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Entry version 81 (02 Dec 2020)
Sequence version 2 (17 Apr 2007)
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Protein
Submitted name:

Topoisomerase (DNA) II binding protein 1

Gene

TOPBP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseImported

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A0AV47

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Topoisomerase (DNA) II binding protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPBP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934073

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0AV47

PRoteomics IDEntifications database

More...
PRIDEi
A0AV47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A0AV47, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85BRCTInterPro annotationAdd BLAST72
Domaini108 – 197BRCTInterPro annotationAdd BLAST90
Domaini267 – 357BRCTInterPro annotationAdd BLAST91
Domaini461 – 546BRCTInterPro annotationAdd BLAST86
Domaini554 – 651BRCTInterPro annotationAdd BLAST98
Domaini813 – 904BRCTInterPro annotationAdd BLAST92
Domaini1172 – 1264BRCTInterPro annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni931 – 971DisorderedSequence analysisAdd BLAST41
Regioni996 – 1030DisorderedSequence analysisAdd BLAST35
Regioni1414 – 1435DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi949 – 971PolarSequence analysisAdd BLAST23

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR035960, Secretoglobin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533, BRCT, 4 hits
PF12738, PTCB-BRCT, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292, BRCT, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48201, SSF48201, 1 hit
SSF52113, SSF52113, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0AV47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHHQRCVPRA EHPVYNMVMS DVTISCTSLE KEKREEVHKY VQMMGGRVYR
60 70 80 90 100
DLNVSVTHLI AGEVGSKKYL VAANLKKPIL LPSWIKTLWE KSQEKKITRY
110 120 130 140 150
TDINMEDFKC PIFLGCIICV TGLCGLDRKE VQQLTVKHGG QYMGQLKMNE
160 170 180 190 200
CTHLIVQEPK GQKYECAKRW NVHCVTTQWF FDSIEKGFCQ DESIYKTEPR
210 220 230 240 250
PEAKTMPNSS TPTSQINTID SRTLSDVSNI SNINASCVSE SICNSLNSKL
260 270 280 290 300
EPTLENLENL DVSAFQAPED LLDGCRIYLC GFSGRKLDKL RRLINSGGGV
310 320 330 340 350
RFNQLNEDVT HVIVGDYDDE LKQFWNKSAH RPHVVGAKWL LECFSKGYML
360 370 380 390 400
SEEPYIHANY QPVEIPVSHK PESKAALLKK KNSSFSKKDF APSEKHEQAD
410 420 430 440 450
EDLLSQYENG SSTVVEAKTS EARPFNDSTH AEPLNDSTHI SLQEENQSSV
460 470 480 490 500
SHCVPDVSTI TEEGLFSQKS FLVLGFSNEN ESNIANIIKE NAGKIMSLLS
510 520 530 540 550
RTVADYAVVP LLGCEVEATV GEVVTNTWLV TCIDYQTLFD PKSNPLFTPV
560 570 580 590 600
PVMTGMTPLE DCVISFSQCA GAEKESLTFL ANLLGASVQE YFVRKSNAKK
610 620 630 640 650
GMFASTHLIL KERGGSKYEA AKKWNLPAVT IAWLLETART GKRADESHFL
660 670 680 690 700
IENSTKEERS LETEITNGIN LNSDTAEHPG TRLQTHRKTV VTPLDMNRFQ
710 720 730 740 750
SKAFRAVVSQ HARQVAASPA VGQPLQKEPS LHLDTPSKFL SKDKLFKPSF
760 770 780 790 800
DVKDALAALE TPGRPSQQKR KPSTPLSEVI VKNLQLALAN SSRNAVALSA
810 820 830 840 850
SPQLKEAQSE KEEAPKPLHK VVVCVSKKLS KKQSELNGIA ASLGADYRWS
860 870 880 890 900
FDETVTHFIY QGRPNDTNRE YKSVKERGVH IVSEHWLLDC AQECKHLPES
910 920 930 940 950
LYPHTYNPKM SLDISAVQDG RLCNSRLLSA VSSTKDDEPD PLILEENDVD
960 970 980 990 1000
NMATNNKESA PSNGSGKNDS KGVLTQTLEM RENFQKQLQE IMSATSIVKP
1010 1020 1030 1040 1050
QGQRTSLSRS GCNSASSTPD STRSARSGRS RVLEALRQSR QTVPDVNTEP
1060 1070 1080 1090 1100
SQNEQIIWDD PTAREERARL ASNLQWPSCP TQYSELQVDI QNLEDSPFQK
1110 1120 1130 1140 1150
PLHDSEIAKQ AVCDPGNIRV TEAPKHPISE ELETPIKDSH LIPTPQAPSI
1160 1170 1180 1190 1200
AFPLANPPVA PHPREKIITI EETHEELKKQ YIFQLSSLNP QERIDYCHLI
1210 1220 1230 1240 1250
EKLGGLVIEK QCFDPTCTHI VVGHPLRNEK YLASVAAGKW VLHRSYLEAC
1260 1270 1280 1290 1300
RTAGHFVQEE DYEWGSSSIL DVLTGINVQQ RRLALAAMRW RKKIQQRQES
1310 1320 1330 1340 1350
GIVEGAFSGW KVILHVDQSR EAGFKRLLQS GGAKVLPGHS VPLFKEATHL
1360 1370 1380 1390 1400
FSDLNKLKPD DSGVNIAEAA AQNVYCLRTE YIADYLMQES PPHVENYCLP
1410 1420 1430
EAISFIQNNK ELGTGLSQKR KAPTEKNKIK RPRVH
Length:1,435
Mass (Da):160,551
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i959EFEBEF5257B00
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC126209 mRNA Translation: AAI26210.2

NCBI Reference Sequences

More...
RefSeqi
NP_008958.2, NM_007027.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11073

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11073

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126209 mRNA Translation: AAI26210.2
RefSeqiNP_008958.2, NM_007027.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0AV47
PRIDEiA0AV47

Genome annotation databases

GeneIDi11073
KEGGihsa:11073

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11073
PharmGKBiPA134934073

Enzyme and pathway databases

SignaLinkiA0AV47

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11073, 707 hits in 855 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TOPBP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11073

Gene expression databases

GenevisibleiA0AV47, HS

Family and domain databases

Gene3Di3.40.50.10190, 8 hits
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR035960, Secretoglobin_sf
PfamiView protein in Pfam
PF00533, BRCT, 4 hits
PF12738, PTCB-BRCT, 2 hits
SMARTiView protein in SMART
SM00292, BRCT, 7 hits
SUPFAMiSSF48201, SSF48201, 1 hit
SSF52113, SSF52113, 6 hits
PROSITEiView protein in PROSITE
PS50172, BRCT, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0AV47_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AV47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: April 17, 2007
Last modified: December 2, 2020
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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