UniProtKB - A0JN95 (MET15_BOVIN)
Protein
12S rRNA N4-methylcytidine methyltransferase
Gene
METTL15
Organism
Bos taurus (Bovine)
Status
Functioni
N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits.By similarity
Catalytic activityi
- cytidine839 in 12S rRNA + S-adenosyl-L-methionine = H+ + N4-methylcytidine839 in 12S rRNA + S-adenosyl-L-homocysteineBy similarityThis reaction proceeds in the forwardBy similarity direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 119 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 146 | S-adenosyl-L-methionine; via amide nitrogenBy similarity | 1 | |
Binding sitei | 169 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 176 | S-adenosyl-L-methionineBy similarity | 1 |
GO - Molecular functioni
- rRNA (cytosine-N4-)-methyltransferase activity Source: GO_Central
GO - Biological processi
- rRNA base methylation Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: 12S rRNA N4-methylcytidine methyltransferase (EC:2.1.1.-)Short name: 12S rRNA m4C methyltransferase Alternative name(s): Methyltransferase 5 domain-containing protein 1 Methyltransferase-like protein 15 |
Gene namesi | Name:METTL15 Synonyms:METT5D1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:54885, METTL15 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000308331 | ? – 407 | 12S rRNA N4-methylcytidine methyltransferase |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 358 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | A0JN95 |
PRIDEi | A0JN95 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000003361, Expressed in longissimus thoracis muscle and 19 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 102 | S-adenosyl-L-methionine bindingBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2782, Eukaryota |
GeneTreei | ENSGT00390000014756 |
HOGENOMi | CLU_038422_1_0_1 |
InParanoidi | A0JN95 |
OMAi | NPAKRTF |
OrthoDBi | 809593at2759 |
TreeFami | TF106425 |
Family and domain databases
Gene3Di | 1.10.150.170, 1 hit |
HAMAPi | MF_01007, 16SrRNA_methyltr_H, 1 hit |
InterProi | View protein in InterPro IPR002903, RsmH IPR023397, SAM-dep_MeTrfase_MraW_recog IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR11265, PTHR11265, 1 hit |
Pfami | View protein in Pfam PF01795, Methyltransf_5, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit SSF81799, SSF81799, 1 hit |
TIGRFAMsi | TIGR00006, TIGR00006, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A0JN95-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRYPYFCRI HKNFLSCWLE SGIYNLGVWP KKIHATAERY NEYEAQEETD
60 70 80 90 100
QTGIQELHRS QDRDSGVMTK LHIPVMVDEV VRCLAPQKGQ VFLDMTFGSG
110 120 130 140 150
GHTRAILQKE PDITLYALDR DPTAYAIAEQ LSELYPKQIR AILGQFSQAE
160 170 180 190 200
ALLMKAGVQP GTLDGVLLDL GCSSMQLDTP ERGFSLRKDG PLDMRMDGDR
210 220 230 240 250
YPDMPTAADV VNALDQQALA SILRAYGEEK HAKKIASAII QARGLYPITR
260 270 280 290 300
TQQLASIVAG AFPPSALYAR KDLLQRPTHI ATKTFQAFRI FVNNELNELY
310 320 330 340 350
TGLKTAQKFL RPGGHLVALS FHSLEDRIIK RFLLGISMTE RFNLSARQKV
360 370 380 390 400
IQKSQLDSDQ ENKEGVSTGK APLMWKLIHK KVLTPEDEDV QDNPRGRSAK
LRAAIKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126575 mRNA Translation: AAI26576.1 |
RefSeqi | NP_001073250.1, NM_001079782.2 XP_005216340.1, XM_005216283.3 XP_005216342.1, XM_005216285.3 XP_010811027.1, XM_010812725.2 |
Genome annotation databases
Ensembli | ENSBTAT00000044672; ENSBTAP00000042150; ENSBTAG00000003361 |
GeneIDi | 533987 |
KEGGi | bta:533987 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126575 mRNA Translation: AAI26576.1 |
RefSeqi | NP_001073250.1, NM_001079782.2 XP_005216340.1, XM_005216283.3 XP_005216342.1, XM_005216285.3 XP_010811027.1, XM_010812725.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000042150 |
Proteomic databases
PaxDbi | A0JN95 |
PRIDEi | A0JN95 |
Genome annotation databases
Ensembli | ENSBTAT00000044672; ENSBTAP00000042150; ENSBTAG00000003361 |
GeneIDi | 533987 |
KEGGi | bta:533987 |
Organism-specific databases
CTDi | 196074 |
VGNCi | VGNC:54885, METTL15 |
Phylogenomic databases
eggNOGi | KOG2782, Eukaryota |
GeneTreei | ENSGT00390000014756 |
HOGENOMi | CLU_038422_1_0_1 |
InParanoidi | A0JN95 |
OMAi | NPAKRTF |
OrthoDBi | 809593at2759 |
TreeFami | TF106425 |
Gene expression databases
Bgeei | ENSBTAG00000003361, Expressed in longissimus thoracis muscle and 19 other tissues |
Family and domain databases
Gene3Di | 1.10.150.170, 1 hit |
HAMAPi | MF_01007, 16SrRNA_methyltr_H, 1 hit |
InterProi | View protein in InterPro IPR002903, RsmH IPR023397, SAM-dep_MeTrfase_MraW_recog IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR11265, PTHR11265, 1 hit |
Pfami | View protein in Pfam PF01795, Methyltransf_5, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit SSF81799, SSF81799, 1 hit |
TIGRFAMsi | TIGR00006, TIGR00006, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MET15_BOVIN | |
Accessioni | A0JN95Primary (citable) accession number: A0JN95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | December 12, 2006 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families