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Entry version 79 (23 Feb 2022)
Sequence version 1 (12 Dec 2006)
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Protein

Clustered mitochondria protein homolog

Gene

cluh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clustered mitochondria protein homologUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cluhUniRule annotation
ORF Names:zgc:152873
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-061103-457, cluha

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003663741 – 1400Clustered mitochondria protein homologAdd BLAST1400

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0JMD0

PeptideAtlas

More...
PeptideAtlasi
A0JMD0

PRoteomics IDEntifications database

More...
PRIDEi
A0JMD0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000047470

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0JMD0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini380 – 622CluPROSITE-ProRule annotationAdd BLAST243
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1088 – 1121TPR 1Add BLAST34
Repeati1130 – 1163TPR 2Add BLAST34
Repeati1172 – 1205TPR 3Add BLAST34
Repeati1214 – 1247TPR 4Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 39DisorderedSequence analysisAdd BLAST39
Regioni56 – 78DisorderedSequence analysisAdd BLAST23
Regioni212 – 243DisorderedSequence analysisAdd BLAST32
Regioni684 – 741DisorderedSequence analysisAdd BLAST58
Regioni1377 – 1400DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 73Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi212 – 227Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi708 – 741Polar residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1839, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0JMD0

Database of Orthologous Groups

More...
OrthoDBi
60958at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0JMD0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15466, CLU-central, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.30.2280.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03013, CLU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033646, CLU-central
IPR025697, CLU_dom
IPR028275, CLU_N
IPR027523, CLU_prot
IPR023231, GSKIP_dom_sf
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12601, PTHR12601, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13236, CLU, 1 hit
PF15044, CLU_N, 1 hit
PF12807, eIF3_p135, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103107, SSF103107, 1 hit
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51823, CLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0JMD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSKTDDIPA SVPNCSPADF ARDGETANSK GTTSKKEASC ACGHGVETAV
60 70 80 90 100
MNGDAGHDQA EEADSKQDGS GDADQAEDAN EQEVIVIQDT GFTVKIQAPG
110 120 130 140 150
TEPFDLQVSP QEMVQEIHQV LMDREDTCHR TCFSLQLDGN VLDNFAELKS
160 170 180 190 200
IEGLQEGSLL KVVEEPYTVR EARIHVRHIR DLLKSLDPSD AYNGVDCNSL
210 220 230 240 250
SFLSVFSEGD LGDTGKRKKK GSELEQIDCT PPEHILPGSK ERPLVPLQPQ
260 270 280 290 300
NKDWKPMQCL KVLTMSSWNP PPGNRKMHGD LMYLYIVTVE DRHVSITAST
310 320 330 340 350
RGFYLNQSTT YNFSPKPANP SFLSHSLVEL LSQISAAFKK NFTTLQKKRV
360 370 380 390 400
QRHPFERIAT PFQVYSWTAP QIDHAMDCVR AEDAYTSRLG YEEHIPGQTR
410 420 430 440 450
DWNEELQTTR ELSRKNLPER LLRERAIFKV HSDFAAAATR GAMAVIDGNV
460 470 480 490 500
MAINPGEETR MQMFIWNNIF FSLGFDVRDH YRELGGDSAA HAAPTNDLNG
510 520 530 540 550
VRAYSAVDVE GLYTLGTVVV DYRGYRVTAQ SIIPGILERE QEQSVIYGSI
560 570 580 590 600
DFGKTVVSHP KYLELLEKTS RPLKVQRHAV LNEKDSAVEL CSSVECKGII
610 620 630 640 650
GNDGRHYILD LLRTFPPDLN FLPVEGEELT PESQKLGFPR QHRHRLACLR
660 670 680 690 700
QELIEAFVEH RYLLFMKMAA LQLMQQKANK DKTAALQDSN AAGAGSENKP
710 720 730 740 750
LALESCDGTP DSPTSSESTL TPEDSEATTV SENSSAENQE AMTEVPVASI
760 770 780 790 800
NGTHEPLAAE RQNGGCDGPL EGKEADENIP GLAQAKELAE SLAAEDGSGI
810 820 830 840 850
DPKSREVVLN ACKAVGSISN TSFDIRFNPD IFSPGVRFPD DSNDDIKKQK
860 870 880 890 900
QLLKDAAAFL VSCQIPSLVK DCLDHSSLPM DGATLTEALH QRGINVRYLG
910 920 930 940 950
TVLEFMDNMP AKAQLEHIYR IGISELITRC AKHIFKTYLQ GVDLSALSAA
960 970 980 990 1000
VSYFLNCLLS SFPDAVAHLP ADELVSRKKS RKRRNRVPGG GDNTAWASLT
1010 1020 1030 1040 1050
PSELWKNITS EAHGYYNFSL QCESVDQAVE KYGLQKITLL REISIKTGIQ
1060 1070 1080 1090 1100
ILIKEYNFDS RHKPAFTEED ILNIFPVVKH VNPKASDAFH FFQSGQAKVQ
1110 1120 1130 1140 1150
QGFLKEGCEL INEALNLFNN VYGAMHVEIC ACLRLLARLN YIMGDHPEAL
1160 1170 1180 1190 1200
SNQQKAVLMS ERVLGIEHPN TIQEYMHLAL YCFANGQLST ALKLLYRARY
1210 1220 1230 1240 1250
LMLVVCGEDH PEMALLDSNI GLVLHGVMEY DLSLRFLENA LAINTKYHGP
1260 1270 1280 1290 1300
RSLKVALSHH LVARVYESKA EFRSALQHEK EGYTIYKNQV GEAHEKTKES
1310 1320 1330 1340 1350
SEYLKYLTQQ AVALQRTMNE IYKNGSNASI MPLKFTAPSM ASVLEQLNII
1360 1370 1380 1390 1400
NGIIFIPLSQ KDLENLKAEV QRRQLMQDSG KIQEQQGSHL ELDDKLPVDD
Length:1,400
Mass (Da):155,810
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i515A6C85819C1ED9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QSU2F1QSU2_DANRE
Clustered mitochondria protein homo...
cluha cluh
1,400Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GER3R4GER3_DANRE
Clustered mitochondria (cluA/CLU1) ...
cluha cluh
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GE19R4GE19_DANRE
Clustered mitochondria (cluA/CLU1) ...
cluha cluh
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GE78R4GE78_DANRE
Clustered mitochondria (cluA/CLU1) ...
cluha cluh
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1304L → S in AAH90714 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC090714 mRNA Translation: AAH90714.1
BC125829 mRNA Translation: AAI25830.1

NCBI Reference Sequences

More...
RefSeqi
NP_001071028.1, NM_001077560.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
562666

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:562666

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090714 mRNA Translation: AAH90714.1
BC125829 mRNA Translation: AAI25830.1
RefSeqiNP_001071028.1, NM_001077560.1

3D structure databases

SMRiA0JMD0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000047470

Proteomic databases

PaxDbiA0JMD0
PeptideAtlasiA0JMD0
PRIDEiA0JMD0

Genome annotation databases

GeneIDi562666
KEGGidre:562666

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
562666
ZFINiZDB-GENE-061103-457, cluha

Phylogenomic databases

eggNOGiKOG1839, Eukaryota
InParanoidiA0JMD0
OrthoDBi60958at2759
PhylomeDBiA0JMD0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A0JMD0

Family and domain databases

CDDicd15466, CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
3.30.2280.10, 1 hit
HAMAPiMF_03013, CLU, 1 hit
InterProiView protein in InterPro
IPR033646, CLU-central
IPR025697, CLU_dom
IPR028275, CLU_N
IPR027523, CLU_prot
IPR023231, GSKIP_dom_sf
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR12601, PTHR12601, 1 hit
PfamiView protein in Pfam
PF13236, CLU, 1 hit
PF15044, CLU_N, 1 hit
PF12807, eIF3_p135, 1 hit
SUPFAMiSSF103107, SSF103107, 1 hit
SSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51823, CLU, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLU_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JMD0
Secondary accession number(s): Q5CZT5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 12, 2006
Last modified: February 23, 2022
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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