UniProtKB - A0FGR8 (ESYT2_HUMAN)
Protein
Extended synaptotagmin-2
Gene
ESYT2
Organism
Homo sapiens (Human)
Status
Functioni
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).5 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 400 | Calcium 1; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 401 | Calcium 11 Publication | 1 | |
Metal bindingi | 401 | Calcium 21 Publication | 1 | |
Metal bindingi | 413 | Calcium 21 Publication | 1 | |
Metal bindingi | 460 | Calcium 11 Publication | 1 | |
Metal bindingi | 460 | Calcium 21 Publication | 1 | |
Metal bindingi | 461 | Calcium 2; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 462 | Calcium 11 Publication | 1 | |
Metal bindingi | 462 | Calcium 21 Publication | 1 | |
Metal bindingi | 462 | Calcium 3; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 464 | Calcium 3; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 466 | Calcium 31 Publication | 1 | |
Metal bindingi | 467 | Calcium 11 Publication | 1 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- calcium-dependent phospholipid binding Source: FlyBase
- calcium ion binding Source: UniProtKB
- identical protein binding Source: IntAct
- phosphatidylcholine binding Source: UniProtKB
- phosphatidylethanolamine binding Source: UniProtKB
- phosphatidylinositol binding Source: UniProtKB
GO - Biological processi
- endocytosis Source: UniProtKB-KW
- endoplasmic reticulum-plasma membrane tethering Source: InterPro
- glycosphingolipid metabolic process Source: Reactome
- lipid transport Source: UniProtKB-KW
Keywordsi
Biological process | Endocytosis, Lipid transport, Transport |
Ligand | Calcium, Lipid-binding, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | A0FGR8 |
Reactomei | R-HSA-1660662, Glycosphingolipid metabolism |
Protein family/group databases
TCDBi | 9.A.57.1.2, the extended-synaptotagmin (e-syt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Extended synaptotagmin-2CuratedShort name: E-Syt21 Publication Alternative name(s): Chr2Syt |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000117868.15 |
HGNCi | HGNC:22211, ESYT2 |
neXtProti | NX_A0FGR8 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Plasma membrane
- Cell membrane 4 Publications; Peripheral membrane protein 1 Publication
Note: Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437).4 Publications
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
- intrinsic component of endoplasmic reticulum membrane Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: FlyBase
Other locations
- endoplasmic reticulum-plasma membrane contact site Source: UniProtKB
- membrane Source: UniProtKB
- organelle membrane contact site Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 103 | CytoplasmicSequence analysisAdd BLAST | 103 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 125 – 127 | LumenalSequence analysis | 3 | |
Transmembranei | 128 – 148 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 149 – 921 | CytoplasmicSequence analysisAdd BLAST | 773 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 401 | D → A: Abolishes calcium binding; when associated with A-413. 1 Publication | 1 | |
Mutagenesisi | 413 | D → A: Abolishes calcium binding; when associated with A-401. 1 Publication | 1 | |
Mutagenesisi | 413 | D → N: Strongly reduces calcium binding. 1 Publication | 1 | |
Mutagenesisi | 466 | D → A: Impairs binding of the third calcium ion, but has no effect on the binding of the other two calcium ions. 1 Publication | 1 | |
Mutagenesisi | 833 – 840 | KRRSGRRK → AAASGAAA: Abolishes location at the cell membrane. 1 Publication | 8 |
Organism-specific databases
DisGeNETi | 57488 |
OpenTargetsi | ENSG00000117868 |
PharmGKBi | PA165617947 |
Miscellaneous databases
Pharosi | A0FGR8, Tbio |
Polymorphism and mutation databases
BioMutai | ESYT2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278258 | 1 – 921 | Extended synaptotagmin-2Add BLAST | 921 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 691 | PhosphoserineCombined sources | 1 | |
Modified residuei | 693 | PhosphoserineCombined sources | 1 | |
Modified residuei | 705 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 736 | PhosphoserineCombined sources | 1 | |
Modified residuei | 738 | PhosphoserineBy similarity | 1 | |
Modified residuei | 739 | PhosphoserineCombined sources | 1 | |
Modified residuei | 743 | PhosphoserineCombined sources | 1 | |
Modified residuei | 748 | PhosphoserineCombined sources | 1 | |
Modified residuei | 755 | PhosphoserineCombined sources | 1 | |
Modified residuei | 758 | PhosphoserineCombined sources | 1 | |
Modified residuei | 761 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | A0FGR8 |
jPOSTi | A0FGR8 |
MassIVEi | A0FGR8 |
MaxQBi | A0FGR8 |
PaxDbi | A0FGR8 |
PeptideAtlasi | A0FGR8 |
PRIDEi | A0FGR8 |
ProteomicsDBi | 30 [A0FGR8-1] 31 [A0FGR8-2] 32 [A0FGR8-4] 33 [A0FGR8-5] 34 [A0FGR8-6] |
PTM databases
iPTMneti | A0FGR8 |
PhosphoSitePlusi | A0FGR8 |
SwissPalmi | A0FGR8 |
Expressioni
Tissue specificityi
Widely expressed with high level in cerebellum.1 Publication
Gene expression databases
Bgeei | ENSG00000117868, Expressed in placenta and 224 other tissues |
ExpressionAtlasi | A0FGR8, baseline and differential |
Genevisiblei | A0FGR8, HS |
Organism-specific databases
HPAi | ENSG00000117868, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with ESYT1 and ESYT3.
Interacts with FGFR1 that has been activated by FGF1 binding.
Interacts with the AP-2 complex; identified in a complex with the AP-2 complex and FGFR1.
4 PublicationsBinary interactionsi
Hide detailsA0FGR8
With | #Exp. | IntAct |
---|---|---|
ESYT1 [Q9BSJ8] | 5 | EBI-3184170,EBI-355956 |
itself | 3 | EBI-3184170,EBI-3184170 |
ESYT3 [A0FGR9] | 4 | EBI-3184170,EBI-8771391 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 121556, 68 interactors |
CORUMi | A0FGR8 |
DIPi | DIP-61039N |
IntActi | A0FGR8, 41 interactors |
MINTi | A0FGR8 |
STRINGi | 9606.ENSP00000251527 |
Miscellaneous databases
RNActi | A0FGR8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | A0FGR8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | A0FGR8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 191 – 370 | SMP-LTDPROSITE-ProRule annotation1 PublicationAdd BLAST | 180 | |
Domaini | 369 – 489 | C2 1PROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 514 – 639 | C2 2PROSITE-ProRule annotationAdd BLAST | 126 | |
Domaini | 786 – 908 | C2 3PROSITE-ProRule annotationAdd BLAST | 123 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 833 – 840 | Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 736 – 739 | Poly-Ser | 4 |
Domaini
Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.1 Publication
The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium (PubMed:24373768). The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for location at the cell membrane (PubMed:23791178).2 Publications
The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior; can bind two lipid molecules simultaneously. Binds a variety of lipids, including phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol (PubMed:24847877).1 Publication
Sequence similaritiesi
Belongs to the extended synaptotagmin family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1012, Eukaryota |
GeneTreei | ENSGT00940000156086 |
InParanoidi | A0FGR8 |
OrthoDBi | 52746at2759 |
PhylomeDBi | A0FGR8 |
TreeFami | TF324255 |
Family and domain databases
CDDi | cd08391, C2A_C2C_Synaptotagmin_like, 1 hit cd04050, C2B_Synaptotagmin-like, 1 hit cd04030, C2C_KIAA1228, 1 hit |
Gene3Di | 2.60.40.150, 3 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037752, C2C_KIAA1228 IPR037733, Ext_Synaptotagmin_C2A IPR037749, Ext_Synaptotagmin_C2B IPR031468, SMP_LBD IPR039010, Synaptotagmin_SMP |
Pfami | View protein in Pfam PF00168, C2, 3 hits PF17047, SMP_LBD, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 3 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 3 hits PS51847, SMP, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A0FGR8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS
60 70 80 90 100
HAPGSRLGAR RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN
110 120 130 140 150
PGGVLSVELP GLLAQLARSF ALLLPVYALG YLGLSFSWVL LALALLAWCR
160 170 180 190 200
RSRGLKALRL CRALALLEDE ERVVRLGVRA CDLPAWVHFP DTERAEWLNK
210 220 230 240 250
TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV DVGQQPLRIN
260 270 280 290 300
GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM
310 320 330 340 350
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI
360 370 380 390 400
ILDIISNYLV LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK
410 420 430 440 450
DTYLKGLVKG KSDPYGIIRV GNQIFQSRVI KENLSPKWNE VYEALVYEHP
460 470 480 490 500
GQELEIELFD EDPDKDDFLG SLMIDLIEVE KERLLDEWFT LDEVPKGKLH
510 520 530 540 550
LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL YLDSARNLPS
560 570 580 590 600
GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL
610 620 630 640 650
EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI
660 670 680 690 700
ALRVLHLEKR ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN
710 720 730 740 750
TAPSTPVIGG SDKPGMEEKA QPPEAGPQGL HDLGRSSSSL LASPGHISVK
760 770 780 790 800
EPTPSIASDI SLPIATQELR QRLRQLENGT TLGQSPLGQI QLTIRHSSQR
810 820 830 840 850
NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK THVSKKTLNP
860 870 880 890 900
VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL
910 920
AKGWTQWYDL TEDGTRPQAM T
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A499FIX8 | A0A499FIX8_HUMAN | Extended synaptotagmin-2 | ESYT2 FAM62B, hCG_20178 | 845 | Annotation score: | ||
H7BXI1 | H7BXI1_HUMAN | Extended synaptotagmin-2 | ESYT2 | 866 | Annotation score: | ||
A0A087WXU3 | A0A087WXU3_HUMAN | Extended synaptotagmin-2 | ESYT2 | 921 | Annotation score: |
Sequence cautioni
The sequence BAA91539 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85769 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 141 | L → V in CAH10642 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 612 | S → P in BAC85769 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 615 | N → S in BAC86489 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 795 | R → Q in BAC85769 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030725 | 210 | C → S. Corresponds to variant dbSNP:rs13233513Ensembl. | 1 | |
Natural variantiVAR_030726 | 638 | S → G1 PublicationCorresponds to variant dbSNP:rs2305473Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023236 | 1 – 593 | Missing in isoform 5. 1 PublicationAdd BLAST | 593 | |
Alternative sequenceiVSP_023238 | 1 – 204 | Missing in isoform 4. 1 PublicationAdd BLAST | 204 | |
Alternative sequenceiVSP_023239 | 1 – 97 | MTANR…PRPGG → MTPPSRAEAGVRRSRVPSEG RWRGAEPPGISASTQPASAG RAARHCGAMSGARGEGPEAG AGGAGGRAA in isoform 2. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_038324 | 550 | S → SNPLEFNPDVLKKTAVQRAL KS in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_023240 | 594 – 603 | NPKRQDLEVE → MPVLPPCVLQ in isoform 5. 1 Publication | 10 | |
Alternative sequenceiVSP_023241 | 706 – 731 | PVIGG…PQGLH → SQSRSRPPASPRTSRCPSPP RSCGKG in isoform 4. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_023242 | 732 – 921 | Missing in isoform 4. 1 PublicationAdd BLAST | 190 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ993201 mRNA Translation: ABJ97706.1 AY368150 mRNA Translation: AAR89381.1 AK001181 mRNA Translation: BAA91539.1 Different initiation. AK124091 mRNA Translation: BAC85769.1 Frameshift. AK126214 mRNA Translation: BAC86489.1 CH236954 Genomic DNA Translation: EAL23931.1 AB033054 mRNA Translation: BAA86542.2 AL833233 mRNA Translation: CAH10642.1 BC013957 mRNA Translation: AAH13957.2 AJ303365 mRNA Translation: CAC33887.1 |
RefSeqi | NP_065779.1, NM_020728.2 |
Genome annotation databases
Ensembli | ENST00000652148; ENSP00000499020; ENSG00000117868 [A0FGR8-2] |
GeneIDi | 57488 |
KEGGi | hsa:57488 |
UCSCi | uc003wob.2, human [A0FGR8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ993201 mRNA Translation: ABJ97706.1 AY368150 mRNA Translation: AAR89381.1 AK001181 mRNA Translation: BAA91539.1 Different initiation. AK124091 mRNA Translation: BAC85769.1 Frameshift. AK126214 mRNA Translation: BAC86489.1 CH236954 Genomic DNA Translation: EAL23931.1 AB033054 mRNA Translation: BAA86542.2 AL833233 mRNA Translation: CAH10642.1 BC013957 mRNA Translation: AAH13957.2 AJ303365 mRNA Translation: CAC33887.1 |
RefSeqi | NP_065779.1, NM_020728.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DMG | NMR | - | A | 785-913 | [»] | |
4NPJ | X-ray | 2.10 | A/B | 363-660 | [»] | |
4NPK | X-ray | 2.55 | A | 363-660 | [»] | |
4P42 | X-ray | 2.44 | A/B | 191-662 | [»] | |
SMRi | A0FGR8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121556, 68 interactors |
CORUMi | A0FGR8 |
DIPi | DIP-61039N |
IntActi | A0FGR8, 41 interactors |
MINTi | A0FGR8 |
STRINGi | 9606.ENSP00000251527 |
Protein family/group databases
TCDBi | 9.A.57.1.2, the extended-synaptotagmin (e-syt) family |
PTM databases
iPTMneti | A0FGR8 |
PhosphoSitePlusi | A0FGR8 |
SwissPalmi | A0FGR8 |
Polymorphism and mutation databases
BioMutai | ESYT2 |
Proteomic databases
EPDi | A0FGR8 |
jPOSTi | A0FGR8 |
MassIVEi | A0FGR8 |
MaxQBi | A0FGR8 |
PaxDbi | A0FGR8 |
PeptideAtlasi | A0FGR8 |
PRIDEi | A0FGR8 |
ProteomicsDBi | 30 [A0FGR8-1] 31 [A0FGR8-2] 32 [A0FGR8-4] 33 [A0FGR8-5] 34 [A0FGR8-6] |
Protocols and materials databases
Antibodypediai | 950, 99 antibodies |
DNASUi | 57488 |
Genome annotation databases
Ensembli | ENST00000652148; ENSP00000499020; ENSG00000117868 [A0FGR8-2] |
GeneIDi | 57488 |
KEGGi | hsa:57488 |
UCSCi | uc003wob.2, human [A0FGR8-1] |
Organism-specific databases
CTDi | 57488 |
DisGeNETi | 57488 |
EuPathDBi | HostDB:ENSG00000117868.15 |
GeneCardsi | ESYT2 |
HGNCi | HGNC:22211, ESYT2 |
HPAi | ENSG00000117868, Low tissue specificity |
neXtProti | NX_A0FGR8 |
OpenTargetsi | ENSG00000117868 |
PharmGKBi | PA165617947 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1012, Eukaryota |
GeneTreei | ENSGT00940000156086 |
InParanoidi | A0FGR8 |
OrthoDBi | 52746at2759 |
PhylomeDBi | A0FGR8 |
TreeFami | TF324255 |
Enzyme and pathway databases
PathwayCommonsi | A0FGR8 |
Reactomei | R-HSA-1660662, Glycosphingolipid metabolism |
Miscellaneous databases
BioGRID-ORCSi | 57488, 9 hits in 845 CRISPR screens |
ChiTaRSi | ESYT2, human |
EvolutionaryTracei | A0FGR8 |
GeneWikii | FAM62B |
GenomeRNAii | 57488 |
Pharosi | A0FGR8, Tbio |
PROi | PR:A0FGR8 |
RNActi | A0FGR8, protein |
Gene expression databases
Bgeei | ENSG00000117868, Expressed in placenta and 224 other tissues |
ExpressionAtlasi | A0FGR8, baseline and differential |
Genevisiblei | A0FGR8, HS |
Family and domain databases
CDDi | cd08391, C2A_C2C_Synaptotagmin_like, 1 hit cd04050, C2B_Synaptotagmin-like, 1 hit cd04030, C2C_KIAA1228, 1 hit |
Gene3Di | 2.60.40.150, 3 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037752, C2C_KIAA1228 IPR037733, Ext_Synaptotagmin_C2A IPR037749, Ext_Synaptotagmin_C2B IPR031468, SMP_LBD IPR039010, Synaptotagmin_SMP |
Pfami | View protein in Pfam PF00168, C2, 3 hits PF17047, SMP_LBD, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 3 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 3 hits PS51847, SMP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ESYT2_HUMAN | |
Accessioni | A0FGR8Primary (citable) accession number: A0FGR8 Secondary accession number(s): A4D229 Q9ULJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | November 28, 2006 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations