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UniProtKB - A0AVT1 (UBA6_HUMAN)

Entry version 138 (10 Feb 2021)
Sequence version 1 (28 Nov 2006)
Previous versions | rss
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Protein

Ubiquitin-like modifier-activating enzyme 6

Gene

UBA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.By similarity EC:6.2.1.45

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei470ATP; via amide nitrogenBy similarity1
Binding sitei497ATPBy similarity1
Binding sitei508ATPBy similarity1
Binding sitei521ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei625Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi569 – 570ATPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • FAT10 activating enzyme activity Source: UniProtKB
  • ubiquitin activating enzyme activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.2.1.B9, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A0AVT1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-like modifier-activating enzyme 6 (EC:6.2.1.45By similarity)
Short name:
Ubiquitin-activating enzyme 6
Alternative name(s):
Monocyte protein 4
Short name:
MOP-4
Ubiquitin-activating enzyme E1-like protein 2
Short name:
E1-L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBA6
Synonyms:MOP4, UBE1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25581, UBA6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611361, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A0AVT1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000033178.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi625C → A or S: Impairs ubiquitin activation. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		55236

Open Targets

More...OpenTargetsi		ENSG00000033178

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162407690

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A0AVT1, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2321622

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBA6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002777971 – 1052Ubiquitin-like modifier-activating enzyme 6Add BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei54PhosphothreonineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei544N6-acetyllysineCombined sources1
Modified residuei729N6-acetyllysineBy similarity1
Modified residuei737PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A0AVT1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0AVT1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A0AVT1

MaxQB - The MaxQuant DataBase

More...MaxQBi		A0AVT1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A0AVT1

PeptideAtlas

More...PeptideAtlasi		A0AVT1

PRoteomics IDEntifications database

More...PRIDEi		A0AVT1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		26 [A0AVT1-1]
27 [A0AVT1-2]
28 [A0AVT1-3]
29 [A0AVT1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A0AVT1

MetOSite database of methionine sulfoxide sites

More...MetOSitei		A0AVT1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A0AVT1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A0AVT1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000033178, Expressed in corpus callosum and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0AVT1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A0AVT1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000033178, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg) (PubMed:17889673, PubMed:25422469).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120529, 90 interactors

Database of interacting proteins

More...DIPi		DIP-57633N

Protein interaction database and analysis system

More...IntActi		A0AVT1, 16 interactors

Molecular INTeraction database

More...MINTi		A0AVT1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000313454

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		A0AVT1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A0AVT1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0AVT1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2012, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158826

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002556_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A0AVT1

Identification of Orthologs from Complete Genome Data

More...OMAi		CPATENT

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0AVT1

TreeFam database of animal gene trees

More...TreeFami		TF300586

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.2660, 1 hit
2.40.30.180, 1 hit
3.10.290.60, 1 hit
3.50.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032420, E1_4HB
IPR032418, E1_FCCH
IPR042302, E1_FCCH_sf
IPR000594, ThiF_NAD_FAD-bd
IPR018965, Ub-activating_enz_E1_C
IPR042449, Ub-E1_IAD_1
IPR038252, UBA_E1_C_sf
IPR019572, UBA_E1_Cys
IPR042063, Ubi_acti_E1_SCCH
IPR035985, Ubiquitin-activating_enz
IPR018075, UBQ-activ_enz_E1
IPR000011, UBQ/SUMO-activ_enz_E1-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16191, E1_4HB, 1 hit
PF16190, E1_FCCH, 1 hit
PF09358, E1_UFD, 1 hit
PF00899, ThiF, 2 hits
PF10585, UBA_e1_thiolCys, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01849, UBIQUITINACT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00985, UBA_e1_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF69572, SSF69572, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01408, Ube1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0AVT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV 
        60         70         80         90        100
LGDTAMQKMA KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD 
       110        120        130        140        150
LGTNFFLSED DVVNKRNRAE AVLKHIAELN PYVHVTSSSV PFNETTDLSF 
       160        170        180        190        200
LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP IKFISADVHG IWSRLFCDFG 
       210        220        230        240        250
DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE TGQFLTFREI 
       260        270        280        290        300
NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE 
       310        320        330        340        350
SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD 
       360        370        380        390        400
SEELLKLATS ISETLEEKPD VNADIVHWLS WTAQGFLSPL AAAVGGVASQ 
       410        420        430        440        450
EVLKAVTGKF SPLCQWLYLE AADIVESLGK PECEEFLPRG DRYDALRACI 
       460        470        480        490        500
GDTLCQKLQN LNIFLVGCGA IGCEMLKNFA LLGVGTSKEK GMITVTDPDL 
       510        520        530        540        550
IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINSQIKIDA HLNKVCPTTE 
       560        570        580        590        600
TIYNDEFYTK QDVIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT 
       610        620        630        640        650
EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS 
       660        670        680        690        700
HKPSLFNKFW QTYSSAEEVL QKIQSGHSLE GCFQVIKLLS RRPRNWSQCV 
       710        720        730        740        750
ELARLKFEKY FNHKALQLLH CFPLDIRLKD GSLFWQSPKR PPSPIKFDLN 
       760        770        780        790        800
EPLHLSFLQN AAKLYATVYC IPFAEEDLSA DALLNILSEV KIQEFKPSNK 
       810        820        830        840        850
VVQTDETARK PDHVPISSED ERNAIFQLEK AILSNEATKS DLQMAVLSFE 
       860        870        880        890        900
KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATTTAT 
       910        920        930        940        950
VSGLVALEMI KVTGGYPFEA YKNCFLNLAI PIVVFTETTE VRKTKIRNGI 
       960        970        980        990       1000
SFTIWDRWTV HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPVMPG 
      1010       1020       1030       1040       1050
HAKRLKLTMH KLVKPTTEKK YVDLTVSFAP DIDGDEDLPG PPVRYYFSHD 

TD
Length:1,052
Mass (Da):117,970
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F9C70EABA750A71
GO
Isoform 2 (identifier: A0AVT1-2) [UniParc]FASTAAdd to basket
Also known as: nUBE1L

The sequence of this isoform differs from the canonical sequence as follows:
     1-474: Missing.

Show »
Length:578
Mass (Da):65,757
Checksum:i33FDBFF4EA8AADF0
GO
Isoform 3 (identifier: A0AVT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-389: PDVNADIVHWLSWTAQGFLSP → VTIEIYGCPNICLLIHKCSVY
     390-1052: Missing.

Show »
Length:389
Mass (Da):43,216
Checksum:iE4534BE50710EF6C
GO
Isoform 4 (identifier: A0AVT1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-340: APLEIHTAMLALDQFQEKYS → VNKHFAGLREAAESEMRISE
     341-1052: Missing.

Show »
Length:340
Mass (Da):37,693
Checksum:iB73DEE549B7E7143
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8S8H0Y8S8_HUMAN
Ubiquitin-like modifier-activating ...
UBA6
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9U5H0Y9U5_HUMAN
Ubiquitin-like modifier-activating ...
UBA6
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91824 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14E → K in CAD89908 (PubMed:17974005).Curated1
Sequence conflicti140V → A in CAD89908 (PubMed:17974005).Curated1
Sequence conflicti197C → Y in BAC04463 (PubMed:14702039).Curated1
Sequence conflicti234N → D in CAD89959 (PubMed:17974005).Curated1
Sequence conflicti297V → A in BAC04463 (PubMed:14702039).Curated1
Sequence conflicti645F → V in AAQ63403 (PubMed:15202508).Curated1
Sequence conflicti803Q → H in BAA91824 (PubMed:14702039).Curated1
Sequence conflicti821E → G in CAD89959 (PubMed:17974005).Curated1
Sequence conflicti868L → P in CAD89908 (PubMed:17974005).Curated1
Sequence conflicti905V → G in AAQ63403 (PubMed:15202508).Curated1
Sequence conflicti909M → K in CAD89959 (PubMed:17974005).Curated1
Sequence conflicti920A → V in BAB19785 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030594224A → T3 PublicationsCorresponds to variant dbSNP:rs10010188Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0230831 – 474Missing in isoform 2. 1 PublicationAdd BLAST474
Alternative sequenceiVSP_023084321 – 340APLEI…QEKYS → VNKHFAGLREAAESEMRISE in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_023085341 – 1052Missing in isoform 4. 1 PublicationAdd BLAST712
Alternative sequenceiVSP_023086369 – 389PDVNA…GFLSP → VTIEIYGCPNICLLIHKCSV Y in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_023087390 – 1052Missing in isoform 3. 1 PublicationAdd BLAST663

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY359880 mRNA Translation: AAQ63403.1
EF623993 mRNA Translation: ABR25253.1
AB014773 mRNA Translation: BAB19785.1
AK001670 mRNA Translation: BAA91824.1 Different initiation.
AK094969 mRNA Translation: BAC04463.1
AK314371 mRNA Translation: BAG37000.1
AL832015 mRNA Translation: CAD89908.1
AL832458 mRNA Translation: CAD89959.1
AC079880 Genomic DNA No translation available.
AC096720 Genomic DNA Translation: AAY40999.1
BC031637 mRNA Translation: AAH31637.1
BC126484 mRNA Translation: AAI26485.1
BC126486 mRNA Translation: AAI26487.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3516.1 [A0AVT1-1]

NCBI Reference Sequences

More...RefSeqi		NP_060697.4, NM_018227.5 [A0AVT1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000322244; ENSP00000313454; ENSG00000033178 [A0AVT1-1]
ENST00000420827; ENSP00000399234; ENSG00000033178 [A0AVT1-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55236

UCSC genome browser

More...UCSCi		uc003hdg.5, human [A0AVT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359880 mRNA Translation: AAQ63403.1
EF623993 mRNA Translation: ABR25253.1
AB014773 mRNA Translation: BAB19785.1
AK001670 mRNA Translation: BAA91824.1 Different initiation.
AK094969 mRNA Translation: BAC04463.1
AK314371 mRNA Translation: BAG37000.1
AL832015 mRNA Translation: CAD89908.1
AL832458 mRNA Translation: CAD89959.1
AC079880 Genomic DNA No translation available.
AC096720 Genomic DNA Translation: AAY40999.1
BC031637 mRNA Translation: AAH31637.1
BC126484 mRNA Translation: AAI26485.1
BC126486 mRNA Translation: AAI26487.1
CCDSiCCDS3516.1 [A0AVT1-1]
RefSeqiNP_060697.4, NM_018227.5 [A0AVT1-1]

3D structure databases

SMRiA0AVT1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120529, 90 interactors
DIPiDIP-57633N
IntActiA0AVT1, 16 interactors
MINTiA0AVT1
STRINGi9606.ENSP00000313454

Chemistry databases

BindingDBiA0AVT1
ChEMBLiCHEMBL2321622

PTM databases

iPTMnetiA0AVT1
MetOSiteiA0AVT1
PhosphoSitePlusiA0AVT1
SwissPalmiA0AVT1

Genetic variation databases

BioMutaiUBA6

Proteomic databases

EPDiA0AVT1
jPOSTiA0AVT1
MassIVEiA0AVT1
MaxQBiA0AVT1
PaxDbiA0AVT1
PeptideAtlasiA0AVT1
PRIDEiA0AVT1
ProteomicsDBi26 [A0AVT1-1]
27 [A0AVT1-2]
28 [A0AVT1-3]
29 [A0AVT1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24140, 275 antibodies

The DNASU plasmid repository

More...DNASUi		55236

Genome annotation databases

EnsembliENST00000322244; ENSP00000313454; ENSG00000033178 [A0AVT1-1]
ENST00000420827; ENSP00000399234; ENSG00000033178 [A0AVT1-3]
GeneIDi55236
KEGGihsa:55236
UCSCiuc003hdg.5, human [A0AVT1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55236
DisGeNETi55236

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBA6
HGNCiHGNC:25581, UBA6
HPAiENSG00000033178, Low tissue specificity
MIMi611361, gene
neXtProtiNX_A0AVT1
OpenTargetsiENSG00000033178
PharmGKBiPA162407690
VEuPathDBiHostDB:ENSG00000033178.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2012, Eukaryota
GeneTreeiENSGT00940000158826
HOGENOMiCLU_002556_0_0_1
InParanoidiA0AVT1
OMAiCPATENT
PhylomeDBiA0AVT1
TreeFamiTF300586

Enzyme and pathway databases

UniPathwayiUPA00143
BRENDAi6.2.1.B9, 2681
PathwayCommonsiA0AVT1
ReactomeiR-HSA-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55236, 230 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBA6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UBE1L2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55236
PharosiA0AVT1, Tchem

Protein Ontology

More...PROi		PR:A0AVT1
RNActiA0AVT1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000033178, Expressed in corpus callosum and 230 other tissues
ExpressionAtlasiA0AVT1, baseline and differential
GenevisibleiA0AVT1, HS

Family and domain databases

Gene3Di1.10.10.2660, 1 hit
2.40.30.180, 1 hit
3.10.290.60, 1 hit
3.50.50.80, 1 hit
InterProiView protein in InterPro
IPR032420, E1_4HB
IPR032418, E1_FCCH
IPR042302, E1_FCCH_sf
IPR000594, ThiF_NAD_FAD-bd
IPR018965, Ub-activating_enz_E1_C
IPR042449, Ub-E1_IAD_1
IPR038252, UBA_E1_C_sf
IPR019572, UBA_E1_Cys
IPR042063, Ubi_acti_E1_SCCH
IPR035985, Ubiquitin-activating_enz
IPR018075, UBQ-activ_enz_E1
IPR000011, UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF16191, E1_4HB, 1 hit
PF16190, E1_FCCH, 1 hit
PF09358, E1_UFD, 1 hit
PF00899, ThiF, 2 hits
PF10585, UBA_e1_thiolCys, 1 hit
PRINTSiPR01849, UBIQUITINACT
SMARTiView protein in SMART
SM00985, UBA_e1_C, 1 hit
SUPFAMiSSF69572, SSF69572, 2 hits
TIGRFAMsiTIGR01408, Ube1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBA6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AVT1
Secondary accession number(s): A6N8M7
, B2RAV3, Q4W5K0, Q6UV21, Q86T78, Q86TC7, Q8N5T3, Q8N9E4, Q9H3T7, Q9NVC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 28, 2006
Last modified: February 10, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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