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Protein

Serine racemase

Gene

SRR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).By similarity

Catalytic activityi

L-serine = D-serine.
L-serine = pyruvate + NH3.
D-serine = pyruvate + NH3.

Cofactori

Activity regulationi

Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPBy similarity1
Active sitei56Proton acceptorBy similarity1
Active sitei84Proton acceptorBy similarity1
Binding sitei121ATPBy similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi210MagnesiumBy similarity1
Metal bindingi214Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi216MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Isomerase, Lyase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-BTA-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine racemase (EC:4.3.1.17, EC:4.3.1.18, EC:5.1.1.18)
Alternative name(s):
D-serine ammonia-lyase
D-serine dehydratase
L-serine ammonia-lyase
L-serine dehydratase
Gene namesi
Name:SRR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:35292 SRR

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002861721 – 334Serine racemaseAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei113S-nitrosocysteineBy similarity1

Post-translational modificationi

S-nitrosylated, leading to decrease the enzyme activity.By similarity

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiA0JNI4
PRIDEiA0JNI4

Expressioni

Gene expression databases

BgeeiENSBTAG00000004223 Expressed in 10 organ(s), highest expression level in testis

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005532

Structurei

3D structure databases

ProteinModelPortaliA0JNI4
SMRiA0JNI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 239Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250 Eukaryota
COG1171 LUCA
GeneTreeiENSGT00550000075026
HOGENOMiHOG000046974
HOVERGENiHBG023167
InParanoidiA0JNI4
KOiK12235
OMAiLIHPFDH
OrthoDBiEOG091G0FSJ
TreeFamiTF313346

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequencei

Sequence statusi: Complete.

A0JNI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDQYCISFA DVEKAHINIR DFIHLTPVLT SSILNQITGR NLFFKCELFQ
60 70 80 90 100
KTGSFKIRGA LNAIRGLISA HPEEKPRAVV AHSSGNHGQA LSFAARLEGI
110 120 130 140 150
PAYVIVPETA PNCKKLAIQA YGASIVYSEQ SEESRENITK RIAEETEGIM
160 170 180 190 200
VHPNQEPAVI AGQGTIAMEV LNQVPLVDAL VVPVGGGGML AGIAVTVKAL
210 220 230 240 250
RPSVKVYAAE PLNADDCYQS KLKGELTPNP YPPETIADGI KSSIGLNTWP
260 270 280 290 300
IIRDLVDDVF TVTEDEIKYA TQLVWERMKL LIEPTAGVGV AVVLSQHFRT
310 320 330
VPAEVKNICI VLSGGNVDLT SLTWVKKQDE KAAP
Length:334
Mass (Da):36,181
Last modified:December 12, 2006 - v1
Checksum:i63277FE33D8FA45F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126700 mRNA Translation: AAI26701.1
RefSeqiNP_001071433.1, NM_001077965.2
XP_010814138.1, XM_010815836.2
XP_010814140.1, XM_010815838.2
UniGeneiBt.102336

Genome annotation databases

EnsembliENSBTAT00000005532; ENSBTAP00000005532; ENSBTAG00000004223
GeneIDi525340
KEGGibta:525340

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126700 mRNA Translation: AAI26701.1
RefSeqiNP_001071433.1, NM_001077965.2
XP_010814138.1, XM_010815836.2
XP_010814140.1, XM_010815838.2
UniGeneiBt.102336

3D structure databases

ProteinModelPortaliA0JNI4
SMRiA0JNI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005532

Proteomic databases

PaxDbiA0JNI4
PRIDEiA0JNI4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005532; ENSBTAP00000005532; ENSBTAG00000004223
GeneIDi525340
KEGGibta:525340

Organism-specific databases

CTDi63826
VGNCiVGNC:35292 SRR

Phylogenomic databases

eggNOGiKOG1250 Eukaryota
COG1171 LUCA
GeneTreeiENSGT00550000075026
HOGENOMiHOG000046974
HOVERGENiHBG023167
InParanoidiA0JNI4
KOiK12235
OMAiLIHPFDH
OrthoDBiEOG091G0FSJ
TreeFamiTF313346

Enzyme and pathway databases

ReactomeiR-BTA-977347 Serine biosynthesis

Gene expression databases

BgeeiENSBTAG00000004223 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRR_BOVIN
AccessioniPrimary (citable) accession number: A0JNI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 12, 2006
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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