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Entry version 1 (02 Jun 2021)
Sequence version 1 (02 Jun 2021)
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Protein
Submitted name:

APC regulator of WNT signaling pathway

Gene

APC

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
APC regulator of WNT signaling pathwayImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9541 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233100 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063749

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A7N9D1E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTRALPIPV GSPLIGWVWA HVTDMWLYWC SPPGCHWRQN GGAVGLGNGD
60 70 80 90 100
TCSGGQKREE TKPLQMADVN LVERATGNER KRRRQEVLKQ LQGSIEDEAM
110 120 130 140 150
ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC
160 170 180 190 200
SPVPMGSFPR RGFVNGSRES TGYLEELEKE RSLLLADLDK EEKEKDWYYA
210 220 230 240 250
QLQNLTKRID SLPLTENFSL QTDMTRRQLE YEARQIRVAM EEQLGTCQDM
260 270 280 290 300
EKRAQRRIAR IQQIEKDILR IRQLLQSQAT EAERSSQNKH ETGSHDAERQ
310 320 330 340 350
NEGQGVAEIN MATSGNGQGS TTRMDHETAS VLSSSSTHSA PRRLTSHLGT
360 370 380 390 400
KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS GCLPLLIQLL
410 420 430 440 450
HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL
460 470 480 490 500
EQIRAYCETC WEWQEAHEQG MDQDKNPMPA PVEHQICPAV CVLMKLSFDE
510 520 530 540 550
EHRHAMNELG RKATRGISSQ ELGQGLSGGL QAIAELLQVD CEMYGLTNDH
560 570 580 590 600
YSITLRRYAG MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ
610 620 630 640 650
VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL
660 670 680 690 700
WNLSAHCTEN KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV
710 720 730 740 750
SSLIATNEDH RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP
760 770 780 790 800
KDQEALWDMG AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI
810 820 830 840 850
MSPGSSLPSL HVRKQKALEA ELDAQHLSET FDNIDNLSPK ASHRSKQRHK
860 870 880 890 900
QSLYGDYVFD TNRHDDNRSD NFNAGNMTVL SPYLNTTVLP SSSSSRGSLD
910 920 930 940 950
SSRSEKDRSL ERERGIGLGN YHPATENPGT SSKRGLQIST TAAQIAKVME
960 970 980 990 1000
EVSAIHTSQE DRSSGSTTEL HCVTDERNAL RRSSAAHTHS NTYNFTKSEN
1010 1020 1030 1040 1050
SNRTCSMPYA KLEYKRSSND SLNSVSSSDG YGKRGQMKPS IESYSEDDES
1060 1070 1080 1090 1100
KFCSYGQYPA DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS
1110 1120 1130 1140 1150
PSQNERWARP KHIIEDEIKQ SEQRQSRSQS TTYPVYTEST DDKHLKFQPH
1160 1170 1180 1190 1200
FGQQECVSPY RSRGANGSET NRVGSNHGIN QNVSQSLCQE DDYEDDKPTN
1210 1220 1230 1240 1250
YSERYSEEEQ HEEEERPTNY SIKYNEEKHH VDQPIDYSLK YATDIPSSQK
1260 1270 1280 1290 1300
QSFSFSKSSS GQSTKTEHIS SSSENTSTPS SNAKRQNQLH PSSAQSRSGQ
1310 1320 1330 1340 1350
TQKAATCKVS SINQETIQTY CVEDTPICFS RCSSLSSLSS AEDEIGCDQT
1360 1370 1380 1390 1400
TQEADSANTL QIAEIKDKIG TRSTEDPVSE VPAVSQHTRT KSSRLQGSSL
1410 1420 1430 1440 1450
SSESTRHKAV EFSSGAKSPS KSGAQTPKSP PEHYVQETPL MFSRCTSVSS
1460 1470 1480 1490 1500
LDSFESRSIA SSVQSEPCSG MVSGIISPSD LPDSPGQTMP PSRSKTPPPP
1510 1520 1530 1540 1550
PQTAQTKREV PKNKTPTAEK RESGRKQAAV NAAVQRVQVL PDADTLLHFA
1560 1570 1580 1590 1600
TESTPDGFSC SSSLSALSLD EPFIQKDVEL RIMPPVQEND NGNETESEQP
1610 1620 1630 1640 1650
KESNENQEKE AEKTIDSEKD LLDDSDDDDI EILEECIISA MPTKSSRKAK
1660 1670 1680 1690 1700
KPAQTASKLP PPVARKPSQL PVYKLLPSQN RLQPQKHVSF TPGDDMPRVY
1710 1720 1730 1740 1750
CVEGTPINFS TATSLSDLTI ESPPNELAAG EGVRAGAQSG EFEKRDTIPT
1760 1770 1780 1790 1800
EGRSTDEAQG GKTSSVTIPE LDDNKAEEGD ILAECINSAM PKGKSHKPFR
1810 1820 1830 1840 1850
VKKIMDQVQQ ASASSSATNK NQLDGKKKKP TSPVKPIPQN TEYRTRIRKN
1860 1870 1880 1890 1900
ADSKNNLNAE RVFSDNKDSK KQNLKNNSKD FNDKLPNNED RVRGSFAFDS
1910 1920 1930 1940 1950
PHHYTPIEGT PYCFSRNDSL SSLDFDDDDV DLSREKAELR KAKENKESEA
1960 1970 1980 1990 2000
KVTSHTELTS NQQSASKTQA IAKHPINRGQ LKPILQKQST FPQSSKDIPD
2010 2020 2030 2040 2050
RGAATDEKLQ NFAIENTPVC FSHNSSLSSL SDIDQENNNN KENEPIKETE
2060 2070 2080 2090 2100
PPDSQGEPSK PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE
2110 2120 2130 2140 2150
CISSAMPKKK KPSRLKGDNE KHSPRNMGGM LAEDLTLDLK DIQRPDSEHG
2160 2170 2180 2190 2200
LSPDSENFDW KAIQEGANSI VSSLHQAAAA ACLSRQASSD SDSILSLKSG
2210 2220 2230 2240 2250
ISLGSPFHLT PDQEEKPFTS NKGPRILKPG EKSTLETKKI ESESKGIKGG
2260 2270 2280 2290 2300
KKVYKSLITG KVRSNSEISG QMKQPLQANM PSISRGRTMI HIPGVRNSSS
2310 2320 2330 2340 2350
STSPVSKKGP PLKTPASKSP SEGQTATTSP RGAKPSVKSE LSPVARQTSQ
2360 2370 2380 2390 2400
IGGSSKAPSR SGSRDSTPSR PAQQPLSRPI QSPGRNSISP GRNGISPPNK
2410 2420 2430 2440 2450
LSQLPRTSSP STASTKSSGS GKMSYTSPGR QMSQQNLTKQ TGLSKNASSI
2460 2470 2480 2490 2500
PRSESASKGL NQVNNGNGAN KKVELSRMSS TKSSGSESDR SERPVLVRQS
2510 2520 2530 2540 2550
TFIKEAPSPT LRRKLEESAS FESLSPSSRP ASPTRSQAQT PVLSPSLPDM
2560 2570 2580 2590 2600
SLSTHSSVQS GGWRKLPPNL SPTIEYNDGR PAKRHDIARS HSESPSRLPI
2610 2620 2630 2640 2650
NRSGTWKREH SKHSSSLPRV STWRRTGSSS SILSASSESS EKAKSEDEKH
2660 2670 2680 2690 2700
VNSISGTKQS KENQVSAKGT WRKIKENEIS PTNSTSQTVS SGATNGAESK
2710 2720 2730 2740 2750
TLIYQMAPAV SKTEDVWVRI EDCPINNPRS GRSPTGNTPP VIDSVSEKGN
2760 2770 2780 2790 2800
PNKDSKDNQA KQNVGNGSVP MRTVGLENRL NSFIQVDAPD QKGTETKPGQ
2810 2820 2830 2840 2850
NNPVPVSETN ESSIVERTPF SSSSSSKHSS PSGTVAARVT PFNYNPSPRK
2860 2870 2880 2890 2900
SSADSTSARP SQIPTPVNNN TKKRDSKTDS TESSGTQSPK RHSGSYLVTS

V
Length:2,901
Mass (Da):317,990
Last modified:June 2, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7751DBFD6F43FAF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5WV06A0A2K5WV06_MACFA
APC regulator of WNT signaling path...
APC
2,843Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5WVL8A0A2K5WVL8_MACFA
APC regulator of WNT signaling path...
APC
2,847Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5WVD6A0A2K5WVD6_MACFA
APC regulator of WNT signaling path...
APC
2,871Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7N9DA91A0A7N9DA91_MACFA
APC regulator of WNT signaling path...
APC
2,861Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMFAT00000077083; ENSMFAP00000057895; ENSMFAG00000041277

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMFAT00000077083; ENSMFAP00000057895; ENSMFAG00000041277

Phylogenomic databases

GeneTreeiENSGT00530000063749

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7N9D1E1_MACFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7N9D1E1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 2, 2021
Last sequence update: June 2, 2021
Last modified: June 2, 2021
This is version 1 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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