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Entry version 61 (11 Dec 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Nephrocystin-3

Gene

nphp3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-5624138 Trafficking of myristoylated proteins to the cilium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nephrocystin-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nphp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-487873 nphp3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004025461 – 1311Nephrocystin-3Add BLAST1311

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0JM23

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati889 – 923TPR 1Add BLAST35
Repeati927 – 960TPR 2Add BLAST34
Repeati969 – 1002TPR 3Add BLAST34
Repeati1011 – 1044TPR 4Add BLAST34
Repeati1077 – 1110TPR 5Add BLAST34
Repeati1119 – 1152TPR 6Add BLAST34
Repeati1161 – 1194TPR 7Add BLAST34
Repeati1203 – 1236TPR 8Add BLAST34
Repeati1245 – 1278TPR 9Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili81 – 183Sequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 23Poly-Gly5
Compositional biasi538 – 541Poly-Ser4
Compositional biasi590 – 594Poly-Ile5

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0JM23

KEGG Orthology (KO)

More...
KOi
K19360

Database of Orthologous Groups

More...
OrthoDBi
377554at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13176 TPR_7, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0JM23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTASSLVNP GEVIEDTYGG GGGEACVIPV EVKPKARLLR SSFRRGPRVI
60 70 80 90 100
GASFKSTASV DLEYAAEYER LKKEYEIFRV SKNNEIASMQ KKEVKLDEEN
110 120 130 140 150
KRLRAELQAL QKTYQKILRE KESAVEAKYQ AMERAATFEH DRDKVKRQFK
160 170 180 190 200
IFRETKEKEI QDLLRAKRDL EAKLQRLQAQ GIQVFDPGES DSDDNGTELT
210 220 230 240 250
VPGTQCEYWT SGGLGSEPSI GSMMQLQQSF RGPEFAHSSI DVEGPFANVN
260 270 280 290 300
RDDWDAAVAS LLQVTPLFSQ SLWSNTVRCY LMYTAETQAE VKIFLKEYSP
310 320 330 340 350
KLQRMCETSG YFFQVTFFPE ECENQYFAVR KWEIEKSSIV ILFICSSLPS
360 370 380 390 400
CLQEDCEEAF LKNTEAKPCL IYHRIEDGRS DSEGLKQLLE QDTNKANKTK
410 420 430 440 450
IVDHYGDPVE GANKIYCQLE QVINQDLLGI EITDPNAKDD SATKEEDDFW
460 470 480 490 500
DVLWDVHDEQ EQMEAFQQAS HSICELGFQK YYDRLNDLVA APAPIPPLLI
510 520 530 540 550
SGGPGSGKSL LLSKWIQLQQ KHSPNTLMLY HFVGRPLSSS SEPSLMIKRL
560 570 580 590 600
FLKLMQHSWS VSSLSLDPAK FLEEFPHWLE KLSIRYQGNI IIIIDSIDHI
610 620 630 640 650
QQSEKHMKWL IDPLPVNVRV IVSVNVETCP QAWRLWPTLH LDPLNSKDVK
660 670 680 690 700
SLINMECGRA NIILTKEQER KLERHCRSAT TCNALYVTLI AKLLTWAGST
710 720 730 740 750
GNIDDVLQLC LQCQDTVSLY RLALHSVQEV MPSAKDKEFM REILCFISAS
760 770 780 790 800
RNGVSECELM ELCPGLTWPV LTSLIFHLYT LVLLKYSCGL IQFQHLQEIL
810 820 830 840 850
SFNILNFKAW DAVNLEYMQG DQSIISEYRE KLIQHFNAQL SCDRVTWRSA
860 870 880 890 900
DELTWLYQQQ GEKQKLHRCL MNLFVSQNLY KRGHFAELLS YWQLVGKDKI
910 920 930 940 950
SMASEYFDAL KQYERSCEGE EKMTSLADLY ETLGRFLKDL GLLSQAVTPL
960 970 980 990 1000
QRSLEIRETA LDPDHPSVAQ SLHQLAGVYV QSKKFGNAEQ LYKQALEISE
1010 1020 1030 1040 1050
NAYGSEHMRV ARELDALAVL YQKQNKFEQA EQLRKKSLKI RQKSARRKGS
1060 1070 1080 1090 1100
MYGFALLRRR ALQLEELTLG KDTSDNARTL NELGVLYYLQ NNLETAETFL
1110 1120 1130 1140 1150
KRSLEMRERV LGADHPDCAQ SINNLAALYN EKKQYDKAEE LYERALDIRR
1160 1170 1180 1190 1200
RALSPDHPSL AYTVKHLAVL YKRKGKLDKA VPLYELAVEI RQKSFGPKHP
1210 1220 1230 1240 1250
SVATALVNLA VLYCQMKKQA EASPLYERAM KIYEDSLGRM HPRVGETLKN
1260 1270 1280 1290 1300
LAVLRYEEGD FEKAAELYKR AMEIKETETS VLGAKAHSGH SSSGGDTYSV
1310
QNALPVCAFP E
Length:1,311
Mass (Da):149,727
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D430BAB8D256F30
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI25710 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC125709 mRNA Translation: AAI25710.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
NP_001072733.2, NM_001079265.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
780190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:780190

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125709 mRNA Translation: AAI25710.1 Frameshift.
RefSeqiNP_001072733.2, NM_001079265.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA0JM23

Genome annotation databases

GeneIDi780190
KEGGixtr:780190

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27031
XenbaseiXB-GENE-487873 nphp3

Phylogenomic databases

InParanoidiA0JM23
KOiK19360
OrthoDBi377554at2759

Enzyme and pathway databases

ReactomeiR-XTR-5624138 Trafficking of myristoylated proteins to the cilium

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13176 TPR_7, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPHP3_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JM23
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: December 11, 2019
This is version 61 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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