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Entry version 96 (11 Dec 2019)
Sequence version 1 (12 Dec 2006)
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Protein

Zinc finger protein 227

Gene

ZNF227

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri243 – 275C2H2-type 1PROSITE-ProRule annotationAdd BLAST33
Zinc fingeri312 – 334C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri648 – 670C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri676 – 698C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri704 – 726C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri732 – 754C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 782C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 227
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF227
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:58349 ZNF227

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002841391 – 787Zinc finger protein 227Add BLAST787

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0JNB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000027431 Expressed in 10 organ(s), highest expression level in brain

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0JNB1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri243 – 275C2H2-type 1PROSITE-ProRule annotationAdd BLAST33
Zinc fingeri312 – 334C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri648 – 670C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri676 – 698C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri704 – 726C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri732 – 754C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 782C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0JNB1

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKQVASE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0JNB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSQDSDFPQ KEHEKMTEFQ EAVTFKDVAV VFTEEELGLL DSAQRKLYQD
60 70 80 90 100
VMVENFRNLV SVGHVPFKAD MVSQLETEEK LWTMERETQR NGHSSEIHSA
110 120 130 140 150
VTSGSKIPNE METLGKVMFK YLSCEELSCW QIWKHTTNDL TLQRKSSWFL
160 170 180 190 200
HGDSLQVSED ENHIMNHKGD HFGCLENQEF LIPTAQASCG SRCLSESENP
210 220 230 240 250
SRGKQMSVKN HLHVCEGFTK NSPLSDPGKT DAKQTPCKGE RPHPCRVCGE
260 270 280 290 300
GFSHGAVLPV HQVDPGEKCS HLQTHQRIHP GGTVNKCPKS GDGFHQNSFH
310 320 330 340 350
PHHSNPTGEK SYRCDSCGKA FGSSTGLIIH YRTHTGEKPY RCEACGKCFS
360 370 380 390 400
QSSNFQCHQR VHTEEKPYKC EECGKGFGWS VNLRVHQRVH RGEKPYKCEE
410 420 430 440 450
CGKGFTQAAH YHIHQRVHTG EKPYKCDVCG KGFSHNSPLI CHRRVHTGEK
460 470 480 490 500
PYRCEACGKG FTRNTDLHIH FRVHTGEKPY TCKECGKGFS QASNLQVHQN
510 520 530 540 550
VHTGEKRFKC ETCGKGFSQS SKLQTHQRVH TGEKPYRCDV CGKDFSYSSN
560 570 580 590 600
LKLHQVIHTG EKPYTCEACG KGFSWRSNLH AHQRVHSGEK PYKCEACDKS
610 620 630 640 650
FSQAIDFRVH QRVHTGEKPY KCGVCGKGFS QSSGLQSHQR VHTGEKPYKC
660 670 680 690 700
DVCGKGFRYS SQFIYHQRGH TGEKPYKCEE CGKGFGRSLN LRHHQRVHTG
710 720 730 740 750
EKPHKCEECG KAFSLPSNLR VHLSVHTREK LFKCEDCGKG FSQSSRLQAH
760 770 780
QRVHTGEKPY KCNICGKDFS HRSRLTYHQK VHTGKNL
Length:787
Mass (Da):89,360
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CDAA23D2ADD56FC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC126592 mRNA Translation: AAI26593.1

NCBI Reference Sequences

More...
RefSeqi
NP_001071428.1, NM_001077960.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
524111

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:524111

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126592 mRNA Translation: AAI26593.1
RefSeqiNP_001071428.1, NM_001077960.1

3D structure databases

SMRiA0JNB1
ModBaseiSearch...

Proteomic databases

PRIDEiA0JNB1

Genome annotation databases

EnsembliENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431
GeneIDi524111
KEGGibta:524111

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7770
VGNCiVGNC:58349 ZNF227

Phylogenomic databases

GeneTreeiENSGT00940000162819
HOGENOMiHOG000234617
InParanoidiA0JNB1
KOiK09228
OMAiWKQVASE
OrthoDBi1318335at2759

Enzyme and pathway databases

ReactomeiR-BTA-212436 Generic Transcription Pathway

Gene expression databases

BgeeiENSBTAG00000027431 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN227_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JNB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: December 11, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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