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Protein

E3 ubiquitin-protein ligase TM129

Gene

TMEM129

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri285 – 350RING-type; degenerateAdd BLAST66

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: ParkinsonsUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway, Unfolded protein response
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TM129 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TM129Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM129
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168936.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25137 TMEM129

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615975 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A0AVI4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6LumenalSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 56CytoplasmicSequence analysisAdd BLAST29
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 94LumenalSequence analysisAdd BLAST17
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 362CytoplasmicSequence analysisAdd BLAST247

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92305

Open Targets

More...
OpenTargetsi
ENSG00000168936

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485649

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM129

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002910411 – 362E3 ubiquitin-protein ligase TM129Add BLAST362

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A0AVI4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A0AVI4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0AVI4

PRoteomics IDEntifications database

More...
PRIDEi
A0AVI4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
22
23 [A0AVI4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0AVI4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0AVI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168936 Expressed in 198 organ(s), highest expression level in tendon

CleanEx database of gene expression profiles

More...
CleanExi
HS_TMEM129

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0AVI4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A0AVI4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060920

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Integral component of ER-resident dislocation complexes.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124932, 12 interactors

Protein interaction database and analysis system

More...
IntActi
A0AVI4, 3 interactors

Molecular INTeraction database

More...
MINTi
A0AVI4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000372394

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A0AVI4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM129 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri285 – 350RING-type; degenerateAdd BLAST66

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3899 Eukaryota
ENOG410XT2B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006582

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG097695

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0AVI4

KEGG Orthology (KO)

More...
KOi
K22380

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMWCVEC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0AYM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0AVI4

TreeFam database of animal gene trees

More...
TreeFami
TF314487

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018801 TM129

The PANTHER Classification System

More...
PANTHERi
PTHR31322 PTHR31322, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10272 Tmpp129, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0AVI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSPEVTFTL AYLVFAVCFV FTPNEFHAAG LTVQNLLSGW LGSEDAAFVP
60 70 80 90 100
FHLRRTAATL LCHSLLPLGY YVGMCLAASE KRLHALSQAP EAWRLFLLLA
110 120 130 140 150
VTLPSIACIL IYYWSRDRWA CHPLARTLAL YALPQSGWQA VASSVNTEFR
160 170 180 190 200
RIDKFATGAP GARVIVTDTW VMKVTTYRVH VAQQQDVHLT VTESRQHELS
210 220 230 240 250
PDSNLPVQLL TIRVASTNPA VQAFDIWLNS TEYGELCEKL RAPIRRAAHV
260 270 280 290 300
VIHQSLGDLF LETFASLVEV NPAYSVPSSQ ELEACIGCMQ TRASVKLVKT
310 320 330 340 350
CQEAATGECQ QCYCRPMWCL TCMGKWFASR QDPLRPDTWL ASRVPCPTCR
360
ARFCILDVCT VR
Length:362
Mass (Da):40,464
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i861C9876B492DC56
GO
Isoform 2 (identifier: A0AVI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-232: LNSTE → SWRPA
     233-362: Missing.

Show »
Length:232
Mass (Da):25,914
Checksum:iBB10F6F61C2DF4B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4G7H7C4G7_HUMAN
E3 ubiquitin-protein ligase TM129
TMEM129
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4I8H7C4I8_HUMAN
E3 ubiquitin-protein ligase TM129
TMEM129
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03280383L → I. Corresponds to variant dbSNP:rs798752Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036641228 – 232LNSTE → SWRPA in isoform 2. 1 Publication5
Alternative sequenceiVSP_036642233 – 362Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC016773 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82569.1
CH471131 Genomic DNA Translation: EAW82570.1
CH471131 Genomic DNA Translation: EAW82571.1
BC009331 mRNA No translation available.
BC126370 mRNA Translation: AAI26371.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3351.1 [A0AVI4-2]
CCDS46998.1 [A0AVI4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001120738.1, NM_001127266.1 [A0AVI4-1]
NP_612394.1, NM_138385.3 [A0AVI4-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.518562

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303277; ENSP00000305243; ENSG00000168936 [A0AVI4-2]
ENST00000382936; ENSP00000372394; ENSG00000168936 [A0AVI4-1]
ENST00000536901; ENSP00000441812; ENSG00000168936 [A0AVI4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92305

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92305

UCSC genome browser

More...
UCSCi
uc003gdm.4 human [A0AVI4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016773 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82569.1
CH471131 Genomic DNA Translation: EAW82570.1
CH471131 Genomic DNA Translation: EAW82571.1
BC009331 mRNA No translation available.
BC126370 mRNA Translation: AAI26371.1
CCDSiCCDS3351.1 [A0AVI4-2]
CCDS46998.1 [A0AVI4-1]
RefSeqiNP_001120738.1, NM_001127266.1 [A0AVI4-1]
NP_612394.1, NM_138385.3 [A0AVI4-2]
UniGeneiHs.518562

3D structure databases

ProteinModelPortaliA0AVI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124932, 12 interactors
IntActiA0AVI4, 3 interactors
MINTiA0AVI4
STRINGi9606.ENSP00000372394

PTM databases

iPTMnetiA0AVI4
PhosphoSitePlusiA0AVI4

Polymorphism and mutation databases

BioMutaiTMEM129

Proteomic databases

EPDiA0AVI4
MaxQBiA0AVI4
PaxDbiA0AVI4
PRIDEiA0AVI4
ProteomicsDBi22
23 [A0AVI4-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
92305
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303277; ENSP00000305243; ENSG00000168936 [A0AVI4-2]
ENST00000382936; ENSP00000372394; ENSG00000168936 [A0AVI4-1]
ENST00000536901; ENSP00000441812; ENSG00000168936 [A0AVI4-1]
GeneIDi92305
KEGGihsa:92305
UCSCiuc003gdm.4 human [A0AVI4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92305
DisGeNETi92305
EuPathDBiHostDB:ENSG00000168936.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM129
HGNCiHGNC:25137 TMEM129
HPAiHPA060920
MIMi615975 gene
neXtProtiNX_A0AVI4
OpenTargetsiENSG00000168936
PharmGKBiPA143485649

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3899 Eukaryota
ENOG410XT2B LUCA
GeneTreeiENSGT00390000013284
HOGENOMiHOG000006582
HOVERGENiHBG097695
InParanoidiA0AVI4
KOiK22380
OMAiPMWCVEC
OrthoDBiEOG091G0AYM
PhylomeDBiA0AVI4
TreeFamiTF314487

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92305

Protein Ontology

More...
PROi
PR:A0AVI4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168936 Expressed in 198 organ(s), highest expression level in tendon
CleanExiHS_TMEM129
ExpressionAtlasiA0AVI4 baseline and differential
GenevisibleiA0AVI4 HS

Family and domain databases

InterProiView protein in InterPro
IPR018801 TM129
PANTHERiPTHR31322 PTHR31322, 1 hit
PfamiView protein in Pfam
PF10272 Tmpp129, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM129_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AVI4
Secondary accession number(s): A6NH49, A6NI98, D3DVP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 28, 2006
Last modified: December 5, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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