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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

SLC25A21

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-71064 Lysine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:SLC25A21
Synonyms:ODC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:34749 SLC25A21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei274 – 290Helical; Name=6Sequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002855981 – 299Mitochondrial 2-oxodicarboxylate carrierAdd BLAST299

Proteomic databases

PaxDbiA0JN87
PRIDEiA0JN87

Expressioni

Gene expression databases

BgeeiENSBTAG00000019350
ExpressionAtlasiA0JN87 baseline

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043163

Structurei

3D structure databases

ProteinModelPortaliA0JN87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 100Solcar 1Add BLAST90
Repeati107 – 196Solcar 2Add BLAST90
Repeati205 – 294Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0754 Eukaryota
ENOG410XRZG LUCA
GeneTreeiENSGT00730000111119
HOGENOMiHOG000168307
HOVERGENiHBG105598
InParanoidiA0JN87
OMAiLESTMWR
OrthoDBiEOG091G0DEF
TreeFamiTF314035

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

A0JN87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKPSVGFV NEASRQILAG GSAGLVEICL MHPLDVVKTR FQIQRCTTDP
60 70 80 90 100
NSYKSLGDSF RMIFRTEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL
110 120 130 140 150
LGYVSLSPAL TFAVAGLGSG LTEAIVVNPF EVVKVGLQAN RNRFTEQPST
160 170 180 190 200
MSYARHIIKK EGLGLGGLNK GFTATLGRHG VFNMVYFGFY FNVKNIIPVN
210 220 230 240 250
KDPTLEFLRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYKTC
260 270 280 290
FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW
Length:299
Mass (Da):33,108
Last modified:December 12, 2006 - v1
Checksum:i934AC7F081507D02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126566 mRNA Translation: AAI26567.1
RefSeqiXP_005222099.1, XM_005222042.3
UniGeneiBt.14112

Genome annotation databases

EnsembliENSBTAT00000045803; ENSBTAP00000043163; ENSBTAG00000019350
GeneIDi513423

Similar proteinsi

Entry informationi

Entry nameiODC_BOVIN
AccessioniPrimary (citable) accession number: A0JN87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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