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UniProtKB - A0AUJ5 (POLG_BVY3)

Entry version 90 (07 Oct 2020)
Sequence version 1 (28 Nov 2006)
Previous versions | rss
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Protein

Genome polyprotein

Gene
N/A
Organism
Blackberry virus Y (isolate Blackberry plant/USA:Arkansas/C3ARK/2005) (BVY)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.By similarity
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.By similarity
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi201IronPROSITE-ProRule annotation1
Metal bindingi203IronPROSITE-ProRule annotation1
Metal bindingi259IronPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2682-oxoglutaratePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei640For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei651For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei692For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei956For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei1029For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2400For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2435For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2504For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1553 – 1560ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Helicase, Hydrolase, Nucleotidyltransferase, Oxidoreductase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Iron, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
Protein P3
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Viral genome-linked protein
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBlackberry virus Y (isolate Blackberry plant/USA:Arkansas/C3ARK/2005) (BVY)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri686949 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Stelpaviricetes › Patatavirales › Potyviridae › Brambyvirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiRubus plicatus [TaxID: 211815]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006703 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004199951 – 3491Genome polyproteinAdd BLAST3491
ChainiPRO_50001479811 – 745P1 proteinaseAdd BLAST745
ChainiPRO_5000147982746 – 1070Helper component proteinaseAdd BLAST325
ChainiPRO_50001479831071 – 1420Protein P3Add BLAST350
ChainiPRO_50001479841421 – 14766 kDa protein 1Add BLAST56
ChainiPRO_50001479851477 – 2096Cytoplasmic inclusion proteinAdd BLAST620
ChainiPRO_50001479862097 – 21636 kDa protein 2Add BLAST67
ChainiPRO_50001479872164 – 2353Viral genome-linked proteinAdd BLAST190
ChainiPRO_50001479882354 – 2590Nuclear inclusion protein AAdd BLAST237
ChainiPRO_50001479892591 – 3143Nuclear inclusion protein BAdd BLAST553
ChainiPRO_50001479903144 – 3491Capsid proteinAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2238O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei745 – 746Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei1070 – 1071Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1420 – 1421Cleavage; by NIa-proBy similarity2
Sitei1476 – 1477Cleavage; by NIa-proBy similarity2
Sitei2096 – 2097Cleavage; by NIa-proBy similarity2
Sitei2163 – 2164Cleavage; by NIa-proBy similarity2
Sitei2353 – 2354Cleavage; by NIa-proBy similarity2
Sitei2590 – 2591Cleavage; by NIa-proBy similarity2
Sitei3143 – 3144Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A0AUJ5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini183 – 277Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST95
Domaini589 – 745Peptidase S30PROSITE-ProRule annotationAdd BLAST157
Domaini948 – 1070Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1540 – 1692Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1696 – 1869Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174
Domaini2354 – 2570Peptidase C4PROSITE-ProRule annotationAdd BLAST217
Domaini2850 – 2974RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1642 – 1645DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2594 – 2597Poly-Thr4
Compositional biasi3166 – 3170Poly-Gln5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potyviridae genome polyprotein family.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
2.60.120.590, 1 hit
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037151, AlkB-like_sf
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51471, FE2OG_OXY, 1 hit
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0AUJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTRYRGADR YGNLGYDKVL QSKADAAKRR GLLFDHGSET YECPRCGEIW 
        60         70         80         90        100
RNLDDYMAEG GKMHPKKCLP EECDSDEEQI SSCNAALIHE KWGDLDSDTS 
       110        120        130        140        150
SKLSEFYKEP SILTYTTRTH CVVEKMRSMT APQCIEDIVG VRLHGRTAWF 
       160        170        180        190        200
FSKDPTLQYG HHPIYYDTHP WNDELDKYLG GAKYNTALVQ VYDGTRDLPY 
       210        220        230        240        250
HKDDEPCYDI TNNPIRTVNV TGTGDLCISK DKRRLYETIP MTSGTVITFP 
       260        270        280        290        300
ATMQENFYHA VRNPSAGRIS ITFRNQIRTV ERQVAHSANK RWVPIVEARV 
       310        320        330        340        350
TTNESRRGDN KQFQEAQSKL QTKTTINFGE FAAEVDGYYP TLSQDHKPAL 
       360        370        380        390        400
PKIIPELGLP TVDFIYVGNM RVPIDFKKNN VPAIVDTARH VAKIIDSQAL 
       410        420        430        440        450
TSEPIKVFTE QREVVGNVVT CTGTGFSVAD AKEAKALLNG LMYNRASNLF 
       460        470        480        490        500
ICPSCSDAAV LPEALLTLEH KRSCELASMK KISLARNMQV HVKQEAVARL 
       510        520        530        540        550
ISQQNSISVP IATLSSCVRG SADTTQVSLH IDEEDSIVDA IHLPNDFITC 
       560        570        580        590        600
DHEHAFETDS ASDNDVETMK KSEKRRKRRK RNPPPVRQVI TRAPVSNIIC 
       610        620        630        640        650
DVILTCLETQ IPVEFIGKSC ITFKPVRVGP VHTVGIQLKH QLHKTGFEVD 
       660        670        680        690        700
DLPDRETTSD IILAATRALR RLRHAHSNAQ QVHNSDITFG TSGAILPWSW 
       710        720        730        740        750
LAHDVIVEGP VQDSLVVRGR NVVSGHVTNA LNLQQDCLAD DYLQYSEELQ 
       760        770        780        790        800
PLHDDLSELK PLNVINNELI RQNMHITTLY SNMSKLQNDA LATKAEMKLP 
       810        820        830        840        850
LFGVAQLVVN QLKYNTTTHE WGERGDYVRK FVGKFFADFP TTQVPKQYMT 
       860        870        880        890        900
RTTNGHIRIT AYKALSLTSD PEIMMSRRMT QPMLTTAKQA DCVFQSTTGA 
       910        920        930        940        950
TCTSASCTTN SSGVVLSNKC ADPAPNTLRV RTMWDDIIIE LPLQGGRVHV 
       960        970        980        990       1000
PLEGLCFSTI FLHMYLLVPD ESVKLFHRTV TERAMPSLGQ WPTLRHLATW 
      1010       1020       1030       1040       1050
VLNLVAMFPV LSTTPMPEIL VHHESQSVHI PDCLGTATSG YHRLNIVTPY 
      1060       1070       1080       1090       1100
DFIIFATEIG RNGCQEYRVG GFAHDIKYTV SLMQDKRKLL HELMLTPTWA 
      1110       1120       1130       1140       1150
FYALSSPTLL KILYRSGALK RTYEHAVMAN HNAVDLVHEL NFLPERVSRA 
      1160       1170       1180       1190       1200
QTLQDEITAW EANVGRVLQQ VDGYLTRNHD PPLQRWYADA SARLQHLKID 
      1210       1220       1230       1240       1250
VDLLKNGFRS SQREHVEKKE QLLCDSFERL YNEQNSSLES LKTRCGMGSA 
      1260       1270       1280       1290       1300
RALIKPSGKC ESPEPAKQLS CKDLICSTKD KYALMLYTQA DALKRKIVAG 
      1310       1320       1330       1340       1350
SQSAFTTVCA GVAYRATKVM LRTPFNLLNA LNTYSLLIAA VNVMVLVQNY 
      1360       1370       1380       1390       1400
RRDQRKRAQY VNNLETQSMI RHYFAHLEQY IVNYVPRDEQ FEVIKAKFDE 
      1410       1420       1430       1440       1450
EFPEYNVMFK EVYKERIQFQ SADEGKNMCK IFASAILVMM VFDAHRADLM 
      1460       1470       1480       1490       1500
YKSFSQVRAL FNTLYDSGNP FNIIFQAERT IAPTMDVIIQ EPKPAIPSTS 
      1510       1520       1530       1540       1550
SCTFETWFRN CVNANNVIPV IPECDLLDFT RDTASSVVAT LTSSVKREFV 
      1560       1570       1580       1590       1600
IRGFVGSGKS TYLPHLLTKH GKVLLCEPVR VLASNVFEAL SGSPFYQSPT 
      1610       1620       1630       1640       1650
LLMRGTTKFG SGKITVATSG YAANYYNANR HRLNEFAYII FDESHQHTAH 
      1660       1670       1680       1690       1700
NFLLRSILDV IGYEGTVLHV SATPIGKEIP FRTMHPVEVV NMSTLSFEDF 
      1710       1720       1730       1740       1750
AIGQRKQVRC DVFNKGANIL VYVASYNDVD RMSTLLLERG LRVKKIDART 
      1760       1770       1780       1790       1800
VANVNNITCD GSDGEPLYLV ATNIVENGVT LNVDVVVDFG LCVKPVINAL 
      1810       1820       1830       1840       1850
QRRVDYVKTP ITWGQRIQRN GRVGRYKNGF CLNVGDVYKT PPIISEDVAL 
      1860       1870       1880       1890       1900
ESALMCFAAN VPPIFDNVDP ALFGQVTRPQ VQTAQMFELP IYITTPMISD 
      1910       1920       1930       1940       1950
AGALQSDIYQ VIKKFVLREG SIQLTQDATY LSNMSNWKTI ADYFPDISDT 
      1960       1970       1980       1990       2000
HAMRHEKVPF FVKDFGENSY IALAEAIRKA RNKSLGARGK LYGDVDATAL 
      2010       2020       2030       2040       2050
LLQTDPGSLD RSIMIVETEL VAQRSKLEDL NHHVHESTGM FQRYVSHLNH 
      2060       2070       2080       2090       2100
CLRGRYQTDQ IQKNIEVLSN MRSTLVGYRQ VVDKVEPEEI PHFVQQNPNI 
      2110       2120       2130       2140       2150
TMIIDFQSDR TKADGFVKHG INGIYNYTKI ASDTFSLLLI ACVVIYYVVQ 
      2160       2170       2180       2190       2200
YFFREMKSHI TFEASGSRRN RLHLRDNKLI KGGYTWAGPS DDMEREFGPE 
      2210       2220       2230       2240       2250
YALKRDKFSE KKARKHMRER IQPRTNMGVK LAPFQVFYGF DVADYDVLQL 
      2260       2270       2280       2290       2300
FDPITGVKID MDPRATAKEI TEEVEDTPFN KEVWSDTHMP EKIQATFVKK 
      2310       2320       2330       2340       2350
GGVNREDVLK QVRVDMTTHN PTMVTGSGGI MGYPEHKGDF RQTGPPKFSI 
      2360       2370       2380       2390       2400
VPEGRSTIKS GNNIAPFISA MGTIKNVYMN GDFDTLACTQ IGNKLVVNAH 
      2410       2420       2430       2440       2450
IFMEPVKKQE LILQHGVYEL PNNGTINIKH VPGIDMVIQT LPMDVPLARQ 
      2460       2470       2480       2490       2500
IKAYRGPIPG ELIRLLKIER NTKTNSTSLS DPGTARVGPG TIWYHNITTK 
      2510       2520       2530       2540       2550
HGDCGSLVLS EKDNKIVGIH TGQQDGTNLN LFAPITKDAI VAIETVLPGE 
      2560       2570       2580       2590       2600
LNDWVFTPDM LDVGSNNAIR KQASDPFPVV KKLLEGITFQ NNRTTTTDSV 
      2610       2620       2630       2640       2650
SNTAILPARK YWVASDLPVN IKYQCDMPTF FNTRHTYEGE SQPFMAYLRE 
      2660       2670       2680       2690       2700
CGDAETFFRP LLSHYIPSNL NGDAFKKDFF KYGKPVPVGL VHGPSFKIAS 
      2710       2720       2730       2740       2750
DRVIKRFERV GYERHSIPFE FDAEAIRDDL NKHAAMGAQY VGKKEQHLDG 
      2760       2770       2780       2790       2800
ISEEQFCDEF VASCCRLANN CDGVWKGSLK AELRSKEKVQ ENKTRVFTSA 
      2810       2820       2830       2840       2850
PYDVLLGGKA CVMHFNKKFY ANNTKGPWTV GINKLGLGWH RLLKSLPEGF 
      2860       2870       2880       2890       2900
VYGTGDGSQF DSSLTPLLIN EVCRIRMYFM QDDELGQAML RGLYRQIIWT 
      2910       2920       2930       2940       2950
LISMPDGSVV RKAKGNPSGQ PSTVDDNTIM VMLAVEYVFA YLGITQEEMD 
      2960       2970       2980       2990       3000
TIFKYYANGD DLIFAIHPDR ESILNEFTHL FAHLGLNYIF EDRTRNRAEL 
      3010       3020       3030       3040       3050
EYMSLTGIER EGFYIPKLSR ERISSIVQWR RKGDTRAMFD ALNAAILESW 
      3060       3070       3080       3090       3100
GYDDLTYWLR KYYEWLIINR YDIDLPEGEK LPYHTETAVE TLYTCDDNTT 
      3110       3120       3130       3140       3150
VYDGRYDFEV PTDASGGVFI IDFQSSSGTD TPPVIPPATS EPALQPVLTR 
      3160       3170       3180       3190       3200
QTSRPPTPPN TILTGQQQQQ LMPKSSQPYQ LEPLLAPTGV QQPTFGTFGM 
      3210       3220       3230       3240       3250
PQAQQTTTEP VVAAARVRGK QKEGDTSLSQ VRDHRRLSPE RIVRHDDDLA 
      3260       3270       3280       3290       3300
PPNESTSGES SHYDELTLPD VPRDKRKGLG ARLKGKPIIT QTQIYNYRPA 
      3310       3320       3330       3340       3350
FGSIHNNKAT DIELEAWKKQ IADYFQVDDV STLILGFMAY VIENGTSPEI 
      3360       3370       3380       3390       3400
FTNQKFVMAT SSGEQREYPL APFRSRSVEL RKIMRRFSEE AIDYIQIQRE 
      3410       3420       3430       3440       3450
HNPQYVPRQA VVRNVKRAIY FPYCFDFIDE TILTPDALEI VHQMKAAALE 
      3460       3470       3480       3490 
SASSKVLGLD GGSARAIDTE RHTTEDATAR THNLRGAAMM A
Length:3,491
Mass (Da):393,838
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE548F95E522B9155
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY994084 Genomic RNA Translation: AAX87001.1

NCBI Reference Sequences

More...RefSeqi		YP_851006.1, NC_008558.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5076635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:5076635

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY994084 Genomic RNA Translation: AAX87001.1
RefSeqiYP_851006.1, NC_008558.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiA0AUJ5

Genome annotation databases

GeneIDi5076635
KEGGivg:5076635

Family and domain databases

Gene3Di2.40.10.10, 2 hits
2.60.120.590, 1 hit
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR037151, AlkB-like_sf
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51471, FE2OG_OXY, 1 hit
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_BVY3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AUJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 28, 2006
Last modified: October 7, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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