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Entry version 82 (02 Dec 2020)
Sequence version 1 (12 Dec 2006)
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Protein

RNA polymerase II-associated protein 1

Gene

RPAP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase II-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:34098, RPAP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002848401 – 1395RNA polymerase II-associated protein 1Add BLAST1395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei321PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0JN53

PRoteomics IDEntifications database

More...
PRIDEi
A0JN53

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000001693, Expressed in skeletal muscle tissue and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0JN53, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000002220

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi827 – 1287Leu-richAdd BLAST461

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RPAP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1894, Eukaryota
KOG4732, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005296_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0JN53

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRPRWCP

Database of Orthologous Groups

More...
OrthoDBi
25908at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324391

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013929, RNA_pol_II_AP1_C
IPR013930, RNA_pol_II_AP1_N
IPR039913, RPAP1/Rba50

The PANTHER Classification System

More...
PANTHERi
PTHR21483, PTHR21483, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08620, RPAP1_C, 1 hit
PF08621, RPAP1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0JN53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSRPKPGES EVDLLRFQSQ FLAAGATPAV QLVKKGSRRA GDANLEQPPL
60 70 80 90 100
QDHRDVVMLD SLPDLPPALV PAPPKRARPS PGHLLPEHED PEERLHRHDQ
110 120 130 140 150
HITAVLTKII ERDTSSMPVN LPVSSGVAFP PVFHRSQGRQ GKPVTAGKRS
160 170 180 190 200
IFAQEIAARR ASGAKVSPVR EVESILDPPE SAMTCEALTP REWGSQPPWN
210 220 230 240 250
SYSFQGPHLV TGKGLKGQEA EQEAQTIHEE NVARLQALAP EEILQEQQRL
260 270 280 290 300
LAQLDPSLVA FLKSHSCTRE QAEEKATREQ RPGRPSAEVI GKEAIAPTSA
310 320 330 340 350
SVPRQENELE PETPALALPV TPQKEWLHMD TVELEKLHWT QDLPPLRRQQ
360 370 380 390 400
TQERMQARFS LQGELLAPDM DLPTHLGLHH HGEEAERAGY SLQELFHLTR
410 420 430 440 450
SQVSQQRALA LHVLAQVIGR AQAGEFGDRL VGSVLHLLLD AGFLFLLRFS
460 470 480 490 500
LDDRVDGVIA AAVRALRALL VAPGDEELLD STFSWYHGAL MFALMPSQED
510 520 530 540 550
KEDEDEDEEP PAEKAKTKSP EEGNRPPSDL ARHDIIKGLL ATNLLPRLRY
560 570 580 590 600
VLEVTCPGPS VVLDILTVLI RLARHSLESA TRVLECPRLV ETVVREFLPT
610 620 630 640 650
SWSPMGSGPT SSLHRVPCAP AMKLLRVLAS ASRNIAARLL SGFDLRSRLS
660 670 680 690 700
RFIAEDPQDL ALPLEEAETL STEAFRLWAV AASYGLGSDL YRELYPVLMQ
710 720 730 740 750
ALQDVPKELS SPPPRPLAVQ RIASLLTLLT QLTLAAGHIA PEHNSHSAEA
760 770 780 790 800
SLLAGSSSVT WTQVSGLQPL VEPCLRQTLK LLPRPEMWSA LGPVPTACLL
810 820 830 840 850
FLDAYYQAWS QQPGLCPEDW LQDMERLSEG LLLPLLKHPS LGSLWDSLGC
860 870 880 890 900
CSPLCNPQSC AVAPETISSL ASLGCAGGHP PLSLAGSASP FPFLTALLSL
910 920 930 940 950
LNTLGRIHKG LCGQLATVLA APGLQDYFLR CVAPVAALHL TPFSAWALRH
960 970 980 990 1000
EYHLQYLALT LAQRAATLQP PMSGTDAALC HGMALALLGR LLPGSEHLAH
1010 1020 1030 1040 1050
ELMLSCVFRL EFLPERASGG PEAADFSDRL SLGSGGDLGC GRGALLAQAC
1060 1070 1080 1090 1100
QDLPSIRSCY LTHCSLARAS LLASQALYRG ELQRVPALLL PVPKEPLLPT
1110 1120 1130 1140 1150
DWPFLPLIQL YHRASDTPSG LPPADTVGTA LRALQWVLVL ESWRPRALWA
1160 1170 1180 1190 1200
VSPAARLARL MCVFLVDSEL FRETPIQRLV AALLARLCQP EVLSNLNLDC
1210 1220 1230 1240 1250
PLPGLTSFPD LYANFLEHFE AVSFGDHLFG ALILLPLQRR FSVTLRLALF
1260 1270 1280 1290 1300
GEHVGALRAL GLPLTQLPVS LECYTAPPED NLALLQLYFR ALVTGALRPR
1310 1320 1330 1340 1350
WCPVLYAVAV AHVNSFIFSQ DPNNSDEIKA ACRSMLQKTW LLTDEGLRQH
1360 1370 1380 1390
LLHYKLPNSA LPEGFELYPQ LPPLRQQYLQ KLRISGVLPN GVSDT
Length:1,395
Mass (Da):152,859
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91236BA09B55F13A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A452DHU8A0A452DHU8_BOVIN
RNA polymerase II-associated protei...
RPAP1
1,305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC126520 mRNA Translation: AAI26521.1

NCBI Reference Sequences

More...
RefSeqi
NP_001071452.1, NM_001077984.2
XP_005211635.1, XM_005211578.3
XP_005211636.1, XM_005211579.2
XP_005211637.1, XM_005211580.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000081849; ENSBTAP00000071505; ENSBTAG00000001693

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
531362

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:531362

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126520 mRNA Translation: AAI26521.1
RefSeqiNP_001071452.1, NM_001077984.2
XP_005211635.1, XM_005211578.3
XP_005211636.1, XM_005211579.2
XP_005211637.1, XM_005211580.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002220

Proteomic databases

PaxDbiA0JN53
PRIDEiA0JN53

Genome annotation databases

EnsembliENSBTAT00000081849; ENSBTAP00000071505; ENSBTAG00000001693
GeneIDi531362
KEGGibta:531362

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26015
VGNCiVGNC:34098, RPAP1

Phylogenomic databases

eggNOGiKOG1894, Eukaryota
KOG4732, Eukaryota
GeneTreeiENSGT00390000007594
HOGENOMiCLU_005296_1_0_1
InParanoidiA0JN53
OMAiLRPRWCP
OrthoDBi25908at2759
TreeFamiTF324391

Gene expression databases

BgeeiENSBTAG00000001693, Expressed in skeletal muscle tissue and 19 other tissues
ExpressionAtlasiA0JN53, baseline

Family and domain databases

InterProiView protein in InterPro
IPR013929, RNA_pol_II_AP1_C
IPR013930, RNA_pol_II_AP1_N
IPR039913, RPAP1/Rba50
PANTHERiPTHR21483, PTHR21483, 1 hit
PfamiView protein in Pfam
PF08620, RPAP1_C, 1 hit
PF08621, RPAP1_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPAP1_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JN53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: December 2, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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