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Protein

Trichoplein keratin filament-binding protein

Gene

tchp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Trichoplein keratin filament-binding protein
Short name:
Protein TCHP
Gene namesi
Name:tchpBy similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-963792 tchp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926131 – 499Trichoplein keratin filament-binding proteinAdd BLAST499

Proteomic databases

PRIDEiA0AUT1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni260 – 426Trichohyalin/plectin homology domainBy similarityAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili17 – 143Sequence analysisAdd BLAST127
Coiled coili169 – 304Sequence analysisAdd BLAST136
Coiled coili405 – 485Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 479Glu-richSequence analysisAdd BLAST409

Sequence similaritiesi

Belongs to the TCHP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG097262
KOiK16811

Family and domain databases

InterProiView protein in InterPro
IPR026773 TCHP
PANTHERiPTHR31183:SF2 PTHR31183:SF2, 1 hit

Sequencei

Sequence statusi: Complete.

A0AUT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPTLPSNW HSRSRVLEQQ IVRQREQEAR LRHQWDQTNQ YFKQSNVCSS
60 70 80 90 100
KQAQWSSRQS YQKSMNAFHQ EKQKEEKKKT LEYRREQLRK LLQEERDLLE
110 120 130 140 150
EELKELRCNK EHNVSDMRQR TEELKSAREE RQKQLAEELL YEQWKKNNVK
160 170 180 190 200
LREVESSLFK KHVVDAWGEQ ITARNQEKEE EDMEKKRLEN EYELARREAI
210 220 230 240 250
ERMKRDKEKR QQQEEELARV LKWQMEELKL KDLEAKKLKK EQEDLLRQQW
260 270 280 290 300
EIEELEEERR KMEQCRKKTE LSHFLSRQYN AQMKRRAQQV QEELEMDKKI
310 320 330 340 350
LSALISKEDE DQHLQSARRE QAIADVAWMK HVIEEQLHLE RQREAELDTL
360 370 380 390 400
FREEAKQVWA KRETEWERER NARNRLMKEV LAGRQMQIQE RIERNQLAQA
410 420 430 440 450
ESVMNRERLL RQLEEARQFT SREKKQEEEQ KTARRTELEA QIAEQLLKGK
460 470 480 490
EAIVQQEEEE KEFKLAEDLE NDLLQQEAEI MTQRGYQKKT YSRPRTAWS
Length:499
Mass (Da):61,197
Last modified:November 28, 2006 - v1
Checksum:iCA7664BE4E2CA03E
GO

Sequence cautioni

The sequence AAH42932 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 426.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43K → I in AAH42932 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042932 mRNA Translation: AAH42932.1 Sequence problems.
BC124854 mRNA Translation: AAI24855.1
RefSeqiNP_001082520.1, NM_001089051.1
UniGeneiXl.19152

Genome annotation databases

GeneIDi398528
KEGGixla:398528

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042932 mRNA Translation: AAH42932.1 Sequence problems.
BC124854 mRNA Translation: AAI24855.1
RefSeqiNP_001082520.1, NM_001089051.1
UniGeneiXl.19152

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0AUT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398528
KEGGixla:398528

Organism-specific databases

CTDi398528
XenbaseiXB-GENE-963792 tchp

Phylogenomic databases

HOVERGENiHBG097262
KOiK16811

Family and domain databases

InterProiView protein in InterPro
IPR026773 TCHP
PANTHERiPTHR31183:SF2 PTHR31183:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCHP_XENLA
AccessioniPrimary (citable) accession number: A0AUT1
Secondary accession number(s): Q7ZYN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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