UniProtKB - A0AJW1 (DEOD_LISW6)
Protein
Purine nucleoside phosphorylase DeoD-type
Gene
deoD
Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)
Status
Functioni
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation
Catalytic activityi
- a purine D-ribonucleoside + phosphate = a purine nucleobase + α-D-ribose 1-phosphateUniRule annotationEC:2.4.2.1UniRule annotation
- a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-α-D-ribose 1-phosphate + a purine nucleobaseUniRule annotationEC:2.4.2.1UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 4 | Purine nucleoside; shared with dimeric partnerBy similarity | 1 | |
Binding sitei | 20 | Phosphate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 24 | PhosphateBy similarity | 1 | |
Binding sitei | 43 | Phosphate; shared with dimeric partnerBy similarity | 1 | |
Active sitei | 203 | Proton donorUniRule annotation | 1 | |
Sitei | 216 | Important for catalytic activityUniRule annotation | 1 |
GO - Molecular functioni
- purine-nucleoside phosphorylase activity Source: UniProtKB-UniRule
GO - Biological processi
- purine nucleoside metabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | LWEL386043:G1GJF-1933-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)Short name: PNPUniRule annotation |
Gene namesi | Name:deoDUniRule annotation Ordered Locus Names:lwe1875 |
Organismi | Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8) |
Taxonomic identifieri | 386043 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000069637 | 1 – 233 | Purine nucleoside phosphorylase DeoD-typeAdd BLAST | 233 |
Interactioni
Subunit structurei
Homohexamer; trimer of homodimers.
UniRule annotationProtein-protein interaction databases
STRINGi | 386043.lwe1875 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 90 | Phosphate bindingBy similarity | 4 | |
Regioni | 178 – 180 | Purine nucleoside bindingBy similarity | 3 | |
Regioni | 202 – 203 | Purine nucleoside bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the PNP/UDP phosphorylase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0813, Bacteria |
HOGENOMi | CLU_068457_2_0_9 |
OMAi | PQCLLCG |
OrthoDBi | 1028277at2 |
Family and domain databases
CDDi | cd09006, PNP_EcPNPI-like, 1 hit |
Gene3Di | 3.40.50.1580, 1 hit |
HAMAPi | MF_01627, Pur_nucleosid_phosp, 1 hit |
InterProi | View protein in InterPro IPR004402, DeoD-type IPR018016, Nucleoside_phosphorylase_CS IPR000845, Nucleoside_phosphorylase_d IPR035994, Nucleoside_phosphorylase_sf |
PANTHERi | PTHR43691:SF2, PTHR43691:SF2, 1 hit |
Pfami | View protein in Pfam PF01048, PNP_UDP_1, 1 hit |
SUPFAMi | SSF53167, SSF53167, 1 hit |
TIGRFAMsi | TIGR00107, deoD, 1 hit |
PROSITEi | View protein in PROSITE PS01232, PNP_UDP_1, 1 hit |
i Sequence
Sequence statusi: Complete.
A0AJW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVHIEAKQG EIAETILLPG DPLRAKYIAE TFLEDVVLFN QVRGMLGFTG
60 70 80 90 100
TYKGEKVSVM GTGMGIPSIS IYVNELIQSY DVKNLIRVGT MGGIQADVKV
110 120 130 140 150
RDVVIAQAAS TDSQINRNTF AGVDFAPVAD FSLLKKAYDA GVEKGLSLKV
160 170 180 190 200
GNVFSADRFY NDQLDKQQLA DYGVLGIEME AAALYTLAQK YGRRALAILT
210 220 230
VSDHIFTGEE TSAEERQTTF NDMIVVALEA AIK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM263198 Genomic DNA Translation: CAK21293.1 |
RefSeqi | WP_003767481.1, NC_008555.1 |
Genome annotation databases
EnsemblBacteriai | CAK21293; CAK21293; lwe1875 |
GeneIDi | 57124507 58713330 |
KEGGi | lwe:lwe1875 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM263198 Genomic DNA Translation: CAK21293.1 |
RefSeqi | WP_003767481.1, NC_008555.1 |
3D structure databases
SMRi | A0AJW1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 386043.lwe1875 |
Genome annotation databases
EnsemblBacteriai | CAK21293; CAK21293; lwe1875 |
GeneIDi | 57124507 58713330 |
KEGGi | lwe:lwe1875 |
Phylogenomic databases
eggNOGi | COG0813, Bacteria |
HOGENOMi | CLU_068457_2_0_9 |
OMAi | PQCLLCG |
OrthoDBi | 1028277at2 |
Enzyme and pathway databases
BioCyci | LWEL386043:G1GJF-1933-MONOMER |
Family and domain databases
CDDi | cd09006, PNP_EcPNPI-like, 1 hit |
Gene3Di | 3.40.50.1580, 1 hit |
HAMAPi | MF_01627, Pur_nucleosid_phosp, 1 hit |
InterProi | View protein in InterPro IPR004402, DeoD-type IPR018016, Nucleoside_phosphorylase_CS IPR000845, Nucleoside_phosphorylase_d IPR035994, Nucleoside_phosphorylase_sf |
PANTHERi | PTHR43691:SF2, PTHR43691:SF2, 1 hit |
Pfami | View protein in Pfam PF01048, PNP_UDP_1, 1 hit |
SUPFAMi | SSF53167, SSF53167, 1 hit |
TIGRFAMsi | TIGR00107, deoD, 1 hit |
PROSITEi | View protein in PROSITE PS01232, PNP_UDP_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DEOD_LISW6 | |
Accessioni | A0AJW1Primary (citable) accession number: A0AJW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | November 28, 2006 | |
Last modified: | April 7, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |