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Entry version 129 (16 Oct 2019)
Sequence version 1 (28 Nov 2006)
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Protein

Extended synaptotagmin-2

Gene

ESYT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi400Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi401Calcium 11 Publication1
Metal bindingi401Calcium 21 Publication1
Metal bindingi413Calcium 21 Publication1
Metal bindingi460Calcium 11 Publication1
Metal bindingi460Calcium 21 Publication1
Metal bindingi461Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi462Calcium 11 Publication1
Metal bindingi462Calcium 21 Publication1
Metal bindingi462Calcium 3; via carbonyl oxygen1 Publication1
Metal bindingi464Calcium 3; via carbonyl oxygen1 Publication1
Metal bindingi466Calcium 31 Publication1
Metal bindingi467Calcium 11 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Lipid transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660662 Glycosphingolipid metabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.57.1.2 the extended-synaptotagmin (e-syt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extended synaptotagmin-2Curated
Short name:
E-Syt21 Publication
Alternative name(s):
Chr2Syt
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESYT2Imported
Synonyms:FAM62B, KIAA1228
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:22211 ESYT2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A0FGR8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 103CytoplasmicSequence analysisAdd BLAST103
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 127LumenalSequence analysis3
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 921CytoplasmicSequence analysisAdd BLAST773

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi401D → A: Abolishes calcium binding; when associated with A-413. 1 Publication1
Mutagenesisi413D → A: Abolishes calcium binding; when associated with A-401. 1 Publication1
Mutagenesisi413D → N: Strongly reduces calcium binding. 1 Publication1
Mutagenesisi466D → A: Impairs binding of the third calcium ion, but has no effect on the binding of the other two calcium ions. 1 Publication1
Mutagenesisi833 – 840KRRSGRRK → AAASGAAA: Abolishes location at the cell membrane. 1 Publication8

Organism-specific databases

DisGeNET

More...
DisGeNETi
57488

Open Targets

More...
OpenTargetsi
ENSG00000117868

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165617947

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A0FGR8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ESYT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782581 – 921Extended synaptotagmin-2Add BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei691PhosphoserineCombined sources1
Modified residuei693PhosphoserineCombined sources1
Modified residuei705PhosphothreonineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei738PhosphoserineBy similarity1
Modified residuei739PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A0FGR8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A0FGR8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
A0FGR8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A0FGR8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0FGR8

PRoteomics IDEntifications database

More...
PRIDEi
A0FGR8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30 [A0FGR8-1]
31 [A0FGR8-2]
32 [A0FGR8-4]
33 [A0FGR8-5]
34 [A0FGR8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0FGR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0FGR8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A0FGR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high level in cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117868 Expressed in 209 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A0FGR8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A0FGR8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002132

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ESYT1 and ESYT3.

Interacts with FGFR1 that has been activated by FGF1 binding.

Interacts with the AP-2 complex; identified in a complex with the AP-2 complex and FGFR1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121556, 51 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
A0FGR8

Database of interacting proteins

More...
DIPi
DIP-61039N

Protein interaction database and analysis system

More...
IntActi
A0FGR8, 40 interactors

Molecular INTeraction database

More...
MINTi
A0FGR8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251527

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1921
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A0FGR8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A0FGR8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 370SMP-LTDPROSITE-ProRule annotation1 PublicationAdd BLAST180
Domaini372 – 473C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini523 – 617C2 2PROSITE-ProRule annotationAdd BLAST95
Domaini788 – 892C2 3PROSITE-ProRule annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni833 – 840Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi736 – 739Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.1 Publication
The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium (PubMed:24373768). The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for location at the cell membrane (PubMed:23791178).2 Publications
The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior; can bind two lipid molecules simultaneously. Binds a variety of lipids, including phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol (PubMed:24847877).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the extended synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISCC Eukaryota
ENOG410XPR4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156086

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A0FGR8

Database of Orthologous Groups

More...
OrthoDBi
52746at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0FGR8

TreeFam database of animal gene trees

More...
TreeFami
TF324255

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08391 C2A_C2C_Synaptotagmin_like, 1 hit
cd04050 C2B_Synaptotagmin-like, 1 hit
cd04030 C2C_KIAA1228, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037752 C2C_KIAA1228
IPR037733 Ext_Synaptotagmin_C2A
IPR037749 Ext_Synaptotagmin_C2B
IPR031468 SMP_LBD
IPR039010 Synaptotagmin_SMP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 3 hits
PF17047 SMP_LBD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 3 hits
PS51847 SMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0FGR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS
60 70 80 90 100
HAPGSRLGAR RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN
110 120 130 140 150
PGGVLSVELP GLLAQLARSF ALLLPVYALG YLGLSFSWVL LALALLAWCR
160 170 180 190 200
RSRGLKALRL CRALALLEDE ERVVRLGVRA CDLPAWVHFP DTERAEWLNK
210 220 230 240 250
TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV DVGQQPLRIN
260 270 280 290 300
GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM
310 320 330 340 350
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI
360 370 380 390 400
ILDIISNYLV LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK
410 420 430 440 450
DTYLKGLVKG KSDPYGIIRV GNQIFQSRVI KENLSPKWNE VYEALVYEHP
460 470 480 490 500
GQELEIELFD EDPDKDDFLG SLMIDLIEVE KERLLDEWFT LDEVPKGKLH
510 520 530 540 550
LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL YLDSARNLPS
560 570 580 590 600
GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL
610 620 630 640 650
EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI
660 670 680 690 700
ALRVLHLEKR ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN
710 720 730 740 750
TAPSTPVIGG SDKPGMEEKA QPPEAGPQGL HDLGRSSSSL LASPGHISVK
760 770 780 790 800
EPTPSIASDI SLPIATQELR QRLRQLENGT TLGQSPLGQI QLTIRHSSQR
810 820 830 840 850
NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK THVSKKTLNP
860 870 880 890 900
VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL
910 920
AKGWTQWYDL TEDGTRPQAM T
Length:921
Mass (Da):102,357
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD57F1BD9BB0A0C8A
GO
Isoform 2 (identifier: A0FGR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MTANRDAALS...RAPSPPRPGG → MTPPSRAEAG...GAGGAGGRAA

Note: No experimental confirmation available.
Show »
Length:893
Mass (Da):98,902
Checksum:i9C059B137A2F1EFB
GO
Isoform 4 (identifier: A0FGR8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.
     706-731: PVIGGSDKPGMEEKAQPPEAGPQGLH → SQSRSRPPASPRTSRCPSPPRSCGKG
     732-921: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):59,403
Checksum:iE4257349511C9C28
GO
Isoform 5 (identifier: A0FGR8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-593: Missing.
     594-603: NPKRQDLEVE → MPVLPPCVLQ

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):35,846
Checksum:iEF531CFF2A35D17C
GO
Isoform 6 (identifier: A0FGR8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-550: S → SNPLEFNPDVLKKTAVQRALKS

Note: No experimental confirmation available.
Show »
Length:942
Mass (Da):104,708
Checksum:i207D6C010DB58248
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A499FIX8A0A499FIX8_HUMAN
Extended synaptotagmin-2
ESYT2 FAM62B, hCG_20178
845Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXI1H7BXI1_HUMAN
Extended synaptotagmin-2
ESYT2
866Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXU3A0A087WXU3_HUMAN
Extended synaptotagmin-2
ESYT2
921Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91539 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85769 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141L → V in CAH10642 (PubMed:17974005).Curated1
Sequence conflicti612S → P in BAC85769 (PubMed:14702039).Curated1
Sequence conflicti615N → S in BAC86489 (PubMed:14702039).Curated1
Sequence conflicti795R → Q in BAC85769 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030725210C → S. Corresponds to variant dbSNP:rs13233513Ensembl.1
Natural variantiVAR_030726638S → G1 PublicationCorresponds to variant dbSNP:rs2305473Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0232361 – 593Missing in isoform 5. 1 PublicationAdd BLAST593
Alternative sequenceiVSP_0232381 – 204Missing in isoform 4. 1 PublicationAdd BLAST204
Alternative sequenceiVSP_0232391 – 97MTANR…PRPGG → MTPPSRAEAGVRRSRVPSEG RWRGAEPPGISASTQPASAG RAARHCGAMSGARGEGPEAG AGGAGGRAA in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_038324550S → SNPLEFNPDVLKKTAVQRAL KS in isoform 6. 1 Publication1
Alternative sequenceiVSP_023240594 – 603NPKRQDLEVE → MPVLPPCVLQ in isoform 5. 1 Publication10
Alternative sequenceiVSP_023241706 – 731PVIGG…PQGLH → SQSRSRPPASPRTSRCPSPP RSCGKG in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_023242732 – 921Missing in isoform 4. 1 PublicationAdd BLAST190

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ993201 mRNA Translation: ABJ97706.1
AY368150 mRNA Translation: AAR89381.1
AK001181 mRNA Translation: BAA91539.1 Different initiation.
AK124091 mRNA Translation: BAC85769.1 Frameshift.
AK126214 mRNA Translation: BAC86489.1
CH236954 Genomic DNA Translation: EAL23931.1
AB033054 mRNA Translation: BAA86542.2
AL833233 mRNA Translation: CAH10642.1
BC013957 mRNA Translation: AAH13957.2
AJ303365 mRNA Translation: CAC33887.1

NCBI Reference Sequences

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RefSeqi
NP_065779.1, NM_020728.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000652148; ENSP00000499020; ENSG00000117868 [A0FGR8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57488

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57488

UCSC genome browser

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UCSCi
uc003wob.2 human [A0FGR8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ993201 mRNA Translation: ABJ97706.1
AY368150 mRNA Translation: AAR89381.1
AK001181 mRNA Translation: BAA91539.1 Different initiation.
AK124091 mRNA Translation: BAC85769.1 Frameshift.
AK126214 mRNA Translation: BAC86489.1
CH236954 Genomic DNA Translation: EAL23931.1
AB033054 mRNA Translation: BAA86542.2
AL833233 mRNA Translation: CAH10642.1
BC013957 mRNA Translation: AAH13957.2
AJ303365 mRNA Translation: CAC33887.1
RefSeqiNP_065779.1, NM_020728.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMGNMR-A785-913[»]
4NPJX-ray2.10A/B363-660[»]
4NPKX-ray2.55A363-660[»]
4P42X-ray2.44A/B191-662[»]
SMRiA0FGR8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121556, 51 interactors
CORUMiA0FGR8
DIPiDIP-61039N
IntActiA0FGR8, 40 interactors
MINTiA0FGR8
STRINGi9606.ENSP00000251527

Protein family/group databases

TCDBi9.A.57.1.2 the extended-synaptotagmin (e-syt) family

PTM databases

iPTMnetiA0FGR8
PhosphoSitePlusiA0FGR8
SwissPalmiA0FGR8

Polymorphism and mutation databases

BioMutaiESYT2

Proteomic databases

EPDiA0FGR8
jPOSTiA0FGR8
MassIVEiA0FGR8
MaxQBiA0FGR8
PaxDbiA0FGR8
PRIDEiA0FGR8
ProteomicsDBi30 [A0FGR8-1]
31 [A0FGR8-2]
32 [A0FGR8-4]
33 [A0FGR8-5]
34 [A0FGR8-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57488

Genome annotation databases

EnsembliENST00000652148; ENSP00000499020; ENSG00000117868 [A0FGR8-2]
GeneIDi57488
KEGGihsa:57488
UCSCiuc003wob.2 human [A0FGR8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57488
DisGeNETi57488

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ESYT2
HGNCiHGNC:22211 ESYT2
HPAiHPA002132
neXtProtiNX_A0FGR8
OpenTargetsiENSG00000117868
PharmGKBiPA165617947

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISCC Eukaryota
ENOG410XPR4 LUCA
GeneTreeiENSGT00940000156086
InParanoidiA0FGR8
OrthoDBi52746at2759
PhylomeDBiA0FGR8
TreeFamiTF324255

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ESYT2 human
EvolutionaryTraceiA0FGR8

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FAM62B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57488
PharosiA0FGR8

Protein Ontology

More...
PROi
PR:A0FGR8

Gene expression databases

BgeeiENSG00000117868 Expressed in 209 organ(s), highest expression level in placenta
ExpressionAtlasiA0FGR8 baseline and differential
GenevisibleiA0FGR8 HS

Family and domain databases

CDDicd08391 C2A_C2C_Synaptotagmin_like, 1 hit
cd04050 C2B_Synaptotagmin-like, 1 hit
cd04030 C2C_KIAA1228, 1 hit
Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037752 C2C_KIAA1228
IPR037733 Ext_Synaptotagmin_C2A
IPR037749 Ext_Synaptotagmin_C2B
IPR031468 SMP_LBD
IPR039010 Synaptotagmin_SMP
PfamiView protein in Pfam
PF00168 C2, 3 hits
PF17047 SMP_LBD, 1 hit
SMARTiView protein in SMART
SM00239 C2, 3 hits
PROSITEiView protein in PROSITE
PS50004 C2, 3 hits
PS51847 SMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESYT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0FGR8
Secondary accession number(s): A4D229
, Q69YJ2, Q6UKI4, Q6ZTU0, Q6ZVU1, Q9BQS0, Q9NW47, Q9ULJ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 28, 2006
Last modified: October 16, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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