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Protein

Tropomodulin-1

Gene

TMOD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-1
Alternative name(s):
Erythrocyte tropomodulin
Short name:
E-Tmod
Gene namesi
Name:TMOD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002823131 – 359Tropomodulin-1Add BLAST359

Proteomic databases

PaxDbiA0JNC0
PRIDEiA0JNC0

Interactioni

Subunit structurei

Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019585

Structurei

3D structure databases

ProteinModelPortaliA0JNC0
SMRiA0JNC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 138Tropomyosin-bindingSequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
HOGENOMiHOG000261624
HOVERGENiHBG056172
InParanoidiA0JNC0
KOiK10370

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR030135 TMOD1
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF8 PTHR10901:SF8, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit

Sequencei

Sequence statusi: Complete.

A0JNC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYRRELEKY RDLDEDEILG GLTEEELRTL ENELDELDPD NALLPAGLRQ
60 70 80 90 100
KDQTTKAPTG PFRREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ
110 120 130 140 150
KPMDPVLESV TLEPELEEAL ANASDAELCD IAAILGMHTL MSNQQYYQAL
160 170 180 190 200
GSSSIVNKEG LNSVIKPTQY KPVPDEEPNA TDVEETLERI KNNDPKLEEV
210 220 230 240 250
NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV AFALAEMLKV
260 270 280 290 300
NKVLKTLNVE SNFISGAGIL RLVEALPYNT SLVELKIDNQ SQPLGNKVEM
310 320 330 340 350
EIVSMLEKNA TLLKFGYHFT QQGPRLRASN AMMNNNDLVR KRRLADLTGP

IIPKCRSGV
Length:359
Mass (Da):40,459
Last modified:December 12, 2006 - v1
Checksum:iB8C637BD6C9D2FE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126605 mRNA Translation: AAI26606.1
RefSeqiNP_001073108.1, NM_001079640.1
UniGeneiBt.101239

Genome annotation databases

GeneIDi780784
KEGGibta:780784

Similar proteinsi

Entry informationi

Entry nameiTMOD1_BOVIN
AccessioniPrimary (citable) accession number: A0JNC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 12, 2006
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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