UniProtKB - A0AVL1 (A0AVL1_HUMAN)
Protein
Submitted name:
ADAM9 protein
Gene
ADAM9
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
Protein family/group databases
MEROPSi | M12.209 |
Names & Taxonomyi
Protein namesi | Submitted name: ADAM9 proteinImportedSubmitted name: Disintegrin and metalloproteinase domain-containing protein 9Imported |
Gene namesi | Name:ADAM9Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:216, ADAM9 |
VEuPathDBi | HostDB:ENSG00000168615.11 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5014564947 | 29 – 712 | Sequence analysisAdd BLAST | 684 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 473 ↔ 493 | PROSITE-ProRule annotation | ||
Disulfide bondi | 664 ↔ 673 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
MaxQBi | A0AVL1 |
PRIDEi | A0AVL1 |
ProteomicsDBi | 25 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168615, Expressed in amniotic fluid and 243 other tissues |
ExpressionAtlasi | A0AVL1, baseline and differential |
Interactioni
Binary interactionsi
A0AVL1
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-25935864,EBI-77613 |
Protein-protein interaction databases
IntActi | A0AVL1, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 212 – 406 | Peptidase M12BInterPro annotationAdd BLAST | 195 | |
Domaini | 414 – 501 | DisintegrinInterPro annotationAdd BLAST | 88 | |
Domaini | 640 – 674 | EGF-likeInterPro annotationAdd BLAST | 35 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156239 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 18 potential isoforms that are computationally mapped.Show allAlign All
A0AVL1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSGARFPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR
60 70 80 90 100
LTRERREAPR PYSKQVSYVI QAEGKEHIIH LERNKDLLPE DFVVYTYNKE
110 120 130 140 150
GTLITDHPNI QNHCHYRGYV EGVHNSSIAL SDCFGLRGLL HLENASYGIE
160 170 180 190 200
PLQNSSHFEH IIYRMDDVYK EPLKCGVSNK DIEKETAKDE EEEPPSMTQL
210 220 230 240 250
LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI LLANYLDSMY
260 270 280 290 300
IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS
310 320 330 340 350
AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG
360 370 380 390 400
HNLGMNHDDG RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN
410 420 430 440 450
CLLNIPKPDE AYSAPSCGNK LVDAGEECDC GTPKECELDP CCEGSTCKLK
460 470 480 490 500
SFAECAYGDC CKDCRFLPGG TLCRGKTSEC DVPEYCNGSS QFCQPDVFIQ
510 520 530 540 550
NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF IEVNSKGDRF
560 570 580 590 600
GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC
610 620 630 640 650
WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC
660 670 680 690 700
HGHGVCNSNK NCHCENGWAP PNCETKGYGG SVDSGPTYNG QMAKIKQTLL
710
DSRGVFLDMF LQ
Computationally mapped potential isoform sequencesi
There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13443 | ADAM9_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 KIAA0021, MCMP, MDC9, MLTNG | 819 | Annotation score: | ||
F8WC54 | F8WC54_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 628 | Annotation score: | ||
C9JPM3 | C9JPM3_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 147 | Annotation score: | ||
C9J6H5 | C9J6H5_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 128 | Annotation score: | ||
A0A0J9YY58 | A0A0J9YY58_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 53 | Annotation score: | ||
A0A7I2V2E1 | A0A7I2V2E1_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 566 | Annotation score: | ||
A0A7I2V2Z6 | A0A7I2V2Z6_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 780 | Annotation score: | ||
A0A7I2V303 | A0A7I2V303_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 446 | Annotation score: | ||
A0A7I2V3B5 | A0A7I2V3B5_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 575 | Annotation score: | ||
A0A7I2V3C1 | A0A7I2V3C1_HUMAN | Disintegrin and metalloproteinase d... | ADAM9 | 533 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105091 Genomic DNA No translation available. AC108863 Genomic DNA No translation available. BC126406 mRNA Translation: AAI26407.1 |
Genome annotation databases
Ensembli | ENST00000481873; ENSP00000418437; ENSG00000168615 |
UCSCi | uc064mex.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105091 Genomic DNA No translation available. AC108863 Genomic DNA No translation available. BC126406 mRNA Translation: AAI26407.1 |
3D structure databases
SMRi | A0AVL1 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0AVL1, 1 interactor |
Protein family/group databases
MEROPSi | M12.209 |
Proteomic databases
MaxQBi | A0AVL1 |
PRIDEi | A0AVL1 |
ProteomicsDBi | 25 |
Genome annotation databases
Ensembli | ENST00000481873; ENSP00000418437; ENSG00000168615 |
UCSCi | uc064mex.1, human |
Organism-specific databases
HGNCi | HGNC:216, ADAM9 |
OpenTargetsi | ENSG00000168615 |
VEuPathDBi | HostDB:ENSG00000168615.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156239 |
Miscellaneous databases
ChiTaRSi | ADAM9, human |
Gene expression databases
Bgeei | ENSG00000168615, Expressed in amniotic fluid and 243 other tissues |
ExpressionAtlasi | A0AVL1, baseline and differential |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0AVL1_HUMAN | |
Accessioni | A0AVL1Primary (citable) accession number: A0AVL1 Secondary accession number(s): C9J643 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |