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Protein

Phosphatidate cytidylyltransferase 2

Gene

CDS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)
  3. Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-BTA-1483148 Synthesis of PG
UniPathwayi
UPA00557;UER00614

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 2 (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-diacylglycerol synthase 2
Short name:
CDS 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CTP:phosphatidate cytidylyltransferase 2
Gene namesi
Name:CDS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:27156 CDS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003048761 – 445Phosphatidate cytidylyltransferase 2Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei31PhosphothreonineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei51PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JNC1
PRIDEiA0JNC1

Expressioni

Gene expression databases

BgeeiENSBTAG00000006066 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007970

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1440 Eukaryota
COG0575 LUCA
GeneTreeiENSGT00390000016175
HOGENOMiHOG000209582
HOVERGENiHBG002485
InParanoidiA0JNC1
KOiK00981
OMAiREVAIMP
OrthoDBiEOG091G06CA
TreeFamiTF313464

Family and domain databases

InterProiView protein in InterPro
IPR000374 PC_trans
IPR016720 PC_Trfase_euk
PIRSFiPIRSF018269 PC_trans_euk, 1 hit
PROSITEiView protein in PROSITE
PS01315 CDS, 1 hit

Sequencei

Sequence statusi: Complete.

A0JNC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTELRQRVAR EPEAPPEDKE SESEAKADGE TASDSESRVE AVTQPPSADD
60 70 80 90 100
TPEVLNRALS NLSSRWKNWW VRGILTLAMI AFFFIIIYLG PMVLMMIVMC
110 120 130 140 150
VQIKCFHEII TIGYNVYHSY DLPWFRTLSW YFLLCVNYFF YGETVTDYFF
160 170 180 190 200
TLVQREEPLR ILSKYHRFIS FTLYLTGFCM FVLSLVKKHY RLQFYMFGWT
210 220 230 240 250
HVTLLIVVTQ SHLVIHNLFE GMIWFIVPIS CVICNDIMAY MFGFFFGRTP
260 270 280 290 300
LIKLSPKKTW EGFIGGFFAT VVFGLLLSYV MSGYRCFVCP VEYNNDTNSF
310 320 330 340 350
TVDCEPSGLF RLQEYNIPGV IQSIIGWKTV RMYPFQIHSI ALSTFASLIG
360 370 380 390 400
PFGGFFASGF KRAFKIKDFA NTIPGHGGIM DRFDCQYLMA TFVNVYIASF
410 420 430 440
IRGPNPSKLV QQFLTLRPDQ QLHIFNTLKS HLTDKGMLTA ATEDK
Length:445
Mass (Da):51,357
Last modified:December 12, 2006 - v1
Checksum:i788FC1B80D41902E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126607 mRNA Translation: AAI26608.1
RefSeqiNP_001071514.1, NM_001078046.1
UniGeneiBt.2342

Genome annotation databases

EnsembliENSBTAT00000007970; ENSBTAP00000007970; ENSBTAG00000006066
GeneIDi614834
KEGGibta:614834

Similar proteinsi

Entry informationi

Entry nameiCDS2_BOVIN
AccessioniPrimary (citable) accession number: A0JNC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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