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Entry version 89 (02 Dec 2020)
Sequence version 1 (28 Nov 2006)
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Protein

Endonuclease MutS2

Gene

mutS2

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi335 – 342ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
LWEL386043:G1GJF-1215-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mutS2UniRule annotation
Ordered Locus Names:lwe1187
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri386043 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000779 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_10000754781 – 785Endonuclease MutS2Add BLAST785

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
386043.lwe1187

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0AHX3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini710 – 785SmrUniRule annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1193, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011252_2_1_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
IHAIIND

Database of Orthologous Groups

More...
OrthoDBi
256392at2

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00092, MutS2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR036187, DNA_mismatch_repair_MutS_sf
IPR005747, MutS2
IPR027417, P-loop_NTPase
IPR002625, Smr_dom
IPR036063, Smr_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11361:SF14, PTHR11361:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00488, MutS_V, 1 hit
PF01713, Smr, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005814, MutS_YshD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00463, SMR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160443, SSF160443, 1 hit
SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01069, mutS2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50828, SMR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0AHX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKVEAILE FDKIKKQLTE FASSSLGEQA ILELAPATNF QVVQKSQLET
60 70 80 90 100
EEGAKIIRLR GSAPITGLTD VFAHLKRLEI GGDLNGLEIY QIGSNLRVSR
110 120 130 140 150
QMKNFMTDLL EMGVELPLLG ALSDELLVLK EVEEDIAISV DESGKILDTA
160 170 180 190 200
SEALSTIRRT LRRTEDRVRE KLESYLRDRN ASKMLSDAVI TIRNDRYVIP
210 220 230 240 250
VKQEYKGHYG GIVHDQSASG QTLFIEPQSV VDLNNERKAL QAKEKQEIER
260 270 280 290 300
ILAEISASLA GWINEIHHNT FILGRYDFIF AKARFGKAMK AVTPHLSDAG
310 320 330 340 350
IVHLIAARHP LLDAANVVAN DIYLGEDFTT IVITGPNTGG KTITLKTLGL
360 370 380 390 400
LTLMAQSGLQ IPAQEDSTIA VFEHVFADIG DEQSIEQSLS TFSSHMTNIV
410 420 430 440 450
SILEKVNHKS LILYDELGAG TDPQEGAALA IAILDASHEK GASVVATTHY
460 470 480 490 500
PELKAYGYNR VHATNASVEF NVETLSPTYK LLIGVPGRSN AFDISRRLGL
510 520 530 540 550
SENIITEARS LVDTESADLN DMISSLEEKR NLAETEYEEA RELARGADAL
560 570 580 590 600
LKDLQKEITN YYQQKDKLME QAREKAANIV TKAEVEAEEI IHELRTMQLN
610 620 630 640 650
GAAGIKEHEL IDAKTRLGKA KPKTINKTIP QAPKQKPHVF QVGDNVRVLS
660 670 680 690 700
LGQKGTLLNK ISDKEWNVQI GIIKMKIKTT DLEYIQPETP KKQRIITSVH
710 720 730 740 750
SSDSPVKSEL DLRGERYEDA LQKVDKYLDE ALLAGYPQVA IIHGKGTGAL
760 770 780
RTGVTEYLKN HRMVKSIRFG AAAEGGNGVT IVEFK
Length:785
Mass (Da):86,842
Last modified:November 28, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF00870663E65CB5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM263198 Genomic DNA Translation: CAK20605.1

NCBI Reference Sequences

More...
RefSeqi
WP_011702001.1, NC_008555.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAK20605; CAK20605; lwe1187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lwe:lwe1187

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA Translation: CAK20605.1
RefSeqiWP_011702001.1, NC_008555.1

3D structure databases

SMRiA0AHX3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi386043.lwe1187

Genome annotation databases

EnsemblBacteriaiCAK20605; CAK20605; lwe1187
KEGGilwe:lwe1187

Phylogenomic databases

eggNOGiCOG1193, Bacteria
HOGENOMiCLU_011252_2_1_9
OMAiIHAIIND
OrthoDBi256392at2

Enzyme and pathway databases

BioCyciLWEL386043:G1GJF-1215-MONOMER

Family and domain databases

HAMAPiMF_00092, MutS2, 1 hit
InterProiView protein in InterPro
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR036187, DNA_mismatch_repair_MutS_sf
IPR005747, MutS2
IPR027417, P-loop_NTPase
IPR002625, Smr_dom
IPR036063, Smr_dom_sf
PANTHERiPTHR11361:SF14, PTHR11361:SF14, 1 hit
PfamiView protein in Pfam
PF00488, MutS_V, 1 hit
PF01713, Smr, 1 hit
PIRSFiPIRSF005814, MutS_YshD, 1 hit
SMARTiView protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00463, SMR, 1 hit
SUPFAMiSSF160443, SSF160443, 1 hit
SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01069, mutS2, 1 hit
PROSITEiView protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50828, SMR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUTS2_LISW6
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0AHX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 28, 2006
Last modified: December 2, 2020
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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