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UniProtKB - A0FGR8 (ESYT2_HUMAN)

Entry version 140 (29 Sep 2021)
Sequence version 1 (28 Nov 2006)
Previous versions | rss
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Protein

Extended synaptotagmin-2

Gene

ESYT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).

5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi400Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi401Calcium 11 Publication1
Metal bindingi401Calcium 21 Publication1
Metal bindingi413Calcium 21 Publication1
Metal bindingi460Calcium 11 Publication1
Metal bindingi460Calcium 21 Publication1
Metal bindingi461Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi462Calcium 11 Publication1
Metal bindingi462Calcium 21 Publication1
Metal bindingi462Calcium 3; via carbonyl oxygen1 Publication1
Metal bindingi464Calcium 3; via carbonyl oxygen1 Publication1
Metal bindingi466Calcium 31 Publication1
Metal bindingi467Calcium 11 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Lipid transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A0FGR8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660662, Glycosphingolipid metabolism

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.57.1.2, the extended-synaptotagmin (e-syt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extended synaptotagmin-2Curated
Short name:
E-Syt21 Publication
Alternative name(s):
Chr2Syt
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESYT2Imported
Synonyms:FAM62B, KIAA1228
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:22211, ESYT2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A0FGR8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000117868

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 103CytoplasmicSequence analysisAdd BLAST103
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 127LumenalSequence analysis3
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 921CytoplasmicSequence analysisAdd BLAST773

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi401D → A: Abolishes calcium binding; when associated with A-413. 1 Publication1
Mutagenesisi413D → A: Abolishes calcium binding; when associated with A-401. 1 Publication1
Mutagenesisi413D → N: Strongly reduces calcium binding. 1 Publication1
Mutagenesisi466D → A: Impairs binding of the third calcium ion, but has no effect on the binding of the other two calcium ions. 1 Publication1
Mutagenesisi833 – 840KRRSGRRK → AAASGAAA: Abolishes location at the cell membrane. 1 Publication8

Organism-specific databases

DisGeNET

More...DisGeNETi		57488

Open Targets

More...OpenTargetsi		ENSG00000117868

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165617947

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A0FGR8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ESYT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782581 – 921Extended synaptotagmin-2Add BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei691PhosphoserineCombined sources1
Modified residuei693PhosphoserineCombined sources1
Modified residuei705PhosphothreonineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei738PhosphoserineBy similarity1
Modified residuei739PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A0FGR8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0FGR8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A0FGR8

MaxQB - The MaxQuant DataBase

More...MaxQBi		A0FGR8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A0FGR8

PeptideAtlas

More...PeptideAtlasi		A0FGR8

PRoteomics IDEntifications database

More...PRIDEi		A0FGR8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30 [A0FGR8-1]
31 [A0FGR8-2]
32 [A0FGR8-4]
33 [A0FGR8-5]
34 [A0FGR8-6]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A0FGR8, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A0FGR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A0FGR8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A0FGR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high level in cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117868, Expressed in placenta and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0FGR8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A0FGR8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000117868, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ESYT1 and ESYT3.

Interacts with FGFR1 that has been activated by FGF1 binding.

Interacts with the AP-2 complex; identified in a complex with the AP-2 complex and FGFR1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121556, 96 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		A0FGR8

Database of interacting proteins

More...DIPi		DIP-61039N

Protein interaction database and analysis system

More...IntActi		A0FGR8, 46 interactors

Molecular INTeraction database

More...MINTi		A0FGR8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000251527

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A0FGR8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1921
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0FGR8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		A0FGR8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 370SMP-LTDPROSITE-ProRule annotation1 PublicationAdd BLAST180
Domaini369 – 489C2 1PROSITE-ProRule annotationAdd BLAST121
Domaini514 – 639C2 2PROSITE-ProRule annotationAdd BLAST126
Domaini786 – 908C2 3PROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 103DisorderedSequence analysisAdd BLAST103
Regioni660 – 754DisorderedSequence analysisAdd BLAST95
Regioni833 – 840Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 36Polar residuesSequence analysisAdd BLAST15
Compositional biasi56 – 71Basic residuesSequence analysisAdd BLAST16
Compositional biasi660 – 686Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi687 – 707Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.1 Publication
The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium (PubMed:24373768). The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for location at the cell membrane (PubMed:23791178).2 Publications
The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior; can bind two lipid molecules simultaneously. Binds a variety of lipids, including phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol (PubMed:24847877).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the extended synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1012, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156086

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A0FGR8

Database of Orthologous Groups

More...OrthoDBi		52746at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0FGR8

TreeFam database of animal gene trees

More...TreeFami		TF324255

Family and domain databases

Conserved Domains Database

More...CDDi		cd08391, C2A_C2C_Synaptotagmin_like, 1 hit
cd04050, C2B_Synaptotagmin-like, 1 hit
cd04030, C2C_KIAA1228, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037752, C2C_KIAA1228
IPR037733, Ext_Synaptotagmin_C2A
IPR037749, Ext_Synaptotagmin_C2B
IPR031468, SMP_LBD
IPR039010, Synaptotagmin_SMP

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 3 hits
PF17047, SMP_LBD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 3 hits
PS51847, SMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0FGR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS 
        60         70         80         90        100
HAPGSRLGAR RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN 
       110        120        130        140        150
PGGVLSVELP GLLAQLARSF ALLLPVYALG YLGLSFSWVL LALALLAWCR 
       160        170        180        190        200
RSRGLKALRL CRALALLEDE ERVVRLGVRA CDLPAWVHFP DTERAEWLNK 
       210        220        230        240        250
TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV DVGQQPLRIN 
       260        270        280        290        300
GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM 
       310        320        330        340        350
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI 
       360        370        380        390        400
ILDIISNYLV LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK 
       410        420        430        440        450
DTYLKGLVKG KSDPYGIIRV GNQIFQSRVI KENLSPKWNE VYEALVYEHP 
       460        470        480        490        500
GQELEIELFD EDPDKDDFLG SLMIDLIEVE KERLLDEWFT LDEVPKGKLH 
       510        520        530        540        550
LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL YLDSARNLPS 
       560        570        580        590        600
GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL 
       610        620        630        640        650
EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI 
       660        670        680        690        700
ALRVLHLEKR ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN 
       710        720        730        740        750
TAPSTPVIGG SDKPGMEEKA QPPEAGPQGL HDLGRSSSSL LASPGHISVK 
       760        770        780        790        800
EPTPSIASDI SLPIATQELR QRLRQLENGT TLGQSPLGQI QLTIRHSSQR 
       810        820        830        840        850
NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK THVSKKTLNP 
       860        870        880        890        900
VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL 
       910        920 
AKGWTQWYDL TEDGTRPQAM T
Length:921
Mass (Da):102,357
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD57F1BD9BB0A0C8A
GO
Isoform 2 (identifier: A0FGR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MTANRDAALS...RAPSPPRPGG → MTPPSRAEAG...GAGGAGGRAA

Show »
Length:893
Mass (Da):98,902
Checksum:i9C059B137A2F1EFB
GO
Isoform 4 (identifier: A0FGR8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.
     706-731: PVIGGSDKPGMEEKAQPPEAGPQGLH → SQSRSRPPASPRTSRCPSPPRSCGKG
     732-921: Missing.

Show »
Length:527
Mass (Da):59,403
Checksum:iE4257349511C9C28
GO
Isoform 5 (identifier: A0FGR8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-593: Missing.
     594-603: NPKRQDLEVE → MPVLPPCVLQ

Show »
Length:328
Mass (Da):35,846
Checksum:iEF531CFF2A35D17C
GO
Isoform 6 (identifier: A0FGR8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-550: S → SNPLEFNPDVLKKTAVQRALKS

Show »
Length:942
Mass (Da):104,708
Checksum:i207D6C010DB58248
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A499FIX8A0A499FIX8_HUMAN
Extended synaptotagmin-2
ESYT2 FAM62B, hCG_20178
845Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXI1H7BXI1_HUMAN
Extended synaptotagmin-2
ESYT2
866Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXU3A0A087WXU3_HUMAN
Extended synaptotagmin-2
ESYT2
921Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91539 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85769 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141L → V in CAH10642 (PubMed:17974005).Curated1
Sequence conflicti612S → P in BAC85769 (PubMed:14702039).Curated1
Sequence conflicti615N → S in BAC86489 (PubMed:14702039).Curated1
Sequence conflicti795R → Q in BAC85769 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030725210C → S. Corresponds to variant dbSNP:rs13233513Ensembl.1
Natural variantiVAR_030726638S → G1 PublicationCorresponds to variant dbSNP:rs2305473Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0232361 – 593Missing in isoform 5. 1 PublicationAdd BLAST593
Alternative sequenceiVSP_0232381 – 204Missing in isoform 4. 1 PublicationAdd BLAST204
Alternative sequenceiVSP_0232391 – 97MTANR…PRPGG → MTPPSRAEAGVRRSRVPSEG RWRGAEPPGISASTQPASAG RAARHCGAMSGARGEGPEAG AGGAGGRAA in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_038324550S → SNPLEFNPDVLKKTAVQRAL KS in isoform 6. 1 Publication1
Alternative sequenceiVSP_023240594 – 603NPKRQDLEVE → MPVLPPCVLQ in isoform 5. 1 Publication10
Alternative sequenceiVSP_023241706 – 731PVIGG…PQGLH → SQSRSRPPASPRTSRCPSPP RSCGKG in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_023242732 – 921Missing in isoform 4. 1 PublicationAdd BLAST190

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ993201 mRNA Translation: ABJ97706.1
AY368150 mRNA Translation: AAR89381.1
AK001181 mRNA Translation: BAA91539.1 Different initiation.
AK124091 mRNA Translation: BAC85769.1 Frameshift.
AK126214 mRNA Translation: BAC86489.1
CH236954 Genomic DNA Translation: EAL23931.1
AB033054 mRNA Translation: BAA86542.2
AL833233 mRNA Translation: CAH10642.1
BC013957 mRNA Translation: AAH13957.2
AJ303365 mRNA Translation: CAC33887.1

NCBI Reference Sequences

More...RefSeqi		NP_065779.1, NM_020728.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000652148; ENSP00000499020; ENSG00000117868 [A0FGR8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57488

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57488

UCSC genome browser

More...UCSCi		uc003wob.2, human [A0FGR8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ993201 mRNA Translation: ABJ97706.1
AY368150 mRNA Translation: AAR89381.1
AK001181 mRNA Translation: BAA91539.1 Different initiation.
AK124091 mRNA Translation: BAC85769.1 Frameshift.
AK126214 mRNA Translation: BAC86489.1
CH236954 Genomic DNA Translation: EAL23931.1
AB033054 mRNA Translation: BAA86542.2
AL833233 mRNA Translation: CAH10642.1
BC013957 mRNA Translation: AAH13957.2
AJ303365 mRNA Translation: CAC33887.1
RefSeqiNP_065779.1, NM_020728.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMGNMR-A785-913[»]
4NPJX-ray2.10A/B363-660[»]
4NPKX-ray2.55A363-660[»]
4P42X-ray2.44A/B191-662[»]
SMRiA0FGR8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121556, 96 interactors
CORUMiA0FGR8
DIPiDIP-61039N
IntActiA0FGR8, 46 interactors
MINTiA0FGR8
STRINGi9606.ENSP00000251527

Protein family/group databases

TCDBi9.A.57.1.2, the extended-synaptotagmin (e-syt) family

PTM databases

GlyGeniA0FGR8, 1 site, 1 O-linked glycan (1 site)
iPTMnetiA0FGR8
PhosphoSitePlusiA0FGR8
SwissPalmiA0FGR8

Genetic variation databases

BioMutaiESYT2

Proteomic databases

EPDiA0FGR8
jPOSTiA0FGR8
MassIVEiA0FGR8
MaxQBiA0FGR8
PaxDbiA0FGR8
PeptideAtlasiA0FGR8
PRIDEiA0FGR8
ProteomicsDBi30 [A0FGR8-1]
31 [A0FGR8-2]
32 [A0FGR8-4]
33 [A0FGR8-5]
34 [A0FGR8-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		950, 107 antibodies

The DNASU plasmid repository

More...DNASUi		57488

Genome annotation databases

EnsembliENST00000652148; ENSP00000499020; ENSG00000117868 [A0FGR8-2]
GeneIDi57488
KEGGihsa:57488
UCSCiuc003wob.2, human [A0FGR8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57488
DisGeNETi57488

GeneCards: human genes, protein and diseases

More...GeneCardsi		ESYT2
HGNCiHGNC:22211, ESYT2
HPAiENSG00000117868, Low tissue specificity
neXtProtiNX_A0FGR8
OpenTargetsiENSG00000117868
PharmGKBiPA165617947
VEuPathDBiHostDB:ENSG00000117868

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1012, Eukaryota
GeneTreeiENSGT00940000156086
InParanoidiA0FGR8
OrthoDBi52746at2759
PhylomeDBiA0FGR8
TreeFamiTF324255

Enzyme and pathway databases

PathwayCommonsiA0FGR8
ReactomeiR-HSA-1660662, Glycosphingolipid metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57488, 10 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ESYT2, human
EvolutionaryTraceiA0FGR8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FAM62B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57488
PharosiA0FGR8, Tbio

Protein Ontology

More...PROi		PR:A0FGR8
RNActiA0FGR8, protein

Gene expression databases

BgeeiENSG00000117868, Expressed in placenta and 225 other tissues
ExpressionAtlasiA0FGR8, baseline and differential
GenevisibleiA0FGR8, HS

Family and domain databases

CDDicd08391, C2A_C2C_Synaptotagmin_like, 1 hit
cd04050, C2B_Synaptotagmin-like, 1 hit
cd04030, C2C_KIAA1228, 1 hit
Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037752, C2C_KIAA1228
IPR037733, Ext_Synaptotagmin_C2A
IPR037749, Ext_Synaptotagmin_C2B
IPR031468, SMP_LBD
IPR039010, Synaptotagmin_SMP
PfamiView protein in Pfam
PF00168, C2, 3 hits
PF17047, SMP_LBD, 1 hit
SMARTiView protein in SMART
SM00239, C2, 3 hits
SUPFAMiSSF49562, SSF49562, 3 hits
PROSITEiView protein in PROSITE
PS50004, C2, 3 hits
PS51847, SMP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESYT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0FGR8
Secondary accession number(s): A4D229
, Q69YJ2, Q6UKI4, Q6ZTU0, Q6ZVU1, Q9BQS0, Q9NW47, Q9ULJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 28, 2006
Last modified: September 29, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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