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UniProtKB - A0JND3 (EOGT_BOVIN)
Protein
EGF domain-specific O-linked N-acetylglucosamine transferase
Gene
EOGT
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
By similarityCatalytic activityi
- L-seryl-[protein] + UDP-N-acetyl-α-D-glucosamine = 3-O-(N-acetyl-β-D-glucosaminyl)-L-seryl-[protein] + H+ + UDPBy similarityEC:2.4.1.255By similarity
- L-threonyl-[protein] + UDP-N-acetyl-α-D-glucosamine = 3-O-(N-acetyl-β-D-glucosaminyl)-L-threonyl-[protein] + H+ + UDPBy similarityEC:2.4.1.255By similarity
GO - Molecular functioni
- glycosyltransferase activity Source: GO_Central
- protein N-acetylglucosaminyltransferase activity Source: UniProtKB
- protein O-GlcNAc transferase activity Source: UniProtKB-EC
GO - Biological processi
- protein O-GlcNAcylation via threonine Source: GO_Central
- protein O-linked glycosylation Source: UniProtKB
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Protein family/group databases
CAZyi | GT61, Glycosyltransferase Family 61 |
Names & Taxonomyi
Protein namesi | Recommended name: EGF domain-specific O-linked N-acetylglucosamine transferase (EC:2.4.1.255By similarity)Alternative name(s): Extracellular O-linked N-acetylglucosamine transferase |
Gene namesi | Name:EOGT Synonyms:AER61 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000022681 |
VGNCi | VGNC:28515, EOGT |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen PROSITE-ProRule annotation
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000301969 | 18 – 527 | EGF domain-specific O-linked N-acetylglucosamine transferaseAdd BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 354 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | A0JND3 |
PRIDEi | A0JND3 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000022681, Expressed in blood and 96 other tissues |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 295 – 297 | Required for optimal activityBy similarity | 3 | |
Motifi | 524 – 527 | Prevents secretion from ERPROSITE-ProRule annotation | 4 |
Sequence similaritiesi
Belongs to the glycosyltransferase 61 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG4698, Eukaryota |
GeneTreei | ENSGT00940000156493 |
HOGENOMi | CLU_039300_0_0_1 |
InParanoidi | A0JND3 |
OMAi | RFQTPQC |
OrthoDBi | 567582at2759 |
TreeFami | TF313716 |
Family and domain databases
InterProi | View protein in InterPro IPR007657, Glycosyltransferase_61 |
PANTHERi | PTHR20961, PTHR20961, 1 hit |
Pfami | View protein in Pfam PF04577, Glyco_transf_61, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A0JND3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFMLLVFGAL LPEVPLSGQD KAPPQADGIS ATPLFNYASL RLPEEHIPFF
60 70 80 90 100
LHNNRHIATV CRKDSHCPYK KYLENLKYCW GYEKSCRPEF RFGYPVCTYV
110 120 130 140 150
DMGWTDTLES AQEIFWKQAD FGYAAERLEE LHVLCQPKEK NDSSLVCSRY
160 170 180 190 200
LQYCRATNIY LDLRNIKRNH DRFKEDFVQS GEIGGYCKLD IRSLMSQGQR
210 220 230 240 250
KSPLQSWFAE LQSYTELNFR PVEDAQCDIV IEKPTYFMKL DAGVNMYHHF
260 270 280 290 300
CDFINLYITQ HVNNSFSTDV YVVMWDTSSY GYGDLFSDTW KAFTDYDVIH
310 320 330 340 350
LKTYDAKRVC FKEAIFSLLP RMRYGLFYNT PLISGCQNTG LFRAFSQHVL
360 370 380 390 400
HRLNITQEGP KGGKIRVTIL ARSTEYRKIL NQNELVNALK TVSTFEVQIV
410 420 430 440 450
DYKYKELGFL DQLRITHNTD IFIGMHGAGL THLLFLPDWA AVFELYNCGD
460 470 480 490 500
ERCYLDLARL RGVHYITWRR QNKVFPQDKG HHPTLGEHPK FTNYSFDVEE
510 520
FMYLVLQAAD YVLQHPKWPF KKKHDEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126625 mRNA Translation: AAI26626.1 |
RefSeqi | NP_001071350.1, NM_001077882.1 XP_005222695.1, XM_005222638.3 XP_005222696.1, XM_005222639.3 XP_005222697.1, XM_005222640.3 XP_005222698.1, XM_005222641.3 |
Genome annotation databases
Ensembli | ENSBTAT00000030754; ENSBTAP00000030725; ENSBTAG00000022681 |
GeneIDi | 508782 |
KEGGi | bta:508782 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126625 mRNA Translation: AAI26626.1 |
RefSeqi | NP_001071350.1, NM_001077882.1 XP_005222695.1, XM_005222638.3 XP_005222696.1, XM_005222639.3 XP_005222697.1, XM_005222640.3 XP_005222698.1, XM_005222641.3 |
3D structure databases
AlphaFoldDBi | A0JND3 |
SMRi | A0JND3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000030725 |
Protein family/group databases
CAZyi | GT61, Glycosyltransferase Family 61 |
Proteomic databases
PaxDbi | A0JND3 |
PRIDEi | A0JND3 |
Genome annotation databases
Ensembli | ENSBTAT00000030754; ENSBTAP00000030725; ENSBTAG00000022681 |
GeneIDi | 508782 |
KEGGi | bta:508782 |
Organism-specific databases
CTDi | 285203 |
VEuPathDBi | HostDB:ENSBTAG00000022681 |
VGNCi | VGNC:28515, EOGT |
Phylogenomic databases
eggNOGi | KOG4698, Eukaryota |
GeneTreei | ENSGT00940000156493 |
HOGENOMi | CLU_039300_0_0_1 |
InParanoidi | A0JND3 |
OMAi | RFQTPQC |
OrthoDBi | 567582at2759 |
TreeFami | TF313716 |
Gene expression databases
Bgeei | ENSBTAG00000022681, Expressed in blood and 96 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR007657, Glycosyltransferase_61 |
PANTHERi | PTHR20961, PTHR20961, 1 hit |
Pfami | View protein in Pfam PF04577, Glyco_transf_61, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EOGT_BOVIN | |
Accessioni | A0JND3Primary (citable) accession number: A0JND3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | December 12, 2006 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families