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UniProtKB - A0JMA9 (KATL2_XENTR)
Protein
Katanin p60 ATPase-containing subunit A-like 2
Gene
katnal2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
UniRule annotationCatalytic activityi
- n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.UniRule annotation EC:5.6.1.1
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 298 – 305 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- isomerase activity Source: UniProtKB-KW
- microtubule binding Source: UniProtKB-UniRule
- microtubule-severing ATPase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Isomerase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Katanin p60 ATPase-containing subunit A-like 2UniRule annotation (EC:5.6.1.1UniRule annotation)Short name: Katanin p60 subunit A-like 2UniRule annotation Alternative name(s): p60 katanin-like 2UniRule annotation |
Gene namesi | Name:katnal2 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5827282, katnal2 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- cytoskeleton UniRule annotation
- spindle By similarity
- spindle pole By similarity
Note: Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.By similarity
Cytoskeleton
- microtubule Source: UniProtKB
- spindle Source: UniProtKB
- spindle pole Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333795 | 1 – 542 | Katanin p60 ATPase-containing subunit A-like 2Add BLAST | 542 |
Proteomic databases
PaxDbi | A0JMA9 |
PRIDEi | A0JMA9 |
Interactioni
GO - Molecular functioni
- microtubule binding Source: UniProtKB-UniRule
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000061187 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 57 | LisHUniRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 126 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 142 – 168 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 126 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 152 – 168 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
InParanoidi | A0JMA9 |
OrthoDBi | 787710at2759 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
i Sequence
Sequence statusi: Complete.
A0JMA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELSYQALRV ASQNREAEEL RTEARRKNLL ILIMHYLLQE GYMDSANSLE
60 70 80 90 100
QETKISLRRF DVCDNVDLET ILMEYESYYY IKFQKYPKIT KKALDHDSRV
110 120 130 140 150
QSKPRSAGKL RRAGSNSTQG LPRIAQQTVL HRPVSGSYFR THAHQKALSR
160 170 180 190 200
ENSKQENGGN SPREASEIGL NVSAISKTSG EGGQTRRRQV IDFRSMIQDT
210 220 230 240 250
IKGASQEIAL NSLNCNPDPS ERLIKPVGAF IGGNSEMREL AAVISRDIYL
260 270 280 290 300
QNPNVRWDDI IGLDAAKRLV KEAVVYPIRY PQLFTGILSP WKGLLLYGPP
310 320 330 340 350
GTGKTLLAKA VATECNTTFF NISASTIVSK WRGDSEKLVR VLFELARYHA
360 370 380 390 400
PSTIFLDELE SVMSQRGTGP GGEHEGSRRM KTELLVQMDG LARSDDLVFV
410 420 430 440 450
LAASNLPWEL DYAMLRRLEK RILVDLPSKE ARQAMIQHWL PPVSNSSGVE
460 470 480 490 500
LRTDLDYSTL GAETDGYSGS DIRLVCKEAA MRPVRKIFDA LENHHSEHKN
510 520 530 540
LPVISLDTVT TSDFLEVLAH TKPSAKSLAE KYAAWQKEFE SV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC125808 mRNA Translation: AAI25809.1 |
RefSeqi | NP_001090643.1, NM_001097174.1 |
Genome annotation databases
GeneIDi | 100036615 |
KEGGi | xtr:100036615 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC125808 mRNA Translation: AAI25809.1 |
RefSeqi | NP_001090643.1, NM_001097174.1 |
3D structure databases
SMRi | A0JMA9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000061187 |
Proteomic databases
PaxDbi | A0JMA9 |
PRIDEi | A0JMA9 |
Protocols and materials databases
DNASUi | 100036615 |
Genome annotation databases
GeneIDi | 100036615 |
KEGGi | xtr:100036615 |
Organism-specific databases
CTDi | 83473 |
Xenbasei | XB-GENE-5827282, katnal2 |
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
InParanoidi | A0JMA9 |
OrthoDBi | 787710at2759 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KATL2_XENTR | |
Accessioni | A0JMA9Primary (citable) accession number: A0JMA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 23, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families