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Entry version 73 (02 Jun 2021)
Sequence version 1 (28 Nov 2006)
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Protein
Submitted name:

Uncharacterized protein

Gene

GSPATT00036646001

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.1.12, the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:GSPATT00036646001Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParamecium tetraureliaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5888 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000600 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei736 – 755HelicalSequence analysisAdd BLAST20
Transmembranei836 – 859HelicalSequence analysisAdd BLAST24
Transmembranei879 – 900HelicalSequence analysisAdd BLAST22
Transmembranei921 – 939HelicalSequence analysisAdd BLAST19
Transmembranei945 – 967HelicalSequence analysisAdd BLAST23
Transmembranei1070 – 1093HelicalSequence analysisAdd BLAST24
Transmembranei1123 – 1141HelicalSequence analysisAdd BLAST19
Transmembranei1161 – 1184HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5888.CAK67865

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 223ANK_REP_REGIONInterPro annotationAdd BLAST61
Domaini404 – 442ANK_REP_REGIONInterPro annotationAdd BLAST39
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati410 – 442ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1323 – 1370B box-typeInterPro annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili78 – 98Sequence analysisAdd BLAST21
Coiled coili369 – 389Sequence analysisAdd BLAST21
Coiled coili641 – 661Sequence analysisAdd BLAST21
Coiled coili1209 – 1243Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 41Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2513, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_243934_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0CAP8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANMELEN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR007632, Anoctamin
IPR000315, Znf_B-box

The PANTHER Classification System

More...
PANTHERi
PTHR12308, PTHR12308, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04547, Anoctamin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 2 hits
PS50088, ANK_REPEAT, 1 hit
PS50119, ZF_BBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0CAP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKQRPKQL DPIKRVKETG PFDSGSPLSF INSMWQQQPS EAKRKQQKKV
60 70 80 90 100
TQIQKKLEYD IQEALKQTDY DERNILHRAC LDQQIKQIKD IIEDLVAKKD
110 120 130 140 150
DVALQECLVK QDKFHCQPLL LCCIKPKTLE SDQIRMLCIQ FLLNPCKEKP
160 170 180 190 200
HIKADVNCFN PRTLWTCLHW AAYYGDKDSV EVLLENNIHV FLPDYKGQYA
210 220 230 240 250
VDLAGKNKYE EVVTLIIMRS IEILDYLKYG SQQKYKAYIE SLTPDLLKHL
260 270 280 290 300
NNPLFLCKLI YWSALYEVDS KNSTLLQFKR AYSFFPLQIK SLKMKTALHA
310 320 330 340 350
ACQSHKGNED FLNEAFRVFE ETMFGFSNDD LTKIIPQKKP TLQMNSVFVF
360 370 380 390 400
SEEDLKKYRD DFQKEVLLLA EWEKEVLNKL KIIKNYTQQK QRQKYYNDFY
410 420 430 440 450
AIYVNQQDAY GNSPLHVASI KAFQKGINIL MEKQANMELE NNEVFKAREL
460 470 480 490 500
TQDENVLVLY KDKLQSITSE AILNELNQTI IQQLMGIFKK DAYDDQLRLR
510 520 530 540 550
NALAPLSKNG DSHYYKLITE LNSYSQNLFV PDFIIRASIK AENLNSDTLE
560 570 580 590 600
TAPAFFDLKD QDCAELIRLN FYISLLLNAN FEVYLMKSQF QQGFYYIMLQ
610 620 630 640 650
HNEKNLEDQA DLMNLQMKLM DSYDLEEFEK VFQNLYEPFR SRQKQQIIEK
660 670 680 690 700
HLTQIKDLNE QINSGIIEAY YRMHKTGGIN KIKERWLVNN KWYLPTPINQ
710 720 730 740 750
ISEYLMEGEN QNFSSITILR LYFGEKISFY FAWKSYITCA LMVLAIPGAA
760 770 780 790 800
IQIYILVTGD YFPSILPFWV CYVCLWSTLQ VEFWKRKTSE ITTRWGCLDL
810 820 830 840 850
LDSKDKGEVR RGFQGYEEIY QVTGELTKHQ KKTETFLKVV LSVLVVLIFL
860 870 880 890 900
TLCVLIFVGV NLMVKRFEGQ IIITTGLNII QGVGIFILNL VYNHIVMFFA
910 920 930 940 950
QYENHKYQED YEQSIIYKNS AFTLLNSYLC IFYAAFVNNK SFLDLFIQLV
960 970 980 990 1000
PVLITKQVQF AALKVLLPRV QYDYYEKQYF KQQQLNIQRQ GQLNRNKEGF
1010 1020 1030 1040 1050
KDKVETLYEA IFKEKKYTIE TCKRAVLKIH EKGKPPTLEM NLDADQVELN
1060 1070 1080 1090 1100
NLKLNYEGTL GYFMEGIIDL GYITLFAAAF PIGPAIAVVA NVAEIRTKLI
1110 1120 1130 1140 1150
SFLEVYKRPE CQRCAGIGDW LNIMQWMGMG CVFSNFALLY VKYKVETVGV
1160 1170 1180 1190 1200
IYGYNGSDQD ITIWLFFLTI AIILIIKLAF QWLIPDKPQW VLNELQNIQE
1210 1220 1230 1240 1250
KQHVNTGQRE ALKKTKVEIQ KKQDRLNQRK KEYLEAKQNC TQKMQAKIST
1260 1270 1280 1290 1300
KIEKETKIER FQKQEESEKL LAKQGVIQKV TEIEIKPEMV TQIRIGLLRQ
1310 1320 1330 1340 1350
KFIEIQHFLL QQRIRQIDQA RTRNIFLCQE CSLVEAVFDC EDCDESQCQE
1360 1370 1380 1390 1400
CFRKVHTKMK NITTHEVMLL KSAKYYDHEL LSRLQVKRKV KVDNKSNLQV
1410 1420 1430 1440 1450
KLNQQQQQEG EFKPKRWQKL QNFCFPTTTS SLAYNSLPTI FNYLKREYLD
1460 1470 1480 1490 1500
NLNLDRIELN SFYRFRREQE KFIMYESENI NKILEMEELN LEEKLWLNRI
1510 1520 1530 1540 1550
GFLCFKKNAK LEYFCELVRK LQNSNIESKL KLVLDLADVD NDELITKHEI
1560 1570 1580 1590 1600
EAIFVPSIVQ DCEGKFSLQS TIENIFNKPL SKQKAMEVLL NQINSDEQFK
1610
EFFQQLTQCE
Length:1,610
Mass (Da):189,547
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF93CDE1EA60E75FF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT868055 Genomic DNA Translation: CAK67865.1

NCBI Reference Sequences

More...
RefSeqi
XP_001435262.1, XM_001435225.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAK67865; CAK67865; GSPATT00036646001

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5021047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ptm:GSPATT00036646001

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868055 Genomic DNA Translation: CAK67865.1
RefSeqiXP_001435262.1, XM_001435225.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5888.CAK67865

Protein family/group databases

TCDBi1.A.17.1.12, the calcium-dependent chloride channel (ca-clc) family

Genome annotation databases

EnsemblProtistsiCAK67865; CAK67865; GSPATT00036646001
GeneIDi5021047
KEGGiptm:GSPATT00036646001

Phylogenomic databases

eggNOGiKOG2513, Eukaryota
HOGENOMiCLU_243934_0_0_1
InParanoidiA0CAP8
OMAiANMELEN

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR007632, Anoctamin
IPR000315, Znf_B-box
PANTHERiPTHR12308, PTHR12308, 1 hit
PfamiView protein in Pfam
PF04547, Anoctamin, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 2 hits
PS50088, ANK_REPEAT, 1 hit
PS50119, ZF_BBOX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0CAP8_PARTE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0CAP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: June 2, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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