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Entry version 78 (08 May 2019)
Sequence version 1 (12 Dec 2006)
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Protein

Tenellin synthetase

Gene

tenS

Organism
Beauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of tellinin that could be linked to insect pathogenicity (PubMed:17216664, PubMed:18266306, PubMed:20575135). The polyketide-amino acid backbone is first assembled by the PKS-NRPS hybrid tenS (PubMed:17216664, PubMed:18266306, PubMed:20575135). Because tenS lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase tenC (PubMed:18266306). Upon formation of the polyketide backbone on the thiotemplate, the triketide is transferred to the NRPS module and linked to tyrosine to produce the acyltetramic acid intermediate called pretenillin A (PubMed:18266306). The cytochrome P450 monooxygenase tenA catalyzse an oxidative ring expansion of pretenellin A to form the 2-pyridone core of tenellin, leading to pretenellin B (PubMed:19067514). The cytochrome P450 monooxygenase tenB is then required for the selective N-hydroxylation of the 2-pyridone nitrogen of pretenellin-B to yield tellinin (PubMed:19067514).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.2 Publications
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Methyltransferase, Multifunctional enzyme, Oxidoreductase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tenellin synthetase1 Publication (EC:2.3.1.-2 Publications, EC:6.3.2.-2 Publications)
Short name:
TENS1 Publication
Alternative name(s):
Hybrid PKS-NRPS synthetase tenS1 Publication
Tenellin biosynthesis protein S1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tenS1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBeauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri176275 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesCordycipitaceaeBeauveria

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impairs the production of tenellin (PubMed:17216664).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004384431 – 4239Tenellin synthetaseAdd BLAST4239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2542O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3795O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0JJU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2502 – 2582Carrier 1PROSITE-ProRule annotationAdd BLAST81
Domaini3751 – 3835Carrier 2PROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 457Ketosynthase (KS) domainSequence analysis1 PublicationAdd BLAST440
Regioni589 – 923Malonyl-CoA:ACP transacylase (MAT) domainSequence analysis1 PublicationAdd BLAST335
Regioni993 – 1310Dehydratase (DH) domainSequence analysis1 PublicationAdd BLAST318
Regioni1459 – 1652Methyltransferase (MT) domainSequence analysis1 PublicationAdd BLAST194
Regioni2209 – 2382Ketoreductase (KR) domainSequence analysis1 PublicationAdd BLAST174
Regioni2723 – 3169Condensation (C) domainSequence analysis1 PublicationAdd BLAST447
Regioni3203 – 3614Adenylation (A) (KR) domainSequence analysis1 PublicationAdd BLAST412
Regioni3899 – 4145Reductase (RED) domainSequence analysis1 PublicationAdd BLAST247

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3867 – 3885Ser-richPROSITE-ProRule annotationAdd BLAST19

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.10.129.110, 1 hit
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0JJU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPMKQNESE SHSVSEPIAI IGSAYRFPGG CNTPSKLWDL LRQPRDILKE
60 70 80 90 100
IDPERLNLRR YYHPDGETHG STDVANKAYT LEEDISRFDA SFFGISPLEA
110 120 130 140 150
ASMDPQQRTL LEVVYESTET AGIPLDKLRG SLTSVHVGVM TTDWAQMQRR
160 170 180 190 200
DPETMPQYTA TGIASSIISN RISYIFDLKG ASETIDTACS SSLVALHNAA
210 220 230 240 250
RALQSGDCEK AIVAGVNLIL DPDPFIYESK LHMLSPDARS RMWDAAANGY
260 270 280 290 300
ARGEGAAAVV LKTLGHALRD GDRIEGVIRS TFVNSDGLSS GLTMPSSAAQ
310 320 330 340 350
TALIRQTYRK AGLDPVRDRP QFFECHGTGT KAGDPVEARA ISDAFLPPSH
360 370 380 390 400
RTNGAATTVD APLYVGSIKT VVGHLEGCAG LAGLVKVLLS LKHGIIPPNL
410 420 430 440 450
WFDKLNPEIA RYYGPLQIPT KAIPWPKLAP GTPLRASVNS FGFGGTNAHA
460 470 480 490 500
IIERYDASQS YCSQWRRNMT EEKTIARTQN NESIEIPVPL VLTAKTGRAL
510 520 530 540 550
WRTVDAYAQH LRQHPKLRVT NLSQFMHSRR STHRVRASFS GASREELVEN
560 570 580 590 600
MAKFVQAHAA DAKSPASQNR IGYSPLHIDP KEAPGILGVF TGQGAQWPAM
610 620 630 640 650
GRDMMHQSPL FRKTIADCES VLQALPAKDA PVWSLSEELK KDASTSRLGE
660 670 680 690 700
AEISQPLCTA VQLALVNVLL ASGVHFDAVV GHSSGEIAAT YASGIINLEA
710 720 730 740 750
AMQIAYYRGL YAKLARGETD AAGGMMAAGL SMNDAVKLCR LPEFEGRIHV
760 770 780 790 800
AASNAPQSVT LSGDKEAIKA AKAKLDADGV FARELKVDTA YHSHHMLPCA
810 820 830 840 850
EPYLKALLAC DIQVSAPTTT PGRKCMWSSS VRGDAELLRH DRNLDSLKGP
860 870 880 890 900
YWVANMVQTV LFSRAVQSTI WHGGPFDLAV EVGPHPALKG PTEQTLKAVY
910 920 930 940 950
GSAPLYTGVL SRGANDAVAF STAIGNIWSH LGPAFVDITG YQSIFSSTCE
960 970 980 990 1000
GHGGGSAAPF ISDLPLYPWD HDEEYWRESR ISRRHRTGKD ESHELLGRRT
1010 1020 1030 1040 1050
PDDNEREIRW RNLLKVSELP WTQGHRVLGE VLLPGAAYIS MAIEAGRRLA
1060 1070 1080 1090 1100
LDQGREARLL EVSDVDILRP VVVADNKEGT ETLFTVRLLD EYASTGKKSD
1110 1120 1130 1140 1150
ELITASFSFY IYNSPASTSI VHTCEGRIAV QLGAKLGSEA GANSMPQLPH
1160 1170 1180 1190 1200
REPSISNLQQ LDCEKLYSVF ETIGLEYSGA FRRIVSSSRC LGHATATASW
1210 1220 1230 1240 1250
PTTDLNDCYL IHPAILDVAF QTIFVARAHP DSGQLSSALL PSRIERVRVV
1260 1270 1280 1290 1300
PSLAMGSKLQ NNENFNAAID SWALNQTASS LTGNINVYDA ESGRALIQVE
1310 1320 1330 1340 1350
GFEVRAVGEP DASKDRLLFY ETVWGRDISI MGLSDPIRDE TSDAMVHNLS
1360 1370 1380 1390 1400
EAIERVSLFY VRQLMGELST ADRRQANWYH TRMLAAFDYH LAKVHEETHL
1410 1420 1430 1440 1450
HLRPEWLADD WAVIQTIDEA YPDAVELQML HAVGQNVADV IRGKKHLLEV
1460 1470 1480 1490 1500
LRVDNLLDRL YTEDKGMHMA NLFLANALEE ITFKFPRCKI LEIGAGTGAT
1510 1520 1530 1540 1550
TWAALSAIGE AFDTYTYTDL SVGFFENAVE RFSAFRHRMV FRALDIEKDP
1560 1570 1580 1590 1600
ASQSFDLNSY DIIIATNVLH ATRNLGVTLG NVRALLKPGG YLLLNEKTGP
1610 1620 1630 1640 1650
ESLRATFNFG GLEGWWLAEE KERQLSPLMS PDGWDAQLQK ASFSGVDHIV
1660 1670 1680 1690 1700
HDVQEDQQDK QQNSMIMSQA VDDTFYARLS PLSEMANLLP MNEPLLIIGG
1710 1720 1730 1740 1750
QTTATLKMIK EIQKLLPRQW RHKVRLIASV DHVEAEGLPA HSDVICLQEL
1760 1770 1780 1790 1800
DRGLFTTAMT SKCLDALKTL FINTRNLLWV TNAQNSSSMT PRASMFRGIT
1810 1820 1830 1840 1850
RVLDGEVPHI RTQVLGIEPR ETPSATARTL LEAFLRLRSD DGRHAGNVDE
1860 1870 1880 1890 1900
DGADGSSQQV LWLHEPEAEL LSNGTMMVPR VKARKSLNDT YLASTRAIST
1910 1920 1930 1940 1950
TVDARCVSVQ AVAGPAKMLL RPVEDFAGEH AISNQTSDSK VHIQVESTLH
1960 1970 1980 1990 2000
IPEALDGTCL YLVCGWTRTA ETSVPVIALS ANNASMVAVE SKAVAMIDEV
2010 2020 2030 2040 2050
DVKPETLLRV FQHMAMQALD SAVKRHGQGQ STALIYGADE ELAKLTSERF
2060 2070 2080 2090 2100
AVRESKVYFA SSRTFAPGDW LKVQPLLSKF ALSQMIPADV EVFIDCLGDT
2110 2120 2130 2140 2150
ESFDACRTLQ SCLSTTRTVQ HRLDACLLSQ MSRCSPDALV DAYSYAKTQS
2160 2170 2180 2190 2200
NAEFSWNGYV KTFTAAELAG KLSHSLIHSV YMTNWQKKDS ILVTVPPLQT
2210 2220 2230 2240 2250
RGLFKSDRTY LMVGAAGGLG TSICRWMVRN GARHVVVTSR NPKADPEMLN
2260 2270 2280 2290 2300
EAERYGAAVQ VVPMDACSKD SVQTVVDMIR ATMPPIAGVC NAAMVLRDKL
2310 2320 2330 2340 2350
FLDMNVDHMK DVLGPKMQGT EHLDSIFAQE PLDFFVLLSS SAAILNNTGQ
2360 2370 2380 2390 2400
SNYHCANLYM DSLVTNRRSR GLAASIIHVG HVCDTGYVAR LVDDTKVQMS
2410 2420 2430 2440 2450
LGTTRVMSVS ETDVHHAFAE AVRGGQPDSR SGSHNIIMGI EPPTKPLDLT
2460 2470 2480 2490 2500
KRKPVWISDP RLGPCLPFST LENQMMASEQ AAAASAVDSL AQQVSEATTD
2510 2520 2530 2540 2550
EEAAVAALKG FATKLEGILL LPLGSIGEDS AGRPVTDLGI DSLVAVEIRT
2560 2570 2580 2590 2600
WFLKQLRVDV PVMKILGGST VGQLSALAAK LARQDAKKRA QLEEPSGNQP
2610 2620 2630 2640 2650
VALPSPPPKD KAGGLNKNGK SPKLPEIAQV DTVVERMEPL VLEASDRGGS
2660 2670 2680 2690 2700
STANLTTSSS VSELDDSLHE STLQSSDNNG ESTPSKSSNC NSDSGSDNQA
2710 2720 2730 2740 2750
PKEIPSNGFF TQPAATARPN VLREAPMSPA QSRIWFLSKH IAEPDAYNMV
2760 2770 2780 2790 2800
FHYRVRGPLS MVRLRHALQT VTNHHECLCM CFYASADNGQ PMQGLLASSA
2810 2820 2830 2840 2850
FQMTHVPGGE EQDVQRELRK LKTRVWSVES GQTLELVVLG PRPGTAAAAE
2860 2870 2880 2890 2900
EEEEEFSLLF GYHHIVMDAI SFYIFLADLD KAYRMLPLDK ASAGSHLDLA
2910 2920 2930 2940 2950
AHQRQQERAG AWEESLEFWR AEFETIPEML PSLSVALPTL HRGAVGTHRV
2960 2970 2980 2990 3000
LRELAHEQGG DAAIKKMCKH LRVSPFNLHI AVLQVVIARL ASIEDVCVGI
3010 3020 3030 3040 3050
VDANRSDSRA SRMVGCFVNM LPVRSRILPT ATLADVARAA SSKALAAFAH
3060 3070 3080 3090 3100
GQVPLDSILD KVKAPRPAGS TPLFQVALNY RPAAAIASKQ ALGGECEMEL
3110 3120 3130 3140 3150
LADDFKDAEN PFEISVLVSE MSGGRIAVEV VCQKSRYTMQ ATEALLDAYL
3160 3170 3180 3190 3200
NVLAGFLSDS AQSVGDCVVH DQSKVEHALD LGRGAQKSFG WPRTLSERVM
3210 3220 3230 3240 3250
SICQQHSTKS AIKDGRNELS YAQLASRVNR TASAILGTGC SVGSRIAVLC
3260 3270 3280 3290 3300
NPSIDAIVAM LAILHIGGVY VPLDTSLPEA RHQSLASNCT PSLIISHAAT
3310 3320 3330 3340 3350
RERAHKLSAA ISAPGHEPAR ELTLDDLSPP EETGYMAPLN AEPNAPAILL
3360 3370 3380 3390 3400
YTSGSTGTPK GVLLTQANFG NHIALKTDIL GLQRGECVLQ QSSLGFDMSL
3410 3420 3430 3440 3450
VQVFCALANG GCLVIVRQDV RRDPVELTTL MTQHKVSLTI ATPSEYLAWL
3460 3470 3480 3490 3500
QYGSDALAQA TSWKNLCMGG EPIPPLLKDE LRRRLERKDL VVTNCYGPTE
3510 3520 3530 3540 3550
TTAAISFQSV ALDSEHGHEL PGESELAQYA VGKALPNYSI RIRDSAGGAW
3560 3570 3580 3590 3600
LPVNHTGEIV IGGAGVALGY LDMPEETRAR FLQTPGEEDG MMLYRTGDKG
3610 3620 3630 3640 3650
RLLSDGTLLC FGRITGDYQV KLRGLRIELG EVEAALLQAS HGLIHTAVVS
3660 3670 3680 3690 3700
RRGDVLVAHC ARSHESSRET TGGGEQQDAT AILRRVSELL PQYSVPAAIA
3710 3720 3730 3740 3750
LLPSLPTNAN GKLDRKAIAA LPLSPQDEAA AATSPSNNNI NNNTPSGGGG
3760 3770 3780 3790 3800
EKMTVRQGEL RLLWERVLPR DAATTTTNSV RITPESDFFL RGGNSLLLMK
3810 3820 3830 3840 3850
LQAAIRESMG VRVSTKALYQ ASTLSGMARC VAEQRSDDDE AEEDIDWAAE
3860 3870 3880 3890 3900
VAVPPSMLAQ IEKLQHSSAS SSSSSSSSSS AGSSSTQRPR KTSGLEILLT
3910 3920 3930 3940 3950
GATGFLGGQL LERLVQSPRV STVHCVAVPV DEQSLLEPFL QQQADGTRRK
3960 3970 3980 3990 4000
VRCYIGNLAA PALGLTAADQ TALSQTADVI VHAGSMGHCL NTYATLAAPN
4010 4020 4030 4040 4050
FASTRHLCSL ALSRSPPIPL AFASSNRVAL LTGSTAPPPA SAAAFPPPPG
4060 4070 4080 4090 4100
AQGFTASKWA SEAFLEKLAA SIMTSKTKST TTTTTTTVPW RVSIHRPCAL
4110 4120 4130 4140 4150
ISDRAPNSDA LNAILRYSTS MRCVPSLPEH RAEGYLDFGQ VDKVVEEMVG
4160 4170 4180 4190 4200
DILGLADERQ QEGPAVVYRH HSGGVKVPIH EFREHMESVY GGRFESVELG
4210 4220 4230
QWIVRAVDAG MDPLISAYLE TFLEGDASMV FPYMGEQAV
Length:4,239
Mass (Da):460,365
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DF488E427353542
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AM409327 Genomic DNA Translation: CAL69597.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM409327 Genomic DNA Translation: CAL69597.1

3D structure databases

SMRiA0JJU1
ModBaseiSearch...

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.10.129.110, 1 hit
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits
SUPFAMiSSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
TIGRFAMsiTIGR01733 AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENS_BEABA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0JJU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: December 12, 2006
Last modified: May 8, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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