Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 90 (07 Oct 2020)
Sequence version 1 (28 Nov 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Genome polyprotein

Gene
N/A
Organism
Blackberry virus Y (isolate Blackberry plant/USA:Arkansas/C3ARK/2005) (BVY)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.By similarity
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.By similarity
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi201IronPROSITE-ProRule annotation1
Metal bindingi203IronPROSITE-ProRule annotation1
Metal bindingi259IronPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2682-oxoglutaratePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei640For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei651For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei692For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei956For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei1029For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2400For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2435For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2504For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1553 – 1560ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Helicase, Hydrolase, Nucleotidyltransferase, Oxidoreductase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Iron, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBlackberry virus Y (isolate Blackberry plant/USA:Arkansas/C3ARK/2005) (BVY)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri686949 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaeBrambyvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiRubus plicatus [TaxID: 211815]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006703 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004199951 – 3491Genome polyproteinAdd BLAST3491
ChainiPRO_50001479811 – 745P1 proteinaseAdd BLAST745
ChainiPRO_5000147982746 – 1070Helper component proteinaseAdd BLAST325
ChainiPRO_50001479831071 – 1420Protein P3Add BLAST350
ChainiPRO_50001479841421 – 14766 kDa protein 1Add BLAST56
ChainiPRO_50001479851477 – 2096Cytoplasmic inclusion proteinAdd BLAST620
ChainiPRO_50001479862097 – 21636 kDa protein 2Add BLAST67
ChainiPRO_50001479872164 – 2353Viral genome-linked proteinAdd BLAST190
ChainiPRO_50001479882354 – 2590Nuclear inclusion protein AAdd BLAST237
ChainiPRO_50001479892591 – 3143Nuclear inclusion protein BAdd BLAST553
ChainiPRO_50001479903144 – 3491Capsid proteinAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2238O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei745 – 746Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei1070 – 1071Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1420 – 1421Cleavage; by NIa-proBy similarity2
Sitei1476 – 1477Cleavage; by NIa-proBy similarity2
Sitei2096 – 2097Cleavage; by NIa-proBy similarity2
Sitei2163 – 2164Cleavage; by NIa-proBy similarity2
Sitei2353 – 2354Cleavage; by NIa-proBy similarity2
Sitei2590 – 2591Cleavage; by NIa-proBy similarity2
Sitei3143 – 3144Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0AUJ5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini183 – 277Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST95
Domaini589 – 745Peptidase S30PROSITE-ProRule annotationAdd BLAST157
Domaini948 – 1070Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1540 – 1692Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1696 – 1869Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174
Domaini2354 – 2570Peptidase C4PROSITE-ProRule annotationAdd BLAST217
Domaini2850 – 2974RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1642 – 1645DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2594 – 2597Poly-Thr4
Compositional biasi3166 – 3170Poly-Gln5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
2.60.120.590, 1 hit
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037151, AlkB-like_sf
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51471, FE2OG_OXY, 1 hit
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0AUJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTRYRGADR YGNLGYDKVL QSKADAAKRR GLLFDHGSET YECPRCGEIW
60 70 80 90 100
RNLDDYMAEG GKMHPKKCLP EECDSDEEQI SSCNAALIHE KWGDLDSDTS
110 120 130 140 150
SKLSEFYKEP SILTYTTRTH CVVEKMRSMT APQCIEDIVG VRLHGRTAWF
160 170 180 190 200
FSKDPTLQYG HHPIYYDTHP WNDELDKYLG GAKYNTALVQ VYDGTRDLPY
210 220 230 240 250
HKDDEPCYDI TNNPIRTVNV TGTGDLCISK DKRRLYETIP MTSGTVITFP
260 270 280 290 300
ATMQENFYHA VRNPSAGRIS ITFRNQIRTV ERQVAHSANK RWVPIVEARV
310 320 330 340 350
TTNESRRGDN KQFQEAQSKL QTKTTINFGE FAAEVDGYYP TLSQDHKPAL
360 370 380 390 400
PKIIPELGLP TVDFIYVGNM RVPIDFKKNN VPAIVDTARH VAKIIDSQAL
410 420 430 440 450
TSEPIKVFTE QREVVGNVVT CTGTGFSVAD AKEAKALLNG LMYNRASNLF
460 470 480 490 500
ICPSCSDAAV LPEALLTLEH KRSCELASMK KISLARNMQV HVKQEAVARL
510 520 530 540 550
ISQQNSISVP IATLSSCVRG SADTTQVSLH IDEEDSIVDA IHLPNDFITC
560 570 580 590 600
DHEHAFETDS ASDNDVETMK KSEKRRKRRK RNPPPVRQVI TRAPVSNIIC
610 620 630 640 650
DVILTCLETQ IPVEFIGKSC ITFKPVRVGP VHTVGIQLKH QLHKTGFEVD
660 670 680 690 700
DLPDRETTSD IILAATRALR RLRHAHSNAQ QVHNSDITFG TSGAILPWSW
710 720 730 740 750
LAHDVIVEGP VQDSLVVRGR NVVSGHVTNA LNLQQDCLAD DYLQYSEELQ
760 770 780 790 800
PLHDDLSELK PLNVINNELI RQNMHITTLY SNMSKLQNDA LATKAEMKLP
810 820 830 840 850
LFGVAQLVVN QLKYNTTTHE WGERGDYVRK FVGKFFADFP TTQVPKQYMT
860 870 880 890 900
RTTNGHIRIT AYKALSLTSD PEIMMSRRMT QPMLTTAKQA DCVFQSTTGA
910 920 930 940 950
TCTSASCTTN SSGVVLSNKC ADPAPNTLRV RTMWDDIIIE LPLQGGRVHV
960 970 980 990 1000
PLEGLCFSTI FLHMYLLVPD ESVKLFHRTV TERAMPSLGQ WPTLRHLATW
1010 1020 1030 1040 1050
VLNLVAMFPV LSTTPMPEIL VHHESQSVHI PDCLGTATSG YHRLNIVTPY
1060 1070 1080 1090 1100
DFIIFATEIG RNGCQEYRVG GFAHDIKYTV SLMQDKRKLL HELMLTPTWA
1110 1120 1130 1140 1150
FYALSSPTLL KILYRSGALK RTYEHAVMAN HNAVDLVHEL NFLPERVSRA
1160 1170 1180 1190 1200
QTLQDEITAW EANVGRVLQQ VDGYLTRNHD PPLQRWYADA SARLQHLKID
1210 1220 1230 1240 1250
VDLLKNGFRS SQREHVEKKE QLLCDSFERL YNEQNSSLES LKTRCGMGSA
1260 1270 1280 1290 1300
RALIKPSGKC ESPEPAKQLS CKDLICSTKD KYALMLYTQA DALKRKIVAG
1310 1320 1330 1340 1350
SQSAFTTVCA GVAYRATKVM LRTPFNLLNA LNTYSLLIAA VNVMVLVQNY
1360 1370 1380 1390 1400
RRDQRKRAQY VNNLETQSMI RHYFAHLEQY IVNYVPRDEQ FEVIKAKFDE
1410 1420 1430 1440 1450
EFPEYNVMFK EVYKERIQFQ SADEGKNMCK IFASAILVMM VFDAHRADLM
1460 1470 1480 1490 1500
YKSFSQVRAL FNTLYDSGNP FNIIFQAERT IAPTMDVIIQ EPKPAIPSTS
1510 1520 1530 1540 1550
SCTFETWFRN CVNANNVIPV IPECDLLDFT RDTASSVVAT LTSSVKREFV
1560 1570 1580 1590 1600
IRGFVGSGKS TYLPHLLTKH GKVLLCEPVR VLASNVFEAL SGSPFYQSPT
1610 1620 1630 1640 1650
LLMRGTTKFG SGKITVATSG YAANYYNANR HRLNEFAYII FDESHQHTAH
1660 1670 1680 1690 1700
NFLLRSILDV IGYEGTVLHV SATPIGKEIP FRTMHPVEVV NMSTLSFEDF
1710 1720 1730 1740 1750
AIGQRKQVRC DVFNKGANIL VYVASYNDVD RMSTLLLERG LRVKKIDART
1760 1770 1780 1790 1800
VANVNNITCD GSDGEPLYLV ATNIVENGVT LNVDVVVDFG LCVKPVINAL
1810 1820 1830 1840 1850
QRRVDYVKTP ITWGQRIQRN GRVGRYKNGF CLNVGDVYKT PPIISEDVAL
1860 1870 1880 1890 1900
ESALMCFAAN VPPIFDNVDP ALFGQVTRPQ VQTAQMFELP IYITTPMISD
1910 1920 1930 1940 1950
AGALQSDIYQ VIKKFVLREG SIQLTQDATY LSNMSNWKTI ADYFPDISDT
1960 1970 1980 1990 2000
HAMRHEKVPF FVKDFGENSY IALAEAIRKA RNKSLGARGK LYGDVDATAL
2010 2020 2030 2040 2050
LLQTDPGSLD RSIMIVETEL VAQRSKLEDL NHHVHESTGM FQRYVSHLNH
2060 2070 2080 2090 2100
CLRGRYQTDQ IQKNIEVLSN MRSTLVGYRQ VVDKVEPEEI PHFVQQNPNI
2110 2120 2130 2140 2150
TMIIDFQSDR TKADGFVKHG INGIYNYTKI ASDTFSLLLI ACVVIYYVVQ
2160 2170 2180 2190 2200
YFFREMKSHI TFEASGSRRN RLHLRDNKLI KGGYTWAGPS DDMEREFGPE
2210 2220 2230 2240 2250
YALKRDKFSE KKARKHMRER IQPRTNMGVK LAPFQVFYGF DVADYDVLQL
2260 2270 2280 2290 2300
FDPITGVKID MDPRATAKEI TEEVEDTPFN KEVWSDTHMP EKIQATFVKK
2310 2320 2330 2340 2350
GGVNREDVLK QVRVDMTTHN PTMVTGSGGI MGYPEHKGDF RQTGPPKFSI
2360 2370 2380 2390 2400
VPEGRSTIKS GNNIAPFISA MGTIKNVYMN GDFDTLACTQ IGNKLVVNAH
2410 2420 2430 2440 2450
IFMEPVKKQE LILQHGVYEL PNNGTINIKH VPGIDMVIQT LPMDVPLARQ
2460 2470 2480 2490 2500
IKAYRGPIPG ELIRLLKIER NTKTNSTSLS DPGTARVGPG TIWYHNITTK
2510 2520 2530 2540 2550
HGDCGSLVLS EKDNKIVGIH TGQQDGTNLN LFAPITKDAI VAIETVLPGE
2560 2570 2580 2590 2600
LNDWVFTPDM LDVGSNNAIR KQASDPFPVV KKLLEGITFQ NNRTTTTDSV
2610 2620 2630 2640 2650
SNTAILPARK YWVASDLPVN IKYQCDMPTF FNTRHTYEGE SQPFMAYLRE
2660 2670 2680 2690 2700
CGDAETFFRP LLSHYIPSNL NGDAFKKDFF KYGKPVPVGL VHGPSFKIAS
2710 2720 2730 2740 2750
DRVIKRFERV GYERHSIPFE FDAEAIRDDL NKHAAMGAQY VGKKEQHLDG
2760 2770 2780 2790 2800
ISEEQFCDEF VASCCRLANN CDGVWKGSLK AELRSKEKVQ ENKTRVFTSA
2810 2820 2830 2840 2850
PYDVLLGGKA CVMHFNKKFY ANNTKGPWTV GINKLGLGWH RLLKSLPEGF
2860 2870 2880 2890 2900
VYGTGDGSQF DSSLTPLLIN EVCRIRMYFM QDDELGQAML RGLYRQIIWT
2910 2920 2930 2940 2950
LISMPDGSVV RKAKGNPSGQ PSTVDDNTIM VMLAVEYVFA YLGITQEEMD
2960 2970 2980 2990 3000
TIFKYYANGD DLIFAIHPDR ESILNEFTHL FAHLGLNYIF EDRTRNRAEL
3010 3020 3030 3040 3050
EYMSLTGIER EGFYIPKLSR ERISSIVQWR RKGDTRAMFD ALNAAILESW
3060 3070 3080 3090 3100
GYDDLTYWLR KYYEWLIINR YDIDLPEGEK LPYHTETAVE TLYTCDDNTT
3110 3120 3130 3140 3150
VYDGRYDFEV PTDASGGVFI IDFQSSSGTD TPPVIPPATS EPALQPVLTR
3160 3170 3180 3190 3200
QTSRPPTPPN TILTGQQQQQ LMPKSSQPYQ LEPLLAPTGV QQPTFGTFGM
3210 3220 3230 3240 3250
PQAQQTTTEP VVAAARVRGK QKEGDTSLSQ VRDHRRLSPE RIVRHDDDLA
3260 3270 3280 3290 3300
PPNESTSGES SHYDELTLPD VPRDKRKGLG ARLKGKPIIT QTQIYNYRPA
3310 3320 3330 3340 3350
FGSIHNNKAT DIELEAWKKQ IADYFQVDDV STLILGFMAY VIENGTSPEI
3360 3370 3380 3390 3400
FTNQKFVMAT SSGEQREYPL APFRSRSVEL RKIMRRFSEE AIDYIQIQRE
3410 3420 3430 3440 3450
HNPQYVPRQA VVRNVKRAIY FPYCFDFIDE TILTPDALEI VHQMKAAALE
3460 3470 3480 3490
SASSKVLGLD GGSARAIDTE RHTTEDATAR THNLRGAAMM A
Length:3,491
Mass (Da):393,838
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE548F95E522B9155
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY994084 Genomic RNA Translation: AAX87001.1

NCBI Reference Sequences

More...
RefSeqi
YP_851006.1, NC_008558.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5076635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:5076635

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY994084 Genomic RNA Translation: AAX87001.1
RefSeqiYP_851006.1, NC_008558.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA0AUJ5

Genome annotation databases

GeneIDi5076635
KEGGivg:5076635

Family and domain databases

Gene3Di2.40.10.10, 2 hits
2.60.120.590, 1 hit
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR037151, AlkB-like_sf
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51471, FE2OG_OXY, 1 hit
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_BVY3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AUJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 28, 2006
Last modified: October 7, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again