Transcription factor E2F8

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.10

    "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."
    Weijts B.G., Bakker W.J., Cornelissen P.W., Liang K.H., Schaftenaar F.H., Westendorp B., de Wolf C.A., Paciejewska M., Scheele C.L., Kent L., Leone G., Schulte-Merker S., de Bruin A.
    EMBO J. 31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HIF1A.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.5

    "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription."
    Christensen J., Cloos P., Toftegaard U., Klinkenberg D., Bracken A.P., Trinh E., Heeran M., Di Stefano L., Helin K.
    Nucleic Acids Res. 33:5458-5470(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• protein homodimerization activity Source: Ensembl
• proximal promoter sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."
    Weijts B.G., Bakker W.J., Cornelissen P.W., Liang K.H., Schaftenaar F.H., Westendorp B., de Wolf C.A., Paciejewska M., Scheele C.L., Kent L., Leone G., Schulte-Merker S., de Bruin A.
    EMBO J. 31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HIF1A.
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • Ref.5

    "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription."
    Christensen J., Cloos P., Toftegaard U., Klinkenberg D., Bracken A.P., Trinh E., Heeran M., Di Stefano L., Helin K.
    Nucleic Acids Res. 33:5458-5470(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription corepressor activity Source: UniProtKB
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell cycle comprising mitosis without cytokinesis Source: UniProtKB
• cell population proliferation Source: Ensembl
• chorionic trophoblast cell differentiation Source: UniProtKB
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
• hepatocyte differentiation Source: UniProtKB
• negative regulation of cytokinesis Source: UniProtKB
• negative regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • Ref.5

    "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription."
    Christensen J., Cloos P., Toftegaard U., Klinkenberg D., Bracken A.P., Trinh E., Heeran M., Di Stefano L., Helin K.
    Nucleic Acids Res. 33:5458-5470(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• placenta development Source: UniProtKB
• positive regulation of DNA endoreduplication Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."
    Weijts B.G., Bakker W.J., Cornelissen P.W., Liang K.H., Schaftenaar F.H., Westendorp B., de Wolf C.A., Paciejewska M., Scheele C.L., Kent L., Leone G., Schulte-Merker S., de Bruin A.
    EMBO J. 31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HIF1A.
• regulation of cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sprouting angiogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."
    Weijts B.G., Bakker W.J., Cornelissen P.W., Liang K.H., Schaftenaar F.H., Westendorp B., de Wolf C.A., Paciejewska M., Scheele C.L., Kent L., Leone G., Schulte-Merker S., de Bruin A.
    EMBO J. 31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HIF1A.
• trophoblast giant cell differentiation Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein homodimerization activity Source: Ensembl
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MENEKENLFC EPHKRGLMKT PLKESTTANI VLAEIQPDFG PLTTPTKPKE 
        60         70         80         90        100
GSQGEPWTPT ANLKMLISAV SPEIRNRDQK RGLFDNRSGL PEAKDCIHEH 
       110        120        130        140        150
LSGDEFEKSQ PSRKEKSLGL LCHKFLARYP NYPNPAVNND ICLDEVAEEL 
       160        170        180        190        200
NVERRRIYDI VNVLESLHMV SRLAKNRYTW HGRHNLNKTL GTLKSIGEEN 
       210        220        230        240        250
KYAEQIMMIK KKEYEQEFDF IKSYSIEDHI IKSNTGPNGH PDMCFVELPG 
       260        270        280        290        300
VEFRAASVNS RKDKSLRVMS QKFVMLFLVS TPQIVSLEVA AKILIGEDHV 
       310        320        330        340        350
EDLDKSKFKT KIRRLYDIAN VLSSLDLIKK VHVTEERGRK PAFKWTGPEI 
       360        370        380        390        400
SPNTSGSSPV IHFTPSDLEV RRSSKENCAK NLFSTRGKPN FTRHPSLIKL 
       410        420        430        440        450
VKSIESDRRK INSAPSSPIK TNKAESSQNS APFPSKMAQL AAICKMQLEE 
       460        470        480        490        500
QSSESRQKVK VQLARSGPCK PVAPLDPPVN AEMELTAPSL IQPLGMVPLI 
       510        520        530        540        550
PSPLSSAVPL ILPQAPSGPS YAIYLQPTQA HQSVTPPQGL SPTVCTTHSS 
       560        570        580        590        600
KATGSKDSTD ATTEKAANDT SKASASTRPG SLLPAPERQG AKSRTREPAG 
       610        620        630        640        650
ERGSKRASML EDSGSKKKFK EDLKGLENVS ATLFPSGYLI PLTQCSSLGA 
       660        670        680        690        700
ESILSGKENS SALSPNHRIY SSPIAGVIPV TSSELTAVNF PSFHVTPLKL 
       710        720        730        740        750
MVSPTSVAAV PVGNSPALAS SHPVPIQNPS SAIVNFTLQH LGLISPNVQL 
       760        770        780        790        800
SASPGSGIVP VSPRIESVNV APENAGTQQG RATNYDSPVP GQSQPNGQSV 
       810        820        830        840        850
AVTGAQQPVP VTPKGSQLVA ESFFRTPGGP TKPTSSSCMD FEGANKTSLG 
       860 
TLFVPQRKLE VSTEDVH                                     

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families
4. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
5. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
6. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot