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Entry version 48 (08 May 2019)
Sequence version 1 (12 Dec 2006)
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Protein

NF-X1-type zinc finger protein NFXL1

Gene

nfxl1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri163 – 224RING-type; atypicalPROSITE-ProRule annotationAdd BLAST62
Zinc fingeri269 – 287NF-X1-type 1Add BLAST19
Zinc fingeri322 – 341NF-X1-type 2Add BLAST20
Zinc fingeri375 – 394NF-X1-type 3Add BLAST20
Zinc fingeri428 – 447NF-X1-type 4Add BLAST20
Zinc fingeri455 – 476NF-X1-type 5Add BLAST22
Zinc fingeri480 – 499NF-X1-type 6Add BLAST20
Zinc fingeri507 – 526NF-X1-type 7Add BLAST20
Zinc fingeri674 – 702NF-X1-type 8Add BLAST29
Zinc fingeri715 – 733NF-X1-type 9Add BLAST19
Zinc fingeri777 – 796NF-X1-type 10Add BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NF-X1-type zinc finger protein NFXL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nfxl1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-964728 nfxl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei892 – 909HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002788281 – 914NF-X1-type zinc finger protein NFXL1Add BLAST914

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A0JMY5

PRoteomics IDEntifications database

More...
PRIDEi
A0JMY5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili830 – 879Sequence analysisAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFX1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri163 – 224RING-type; atypicalPROSITE-ProRule annotationAdd BLAST62
Zinc fingeri269 – 287NF-X1-type 1Add BLAST19
Zinc fingeri322 – 341NF-X1-type 2Add BLAST20
Zinc fingeri375 – 394NF-X1-type 3Add BLAST20
Zinc fingeri428 – 447NF-X1-type 4Add BLAST20
Zinc fingeri455 – 476NF-X1-type 5Add BLAST22
Zinc fingeri480 – 499NF-X1-type 6Add BLAST20
Zinc fingeri507 – 526NF-X1-type 7Add BLAST20
Zinc fingeri674 – 702NF-X1-type 8Add BLAST29
Zinc fingeri715 – 733NF-X1-type 9Add BLAST19
Zinc fingeri777 – 796NF-X1-type 10Add BLAST20

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K15683

Database of Orthologous Groups

More...
OrthoDBi
299100at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034078 NFX1_fam
IPR019786 Zinc_finger_PHD-type_CS
IPR000967 Znf_NFX1
IPR001841 Znf_RING

The PANTHER Classification System

More...
PANTHERi
PTHR12360 PTHR12360, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01422 zf-NF-X1, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00438 ZnF_NFX, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0JMY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAPWRQAGR GRARGRATSA SGGSSQAPGP VSASNRNASY PRGVPTDGNG
60 70 80 90 100
VQRPGTGWGN STYASASKPV TTENVKRETN EENSKKKFEE IQKANQAAVK
110 120 130 140 150
KLAEDHYSSS DDEDGDEDAD GKQKKILALT FTSYTSQTDG DLSELARTQQ
160 170 180 190 200
YVNEAFQAGA VTCLICIASV KRNQAVWSCS GCFCIFHMPC IQKWAKDSVF
210 220 230 240 250
LVSSPLTDDD FEKKDYPWPC PKCRYEYKRS ETPCRYYCYC GKVEDPPLDP
260 270 280 290 300
WLVPHSCGQV CEREFKPTCG HKCLLLCHPG PCPPCPKMVT ITCFCQKAKP
310 320 330 340 350
VPRRCSAKEW SCQQPCRKTL MCKQHKCENP CHKGDCLPCP RVSKQKCLCG
360 370 380 390 400
RNVAQRPCAS PTWQCEQVCG KTLPCGNHTC EKICHAGPCG QCPRSGNRLC
410 420 430 440 450
PCAKSKYTLP CTEDVPTCGD SCDKLLECAL HKCSQRCHRG PCETCRQEVE
460 470 480 490 500
KQCRCGKHTK RMPCHKPYLC ETKCAKVRDC QRHQCKRKCC SGNCPGCDQQ
510 520 530 540 550
CGRSLGCRNH KCPSVCHRGS CYPCPETIDV KCNCSKTVLK VPCGRERTTK
560 570 580 590 600
PPKCKEVCSC PSTCHHEARE RHRCHFGPCP PCRQTCKKIL NRCSHLCPVP
610 620 630 640 650
CHDEALVKQK GLPQPAGPWE QPSEPTFIQT ALPCPPCQVP IPTECLGKHE
660 670 680 690 700
ISPLPCHAAG PFSCKRPCGR PLACGNHTCS RECHKVTDVN GNKERAGVEC
710 720 730 740 750
AACEEECNKP RPPECPHRCN LPCHSDDCPP CVQMIRTKCH CKISNLFIEC
760 770 780 790 800
TKLSMADAKE KNNLTSCKNQ CPKELPCGHR CKEICHQGNC SLNCIQKVKL
810 820 830 840 850
RCPCRRIKKE MPCNSVREGH ISLECDSVCL DVRKKAAEMK AEEENAAVEQ
860 870 880 890 900
ERRRQQAELE AFENRLKGKR RKNKRKDEVE VQQTAWQKYK KYIMMPVCGI
910
ALAVFTLYYT QVDV
Length:914
Mass (Da):102,146
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC0B384F2718B2E1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC126051 mRNA Translation: AAI26052.1

NCBI Reference Sequences

More...
RefSeqi
NP_001090441.1, NM_001096972.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
779353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:779353

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126051 mRNA Translation: AAI26052.1
RefSeqiNP_001090441.1, NM_001096972.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiA0JMY5
PRIDEiA0JMY5

Genome annotation databases

GeneIDi779353
KEGGixla:779353

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
779353
XenbaseiXB-GENE-964728 nfxl1

Phylogenomic databases

KOiK15683
OrthoDBi299100at2759

Family and domain databases

InterProiView protein in InterPro
IPR034078 NFX1_fam
IPR019786 Zinc_finger_PHD-type_CS
IPR000967 Znf_NFX1
IPR001841 Znf_RING
PANTHERiPTHR12360 PTHR12360, 1 hit
PfamiView protein in Pfam
PF01422 zf-NF-X1, 11 hits
SMARTiView protein in SMART
SM00438 ZnF_NFX, 11 hits
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFXL1_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JMY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 12, 2006
Last modified: May 8, 2019
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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