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Entry version 1 (02 Jun 2021)
Sequence version 1 (02 Jun 2021)
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Protein
Submitted name:

Rho GTPase-activating protein 21

Gene

ARHGAP21

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho GTPase-activating protein 21Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP21Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23725, ARHGAP21

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000107863

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155406

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

A0A7P0TAS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQFRILDCM INHNWSLLCN LYCAWSGQVS KNKDGKEQSE TVSLSEDETF
60 70 80 90 100
SWPGPKTVTL KRTSQGFGFT LRHFIVYPPE SAIQFSYKDE ENGNRGGKQR
110 120 130 140 150
NRLEPMDTIF VKQVKEGGPA FEAGLCTGDR IIKVNGESVI GKTYSQVIAL
160 170 180 190 200
IQNSDTTLEL SVMPKDEDIL QVLQFTKDVT ALAYSQDAYL KGNEAYSGNA
210 220 230 240 250
RNIPEPPPIC YPWLPSAPSA MAQPVEISPP DSSLSKQQTS TPVLTQPGRA
260 270 280 290 300
YRMEIQVPPS PTDVAKSNTA VCVCNESVRT VIVPSEKVVD LLSNRNNHTG
310 320 330 340 350
PSHRTEEVRY GVSEQTSLKT VSRTTSPPLS IPTTHLIHQP AGSRSLEPSG
360 370 380 390 400
ILLKSGNYSG HSDGISSSRS QAVEAPSVSV NHYSPNSHQH IDWKNYKTYK
410 420 430 440 450
EYIDNRRLHI GCRTIQERLD SLRAASQSTT DYNQVVPNRT TLQGRRRSTS
460 470 480 490 500
HDRVPQSVQI RQRSVSQERL EDSVLMKYCP RSASQGALTS PSVSFSNHRT
510 520 530 540 550
RSWDYIEGQD ETLENVNSGT PIPDSNGEKK QTYKWSGFTE QDDRRGICER
560 570 580 590 600
PRQQEIHKSF RGSNFTVAPS VVNSDNRRMS GRGVGSVSQF KKIPPDLKTL
610 620 630 640 650
QSNRNFQTTC GMSLPRGISQ DRSPLVKVRS NSLKAPSTHV TKPSFSQKSF
660 670 680 690 700
VSIKDQRPVN HLHQNSLLNQ QTWVRTDSAP DQQVETGKSP SLSGASAKPA
710 720 730 740 750
PQSSENAGTS DLELPVSQRN QDLSLQEAET EQSDTLDNKE AVILREKPPS
760 770 780 790 800
GRQTPQPLRH QSYILAVNDQ ETGSDTTCWL PNDARREVHI KRMEERKASS
810 820 830 840 850
TSPPGDSLAS IPFIDEPTSP SIDHDIAHIP ASAVISASTS QVPSIATVPP
860 870 880 890 900
CLTTSAPLIR RQLSHDHESV GPPSLDAQPN SKTERSKSYD EGLDDYREDA
910 920 930 940 950
KLSFKHVSSL KGIKIADSQK SSEDSGSRKD SSSEVFSDAA KEGWLHFRPL
960 970 980 990 1000
VTDKGKRVGG SIRPWKQMYV VLRGHSLYLY KDKREQTTPS EEEQPISVNA
1010 1020 1030 1040 1050
CLIDISYSET KRKNVFRLTT SDCECLFQAE DRDDMLAWIK TIQESSNLNE
1060 1070 1080 1090 1100
EDTGVTNRDL ISRRIKEYNN LMSKAEQLPK TPRQSLSIRQ TLLGAKSEPK
1110 1120 1130 1140 1150
TQSPHSPKEE SERKLLSKDD TSPPKDKGTW RKGIPSIMRK TFEKKPTATG
1160 1170 1180 1190 1200
TFGVRLDDCP PAHTNRYIPL IVDICCKLVE ERGLEYTGIY RVPGNNAAIS
1210 1220 1230 1240 1250
SMQEELNKGM ADIDIQDDKW RDLNVISSLL KSFFRKLPEP LFTNDKYADF
1260 1270 1280 1290 1300
IEANRKEDPL DRLKTLKRLI HDLPEHHYET LKFLSAHLKT VAENSEKNKM
1310 1320 1330 1340 1350
EPRNLAIVFG PTLVRTSEDN MTHMVTHMPD QYKIVETLIQ HHDWFFTEEG
1360 1370 1380 1390 1400
AEEPLTTVQE ESTVDSQPVP NIDHLLTNIG RTGVSPGDVS DSATSDSTKS
1410 1420 1430 1440 1450
KGSWGSGKDQ YSRELLVSSI FAAASRKRKK PKEKAQPSSS EDELDNVFFK
1460 1470 1480 1490 1500
KENVEQCHND TKEESKKESE TLGRKQKIII AKENSTRKDP STTKDEKISL
1510 1520 1530 1540 1550
GKESTPSEEP SPPHNSKHNK SPTLSCRFAI LKESPRSLLA QKSSHLEETG
1560 1570 1580 1590 1600
SDSGTLLSTS SQASLARFSM KKSTSPETKH SEFLANVSTI TSDYSTTSSA
1610 1620 1630 1640 1650
TYLTSLDSSR LSPEVQSVAE SKGDEADDER SELISEGRPV ETDSESEFPV
1660 1670 1680 1690 1700
FPTALTSERL FRGKLQEVTK SSRRNSEGSE LSCTEGSLTS SLDSRRQLFS
1710 1720 1730 1740 1750
SHKLIECDTL SRKKSARFKS DSGSLGDAKN EKEAPSLTKV FDVMKKGKST
1760 1770 1780 1790 1800
GSLLTPTRGE SEKQEPTWKT KIADRLKLRP RAPADDMFGV GNHKVNAETA
1810 1820 1830 1840 1850
KRKSIRRRHT LGGHRDATEI SVLNFWKVHE QSGERESELS AVNRLKPKCS
1860 1870 1880 1890 1900
AQDLSISDWL ARERLRTSTS DLSRGEIGDP QTENPSTREI ATTDTPLSLH
1910 1920 1930 1940 1950
CNTGSSSSTL ASTNRPLLSI PPQSPDQING ESFQNVSKNA SSAANAQPHK
1960
LSETPGSKAE FHPCL
Length:1,965
Mass (Da):218,524
Last modified:June 2, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i225937D60A69DEF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T5U3RHG21_HUMAN
Rho GTPase-activating protein 21
ARHGAP21 ARHGAP10, KIAA1424
1,958Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW76A0A087WW76_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV73A0A1B0GV73_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTZ9A0A1B0GTZ9_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESW5E7ESW5_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A452Q6Z5A0A452Q6Z5_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5T2H0Y5T2_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y468H0Y468_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JSD8Q5JSD8_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL355979 Genomic DNA No translation available.
AL392104 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000680286; ENSP00000506388; ENSG00000107863

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355979 Genomic DNA No translation available.
AL392104 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENST00000680286; ENSP00000506388; ENSG00000107863

Organism-specific databases

HGNCiHGNC:23725, ARHGAP21
OpenTargetsiENSG00000107863

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155406

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7P0TAS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7P0TAS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 2, 2021
Last sequence update: June 2, 2021
Last modified: June 2, 2021
This is version 1 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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