UniProtKB - A0AUZ9 (KAL1L_HUMAN)
Protein
KAT8 regulatory NSL complex subunit 1-like protein
Gene
KANSL1L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- histone acetyltransferase binding Source: GO_Central
GO - Biological processi
- histone H4-K16 acetylation Source: GOC
- histone H4-K5 acetylation Source: GOC
- histone H4-K8 acetylation Source: GOC
Enzyme and pathway databases
PathwayCommonsi | A0AUZ9 |
Names & Taxonomyi
Protein namesi | Recommended name: KAT8 regulatory NSL complex subunit 1-like proteinAlternative name(s): MSL1v2 |
Gene namesi | Name:KANSL1L Synonyms:C2orf67 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26310, KANSL1L |
MIMi | 613833, gene |
neXtProti | NX_A0AUZ9 |
VEuPathDBi | HostDB:ENSG00000144445.16 |
Subcellular locationi
Nucleus
- NSL complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 151050 |
OpenTargetsi | ENSG00000144445 |
PharmGKBi | PA162379439 |
Miscellaneous databases
Pharosi | A0AUZ9, Tdark |
Genetic variation databases
BioMutai | KANSL1L |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319582 | 1 – 987 | KAT8 regulatory NSL complex subunit 1-like proteinAdd BLAST | 987 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 134 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 462 | PhosphoserineBy similarity | 1 | |
Modified residuei | 859 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.1 Publication
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | A0AUZ9 |
jPOSTi | A0AUZ9 |
MassIVEi | A0AUZ9 |
PaxDbi | A0AUZ9 |
PeptideAtlasi | A0AUZ9 |
PRIDEi | A0AUZ9 |
ProteomicsDBi | 5 [A0AUZ9-1] 6 [A0AUZ9-2] 7 [A0AUZ9-3] 8 [A0AUZ9-4] |
PTM databases
iPTMneti | A0AUZ9 |
PhosphoSitePlusi | A0AUZ9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000144445, Expressed in kidney and 217 other tissues |
ExpressionAtlasi | A0AUZ9, baseline and differential |
Genevisiblei | A0AUZ9, HS |
Organism-specific databases
HPAi | ENSG00000144445, Tissue enriched (parathyroid) |
Interactioni
GO - Molecular functioni
- histone acetyltransferase binding Source: GO_Central
Protein-protein interaction databases
IntActi | A0AUZ9, 2 interactors |
STRINGi | 9606.ENSP00000281772 |
Miscellaneous databases
RNActi | A0AUZ9, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QRI7, Eukaryota |
GeneTreei | ENSGT00530000063688 |
HOGENOMi | CLU_011035_1_0_1 |
InParanoidi | A0AUZ9 |
OMAi | QPLDECN |
OrthoDBi | 191128at2759 |
PhylomeDBi | A0AUZ9 |
TreeFami | TF336511 |
Family and domain databases
InterProi | View protein in InterPro IPR026180, NSL1 IPR029332, PEHE_dom |
PANTHERi | PTHR22443, PTHR22443, 1 hit |
Pfami | View protein in Pfam PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A0AUZ9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG
60 70 80 90 100
FPTPEPTLNT NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK
110 120 130 140 150
LGEPSCNKLK NILYNGSNIQ LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ
160 170 180 190 200
IILDSNITKD TNVDKVQLQN CKWYQENALL DKVTDAEIKK GLLHCTQKKI
210 220 230 240 250
VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR TQKHLQMLLA
260 270 280 290 300
KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT
310 320 330 340 350
AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD
360 370 380 390 400
DLDEYTLRKN VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT
410 420 430 440 450
DIHRQIRASK GIVVLEECQL PKDILKKQMQ FADQAASLNI LGNPQVPQEC
460 470 480 490 500
QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL TEIINSLIAP LNLSPTSSPL
510 520 530 540 550
SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK KRKDRTRLKS
560 570 580 590 600
SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM
610 620 630 640 650
PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET
660 670 680 690 700
LLKKTEIKGN LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES
710 720 730 740 750
SAQLLQGRKK RHLSETALGE RTKLEESDFQ HTESGSHSNF TAVSNVNVLS
760 770 780 790 800
RIQNSSRNTA RRRLRSESSY DIDNIVIPMS LVAPAKLEKL QYKEILTPSW
810 820 830 840 850
RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR WSLWEQSKWH
860 870 880 890 900
RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG
910 920 930 940 950
LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE
960 970 980
IFGTSVPENG HHPKKQSDGM EEYKTFGLGL TNVKKNR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZ78 | H7BZ78_HUMAN | KAT8 regulatory NSL complex subunit... | KANSL1L | 199 | Annotation score: | ||
H7C1T2 | H7C1T2_HUMAN | KAT8 regulatory NSL complex subunit... | KANSL1L | 343 | Annotation score: | ||
H7C2S5 | H7C2S5_HUMAN | KAT8 regulatory NSL complex subunit... | KANSL1L | 191 | Annotation score: | ||
A0A0U1RR24 | A0A0U1RR24_HUMAN | KAT8 regulatory NSL complex subunit... | KANSL1L | 70 | Annotation score: |
Sequence cautioni
The sequence BAB85085 differs from that shown. Reason: Frameshift.Curated
The sequence BAB85085 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB85085 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 401 | D → G in BAB71308 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 458 | D → G in BAB71308 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 471 | R → G in BAB85085 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 501 | S → F in BAB85085 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 587 | L → W in CAB61379 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 606 | A → T in BAB71308 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 756 | S → I in BAB85085 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 848 | K → Q in BAB85085 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031497 | 641 – 648 | DVPLHFHF → GKPPCNNF in isoform 4. 1 Publication | 8 | |
Alternative sequenceiVSP_031498 | 649 – 987 | Missing in isoform 4. 1 PublicationAdd BLAST | 339 | |
Alternative sequenceiVSP_031499 | 677 – 718 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_031500 | 677 – 705 | VHSTL…SAQLL → GMSHLQFLYSICLFMSLYLL FLHSKKNKI in isoform 3. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_031501 | 706 – 987 | Missing in isoform 3. 2 PublicationsAdd BLAST | 282 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056911 mRNA Translation: BAB71308.1 AK074441 mRNA Translation: BAB85085.1 Sequence problems. AC006994 Genomic DNA Translation: AAY14880.1 AC007038 Genomic DNA Translation: AAX93088.1 CH471063 Genomic DNA Translation: EAW70479.1 BC032837 mRNA Translation: AAH32837.1 BC070141 mRNA Translation: AAH70141.1 BC126155 mRNA Translation: AAI26156.1 BC143914 mRNA Translation: AAI43915.1 AL133053 mRNA Translation: CAB61379.1 |
CCDSi | CCDS33370.1 [A0AUZ9-1] CCDS77519.1 [A0AUZ9-2] |
PIRi | T42655 |
RefSeqi | NP_001294905.1, NM_001307976.1 [A0AUZ9-2] NP_689732.2, NM_152519.3 [A0AUZ9-1] XP_005246386.1, XM_005246329.4 [A0AUZ9-1] XP_005246387.1, XM_005246330.4 [A0AUZ9-1] XP_011509008.1, XM_011510706.2 [A0AUZ9-1] XP_011509009.1, XM_011510707.2 [A0AUZ9-1] XP_016858919.1, XM_017003430.1 [A0AUZ9-1] |
Genome annotation databases
Ensembli | ENST00000281772; ENSP00000281772; ENSG00000144445 [A0AUZ9-1] ENST00000418791; ENSP00000405724; ENSG00000144445 [A0AUZ9-2] ENST00000452086; ENSP00000401408; ENSG00000144445 [A0AUZ9-3] ENST00000457374; ENSP00000393432; ENSG00000144445 [A0AUZ9-3] |
GeneIDi | 151050 |
KEGGi | hsa:151050 |
UCSCi | uc002vds.4, human [A0AUZ9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056911 mRNA Translation: BAB71308.1 AK074441 mRNA Translation: BAB85085.1 Sequence problems. AC006994 Genomic DNA Translation: AAY14880.1 AC007038 Genomic DNA Translation: AAX93088.1 CH471063 Genomic DNA Translation: EAW70479.1 BC032837 mRNA Translation: AAH32837.1 BC070141 mRNA Translation: AAH70141.1 BC126155 mRNA Translation: AAI26156.1 BC143914 mRNA Translation: AAI43915.1 AL133053 mRNA Translation: CAB61379.1 |
CCDSi | CCDS33370.1 [A0AUZ9-1] CCDS77519.1 [A0AUZ9-2] |
PIRi | T42655 |
RefSeqi | NP_001294905.1, NM_001307976.1 [A0AUZ9-2] NP_689732.2, NM_152519.3 [A0AUZ9-1] XP_005246386.1, XM_005246329.4 [A0AUZ9-1] XP_005246387.1, XM_005246330.4 [A0AUZ9-1] XP_011509008.1, XM_011510706.2 [A0AUZ9-1] XP_011509009.1, XM_011510707.2 [A0AUZ9-1] XP_016858919.1, XM_017003430.1 [A0AUZ9-1] |
3D structure databases
SMRi | A0AUZ9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0AUZ9, 2 interactors |
STRINGi | 9606.ENSP00000281772 |
PTM databases
iPTMneti | A0AUZ9 |
PhosphoSitePlusi | A0AUZ9 |
Genetic variation databases
BioMutai | KANSL1L |
Proteomic databases
EPDi | A0AUZ9 |
jPOSTi | A0AUZ9 |
MassIVEi | A0AUZ9 |
PaxDbi | A0AUZ9 |
PeptideAtlasi | A0AUZ9 |
PRIDEi | A0AUZ9 |
ProteomicsDBi | 5 [A0AUZ9-1] 6 [A0AUZ9-2] 7 [A0AUZ9-3] 8 [A0AUZ9-4] |
Protocols and materials databases
Antibodypediai | 63309, 32 antibodies |
DNASUi | 151050 |
Genome annotation databases
Ensembli | ENST00000281772; ENSP00000281772; ENSG00000144445 [A0AUZ9-1] ENST00000418791; ENSP00000405724; ENSG00000144445 [A0AUZ9-2] ENST00000452086; ENSP00000401408; ENSG00000144445 [A0AUZ9-3] ENST00000457374; ENSP00000393432; ENSG00000144445 [A0AUZ9-3] |
GeneIDi | 151050 |
KEGGi | hsa:151050 |
UCSCi | uc002vds.4, human [A0AUZ9-1] |
Organism-specific databases
CTDi | 151050 |
DisGeNETi | 151050 |
GeneCardsi | KANSL1L |
HGNCi | HGNC:26310, KANSL1L |
HPAi | ENSG00000144445, Tissue enriched (parathyroid) |
MIMi | 613833, gene |
neXtProti | NX_A0AUZ9 |
OpenTargetsi | ENSG00000144445 |
PharmGKBi | PA162379439 |
VEuPathDBi | HostDB:ENSG00000144445.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRI7, Eukaryota |
GeneTreei | ENSGT00530000063688 |
HOGENOMi | CLU_011035_1_0_1 |
InParanoidi | A0AUZ9 |
OMAi | QPLDECN |
OrthoDBi | 191128at2759 |
PhylomeDBi | A0AUZ9 |
TreeFami | TF336511 |
Enzyme and pathway databases
PathwayCommonsi | A0AUZ9 |
Miscellaneous databases
BioGRID-ORCSi | 151050, 5 hits in 880 CRISPR screens |
ChiTaRSi | KANSL1L, human |
GenomeRNAii | 151050 |
Pharosi | A0AUZ9, Tdark |
PROi | PR:A0AUZ9 |
RNActi | A0AUZ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144445, Expressed in kidney and 217 other tissues |
ExpressionAtlasi | A0AUZ9, baseline and differential |
Genevisiblei | A0AUZ9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026180, NSL1 IPR029332, PEHE_dom |
PANTHERi | PTHR22443, PTHR22443, 1 hit |
Pfami | View protein in Pfam PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KAL1L_HUMAN | |
Accessioni | A0AUZ9Primary (citable) accession number: A0AUZ9 Secondary accession number(s): B7ZLN1 Q9UFC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 10, 2021 | |
This is version 104 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot