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Entry version 117 (02 Dec 2020)
Sequence version 2 (30 Nov 2010)
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Protein

RNA-binding protein 47

Gene

RBM47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A0AV96

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 47
Alternative name(s):
RNA-binding motif protein 47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000163694.14

Human Gene Nomenclature Database

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HGNCi
HGNC:30358, RBM47

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A0AV96

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54502

Open Targets

More...
OpenTargetsi
ENSG00000163694

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400825

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A0AV96, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBM47

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003078551 – 593RNA-binding protein 47Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei332Omega-N-methylarginineCombined sources1
Modified residuei394Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei394Omega-N-methylarginine; alternateCombined sources1
Modified residuei405Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei405Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A0AV96

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0AV96

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A0AV96

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A0AV96

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0AV96

PeptideAtlas

More...
PeptideAtlasi
A0AV96

PRoteomics IDEntifications database

More...
PRIDEi
A0AV96

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
14 [A0AV96-1]
15 [A0AV96-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0AV96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0AV96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163694, Expressed in adult mammalian kidney and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0AV96, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A0AV96, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163694, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119998, 73 interactors

Protein interaction database and analysis system

More...
IntActi
A0AV96, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371212

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A0AV96, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A0AV96

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A0AV96

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 149RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini151 – 233RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini246 – 318RRM 3PROSITE-ProRule annotationAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi487 – 581Ala-richAdd BLAST95

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM RBM47 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0117, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156979

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0AV96

Identification of Orthologs from Complete Genome Data

More...
OMAi
APNIQRI

Database of Orthologous Groups

More...
OrthoDBi
1384330at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0AV96

TreeFam database of animal gene trees

More...
TreeFami
TF314932

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12491, RRM2_RBM47, 1 hit
cd12497, RRM3_RBM47, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006535, HnRNP_R/Q_splicing_fac
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034442, RBM47
IPR034440, RBM47_RRM2
IPR034445, RBM47_RRM3
IPR000504, RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR21245:SF6, PTHR21245:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01648, hnRNP-R-Q, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0AV96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEDSTAAM SSDSAAGSSA KVPEGVAGAP NEAALLALME RTGYSMVQEN
60 70 80 90 100
GQRKYGGPPP GWEGPHPQRG CEVFVGKIPR DVYEDELVPV FEAVGRIYEL
110 120 130 140 150
RLMMDFDGKN RGYAFVMYCH KHEAKRAVRE LNNYEIRPGR LLGVCCSVDN
160 170 180 190 200
CRLFIGGIPK MKKREEILEE IAKVTEGVLD VIVYASAADK MKNRGFAFVE
210 220 230 240 250
YESHRAAAMA RRKLMPGRIQ LWGHQIAVDW AEPEIDVDED VMETVKILYV
260 270 280 290 300
RNLMIETTED TIKKSFGQFN PGCVERVKKI RDYAFVHFTS REDAVHAMNN
310 320 330 340 350
LNGTELEGSC LEVTLAKPVD KEQYSRYQKA ARGGGAAEAA QQPSYVYSCD
360 370 380 390 400
PYTLAYYGYP YNALIGPNRD YFVKAGSIRG RGRGAAGNRA PGPRGSYLGG
410 420 430 440 450
YSAGRGIYSR YHEGKGKQQE KGYELVPNLE IPTVNPVAIK PGTVAIPAIG
460 470 480 490 500
AQYSMFPAAP APKMIEDGKI HTVEHMISPI AVQPDPASAA AAAAAAAAAA
510 520 530 540 550
AAVIPTVSTP PPFQGRPITP VYTVAPNVQR IPTAGIYGAS YVPFAAPATA
560 570 580 590
TIATLQKNAA AAAAMYGGYA GYIPQAFPAA AIQVPIPDVY QTY
Length:593
Mass (Da):64,099
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEA061F89A68010B
GO
Isoform 2 (identifier: A0AV96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-443: Missing.

Show »
Length:524
Mass (Da):56,920
Checksum:i4C7004D92117D5B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9D6D6R9D6_HUMAN
RNA-binding motif protein 47
RBM47
393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z8Z7B7Z8Z7_HUMAN
RNA-binding motif protein 47
RBM47
555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBS9D6RBS9_HUMAN
RNA-binding protein 47
RBM47
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REZ6D6REZ6_HUMAN
RNA-binding protein 47
RBM47
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBP6D6RBP6_HUMAN
RNA-binding protein 47
RBM47
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFL5D6RFL5_HUMAN
RNA-binding protein 47
RBM47
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9M7D6R9M7_HUMAN
RNA-binding protein 47
RBM47
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA49D6RA49_HUMAN
RNA-binding protein 47
RBM47
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCT1D6RCT1_HUMAN
RNA-binding protein 47
RBM47
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM21973 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9A → T in AAM21973 (Ref. 1) Curated1
Sequence conflicti97I → T in BAA91049 (PubMed:14702039).Curated1
Sequence conflicti515G → V in AAM21972 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061832538G → R. Corresponds to variant dbSNP:rs35529250Ensembl.1
Natural variantiVAR_054770565M → V2 PublicationsCorresponds to variant dbSNP:rs278981Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028839375 – 443Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF261889 Genomic DNA Translation: AAM21972.1
AF262323 mRNA Translation: AAM21973.1 Frameshift.
AK000280 mRNA Translation: BAA91049.1
AC098869 Genomic DNA No translation available.
AC112717 Genomic DNA No translation available.
BC034402 mRNA Translation: AAH34402.1
BC126261 mRNA Translation: AAI26262.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3460.1 [A0AV96-2]
CCDS43223.1 [A0AV96-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001092104.1, NM_001098634.1 [A0AV96-1]
NP_061900.2, NM_019027.3 [A0AV96-2]
XP_005248160.1, XM_005248103.3 [A0AV96-1]
XP_005248164.1, XM_005248107.3
XP_005248165.1, XM_005248108.3 [A0AV96-1]
XP_005248166.1, XM_005248109.4 [A0AV96-1]
XP_011512006.1, XM_011513704.2
XP_011512009.1, XM_011513707.2 [A0AV96-1]
XP_011512010.1, XM_011513708.2 [A0AV96-1]
XP_016863793.1, XM_017008304.1 [A0AV96-1]
XP_016863794.1, XM_017008305.1
XP_016863795.1, XM_017008306.1 [A0AV96-1]
XP_016863796.1, XM_017008307.1 [A0AV96-1]
XP_016863797.1, XM_017008308.1 [A0AV96-1]
XP_016863799.1, XM_017008310.1 [A0AV96-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295971; ENSP00000295971; ENSG00000163694 [A0AV96-1]
ENST00000381793; ENSP00000371212; ENSG00000163694 [A0AV96-1]
ENST00000381795; ENSP00000371214; ENSG00000163694 [A0AV96-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54502

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54502

UCSC genome browser

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UCSCi
uc003gvc.3, human [A0AV96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261889 Genomic DNA Translation: AAM21972.1
AF262323 mRNA Translation: AAM21973.1 Frameshift.
AK000280 mRNA Translation: BAA91049.1
AC098869 Genomic DNA No translation available.
AC112717 Genomic DNA No translation available.
BC034402 mRNA Translation: AAH34402.1
BC126261 mRNA Translation: AAI26262.1
CCDSiCCDS3460.1 [A0AV96-2]
CCDS43223.1 [A0AV96-1]
RefSeqiNP_001092104.1, NM_001098634.1 [A0AV96-1]
NP_061900.2, NM_019027.3 [A0AV96-2]
XP_005248160.1, XM_005248103.3 [A0AV96-1]
XP_005248164.1, XM_005248107.3
XP_005248165.1, XM_005248108.3 [A0AV96-1]
XP_005248166.1, XM_005248109.4 [A0AV96-1]
XP_011512006.1, XM_011513704.2
XP_011512009.1, XM_011513707.2 [A0AV96-1]
XP_011512010.1, XM_011513708.2 [A0AV96-1]
XP_016863793.1, XM_017008304.1 [A0AV96-1]
XP_016863794.1, XM_017008305.1
XP_016863795.1, XM_017008306.1 [A0AV96-1]
XP_016863796.1, XM_017008307.1 [A0AV96-1]
XP_016863797.1, XM_017008308.1 [A0AV96-1]
XP_016863799.1, XM_017008310.1 [A0AV96-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DISNMR-A150-245[»]
SMRiA0AV96
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119998, 73 interactors
IntActiA0AV96, 14 interactors
STRINGi9606.ENSP00000371212

PTM databases

iPTMnetiA0AV96
PhosphoSitePlusiA0AV96

Polymorphism and mutation databases

BioMutaiRBM47

Proteomic databases

EPDiA0AV96
jPOSTiA0AV96
MassIVEiA0AV96
MaxQBiA0AV96
PaxDbiA0AV96
PeptideAtlasiA0AV96
PRIDEiA0AV96
ProteomicsDBi14 [A0AV96-1]
15 [A0AV96-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1338, 42 antibodies

The DNASU plasmid repository

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DNASUi
54502

Genome annotation databases

EnsembliENST00000295971; ENSP00000295971; ENSG00000163694 [A0AV96-1]
ENST00000381793; ENSP00000371212; ENSG00000163694 [A0AV96-1]
ENST00000381795; ENSP00000371214; ENSG00000163694 [A0AV96-2]
GeneIDi54502
KEGGihsa:54502
UCSCiuc003gvc.3, human [A0AV96-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54502
DisGeNETi54502
EuPathDBiHostDB:ENSG00000163694.14

GeneCards: human genes, protein and diseases

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GeneCardsi
RBM47
HGNCiHGNC:30358, RBM47
HPAiENSG00000163694, Low tissue specificity
neXtProtiNX_A0AV96
OpenTargetsiENSG00000163694
PharmGKBiPA162400825

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0117, Eukaryota
GeneTreeiENSGT00940000156979
InParanoidiA0AV96
OMAiAPNIQRI
OrthoDBi1384330at2759
PhylomeDBiA0AV96
TreeFamiTF314932

Enzyme and pathway databases

PathwayCommonsiA0AV96

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54502, 17 hits in 850 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBM47, human
EvolutionaryTraceiA0AV96

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54502
PharosiA0AV96, Tdark

Protein Ontology

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PROi
PR:A0AV96
RNActiA0AV96, protein

Gene expression databases

BgeeiENSG00000163694, Expressed in adult mammalian kidney and 212 other tissues
ExpressionAtlasiA0AV96, baseline and differential
GenevisibleiA0AV96, HS

Family and domain databases

CDDicd12491, RRM2_RBM47, 1 hit
cd12497, RRM3_RBM47, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535, HnRNP_R/Q_splicing_fac
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034442, RBM47
IPR034440, RBM47_RRM2
IPR034445, RBM47_RRM3
IPR000504, RRM_dom
PANTHERiPTHR21245:SF6, PTHR21245:SF6, 1 hit
PfamiView protein in Pfam
PF00076, RRM_1, 3 hits
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SUPFAMiSSF54928, SSF54928, 3 hits
TIGRFAMsiTIGR01648, hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM47_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AV96
Secondary accession number(s): A0PJK2
, B5MED4, Q8NI52, Q8NI53, Q9NXG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 30, 2010
Last modified: December 2, 2020
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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