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Protein

Fer-1-like protein 5

Gene

FER1L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fer-1-like protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FER1L5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000249715.9

Human Gene Nomenclature Database

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HGNCi
HGNC:19044 FER1L5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A0AVI2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1962 – 1982HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000249715

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671764

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FER1L5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003004981 – 2057Fer-1-like protein 5Add BLAST2057

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0AVI2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
19
20 [A0AVI2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0AVI2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0AVI2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000249715 Expressed in 63 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_FER1L5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A0AVI2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A0AVI2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via second C2 domain) with EHD1 and EHD2.By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A0AVI2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A0AVI2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 83C2 1PROSITE-ProRule annotationAdd BLAST83
Domaini168 – 249C2 2PROSITE-ProRule annotationAdd BLAST82
Domaini327 – 408C2 3PROSITE-ProRule annotationAdd BLAST82
Domaini1063 – 1168C2 4PROSITE-ProRule annotationAdd BLAST106
Domaini1488 – 1571C2 5PROSITE-ProRule annotationAdd BLAST84
Domaini1706 – 1836C2 6PROSITE-ProRule annotationAdd BLAST131

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ferlin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000161318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000006771

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018972

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A0AVI2

KEGG Orthology (KO)

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KOi
K22126

Database for complete collections of gene phylogenies

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PhylomeDBi
A0AVI2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08373 C2A_Ferlin, 1 hit
cd04011 C2B_Ferlin, 1 hit
cd04017 C2D_Ferlin, 1 hit
cd04037 C2E_Ferlin, 1 hit
cd08374 C2F_Ferlin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 6 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037726 C2A_Ferlin
IPR037720 C2B_Ferlin
IPR037723 C2D_Ferlin
IPR037724 C2E_Ferlin
IPR037725 C2F_Ferlin
IPR029997 Fer1L5
IPR012968 FerIin_dom
IPR037721 Ferlin
IPR012560 Ferlin_A-domain
IPR012561 Ferlin_B-domain
IPR032362 Ferlin_C
IPR006614 Peroxin/Ferlin

The PANTHER Classification System

More...
PANTHERi
PTHR12546 PTHR12546, 1 hit
PTHR12546:SF34 PTHR12546:SF34, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00168 C2, 7 hits
PF08165 FerA, 1 hit
PF08150 FerB, 1 hit
PF16165 Ferlin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 6 hits
SM00694 DysFC, 2 hits
SM00693 DysFN, 2 hits
SM01200 FerA, 1 hit
SM01201 FerB, 1 hit
SM01202 FerI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0AVI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRLVVQSAK IDPPLAPLPR PCMSIDFRDI KKRTRVVEGN DPVWNETLIW
60 70 80 90 100
HLWNRPLEND SFLQVTLQDM GSQKKERFIG LATVLLKPLL KQPSEVLFVK
110 120 130 140 150
DLTLLNHSMK PTDCTVTLQV AHMSNQDIEK TGAEDHLGIT AREAASQKLM
160 170 180 190 200
VPGSTAHRAL SSKPQHFQVR VKVFEARQLM GNNIKPVVKV SIAGQQHQTR
210 220 230 240 250
IKMGNNPFFN EIFFQNFHEV PAKFFDETIL IQVVNSSAMR YKAEIGRFQT
260 270 280 290 300
DIGFIYHSPG HTLLRKWLGL CQPNNPGSGV TGYLKVTIYA LGVGDQALID
310 320 330 340 350
QKLLYGTDDT DIQIFKSAVV PINMAYLQLF IYCAEDLHLK KHQSVNPQLE
360 370 380 390 400
VELIGEKLRT HMQTQTDNPI WNQILTFRIQ LPCLSSYIKF RVLDCRKKDC
410 420 430 440 450
PDEIGTASLS LNQISSTGEE IEGVYSGFLP CFGPSFLTLH GGKKAPFRIQ
460 470 480 490 500
EEGACIPDSV RDGLAYRGRV FLELITQIKS YQDSTIKDLS HEVTRIEKHQ
510 520 530 540 550
NRQKYGLCVI FLSCTMMPNF KELIHFEVSI GHYGNKMDLN YKPLVSSTPY
560 570 580 590 600
SPVIYDGNIY HYVPWYNTKP VVAVTSNWED VSFRMNCLNL LHFTRDRLKA
610 620 630 640 650
NLDTLKSTRN PKDPALLYQW EKLLRELAED CKRPLPCMTY QPKATSLDRK
660 670 680 690 700
RWQLRSLLLQ ELAQKAKQAK PKDMVATAED WLYRLNTVLP EPQMGLPDVM
710 720 730 740 750
IWLVAKEQRV AYAQVPAHSV LFSPAGALHS GRLCGKIQTL FLQYPEGEGQ
760 770 780 790 800
KDVLPAHLRV CMWLGNVTDS KDLQLLRQGD TAVYAEMYEN QAKYKDQWGQ
810 820 830 840 850
QGLYHCPNFS DVMGNKTLPM TDFQPPLGWH WQDSWTVEPQ RRLLLDIDIN
860 870 880 890 900
KSQVLEEVYE NQGRDTRGAW GPAAIPNTDV NGQPMEAREN VKCPQGWHFK
910 920 930 940 950
KDWVVELNHA VDSKGWEYGV GIPPSGLPQV WSPVEKTYHS CRRRRWARVR
960 970 980 990 1000
FRNHGELSHE QETLSFLQLG LAKGEEEGWE YDTFGSKFHL NPQPQSRFRR
1010 1020 1030 1040 1050
RCWRRRLAPN KDKGIAPIFL LEGSLAMDLK YHAGKEEDSK TWPWGLDRQF
1060 1070 1080 1090 1100
RDPQRQDTRP PNLPFIYCTF NKPHYYQLFC YIYQARNLVS NQILTFQGPF
1110 1120 1130 1140 1150
IRVVFLNHSQ CTQTLRSSAG PTWAQTLIFQ HLLLYENPQD TKESPPLVVL
1160 1170 1180 1190 1200
ELWQRDFWGK ESLWGRSVWP PMVWLDLQDR ILPPMRWHPL VKELGKEEGE
1210 1220 1230 1240 1250
ILASCELILQ TEKLGEKQLP ILSVPWKNGA YTLPKSIQPT IKRMAIEILA
1260 1270 1280 1290 1300
WGLRNMKKAS SPQLLVEFGE ESLRTEPIRD FQTNPNFPES ESVLVLTVLM
1310 1320 1330 1340 1350
PTEEAYALPL VVKVVDNWAF GQQTVTGQAN IDFLQPYFCD PWAQDYMHPK
1360 1370 1380 1390 1400
LPTLSEKKHQ DFLGYLYRKF WFKSSKAEDE YEHEVDWWSK LFWATDEHKS
1410 1420 1430 1440 1450
LKYKYKDYHT LKVYECELEA VPAFQGLQDF CQTFKLYQEQ PKLDSPVVGE
1460 1470 1480 1490 1500
FKGLFRIYPF PENPEAPKPP LQFLVWPERE DFPQPCLVRV YMVRAINLQP
1510 1520 1530 1540 1550
QDYNGLCDPY VILKLGKTEL GNRDMYQPNT LDPIFGMMFE LTCNIPLEKD
1560 1570 1580 1590 1600
LEIQLYDFDL FSPDDKIGTT VIDLENRLLS GFGAHCGLSK SYCQSGPFRW
1610 1620 1630 1640 1650
RDQMPPSYLL ERYAKRKGLP PPLFSPEEDA VFYNGKKFKL QSFEPKTPTV
1660 1670 1680 1690 1700
HGLGPKKERL ALYLLHTQGL VPEHVETRTL YSHSQPGIDQ GKVQMWVDIF
1710 1720 1730 1740 1750
PKKLGPPGPQ VNINPRKPKR YELRCIIWKT ANVDLVDDNL SREKTSDIYI
1760 1770 1780 1790 1800
KGWLYGLEKD MQKTDIHYHS LTGEADFNWR FIFTMDYLAA ERTCVQSQKD
1810 1820 1830 1840 1850
YIWSLDATSM KFPARLIIQV WDNDIFSPDD FLGVLELDLS DMPLPARHAK
1860 1870 1880 1890 1900
QCSIRMMDAD PKWPYFIQYK HFSLFKKKTV TGWWPCQVLD GGKWRLSGKV
1910 1920 1930 1940 1950
KMSLEILSEK EALIKPAGRG QSEPNQYPTL HPPLRTNTSF TWLRSPVQNF
1960 1970 1980 1990 2000
CYIFWKRYRF KLIAFMVISI IALMLFNFIY SAPHYLAMSW IKPQLQLYPP
2010 2020 2030 2040 2050
IKIFNIINSL NTSNASSSIL PTQDPNLKPT IDHEWKLHPG PTNHLSDIFP

ELPAPGD
Note: Gene prediction based on partial mRNA data.Curated
Length:2,057
Mass (Da):237,935
Last modified:September 27, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE48E0652AD6CE253
GO
Isoform 2 (identifier: A0AVI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1255: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:802
Mass (Da):93,407
Checksum:i328133209236184F
GO
Isoform 3 (identifier: A0AVI2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1255: Missing.
     1298-1298: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:801
Mass (Da):93,307
Checksum:i6A620DA086DFD2F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YFD1A0A286YFD1_HUMAN
Fer-1-like protein 5
FER1L5 hCG_1810857
2,093Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFJ1A0A286YFJ1_HUMAN
Fer-1-like protein 5
FER1L5
2,097Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEQ6A0A286YEQ6_HUMAN
Fer-1-like protein 5
FER1L5
1,761Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFD8A0A286YFD8_HUMAN
Fer-1-like protein 5
FER1L5
768Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059285354I → T. Corresponds to variant dbSNP:rs4907201Ensembl.1
Natural variantiVAR_059286687T → A. Corresponds to variant dbSNP:rs7599598Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0318521 – 1255Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST1255
Alternative sequenceiVSP_0590711298Missing in isoform 3. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068539 Genomic DNA No translation available.
AC079754 Genomic DNA No translation available.
BC117324 mRNA Translation: AAI17325.1
BC126368 mRNA Translation: AAI26369.1
AK126032 mRNA Translation: BAC86403.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS77438.1 [A0AVI2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001280012.1, NM_001293083.1 [A0AVI2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.534025

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000624922; ENSP00000485238; ENSG00000249715 [A0AVI2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90342

UCSC genome browser

More...
UCSCi
uc010fia.3 human [A0AVI2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068539 Genomic DNA No translation available.
AC079754 Genomic DNA No translation available.
BC117324 mRNA Translation: AAI17325.1
BC126368 mRNA Translation: AAI26369.1
AK126032 mRNA Translation: BAC86403.1
CCDSiCCDS77438.1 [A0AVI2-1]
RefSeqiNP_001280012.1, NM_001293083.1 [A0AVI2-1]
UniGeneiHs.534025

3D structure databases

ProteinModelPortaliA0AVI2
SMRiA0AVI2
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA0AVI2
PhosphoSitePlusiA0AVI2

Polymorphism and mutation databases

BioMutaiFER1L5

Proteomic databases

PRIDEiA0AVI2
ProteomicsDBi19
20 [A0AVI2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624922; ENSP00000485238; ENSG00000249715 [A0AVI2-1]
GeneIDi90342
KEGGihsa:90342
UCSCiuc010fia.3 human [A0AVI2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90342
EuPathDBiHostDB:ENSG00000249715.9

GeneCards: human genes, protein and diseases

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GeneCardsi
FER1L5
HGNCiHGNC:19044 FER1L5
neXtProtiNX_A0AVI2
OpenTargetsiENSG00000249715
PharmGKBiPA142671764

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000161318
HOGENOMiHOG000006771
HOVERGENiHBG018972
InParanoidiA0AVI2
KOiK22126
PhylomeDBiA0AVI2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FER1L5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
90342

Protein Ontology

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PROi
PR:A0AVI2

Gene expression databases

BgeeiENSG00000249715 Expressed in 63 organ(s), highest expression level in sperm
CleanExiHS_FER1L5
ExpressionAtlasiA0AVI2 baseline and differential
GenevisibleiA0AVI2 HS

Family and domain databases

CDDicd08373 C2A_Ferlin, 1 hit
cd04011 C2B_Ferlin, 1 hit
cd04017 C2D_Ferlin, 1 hit
cd04037 C2E_Ferlin, 1 hit
cd08374 C2F_Ferlin, 1 hit
Gene3Di2.60.40.150, 6 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037726 C2A_Ferlin
IPR037720 C2B_Ferlin
IPR037723 C2D_Ferlin
IPR037724 C2E_Ferlin
IPR037725 C2F_Ferlin
IPR029997 Fer1L5
IPR012968 FerIin_dom
IPR037721 Ferlin
IPR012560 Ferlin_A-domain
IPR012561 Ferlin_B-domain
IPR032362 Ferlin_C
IPR006614 Peroxin/Ferlin
PANTHERiPTHR12546 PTHR12546, 1 hit
PTHR12546:SF34 PTHR12546:SF34, 1 hit
PfamiView protein in Pfam
PF00168 C2, 7 hits
PF08165 FerA, 1 hit
PF08150 FerB, 1 hit
PF16165 Ferlin_C, 1 hit
SMARTiView protein in SMART
SM00239 C2, 6 hits
SM00694 DysFC, 2 hits
SM00693 DysFN, 2 hits
SM01200 FerA, 1 hit
SM01201 FerB, 1 hit
SM01202 FerI, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFR1L5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AVI2
Secondary accession number(s): A0A096LNV2, Q17RH2, Q6ZU24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 27, 2017
Last modified: December 5, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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