UniProtKB - A0JN53 (RPAP1_BOVIN)
Protein
RNA polymerase II-associated protein 1
Gene
RPAP1
Organism
Bos taurus (Bovine)
Status
Functioni
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).By similarity
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Nucleotidyltransferase, Transferase |
Biological process | Transcription |
Names & Taxonomyi
Protein namesi | Recommended name: RNA polymerase II-associated protein 1 |
Gene namesi | Name:RPAP1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:34098, RPAP1 |
Subcellular locationi
Keywords - Cellular componenti
DNA-directed RNA polymerase, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284840 | 1 – 1395 | RNA polymerase II-associated protein 1Add BLAST | 1395 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 321 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | A0JN53 |
PRIDEi | A0JN53 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000001693, Expressed in skeletal muscle tissue and 19 other tissues |
ExpressionAtlasi | A0JN53, baseline |
Interactioni
Subunit structurei
Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000002220 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 827 – 1287 | Leu-richAdd BLAST | 461 |
Sequence similaritiesi
Belongs to the RPAP1 family.Curated
Phylogenomic databases
eggNOGi | KOG1894, Eukaryota KOG4732, Eukaryota |
GeneTreei | ENSGT00390000007594 |
HOGENOMi | CLU_005296_1_0_1 |
InParanoidi | A0JN53 |
OMAi | LRPRWCP |
OrthoDBi | 25908at2759 |
TreeFami | TF324391 |
Family and domain databases
InterProi | View protein in InterPro IPR013929, RNA_pol_II_AP1_C IPR013930, RNA_pol_II_AP1_N IPR039913, RPAP1/Rba50 |
PANTHERi | PTHR21483, PTHR21483, 1 hit |
Pfami | View protein in Pfam PF08620, RPAP1_C, 1 hit PF08621, RPAP1_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0JN53-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSRPKPGES EVDLLRFQSQ FLAAGATPAV QLVKKGSRRA GDANLEQPPL
60 70 80 90 100
QDHRDVVMLD SLPDLPPALV PAPPKRARPS PGHLLPEHED PEERLHRHDQ
110 120 130 140 150
HITAVLTKII ERDTSSMPVN LPVSSGVAFP PVFHRSQGRQ GKPVTAGKRS
160 170 180 190 200
IFAQEIAARR ASGAKVSPVR EVESILDPPE SAMTCEALTP REWGSQPPWN
210 220 230 240 250
SYSFQGPHLV TGKGLKGQEA EQEAQTIHEE NVARLQALAP EEILQEQQRL
260 270 280 290 300
LAQLDPSLVA FLKSHSCTRE QAEEKATREQ RPGRPSAEVI GKEAIAPTSA
310 320 330 340 350
SVPRQENELE PETPALALPV TPQKEWLHMD TVELEKLHWT QDLPPLRRQQ
360 370 380 390 400
TQERMQARFS LQGELLAPDM DLPTHLGLHH HGEEAERAGY SLQELFHLTR
410 420 430 440 450
SQVSQQRALA LHVLAQVIGR AQAGEFGDRL VGSVLHLLLD AGFLFLLRFS
460 470 480 490 500
LDDRVDGVIA AAVRALRALL VAPGDEELLD STFSWYHGAL MFALMPSQED
510 520 530 540 550
KEDEDEDEEP PAEKAKTKSP EEGNRPPSDL ARHDIIKGLL ATNLLPRLRY
560 570 580 590 600
VLEVTCPGPS VVLDILTVLI RLARHSLESA TRVLECPRLV ETVVREFLPT
610 620 630 640 650
SWSPMGSGPT SSLHRVPCAP AMKLLRVLAS ASRNIAARLL SGFDLRSRLS
660 670 680 690 700
RFIAEDPQDL ALPLEEAETL STEAFRLWAV AASYGLGSDL YRELYPVLMQ
710 720 730 740 750
ALQDVPKELS SPPPRPLAVQ RIASLLTLLT QLTLAAGHIA PEHNSHSAEA
760 770 780 790 800
SLLAGSSSVT WTQVSGLQPL VEPCLRQTLK LLPRPEMWSA LGPVPTACLL
810 820 830 840 850
FLDAYYQAWS QQPGLCPEDW LQDMERLSEG LLLPLLKHPS LGSLWDSLGC
860 870 880 890 900
CSPLCNPQSC AVAPETISSL ASLGCAGGHP PLSLAGSASP FPFLTALLSL
910 920 930 940 950
LNTLGRIHKG LCGQLATVLA APGLQDYFLR CVAPVAALHL TPFSAWALRH
960 970 980 990 1000
EYHLQYLALT LAQRAATLQP PMSGTDAALC HGMALALLGR LLPGSEHLAH
1010 1020 1030 1040 1050
ELMLSCVFRL EFLPERASGG PEAADFSDRL SLGSGGDLGC GRGALLAQAC
1060 1070 1080 1090 1100
QDLPSIRSCY LTHCSLARAS LLASQALYRG ELQRVPALLL PVPKEPLLPT
1110 1120 1130 1140 1150
DWPFLPLIQL YHRASDTPSG LPPADTVGTA LRALQWVLVL ESWRPRALWA
1160 1170 1180 1190 1200
VSPAARLARL MCVFLVDSEL FRETPIQRLV AALLARLCQP EVLSNLNLDC
1210 1220 1230 1240 1250
PLPGLTSFPD LYANFLEHFE AVSFGDHLFG ALILLPLQRR FSVTLRLALF
1260 1270 1280 1290 1300
GEHVGALRAL GLPLTQLPVS LECYTAPPED NLALLQLYFR ALVTGALRPR
1310 1320 1330 1340 1350
WCPVLYAVAV AHVNSFIFSQ DPNNSDEIKA ACRSMLQKTW LLTDEGLRQH
1360 1370 1380 1390
LLHYKLPNSA LPEGFELYPQ LPPLRQQYLQ KLRISGVLPN GVSDT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A452DHU8 | A0A452DHU8_BOVIN | RNA polymerase II-associated protei... | RPAP1 | 1,305 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126520 mRNA Translation: AAI26521.1 |
RefSeqi | NP_001071452.1, NM_001077984.2 XP_005211635.1, XM_005211578.3 XP_005211636.1, XM_005211579.2 XP_005211637.1, XM_005211580.3 |
Genome annotation databases
Ensembli | ENSBTAT00000081849; ENSBTAP00000071505; ENSBTAG00000001693 |
GeneIDi | 531362 |
KEGGi | bta:531362 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126520 mRNA Translation: AAI26521.1 |
RefSeqi | NP_001071452.1, NM_001077984.2 XP_005211635.1, XM_005211578.3 XP_005211636.1, XM_005211579.2 XP_005211637.1, XM_005211580.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000002220 |
Proteomic databases
PaxDbi | A0JN53 |
PRIDEi | A0JN53 |
Genome annotation databases
Ensembli | ENSBTAT00000081849; ENSBTAP00000071505; ENSBTAG00000001693 |
GeneIDi | 531362 |
KEGGi | bta:531362 |
Organism-specific databases
CTDi | 26015 |
VGNCi | VGNC:34098, RPAP1 |
Phylogenomic databases
eggNOGi | KOG1894, Eukaryota KOG4732, Eukaryota |
GeneTreei | ENSGT00390000007594 |
HOGENOMi | CLU_005296_1_0_1 |
InParanoidi | A0JN53 |
OMAi | LRPRWCP |
OrthoDBi | 25908at2759 |
TreeFami | TF324391 |
Gene expression databases
Bgeei | ENSBTAG00000001693, Expressed in skeletal muscle tissue and 19 other tissues |
ExpressionAtlasi | A0JN53, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR013929, RNA_pol_II_AP1_C IPR013930, RNA_pol_II_AP1_N IPR039913, RPAP1/Rba50 |
PANTHERi | PTHR21483, PTHR21483, 1 hit |
Pfami | View protein in Pfam PF08620, RPAP1_C, 1 hit PF08621, RPAP1_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPAP1_BOVIN | |
Accessioni | A0JN53Primary (citable) accession number: A0JN53 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | December 12, 2006 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families