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Entry version 100 (13 Feb 2019)
Sequence version 1 (12 Dec 2006)
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Protein
Submitted name:

Ubiquitin-conjugating enzyme E2 D1

Gene

ube2d1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • ubiquitin conjugating enzyme activity Source: GO_Central
  • ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-XTR-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-XTR-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-XTR-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-XTR-174154 APC/C:Cdc20 mediated degradation of Securin
R-XTR-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-XTR-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-XTR-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-XTR-176408 Regulation of APC/C activators between G1/S and early anaphase
R-XTR-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-XTR-176412 Phosphorylation of the APC/C
R-XTR-179409 APC-Cdc20 mediated degradation of Nek2A
R-XTR-202424 Downstream TCR signaling
R-XTR-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-2467813 Separation of Sister Chromatids
R-XTR-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-XTR-2871837 FCERI mediated NF-kB activation
R-XTR-5607764 CLEC7A (Dectin-1) signaling
R-XTR-69017 CDK-mediated phosphorylation and removal of Cdc6
R-XTR-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-XTR-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-XTR-8951664 Neddylation
R-XTR-9033241 Peroxisomal protein import
R-XTR-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme E2 D1Imported
Submitted name:
Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ube2d1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-954784 ube2d1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000025140 Expressed in 14 organ(s), highest expression level in gastrula

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000046119

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 136UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST133

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0417 Eukaryota
COG5078 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233455

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG063308

KEGG Orthology (KO)

More...
KOi
K06689

Identification of Orthologs from Complete Genome Data

More...
OMAi
MIHFPPD

Database of Orthologous Groups

More...
OrthoDBi
1337945at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101108

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00195 UBCc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00179 UQ_con, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54495 SSF54495, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0JM78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKRIQKEL NDLQRDPPAQ CSAGPVGDDL FHWQATIMGP TDSPYQGGVF
60 70 80 90 100
FLTIHFPTDY PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS
110 120 130 140
KVLLSICSLL CDPNPDDPLV PDIAQIYKSD KEKYNRLARE WTQKYAM
Length:147
Mass (Da):16,626
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF135D05934F55EE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01065923 Genomic DNA No translation available.
AAMC01065924 Genomic DNA No translation available.
BC125770 mRNA Translation: AAI25771.1

NCBI Reference Sequences

More...
RefSeqi
NP_001072891.1, NM_001079423.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Str.55444

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000046119; ENSXETP00000046119; ENSXETG00000025140

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
780353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:780353

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01065923 Genomic DNA No translation available.
AAMC01065924 Genomic DNA No translation available.
BC125770 mRNA Translation: AAI25771.1
RefSeqiNP_001072891.1, NM_001079423.1
UniGeneiStr.55444

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000046119

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000046119; ENSXETP00000046119; ENSXETG00000025140
GeneIDi780353
KEGGixtr:780353

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7321
XenbaseiXB-GENE-954784 ube2d1

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00940000155109
HOGENOMiHOG000233455
HOVERGENiHBG063308
KOiK06689
OMAiMIHFPPD
OrthoDBi1337945at2759
TreeFamiTF101108

Enzyme and pathway databases

ReactomeiR-XTR-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-XTR-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-XTR-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-XTR-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-XTR-174154 APC/C:Cdc20 mediated degradation of Securin
R-XTR-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-XTR-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-XTR-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-XTR-176408 Regulation of APC/C activators between G1/S and early anaphase
R-XTR-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-XTR-176412 Phosphorylation of the APC/C
R-XTR-179409 APC-Cdc20 mediated degradation of Nek2A
R-XTR-202424 Downstream TCR signaling
R-XTR-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-2467813 Separation of Sister Chromatids
R-XTR-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-XTR-2871837 FCERI mediated NF-kB activation
R-XTR-5607764 CLEC7A (Dectin-1) signaling
R-XTR-69017 CDK-mediated phosphorylation and removal of Cdc6
R-XTR-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-XTR-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-XTR-8951664 Neddylation
R-XTR-9033241 Peroxisomal protein import
R-XTR-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSXETG00000025140 Expressed in 14 organ(s), highest expression level in gastrula

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0JM78_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JM78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: February 13, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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