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Entry version 75 (10 Apr 2019)
Sequence version 1 (28 Nov 2006)
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Protein

DNA polymerase

Gene

GSPATT00028328001

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:GSPATT00028328001Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParamecium tetraureliaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5888 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000600 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5888.CAK57293

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 252DNA_pol_B_exo1InterPro annotationAdd BLAST204
Domaini651 – 780DNA_pol_B_exo1InterPro annotationAdd BLAST130
Domaini956 – 1402DNA_pol_BInterPro annotationAdd BLAST447

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili408 – 443Sequence analysisAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0968 Eukaryota
COG0417 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0BFH6

KEGG Orthology (KO)

More...
KOi
K02350

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMHFYSD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 2 hits
3.90.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00106 DNAPOLB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00486 POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0BFH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLPAPGTKM SQPNQETLFE TLKYSNTDYL DRPIQFAPVI RLFGYEPKTK
60 70 80 90 100
ERMCVHVHGY FPYFYIKVDE LRHLFTDLDF VKDFINKVHQ VYASTFLAHY
110 120 130 140 150
PKKSQEKFKI IYQYELCQKL DFYGFHMQKQ LFLKLFMYDK QYMSQLVMLL
160 170 180 190 200
ASGAIMNYKF QSYESHLTYF MHFYSDANLF GMSQIKILKL KYRKRFDKDL
210 220 230 240 250
ESLLTKPILF RDLHASQYSH LYRVTTCPLE IDCHYTCILN ERYKDEKDRL
260 270 280 290 300
EIARAFTHNK EFEVELTPSL NKLWSDEEIN RARFKFNQPV SFIVDKSKNK
310 320 330 340 350
EGQLWEHYPS VNVLNKQFMK QYFQLYEDAK KNHIKFDINS CIINQNIAQM
360 370 380 390 400
FFNGQQDEME LCKKSIIQRF QEYKTRKKDL FELIKEEGNI DYEYDFDDKF
410 420 430 440 450
IDQQDLQQDN EDEDLEDAES IIKSQEEKNV FDIMKENQKL QDKNRFRKKY
460 470 480 490 500
HANKNNIKLG QMFQICEFCN SNFLMCNCIE KKQKKYSLLI PKSHKSQIYQ
510 520 530 540 550
YKVKPPSPNE VYLQLHKQMK LSEHQYAYFG DIKDLYKHYN IKHKQLPQNH
560 570 580 590 600
MYALLLDQQC IKIPENRFYA ISIQNSTKLP QSYKLDVFKE QQYNCNLRQY
610 620 630 640 650
QYQHEPPAVQ EVVLDIKRRS AMRNDPLDSI IETSQYFYPT PLSILSEDDI
660 670 680 690 700
TFQEDLVLMI FEIFSYKDSK LLPDPEKDEI SFIILHSYNV KSSKIMNKML
710 720 730 740 750
IIQNEENYLK AVNGYFERMN APVEYTIVLT QNEINLMKAF TLIVHLIDPD
760 770 780 790 800
FISGYDLETR SLYYVANRAE FIGYDFLTEI SRGQPTYDKL IEIFDIDEIL
810 820 830 840 850
FNFGQPQPIN EKLQKYMDYR MQRPTASKKQ SFNQDAKTKS YNSKGKLNQI
860 870 880 890 900
NSRRKKLRFI TFVVGRVLIN VWRNVATDIK IIDYSIENVY FQMFKQKNAL
910 920 930 940 950
IHNQTLSQWF KSETFLVFQY YAKRINMTFD ILEMIGLIPR TIEIAKLFGC
960 970 980 990 1000
EYESVGFRGS QFKIESILNR VTKLNDYLLL SATRVQVSTQ KILECMPLVV
1010 1020 1030 1040 1050
EPPKIFTVDP LIVLDFQSLY PSIMIAYNLC FSTCLGSIKE EFQEGGKKRF
1060 1070 1080 1090 1100
GVVATDIDFE SLLQKYQNQE ELMKHILITP NNVAFLTKDV RVGIIPQILN
1110 1120 1130 1140 1150
EFLMTRIMIK KSTSLYDKHP KIQKQHGFRQ LAIKLFMNVM YGYCGASFSG
1160 1170 1180 1190 1200
RMPSGDIADS VVELGRTILN QCIECINTNP AWQAKVLYGD TDSLFVMLPG
1210 1220 1230 1240 1250
RTVNEALLIG NQIAQHCTSL YPHPIELKFE KVYSEALLVA KKRYVGNKFE
1260 1270 1280 1290 1300
KGEFQLDGKG LEIIRRDGFP ALQKIQKKAI NILFKTKDLS QLKLYMQKQW
1310 1320 1330 1340 1350
AKILQDHVDI QDYIMAKEVK LGSYKEGRLP AHAVVATKIM NSDPMRRPKG
1360 1370 1380 1390 1400
GERVPYVVIQ AQGTSKLADL VVNIYDFQST MKLNPHYYIK QINAAVGRLF
1410 1420 1430 1440 1450
ACFDIDIADW YSNLPKMLAK RDQFKQHLTY SNAHQTKATQ YTLVKYLNIQ
1460 1470 1480 1490 1500
QCLLCGEESK YELCKSCSQD GRTALFLLQY KQNLLEIDKA NITSSCKSCS
1510 1520 1530 1540
IGYQNCKLWS CSLLFKREKL NNYLNTVAQM NQKYQQLIEF MSDY
Length:1,544
Mass (Da):182,068
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8A2E5D573246D0C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT867991 Genomic DNA Translation: CAK57293.1

NCBI Reference Sequences

More...
RefSeqi
XP_001424691.1, XM_001424654.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAK57293; CAK57293; GSPATT00028328001

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5010475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ptm:GSPATT00028328001

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT867991 Genomic DNA Translation: CAK57293.1
RefSeqiXP_001424691.1, XM_001424654.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi5888.CAK57293

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAK57293; CAK57293; GSPATT00028328001
GeneIDi5010475
KEGGiptm:GSPATT00028328001

Phylogenomic databases

eggNOGiKOG0968 Eukaryota
COG0417 LUCA
InParanoidiA0BFH6
KOiK02350
OMAiFMHFYSD

Family and domain databases

Gene3Di3.30.420.10, 2 hits
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0BFH6_PARTE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0BFH6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: April 10, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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