYTVLECQ PLFDSSDMTI TEWVQIAQTI
110 120 130 140 150
ERHYAQYQGF VVIHGTDTMA FAASVLSFML ENLQKPVVLT GAQVPIHALW
160 170 180 190 200
SDGRENLLGA LLMAGQYVIP EVCLFFQNQL FRGNRTTKVD ARRFAAFCSP
210 220 230 240 250
NLPPLATVGA DVTINRELVR KACGKSHLVV HSSMEPDVGL LRLYPGIPAS
260 270 280 290 300
LVRTFLQPPL KGVVMETFGS GNGPTKPDLL QELRVAAEQG LIIVNCTHCL
310 320 330 340 350
QGAVTSDYAS GMAMAGAGIV SGFDMTSEAA LAKLSYVLGQ PGLSLNDRKK
360 370 380 390 400
LLAKDLRGEM TLPATDVLLQ DGMLGCRVAW LLSMNGSQEA DTMKDVLLPG
410 420 430 440 450
LALAAAHAGD LDTLQAFVEL DRDLNLKDYS GQTPLHVAAR RGHAAVVTML
460 470 480 490 500
LQRGADVDAR NEDGQSPLLL AVRGRHQSVI GLLRAAGARL SPQELEDVGT
510 520 530 540 550
ELCRLASRGD SEGLRAWWQA GADLGQPDYD GHCALQVAEA AGNADVVALL
560
QSFKDSVCAQ PQPH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VIV3 | A0A1Y7VIV3_MOUSE | 60 kDa lysophospholipase | Aspg | 179 | Annotation score: | ||
A0A1Y7VLT0 | A0A1Y7VLT0_MOUSE | 60 kDa lysophospholipase | Aspg | 68 | Annotation score: | ||
A0A1Y7VK88 | A0A1Y7VK88_MOUSE | 60 kDa lysophospholipase | Aspg | 156 | Annotation score: | ||
A0A1Y7VK61 | A0A1Y7VK61_MOUSE | 60 kDa lysophospholipase | Aspg | 103 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126962 mRNA Translation: AAI26963.1 |
CCDSi | CCDS36567.1 |
RefSeqi | NP_001074638.1, NM_001081169.1 |
UniGenei | Mm.77133 |
Genome annotation databases
Ensembli | ENSMUST00000079400; ENSMUSP00000078369; ENSMUSG00000037686 |
GeneIDi | 104816 |
KEGGi | mmu:104816 |
UCSCi | uc007pek.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126962 mRNA Translation: AAI26963.1 |
CCDSi | CCDS36567.1 |
RefSeqi | NP_001074638.1, NM_001081169.1 |
UniGenei | Mm.77133 |
3D structure databases
ProteinModelPortali | A0JNU3 |
SMRi | A0JNU3 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 222710, 1 interactor |
STRINGi | 10090.ENSMUSP00000078369 |
PTM databases
iPTMneti | A0JNU3 |
PhosphoSitePlusi | A0JNU3 |
Proteomic databases
jPOSTi | A0JNU3 |
MaxQBi | A0JNU3 |
PaxDbi | A0JNU3 |
PRIDEi | A0JNU3 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000079400; ENSMUSP00000078369; ENSMUSG00000037686 |
GeneIDi | 104816 |
KEGGi | mmu:104816 |
UCSCi | uc007pek.1 mouse |
Organism-specific databases
CTDi | 374569 |
MGIi | MGI:2144822 Aspg |
Phylogenomic databases
eggNOGi | KOG0503 Eukaryota COG0252 LUCA |
GeneTreei | ENSGT00390000001610 |
HOGENOMi | HOG000227974 |
HOVERGENi | HBG079531 |
InParanoidi | A0JNU3 |
KOi | K13278 |
OMAi | LAKQDPC |
OrthoDBi | 886725at2759 |
PhylomeDBi | A0JNU3 |
TreeFami | TF315247 |
Enzyme and pathway databases
BRENDAi | 3.1.1.47 3474 |
Reactomei | R-MMU-70614 Amino acid synthesis and interconversion (transamination) |
Miscellaneous databases
ChiTaRSi | Aspg mouse |
PROi | PR:A0JNU3 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037686 Expressed in 93 organ(s), highest expression level in liver |
ExpressionAtlasi | A0JNU3 baseline and differential |
Genevisiblei | A0JNU3 MM |
Family and domain databases
CDDi | cd00204 ANK, 1 hit |
Gene3Di | 1.25.40.20, 2 hits 3.40.50.1170, 1 hit 3.40.50.40, 1 hit |
InterProi | View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR006033 AsnASEI IPR036152 Asp/glu_Ase-like_sf IPR006034 Asparaginase/glutaminase-like IPR027475 Asparaginase/glutaminase_AS2 IPR027473 L-asparaginase_C IPR027474 L-asparaginase_N IPR037152 L-asparaginase_N_sf |
Pfami | View protein in Pfam PF00710 Asparaginase, 1 hit |
PRINTSi | PR00139 ASNGLNASE |
SMARTi | View protein in SMART SM00248 ANK, 4 hits SM00870 Asparaginase, 1 hit |
SUPFAMi | SSF48403 SSF48403, 1 hit SSF53774 SSF53774, 1 hit |
TIGRFAMsi | TIGR00519 asnASE_I, 1 hit |
PROSITEi | View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS00917 ASN_GLN_ASE_2, 1 hit PS51732 ASN_GLN_ASE_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | LPP60_MOUSE | |
Accessioni | A0JNU3Primary (citable) accession number: A0JNU3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 13, 2019 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot