UniProtKB - A0JNB0 (FYN_BOVIN)
Tyrosine-protein kinase Fyn
FYN
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation1 PublicationEC:2.7.10.2PROSITE-ProRule annotation1 Publication
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 299 | ATPPROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 390 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 277 – 285 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- alpha-tubulin binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- disordered domain specific binding Source: Ensembl
- enzyme binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- G protein-coupled receptor binding Source: Ensembl
- growth factor receptor binding Source: Ensembl
- identical protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- protein tyrosine kinase activity Source: UniProtKB
- signaling receptor binding Source: GO_Central
- tau protein binding Source: Ensembl
- transmembrane receptor protein tyrosine kinase activity Source: RHEA
GO - Biological processi
- activated T cell proliferation Source: Ensembl
- adaptive immune response Source: UniProtKB-KW
- cell differentiation Source: GO_Central
- cellular response to amyloid-beta Source: Ensembl
- cellular response to platelet-derived growth factor stimulus Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- dendrite morphogenesis Source: Ensembl
- detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
- forebrain development Source: Ensembl
- heart process Source: Ensembl
- innate immune response Source: GO_Central
- modulation of chemical synaptic transmission Source: Ensembl
- negative regulation of dendritic spine maintenance Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of protein catabolic process Source: Ensembl
- negative regulation of protein ubiquitination Source: Ensembl
- neuron migration Source: Ensembl
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of neuron death Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of protein localization to nucleus Source: Ensembl
- positive regulation of protein targeting to membrane Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- protein autophosphorylation Source: Ensembl
- regulation of calcium ion import across plasma membrane Source: Ensembl
- regulation of cell shape Source: Ensembl
- regulation of glutamate receptor signaling pathway Source: Ensembl
- response to ethanol Source: Ensembl
- T cell receptor signaling pathway Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Developmental protein, Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Immunity |
Ligand | ATP-binding, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-BTA-114604, GPVI-mediated activation cascade R-BTA-1227986, Signaling by ERBB2 R-BTA-1257604, PIP3 activates AKT signaling R-BTA-1433557, Signaling by SCF-KIT R-BTA-1433559, Regulation of KIT signaling R-BTA-210990, PECAM1 interactions R-BTA-2424491, DAP12 signaling R-BTA-375165, NCAM signaling for neurite out-growth R-BTA-389356, CD28 co-stimulation R-BTA-389357, CD28 dependent PI3K/Akt signaling R-BTA-389359, CD28 dependent Vav1 pathway R-BTA-389513, CTLA4 inhibitory signaling R-BTA-3928663, EPHA-mediated growth cone collapse R-BTA-3928664, Ephrin signaling R-BTA-3928665, EPH-ephrin mediated repulsion of cells R-BTA-399954, Sema3A PAK dependent Axon repulsion R-BTA-399956, CRMPs in Sema3A signaling R-BTA-4420097, VEGFA-VEGFR2 Pathway R-BTA-5621480, Dectin-2 family R-BTA-5673001, RAF/MAP kinase cascade R-BTA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-BTA-75892, Platelet Adhesion to exposed collagen R-BTA-912631, Regulation of signaling by CBL |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase Fyn (EC:2.7.10.2)Alternative name(s): Proto-oncogene c-Fyn p59-Fyn |
Gene namesi | Name:FYNImported |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:29163, FYN |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane By similarity
Note: Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking (By similarity).By similarity
Cytoskeleton
- actin filament Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Endosome
- endosome Source: Ensembl
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
Other locations
- cell body Source: Ensembl
- dendrite Source: Ensembl
- glial cell projection Source: Ensembl
- membrane raft Source: Ensembl
- postsynaptic density Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000282314 | 2 – 537 | Tyrosine-protein kinase FynAdd BLAST | 536 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 | |
Lipidationi | 3 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 6 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 12 | Phosphothreonine; by PKCBy similarity | 1 | |
Modified residuei | 21 | PhosphoserineBy similarity | 1 | |
Modified residuei | 26 | PhosphoserineBy similarity | 1 | |
Modified residuei | 185 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 420 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 531 | Phosphotyrosine; by CSKBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, Palmitate, PhosphoproteinProteomic databases
PaxDbi | A0JNB0 |
PRIDEi | A0JNB0 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000011851, Expressed in spleen and 17 other tissues |
Interactioni
Subunit structurei
Interacts (via its SH3 domain) with PIK3R1 and PRMT8.
Interacts with FYB1, PAG1, and SH2D1A.
Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity.
Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity).
Interacts with TOM1L1 (phosphorylated form).
Interacts with KDR (tyrosine phosphorylated).
Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity).
Interacts with SH2D1A and SLAMF1.
Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity.
Interacts with FASLG.
Interacts with RUNX3.
Interacts with KIT.
Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion.
Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation.
Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway.
Interacts with UNC119.
Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity).
Interacts with PTPRO (phosphorylated form) (By similarity).
Interacts with PTPRB (phosphorylated form) (By similarity).
Interacts with FYB2 (By similarity).
Interacts with DSCAM (By similarity).
Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity).
By similarityGO - Molecular functioni
- alpha-tubulin binding Source: Ensembl
- disordered domain specific binding Source: Ensembl
- enzyme binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- G protein-coupled receptor binding Source: Ensembl
- growth factor receptor binding Source: Ensembl
- identical protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- signaling receptor binding Source: GO_Central
- tau protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000015730 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 143 | SH3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 149 – 246 | SH2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 271 – 524 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Sequence similaritiesi
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155462 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | A0JNB0 |
OMAi | XWYFGKL |
OrthoDBi | 539311at2759 |
TreeFami | TF351634 |
Family and domain databases
CDDi | cd12006, SH3_Fyn_Yrk, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035750, Fyn/Yrk_SH3 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY
60 70 80 90 100
NNFHGAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD
110 120 130 140 150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY
160 170 180 190 200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV
210 220 230 240 250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM
260 270 280 290 300
PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
310 320 330 340 350
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL
360 370 380 390 400
LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN
410 420 430 440 450
GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW
460 470 480 490 500
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI
510 520 530
HCWKKDPEER PTFEYLQGFL EDYFTATEPQ YQPGENL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126591 mRNA Translation: AAI26592.1 |
RefSeqi | NP_001071440.1, NM_001077972.1 XP_005210845.1, XM_005210788.2 XP_005210846.1, XM_005210789.3 XP_005210847.1, XM_005210790.3 |
Genome annotation databases
Ensembli | ENSBTAT00000015730; ENSBTAP00000015730; ENSBTAG00000011851 |
GeneIDi | 527263 |
KEGGi | bta:527263 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126591 mRNA Translation: AAI26592.1 |
RefSeqi | NP_001071440.1, NM_001077972.1 XP_005210845.1, XM_005210788.2 XP_005210846.1, XM_005210789.3 XP_005210847.1, XM_005210790.3 |
3D structure databases
BMRBi | A0JNB0 |
SMRi | A0JNB0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000015730 |
Proteomic databases
PaxDbi | A0JNB0 |
PRIDEi | A0JNB0 |
Genome annotation databases
Ensembli | ENSBTAT00000015730; ENSBTAP00000015730; ENSBTAG00000011851 |
GeneIDi | 527263 |
KEGGi | bta:527263 |
Organism-specific databases
CTDi | 2534 |
VGNCi | VGNC:29163, FYN |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155462 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | A0JNB0 |
OMAi | XWYFGKL |
OrthoDBi | 539311at2759 |
TreeFami | TF351634 |
Enzyme and pathway databases
Reactomei | R-BTA-114604, GPVI-mediated activation cascade R-BTA-1227986, Signaling by ERBB2 R-BTA-1257604, PIP3 activates AKT signaling R-BTA-1433557, Signaling by SCF-KIT R-BTA-1433559, Regulation of KIT signaling R-BTA-210990, PECAM1 interactions R-BTA-2424491, DAP12 signaling R-BTA-375165, NCAM signaling for neurite out-growth R-BTA-389356, CD28 co-stimulation R-BTA-389357, CD28 dependent PI3K/Akt signaling R-BTA-389359, CD28 dependent Vav1 pathway R-BTA-389513, CTLA4 inhibitory signaling R-BTA-3928663, EPHA-mediated growth cone collapse R-BTA-3928664, Ephrin signaling R-BTA-3928665, EPH-ephrin mediated repulsion of cells R-BTA-399954, Sema3A PAK dependent Axon repulsion R-BTA-399956, CRMPs in Sema3A signaling R-BTA-4420097, VEGFA-VEGFR2 Pathway R-BTA-5621480, Dectin-2 family R-BTA-5673001, RAF/MAP kinase cascade R-BTA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-BTA-75892, Platelet Adhesion to exposed collagen R-BTA-912631, Regulation of signaling by CBL |
Gene expression databases
Bgeei | ENSBTAG00000011851, Expressed in spleen and 17 other tissues |
Family and domain databases
CDDi | cd12006, SH3_Fyn_Yrk, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035750, Fyn/Yrk_SH3 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FYN_BOVIN | |
Accessioni | A0JNB0Primary (citable) accession number: A0JNB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | December 12, 2006 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families