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Protein

Proteasome subunit beta type

Gene

Prosbeta1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.010

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:Prosbeta1Imported
Synonyms:l(2)05070Imported, l(2)05070-RAImported
ORF Names:CG8392Imported, Dmel_CG8392Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010590 Prosbeta1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

PRIDEiA0AQH0

Expressioni

Gene expression databases

BgeeiFBgn0010590

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.UniRule annotation

Protein-protein interaction databases

IntActiA0AQH0, 3 interactors
STRINGi7227.FBpp0086400

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0174 Eukaryota
ENOG410XS23 LUCA
GeneTreeiENSGT00510000046484
KOiK02738
OMAiHDRIYCC
OrthoDBiEOG091G0GUI

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR000243 Pept_T1A_subB
IPR037559 Proteasome_beta_Pre3
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF4 PTHR11599:SF4, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0AQH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPDFDFTDT PVSTGTTIMA VEFDGGVVIG ADSRTSSGAY VANRVTDKLT
60 70 80 90 100
RITDKVYCCR SGSAADTQAI ADIVAYSLNY HENQTNKDAL VFEAASEFRN
110 120 130 140 150
YCYSYRESLL AGIIVAGWDE QRGGQVYSIP LGGMLTRESC TIGGSGSSFI
160 170 180 190 200
YGFVREHYRP NMALEDCVTF VKKAVQHAIY HDGSSGGVVR IGIITKDGIE
210 220
RRIFYNTESG ASAVSSTPSF ISSE
Length:224
Mass (Da):24,264
Last modified:November 28, 2006 - v1
Checksum:iD52648A5240701BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58077.1
BT044319 mRNA Translation: ACH92384.1
AM294908 Genomic DNA Translation: CAL26894.1
AM294909 Genomic DNA Translation: CAL26895.1
AM294910 Genomic DNA Translation: CAL26896.1
AM294911 Genomic DNA Translation: CAL26897.1
AM294912 Genomic DNA Translation: CAL26898.1
AM294913 Genomic DNA Translation: CAL26899.1
AM294914 Genomic DNA Translation: CAL26900.1
AM294915 Genomic DNA Translation: CAL26901.1
AM294916 Genomic DNA Translation: CAL26902.1
AM294917 Genomic DNA Translation: CAL26903.1
AM294918 Genomic DNA Translation: CAL26904.1
FM245703 Genomic DNA Translation: CAR93629.1
FM245704 Genomic DNA Translation: CAR93630.1
FM245705 Genomic DNA Translation: CAR93631.1
FM245706 Genomic DNA Translation: CAR93632.1
FM245707 Genomic DNA Translation: CAR93633.1
FM245708 Genomic DNA Translation: CAR93634.1
FM245709 Genomic DNA Translation: CAR93635.1
FM245710 Genomic DNA Translation: CAR93636.1
FM245711 Genomic DNA Translation: CAR93637.1
FM245712 Genomic DNA Translation: CAR93638.1
FM245713 Genomic DNA Translation: CAR93639.1
FM245714 Genomic DNA Translation: CAR93640.1
RefSeqiNP_652031.2, NM_143774.3
UniGeneiDm.20314

Genome annotation databases

EnsemblMetazoaiFBtr0087262; FBpp0086400; FBgn0010590
GeneIDi46058
KEGGidme:Dmel_CG8392

Similar proteinsi

Entry informationi

Entry nameiA0AQH0_DROME
AccessioniPrimary (citable) accession number: A0AQH0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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