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UniProtKB - A0JNI4 (SRR_BOVIN)
Protein
Serine racemase
Gene
SRR
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).
By similarityCatalytic activityi
Cofactori
pyridoxal 5'-phosphateBy similarity
Activity regulationi
Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 51 | ATPBy similarity | 1 | |
Active sitei | 56 | Proton acceptorBy similarity | 1 | |
Active sitei | 84 | Proton acceptorBy similarity | 1 | |
Binding sitei | 121 | ATPBy similarity | 1 | |
Binding sitei | 135 | SubstrateBy similarity | 1 | |
Metal bindingi | 210 | MagnesiumBy similarity | 1 | |
Metal bindingi | 214 | Magnesium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 216 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- calcium ion binding Source: Ensembl
- D-serine ammonia-lyase activity Source: UniProtKB-EC
- glycine binding Source: Ensembl
- L-serine ammonia-lyase activity Source: GO_Central
- magnesium ion binding Source: UniProtKB
- PDZ domain binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- pyridoxal phosphate binding Source: UniProtKB
- serine racemase activity Source: UniProtKB
- threonine racemase activity Source: GO_Central
GO - Biological processi
- D-serine biosynthetic process Source: GO_Central
- D-serine metabolic process Source: UniProtKB
- L-serine metabolic process Source: UniProtKB
- pyruvate biosynthetic process Source: GO_Central
- response to lipopolysaccharide Source: Ensembl
Keywordsi
Molecular function | Allosteric enzyme, Isomerase, Lyase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyridoxal phosphate |
Enzyme and pathway databases
Reactomei | R-BTA-977347, Serine biosynthesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SRR |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000004223 |
VGNCi | VGNC:35292, SRR |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286172 | 1 – 334 | Serine racemaseAdd BLAST | 334 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 56 | N6-(pyridoxal phosphate)lysineBy similarity | 1 | |
Modified residuei | 113 | S-nitrosocysteineBy similarity | 1 |
Post-translational modificationi
S-nitrosylated, leading to decrease the enzyme activity.By similarity
Keywords - PTMi
S-nitrosylationProteomic databases
PaxDbi | A0JNI4 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000004223, Expressed in testis and 96 other tissues |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- PDZ domain binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000005532 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 238 – 239 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the serine/threonine dehydratase family.Curated
Phylogenomic databases
eggNOGi | KOG1251, Eukaryota |
GeneTreei | ENSGT00550000075026 |
HOGENOMi | CLU_021152_4_2_1 |
InParanoidi | A0JNI4 |
OMAi | LIHPFDH |
OrthoDBi | 943371at2759 |
TreeFami | TF313346 |
Family and domain databases
Gene3Di | 3.40.50.1100, 2 hits |
InterProi | View protein in InterPro IPR001926, PLP-dep IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS IPR036052, Trypto_synt_PLP_dependent |
Pfami | View protein in Pfam PF00291, PALP, 1 hit |
SUPFAMi | SSF53686, SSF53686, 1 hit |
PROSITEi | View protein in PROSITE PS00165, DEHYDRATASE_SER_THR, 1 hit |
i Sequence
Sequence statusi: Complete.
A0JNI4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDQYCISFA DVEKAHINIR DFIHLTPVLT SSILNQITGR NLFFKCELFQ
60 70 80 90 100
KTGSFKIRGA LNAIRGLISA HPEEKPRAVV AHSSGNHGQA LSFAARLEGI
110 120 130 140 150
PAYVIVPETA PNCKKLAIQA YGASIVYSEQ SEESRENITK RIAEETEGIM
160 170 180 190 200
VHPNQEPAVI AGQGTIAMEV LNQVPLVDAL VVPVGGGGML AGIAVTVKAL
210 220 230 240 250
RPSVKVYAAE PLNADDCYQS KLKGELTPNP YPPETIADGI KSSIGLNTWP
260 270 280 290 300
IIRDLVDDVF TVTEDEIKYA TQLVWERMKL LIEPTAGVGV AVVLSQHFRT
310 320 330
VPAEVKNICI VLSGGNVDLT SLTWVKKQDE KAAP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126700 mRNA Translation: AAI26701.1 |
RefSeqi | NP_001071433.1, NM_001077965.2 XP_010814138.1, XM_010815836.2 XP_010814140.1, XM_010815838.2 |
Genome annotation databases
Ensembli | ENSBTAT00000005532; ENSBTAP00000005532; ENSBTAG00000004223 |
GeneIDi | 525340 |
KEGGi | bta:525340 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126700 mRNA Translation: AAI26701.1 |
RefSeqi | NP_001071433.1, NM_001077965.2 XP_010814138.1, XM_010815836.2 XP_010814140.1, XM_010815838.2 |
3D structure databases
SMRi | A0JNI4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000005532 |
Proteomic databases
PaxDbi | A0JNI4 |
Genome annotation databases
Ensembli | ENSBTAT00000005532; ENSBTAP00000005532; ENSBTAG00000004223 |
GeneIDi | 525340 |
KEGGi | bta:525340 |
Organism-specific databases
CTDi | 63826 |
VEuPathDBi | HostDB:ENSBTAG00000004223 |
VGNCi | VGNC:35292, SRR |
Phylogenomic databases
eggNOGi | KOG1251, Eukaryota |
GeneTreei | ENSGT00550000075026 |
HOGENOMi | CLU_021152_4_2_1 |
InParanoidi | A0JNI4 |
OMAi | LIHPFDH |
OrthoDBi | 943371at2759 |
TreeFami | TF313346 |
Enzyme and pathway databases
Reactomei | R-BTA-977347, Serine biosynthesis |
Gene expression databases
Bgeei | ENSBTAG00000004223, Expressed in testis and 96 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1100, 2 hits |
InterProi | View protein in InterPro IPR001926, PLP-dep IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS IPR036052, Trypto_synt_PLP_dependent |
Pfami | View protein in Pfam PF00291, PALP, 1 hit |
SUPFAMi | SSF53686, SSF53686, 1 hit |
PROSITEi | View protein in PROSITE PS00165, DEHYDRATASE_SER_THR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SRR_BOVIN | |
Accessioni | A0JNI4Primary (citable) accession number: A0JNI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | December 12, 2006 | |
Last modified: | September 29, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families