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UniProtKB - A0JNT0 (A0JNT0_MOUSE)

Entry version 86 (19 Jan 2022)
Sequence version 1 (12 Dec 2006)
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Protein
Submitted name:

Invs protein

Gene

Invs

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Invs proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:InvsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1335082, Invs

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A0JNT0, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 88ANKPROSITE-ProRule annotationAdd BLAST21
Repeati102 – 134ANKPROSITE-ProRule annotationAdd BLAST33
Repeati136 – 168ANKPROSITE-ProRule annotationAdd BLAST33
Repeati204 – 236ANKPROSITE-ProRule annotationAdd BLAST33
Repeati237 – 269ANKPROSITE-ProRule annotationAdd BLAST33
Repeati270 – 302ANKPROSITE-ProRule annotationAdd BLAST33
Repeati303 – 335ANKPROSITE-ProRule annotationAdd BLAST33
Repeati336 – 368ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni437 – 697DisorderedSequence analysisAdd BLAST261
Regioni890 – 910DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi437 – 462Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi483 – 508Polar residuesSequence analysisAdd BLAST26
Compositional biasi525 – 539Polar residuesSequence analysisAdd BLAST15
Compositional biasi572 – 591Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi624 – 652Basic and acidic residuesSequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		316949at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR000048, IQ_motif_EF-hand-BS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 4 hits
PF00612, IQ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 11 hits
SM00015, IQ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50088, ANK_REPEAT, 8 hits
PS50096, IQ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0JNT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLLTRRAN WMQKDLEEMT PLHLSTRHRS PKCLALLLKF MAPGEVDTQD 
        60         70         80         90        100
KNKDAAPTES LLNWQDYEGR TPLHFAVADG NLTVVDVLTS YESCNITSYD 
       110        120        130        140        150
NLFRTPLHWA ALLGHAQIVH LLLERNKSGT IPSDSQGATP LHYAAQSNFA 
       160        170        180        190        200
ETVKVFLQHP SVKDDSDLEG RTSFMWAAGK GNDDVLRTML SLKSDIDINM 
       210        220        230        240        250
SDKYGGTALH AAALSGHVST VKLLLDNDAQ VDATDVMKHT PLFRACEMGH 
       260        270        280        290        300
RDVIQTLIKG GARVDLVDQD GHSLLHWAAL GGNADVCQIL IENKINPNVQ 
       310        320        330        340        350
DYAGRTPLQC AAYGGYINCM AVLMENNADP NIQDKEGRTA LHWSCNNGYL 
       360        370        380        390        400
DAIKLLLDFA AFPNQMENNE ERYTPLDYAL LGERHEVIQF MLEHGALSIA 
       410        420        430        440        450
AIQDIAAFKI QAVYKGYKVR KAFRDRKNLL MKHEQLRKDA AAKKREEENK 
       460        470        480        490        500
RKEAEQQKGQ LDTDPPRSHC SSSAPVLPCP PSPQNEASKQ DATPSKQPPA 
       510        520        530        540        550
SHTVQSPDPE HSRPPGRCPG RASQGDSSID LQGTASRKPS ETPIEHCRGP 
       560        570        580        590        600
SACVHPRSWE GGNSSKNQGT SSVEKRRGET NGKHRRCEEG PSSARQPLCT 
       610        620        630        640        650
GSGRPAEKGE DSSPAVASAS QQDHPRKPNK RQDRAARPRG ASQKRRTHQL 
       660        670        680        690        700
RDRCSPAGSS RPGSAKGEVA CADQSSLHRH TPRSKVTQDK LIGGVSSGLP 
       710        720        730        740        750
LSTEASRSGC KQLYEDICAS PETGVAHGPP PGQCMNIHLL PVEQRLLIIQ 
       760        770        780        790        800
RERSRKELFR RKNKAAAVIQ RAWRSYQLRK HLSRLLHLKQ LGAREVLRCT 
       810        820        830        840        850
QVCTALLLQV WRKELELKFP KSISVSRTSK SPSKGSSATK YARHSVLRQI 
       860        870        880        890        900
YGCSQEGKGH HPIKSSKAPA VLHLSSVNSL QSIHLDNSGR SKKFSYNLQP 
       910
SSQSKNKPKL
Length:910
Mass (Da):100,513
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8084F390D54DE426
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC126929 mRNA Translation: AAI26930.1

NCBI Reference Sequences

More...RefSeqi		NP_001268906.1, NM_001281977.1
NP_001268907.1, NM_001281978.1
NP_034699.3, NM_010569.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:16348

UCSC genome browser

More...UCSCi		uc008svb.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126929 mRNA Translation: AAI26930.1
RefSeqiNP_001268906.1, NM_001281977.1
NP_001268907.1, NM_001281978.1
NP_034699.3, NM_010569.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiA0JNT0, 1 interactor

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		16348

Genome annotation databases

GeneIDi16348
KEGGimmu:16348
UCSCiuc008svb.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27130
MGIiMGI:1335082, Invs

Phylogenomic databases

OrthoDBi316949at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		16348, 0 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Invs, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR000048, IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 4 hits
PF00612, IQ, 2 hits
SMARTiView protein in SMART
SM00248, ANK, 11 hits
SM00015, IQ, 2 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 8 hits
PS50096, IQ, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0JNT0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JNT0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: January 19, 2022
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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