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UniProtKB - A0JMK6 (A0JMK6_DANRE)
Protein
Secretogranin II
Gene
scg2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Biological processi
- regulation of sprouting angiogenesis Source: ZFIN
Enzyme and pathway databases
Reactomei | R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DRE-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Secretogranin IIARBA annotationAlternative name(s): Secretogranin-2ARBA annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-061103-160, scg2b |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- secretory granule Source: InterPro
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5015085829 | 29 – 583 | Secretogranin IISequence analysisAdd BLAST | 555 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000038574, Expressed in brain and 17 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 123 – 159 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 526 – 583 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 132 – 147 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 526 – 548 | Basic and acidic residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the chromogranin/secretogranin protein family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | ENOG502QV5W, Eukaryota |
GeneTreei | ENSGT00390000010895 |
HOGENOMi | CLU_031294_0_0_1 |
OMAi | ILTEYPN |
OrthoDBi | 587478at2759 |
TreeFami | TF334018 |
Family and domain databases
InterProi | View protein in InterPro IPR001990, Granin IPR038858, ScgII |
PANTHERi | PTHR15119, PTHR15119, 1 hit |
Pfami | View protein in Pfam PF01271, Granin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0JMK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLSLPKLSA GGVVVLLATL LHTLTVQGAS VRHHRLRGGD QGGFLAPSSD
60 70 80 90 100
MIKALEYIES LKQRADGPES PTGDYDEVDK FRFLVQLASL QDENTPTHED
110 120 130 140 150
ATRWPDNKVP QWVRSLLRVL DQAGESPESQ AAGNERRLHK TRRPVADGES
160 170 180 190 200
PAGDYAGFVK PHKKYPLMFE DEENGRDNKR ATEDLDEQYT PQSLANMRSI
210 220 230 240 250
FEELGKLSAA QKRDDEEDGE DDDDLYRVRN AAYEDVTGGE EWVPLEEQLE
260 270 280 290 300
TEELVKGSHE EYKRALGDIS EQGMENMERR GEEEDENPDD DTKLVDYYLL
310 320 330 340 350
KVLEMTDQAQ KRDLMEGRRR LLSRPSLIDP RAIKQLLSAI SMKLQVPPED
360 370 380 390 400
LVGMLFMEET RKQQQRLPEP QLARNPSQPR YKSRVIKYYN GRQPEVTVSD
410 420 430 440 450
IPHDVKTEDI LKVLGLGNLA NKNAKFSLLK QRPYKTAMTN YFNPNGRRGS
460 470 480 490 500
LFLSELNKAP SKRKDDYDDD DAVDEDEEST FLAAKLLTEY PDTSSSNRKR
510 520 530 540 550
AIDSAANGQL PYELYEEAMK DFFDQVDNGK SALAKRDTQG KEEPEGPQKP
560 570 580
PAQDPAQETV DQTPPESGTE DGKEYHGKIV AGM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8W4K5 | F8W4K5_DANRE | Secretogranin II | scg2b | 229 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU467824 Genomic DNA No translation available. BC125913 mRNA Translation: AAI25914.1 BC164414 mRNA Translation: AAI64414.1 |
RefSeqi | NP_001071216.1, NM_001077748.1 |
Genome annotation databases
Ensembli | ENSDART00000112579; ENSDARP00000099613; ENSDARG00000038574 ENSDART00000187579; ENSDARP00000154471; ENSDARG00000038574 |
GeneIDi | 777641 |
KEGGi | dre:777641 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU467824 Genomic DNA No translation available. BC125913 mRNA Translation: AAI25914.1 BC164414 mRNA Translation: AAI64414.1 |
RefSeqi | NP_001071216.1, NM_001077748.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000099613 |
Genome annotation databases
Ensembli | ENSDART00000112579; ENSDARP00000099613; ENSDARG00000038574 ENSDART00000187579; ENSDARP00000154471; ENSDARG00000038574 |
GeneIDi | 777641 |
KEGGi | dre:777641 |
Organism-specific databases
CTDi | 777641 |
ZFINi | ZDB-GENE-061103-160, scg2b |
Phylogenomic databases
eggNOGi | ENOG502QV5W, Eukaryota |
GeneTreei | ENSGT00390000010895 |
HOGENOMi | CLU_031294_0_0_1 |
OMAi | ILTEYPN |
OrthoDBi | 587478at2759 |
TreeFami | TF334018 |
Enzyme and pathway databases
Reactomei | R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DRE-8957275, Post-translational protein phosphorylation |
Gene expression databases
Bgeei | ENSDARG00000038574, Expressed in brain and 17 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR001990, Granin IPR038858, ScgII |
PANTHERi | PTHR15119, PTHR15119, 1 hit |
Pfami | View protein in Pfam PF01271, Granin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0JMK6_DANRE | |
Accessioni | A0JMK6Primary (citable) accession number: A0JMK6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 12, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | January 19, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |