Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TRIM11

Gene

TRIM11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri87 – 128B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAntiviral defense, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM11 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM11Curated
Tripartite motif-containing protein 11
Gene namesi
Name:TRIM11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:36313 TRIM11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003969341 – 468E3 ubiquitin-protein ligase TRIM11Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JN74
PRIDEiA0JN74

Expressioni

Gene expression databases

BgeeiENSBTAG00000039246 Expressed in 9 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Binds cytoplasmic tail of integrin alpha-1. Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation. Interacts with the HN peptide. Interacts with PHOX2B. Interacts with PAX6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024852

Structurei

3D structure databases

ProteinModelPortaliA0JN74
SMRiA0JN74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 461B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili128 – 233Sequence analysisAdd BLAST106

Domaini

The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6. They are also involved in MED15-binding.By similarity
The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri87 – 128B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiA0JN74
KOiK10650
OMAiFAGNGFW
OrthoDBiEOG091G05W2
TreeFamiTF338674

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0JN74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP
60 70 80 90 100
YACPECRELF PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCAAHREPLA
110 120 130 140 150
AFCGDELRLL CAACERSGEH WAHRVRPLQD AAEDLKSKLE KSLEHLRKQM
160 170 180 190 200
EDALLFQAQA EETCSLWQKM VETQRQNVLT EFERLRRLLV EEEQLLLQRL
210 220 230 240 250
EEEELEVLPP LRESAARLGQ QSAQLAELIT ELEGRCQLPA LGLLQDIRDT
260 270 280 290 300
LRRVQDVKLQ PPEVVPMEMR TVCRVPGLVE ALRRFRGDMT LDPDTANPEL
310 320 330 340 350
VLSEDRRSVR RGDLRQALPD SPERFDPGPC VLGREPLTSG RHYWEVEVGE
360 370 380 390 400
RASWALGVCR ENANRKEKGE LFAGNGFWIL VFLGSYYNSS ERAFAPLRDP
410 420 430 440 450
PRRVGIFLDY EAGHLSFYSA NDGSLLYTFP ETPFSGTLRA LFSPLSSSPT
460
PMTICRLKGG PGDGLAPQ
Length:468
Mass (Da):52,947
Last modified:December 12, 2006 - v1
Checksum:iA2B6330F6B629ADF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126548 mRNA Translation: AAI26549.1
RefSeqiNP_001071388.1, NM_001077920.2
UniGeneiBt.34145

Genome annotation databases

EnsembliENSBTAT00000024852; ENSBTAP00000024852; ENSBTAG00000039246
GeneIDi514580
KEGGibta:514580

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126548 mRNA Translation: AAI26549.1
RefSeqiNP_001071388.1, NM_001077920.2
UniGeneiBt.34145

3D structure databases

ProteinModelPortaliA0JN74
SMRiA0JN74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024852

Proteomic databases

PaxDbiA0JN74
PRIDEiA0JN74

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024852; ENSBTAP00000024852; ENSBTAG00000039246
GeneIDi514580
KEGGibta:514580

Organism-specific databases

CTDi81559
VGNCiVGNC:36313 TRIM11

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiA0JN74
KOiK10650
OMAiFAGNGFW
OrthoDBiEOG091G05W2
TreeFamiTF338674

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-BTA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSBTAG00000039246 Expressed in 9 organ(s), highest expression level in spleen

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI11_BOVIN
AccessioniPrimary (citable) accession number: A0JN74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again