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UniProtKB - A0AUZ9 (KAL1L_HUMAN)

Entry version 104 (10 Feb 2021)
Sequence version 2 (26 Feb 2008)
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Protein

KAT8 regulatory NSL complex subunit 1-like protein

Gene

KANSL1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A0AUZ9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 1-like protein
Alternative name(s):
MSL1v2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KANSL1L
Synonyms:C2orf67
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26310, KANSL1L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613833, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A0AUZ9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000144445.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		151050

Open Targets

More...OpenTargetsi		ENSG00000144445

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162379439

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A0AUZ9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KANSL1L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003195821 – 987KAT8 regulatory NSL complex subunit 1-like proteinAdd BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei462PhosphoserineBy similarity1
Modified residuei859N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A0AUZ9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0AUZ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A0AUZ9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A0AUZ9

PeptideAtlas

More...PeptideAtlasi		A0AUZ9

PRoteomics IDEntifications database

More...PRIDEi		A0AUZ9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5 [A0AUZ9-1]
6 [A0AUZ9-2]
7 [A0AUZ9-3]
8 [A0AUZ9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A0AUZ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A0AUZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144445, Expressed in kidney and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0AUZ9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A0AUZ9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144445, Tissue enriched (parathyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A0AUZ9, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000281772

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A0AUZ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0AUZ9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRI7, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063688

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011035_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A0AUZ9

Identification of Orthologs from Complete Genome Data

More...OMAi		QPLDECN

Database of Orthologous Groups

More...OrthoDBi		191128at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0AUZ9

TreeFam database of animal gene trees

More...TreeFami		TF336511

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026180, NSL1
IPR029332, PEHE_dom

The PANTHER Classification System

More...PANTHERi		PTHR22443, PTHR22443, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15275, PEHE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01300, PEHE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0AUZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG 
        60         70         80         90        100
FPTPEPTLNT NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK 
       110        120        130        140        150
LGEPSCNKLK NILYNGSNIQ LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ 
       160        170        180        190        200
IILDSNITKD TNVDKVQLQN CKWYQENALL DKVTDAEIKK GLLHCTQKKI 
       210        220        230        240        250
VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR TQKHLQMLLA 
       260        270        280        290        300
KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT 
       310        320        330        340        350
AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD 
       360        370        380        390        400
DLDEYTLRKN VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT 
       410        420        430        440        450
DIHRQIRASK GIVVLEECQL PKDILKKQMQ FADQAASLNI LGNPQVPQEC 
       460        470        480        490        500
QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL TEIINSLIAP LNLSPTSSPL 
       510        520        530        540        550
SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK KRKDRTRLKS 
       560        570        580        590        600
SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM 
       610        620        630        640        650
PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET 
       660        670        680        690        700
LLKKTEIKGN LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES 
       710        720        730        740        750
SAQLLQGRKK RHLSETALGE RTKLEESDFQ HTESGSHSNF TAVSNVNVLS 
       760        770        780        790        800
RIQNSSRNTA RRRLRSESSY DIDNIVIPMS LVAPAKLEKL QYKEILTPSW 
       810        820        830        840        850
RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR WSLWEQSKWH 
       860        870        880        890        900
RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG 
       910        920        930        940        950
LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE 
       960        970        980 
IFGTSVPENG HHPKKQSDGM EEYKTFGLGL TNVKKNR
Length:987
Mass (Da):112,253
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAAF236C850E6254
GO
Isoform 2 (identifier: A0AUZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-718: Missing.

Show »
Length:945
Mass (Da):107,452
Checksum:i601547FF92939BA6
GO
Isoform 3 (identifier: A0AUZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-705: VHSTLNQWRNGYSPICKPQIRSESSAQLL → GMSHLQFLYSICLFMSLYLLFLHSKKNKI
     706-987: Missing.

Show »
Length:705
Mass (Da):79,988
Checksum:iAFB81C92AEC5238E
GO
Isoform 4 (identifier: A0AUZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     641-648: DVPLHFHF → GKPPCNNF
     649-987: Missing.

Show »
Length:648
Mass (Da):73,235
Checksum:iEB01EB1EF725D095
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ78H7BZ78_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL1L
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1T2H7C1T2_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL1L
343Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2S5H7C2S5_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL1L
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR24A0A0U1RR24_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL1L
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85085 differs from that shown. Reason: Frameshift.Curated
The sequence BAB85085 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB85085 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti401D → G in BAB71308 (PubMed:14702039).Curated1
Sequence conflicti458D → G in BAB71308 (PubMed:14702039).Curated1
Sequence conflicti471R → G in BAB85085 (PubMed:14702039).Curated1
Sequence conflicti501S → F in BAB85085 (PubMed:14702039).Curated1
Sequence conflicti587L → W in CAB61379 (PubMed:17974005).Curated1
Sequence conflicti606A → T in BAB71308 (PubMed:14702039).Curated1
Sequence conflicti756S → I in BAB85085 (PubMed:14702039).Curated1
Sequence conflicti848K → Q in BAB85085 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031497641 – 648DVPLHFHF → GKPPCNNF in isoform 4. 1 Publication8
Alternative sequenceiVSP_031498649 – 987Missing in isoform 4. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_031499677 – 718Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_031500677 – 705VHSTL…SAQLL → GMSHLQFLYSICLFMSLYLL FLHSKKNKI in isoform 3. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_031501706 – 987Missing in isoform 3. 2 PublicationsAdd BLAST282

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK056911 mRNA Translation: BAB71308.1
AK074441 mRNA Translation: BAB85085.1 Sequence problems.
AC006994 Genomic DNA Translation: AAY14880.1
AC007038 Genomic DNA Translation: AAX93088.1
CH471063 Genomic DNA Translation: EAW70479.1
BC032837 mRNA Translation: AAH32837.1
BC070141 mRNA Translation: AAH70141.1
BC126155 mRNA Translation: AAI26156.1
BC143914 mRNA Translation: AAI43915.1
AL133053 mRNA Translation: CAB61379.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33370.1 [A0AUZ9-1]
CCDS77519.1 [A0AUZ9-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T42655

NCBI Reference Sequences

More...RefSeqi		NP_001294905.1, NM_001307976.1 [A0AUZ9-2]
NP_689732.2, NM_152519.3 [A0AUZ9-1]
XP_005246386.1, XM_005246329.4 [A0AUZ9-1]
XP_005246387.1, XM_005246330.4 [A0AUZ9-1]
XP_011509008.1, XM_011510706.2 [A0AUZ9-1]
XP_011509009.1, XM_011510707.2 [A0AUZ9-1]
XP_016858919.1, XM_017003430.1 [A0AUZ9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000281772; ENSP00000281772; ENSG00000144445 [A0AUZ9-1]
ENST00000418791; ENSP00000405724; ENSG00000144445 [A0AUZ9-2]
ENST00000452086; ENSP00000401408; ENSG00000144445 [A0AUZ9-3]
ENST00000457374; ENSP00000393432; ENSG00000144445 [A0AUZ9-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		151050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:151050

UCSC genome browser

More...UCSCi		uc002vds.4, human [A0AUZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056911 mRNA Translation: BAB71308.1
AK074441 mRNA Translation: BAB85085.1 Sequence problems.
AC006994 Genomic DNA Translation: AAY14880.1
AC007038 Genomic DNA Translation: AAX93088.1
CH471063 Genomic DNA Translation: EAW70479.1
BC032837 mRNA Translation: AAH32837.1
BC070141 mRNA Translation: AAH70141.1
BC126155 mRNA Translation: AAI26156.1
BC143914 mRNA Translation: AAI43915.1
AL133053 mRNA Translation: CAB61379.1
CCDSiCCDS33370.1 [A0AUZ9-1]
CCDS77519.1 [A0AUZ9-2]
PIRiT42655
RefSeqiNP_001294905.1, NM_001307976.1 [A0AUZ9-2]
NP_689732.2, NM_152519.3 [A0AUZ9-1]
XP_005246386.1, XM_005246329.4 [A0AUZ9-1]
XP_005246387.1, XM_005246330.4 [A0AUZ9-1]
XP_011509008.1, XM_011510706.2 [A0AUZ9-1]
XP_011509009.1, XM_011510707.2 [A0AUZ9-1]
XP_016858919.1, XM_017003430.1 [A0AUZ9-1]

3D structure databases

SMRiA0AUZ9
ModBaseiSearch...

Protein-protein interaction databases

IntActiA0AUZ9, 2 interactors
STRINGi9606.ENSP00000281772

PTM databases

iPTMnetiA0AUZ9
PhosphoSitePlusiA0AUZ9

Genetic variation databases

BioMutaiKANSL1L

Proteomic databases

EPDiA0AUZ9
jPOSTiA0AUZ9
MassIVEiA0AUZ9
PaxDbiA0AUZ9
PeptideAtlasiA0AUZ9
PRIDEiA0AUZ9
ProteomicsDBi5 [A0AUZ9-1]
6 [A0AUZ9-2]
7 [A0AUZ9-3]
8 [A0AUZ9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		63309, 32 antibodies

The DNASU plasmid repository

More...DNASUi		151050

Genome annotation databases

EnsembliENST00000281772; ENSP00000281772; ENSG00000144445 [A0AUZ9-1]
ENST00000418791; ENSP00000405724; ENSG00000144445 [A0AUZ9-2]
ENST00000452086; ENSP00000401408; ENSG00000144445 [A0AUZ9-3]
ENST00000457374; ENSP00000393432; ENSG00000144445 [A0AUZ9-3]
GeneIDi151050
KEGGihsa:151050
UCSCiuc002vds.4, human [A0AUZ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		151050
DisGeNETi151050

GeneCards: human genes, protein and diseases

More...GeneCardsi		KANSL1L
HGNCiHGNC:26310, KANSL1L
HPAiENSG00000144445, Tissue enriched (parathyroid)
MIMi613833, gene
neXtProtiNX_A0AUZ9
OpenTargetsiENSG00000144445
PharmGKBiPA162379439
VEuPathDBiHostDB:ENSG00000144445.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRI7, Eukaryota
GeneTreeiENSGT00530000063688
HOGENOMiCLU_011035_1_0_1
InParanoidiA0AUZ9
OMAiQPLDECN
OrthoDBi191128at2759
PhylomeDBiA0AUZ9
TreeFamiTF336511

Enzyme and pathway databases

PathwayCommonsiA0AUZ9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		151050, 5 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KANSL1L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		151050
PharosiA0AUZ9, Tdark

Protein Ontology

More...PROi		PR:A0AUZ9
RNActiA0AUZ9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144445, Expressed in kidney and 217 other tissues
ExpressionAtlasiA0AUZ9, baseline and differential
GenevisibleiA0AUZ9, HS

Family and domain databases

InterProiView protein in InterPro
IPR026180, NSL1
IPR029332, PEHE_dom
PANTHERiPTHR22443, PTHR22443, 1 hit
PfamiView protein in Pfam
PF15275, PEHE, 1 hit
SMARTiView protein in SMART
SM01300, PEHE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAL1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AUZ9
Secondary accession number(s): B7ZLN1
, I6L9A8, Q53TV8, Q53TW3, Q6IS05, Q8TCI1, Q96MI0, Q9UFC3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 10, 2021
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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