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UniProtKB - A0A7L0BVW6 (A0A7L0BVW6_9AVES)

Entry version 5 (25 May 2022)
Sequence version 1 (07 Apr 2021)
Previous versions | rss
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Protein
Submitted name:

MACF1 factor

Gene

Macf1_1

Organism
Spizaetus tyrannus (black hawk-eagle)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MACF1 factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Macf1_1Imported
ORF Names:SPITYR_R04624Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSpizaetus tyrannus (black hawk-eagle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri252798 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Accipitriformes › Accipitridae › Accipitrinae › Spizaetus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000519115 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 57Calponin-homology (CH)InterPro annotationAdd BLAST57
Domaini70 – 174Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini744 – 801SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1812 – 1839DisorderedSequence analysisAdd BLAST28
Regioni1978 – 2013DisorderedSequence analysisAdd BLAST36
Regioni2024 – 2043DisorderedSequence analysisAdd BLAST20
Regioni2115 – 2153DisorderedSequence analysisAdd BLAST39
Regioni2672 – 2699DisorderedSequence analysisAdd BLAST28
Regioni2836 – 3000DisorderedSequence analysisAdd BLAST165
Regioni3073 – 3111DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili121 – 141Sequence analysisAdd BLAST21
Coiled coili353 – 373Sequence analysisAdd BLAST21
Coiled coili378 – 405Sequence analysisAdd BLAST28
Coiled coili697 – 717Sequence analysisAdd BLAST21
Coiled coili891 – 915Sequence analysisAdd BLAST25
Coiled coili922 – 942Sequence analysisAdd BLAST21
Coiled coili970 – 990Sequence analysisAdd BLAST21
Coiled coili1279 – 1309Sequence analysisAdd BLAST31
Coiled coili1336 – 1363Sequence analysisAdd BLAST28
Coiled coili1391 – 1418Sequence analysisAdd BLAST28
Coiled coili3174 – 3194Sequence analysisAdd BLAST21
Coiled coili3221 – 3241Sequence analysisAdd BLAST21
Coiled coili3343 – 3363Sequence analysisAdd BLAST21
Coiled coili3565 – 3592Sequence analysisAdd BLAST28
Coiled coili3612 – 3639Sequence analysisAdd BLAST28
Coiled coili3885 – 3909Sequence analysisAdd BLAST25
Coiled coili4025 – 4052Sequence analysisAdd BLAST28
Coiled coili4065 – 4085Sequence analysisAdd BLAST21
Coiled coili4224 – 4244Sequence analysisAdd BLAST21
Coiled coili4288 – 4308Sequence analysisAdd BLAST21
Coiled coili4395 – 4415Sequence analysisAdd BLAST21
Coiled coili4430 – 4450Sequence analysisAdd BLAST21
Coiled coili4495 – 4529Sequence analysisAdd BLAST35
Coiled coili4602 – 4622Sequence analysisAdd BLAST21
Coiled coili4767 – 4815Sequence analysisAdd BLAST49
Coiled coili4945 – 4965Sequence analysisAdd BLAST21
Coiled coili4971 – 4998Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1812 – 1832Polar residuesSequence analysisAdd BLAST21
Compositional biasi2131 – 2145Acidic residuesSequence analysisAdd BLAST15
Compositional biasi2672 – 2696Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi2894 – 2911Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi2947 – 2962Polar residuesSequence analysisAdd BLAST16
Compositional biasi2964 – 2986Basic and acidic residuesSequence analysisAdd BLAST23

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00176, SPEC, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 11 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF00681, Plectin, 10 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 5 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 1 hit
SM00250, PLEC, 21 hits
SM00150, SPEC, 18 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A7L0BVW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PREKGRMRFH RLQNVQIALD FLKQRQVKLV NIRNDDITDG NPKLTLGLIW 
        60         70         80         90        100
TIILHFQISD IYISGESGDM SAKEKLLLWT QKVTAGYIGV KCTNFSSCWS 
       110        120        130        140        150
DGKMFNALIH RYRPDLVDME RVQIQSNREN LEQAFEIAER LGVTRLLDAE 
       160        170        180        190        200
DVDVPSPDEK SVITYVSSIY DAFPKVPEGG EGISAIEVDS RWLEYQSRVE 
       210        220        230        240        250
SLISWIKQHT ILMSDKSFPQ NPVELKALYN QYIHFKETEI PAKEQEKGRI 
       260        270        280        290        300
EELYKLLEVW IEFGRIKLPQ GYHPNDVEEE WGKLIIEMLE REKLLRPAVE 
       310        320        330        340        350
RLELLLQIAN KIQNGALSCE EKLTLAKNTL QADAAHLESG QPVQYESDVV 
       360        370        380        390        400
VYLQECEGLI RQLQVDVQIL RDENYYQLEE LVFRIMRLQD ELVTLRLECT 
       410        420        430        440        450
NLYRKGHFST LELVPSSMLS TMHLKGESLT KGLHTSSASW FRKPMTRTEL 
       460        470        480        490        500
VAISSSEDEG SLRFVYELLA WVEEMQMRLE RAEWGTDLPS VETQLETQRH 
       510        520        530        540        550
IHSSVEDLGS SVKEARMYEG KMSQNFRASY TETLGKLETQ YCKLMETSSF 
       560        570        580        590        600
RLRHLQSLHG FVSRATAELI WLNEKEEEEL AYDWSDNNPN IAAKKNYFLE 
       610        620        630        640        650
LTTELEEKQD IFRSLQDTAE LLSLENHPAK QTVEAYSAAV QTQWQWIKQL 
       660        670        680        690        700
CLCVEQHVKE NAAYFQFFSD ARESETYLRN LQDSIKRKYS CDHNTSLTRL 
       710        720        730        740        750
EDLLQDSMDE KEQLIQSKSS VASLVGRSKT IVQLRPRNPE HLVKSTIPIK 
       760        770        780        790        800
AVCDYRQIEI TICRNDECVL EDNSQRTKWK VISPTGNEAM VPSVCFLIPP 
       810        820        830        840        850
PNKEAIEMAN RVEQLYQKVM ALWHQLHMNT KSLISWNYLR KDIALVQSFS 
       860        870        880        890        900
MEKLRSLAQG ECQQAMKSLQ AHYEDFLQDS RDSELFSVSD RLRLEEEVES 
       910        920        930        940        950
SKEHIRQLLE SMENEDKDET VARTYLSELK NIRLRLEECE QRLVSQIQSP 
       960        970        980        990       1000
SSARADGDTI QENTIRIAEQ ERMQEDLQRL QSDLRFVSER CYSFLDKAPA 
      1010       1020       1030       1040       1050
GSSTPHLRSE LDLLVNKMDQ MYGLSSIYLD KLKTVDVIIR NTQGAESLVK 
      1060       1070       1080       1090       1100
GYEVKLSQEE AVPADLAAIQ SHRTALQQWL GEVKDKSSVF SMLEEEMAKA 
      1110       1120       1130       1140       1150
KAVGEQLYRL RQERSIDLER YQEKGSQLWD RWQRVCTQIE TRHAELESIQ 
      1160       1170       1180       1190       1200
EVLSDYRQCH SALIQWIEEI TVQQELMKPG QAEDSRVLSE QLSQQTALAA 
      1210       1220       1230       1240       1250
EIEKNQAKLD QCQKFSQQYS AAVKDYELQL MTYRAFVESQ QKSPMKRRRM 
      1260       1270       1280       1290       1300
LSSSDAITQE FMDLRTRYTA LVTLTTQHVK YISDALRRLE EEEKVVEEEK 
      1310       1320       1330       1340       1350
QEHVDKVKEL LGWALGLKQS VQGRTAAAGS RELGDIEKSI SEQQALNEEL 
      1360       1370       1380       1390       1400
AAKKEQVSEA IKTSQIFLAK HSHKLSHPEK EQISAQISAL KETYQALCSD 
      1410       1420       1430       1440       1450
STEQLQQLQS QLAQETEHKG SEAVAGVIDL GTVEIFPVFG AMQRGLIDQD 
      1460       1470       1480       1490       1500
TGLVLLEAQV ITSDLVVPET NEKLSLKKGL ARKIIDLRTF QVLQELKDAL 
      1510       1520       1530       1540       1550
HQVEEVSCEG RQVLPVVAAI EEGRISESIG LKILEAELIT GGFKVHKGRI 
      1560       1570       1580       1590       1600
SMETAVQERL LTPQLYSRLL SHLEGGKDLI DPNTAEKISL LELMHRCIIH 
      1610       1620       1630       1640       1650
QETGLRLLPV KQLAGGMVSL KSGRKVSIFR AVQEGLIDRQ VTVRLLEAHL 
      1660       1670       1680       1690       1700
FAGGIVDPRT GHRLTVDEAV RHNLIDQDLA CTLLVRQLQT GGIIDTVTGE 
      1710       1720       1730       1740       1750
RLTIDEALRK ELVAPRIALV VLESLWSFMG LLWPETGEIV PVADALDQGI 
      1760       1770       1780       1790       1800
LSTEMVYKIL SKRQLIKAVF IPETTEVLSW KKAVEHGILE RDVAKKLKST 
      1810       1820       1830       1840       1850
LIPDVMASVQ LAGSPNRSRH GQSNSGRSPT GHKEQSDPLL RSDDERLMFH 
      1860       1870       1880       1890       1900
LMTHSYINIH DGQKLLLVDG ELNNLTKALI RTQENGSCAD TLEGSEGFEE 
      1910       1920       1930       1940       1950
TKADAALERE PCNGLALQQL EFQFAPSKEQ REKVLPPRAL ENGEVVMGPE 
      1960       1970       1980       1990       2000
GLLLEDAEDI LLVEEQEQIY TKQATMKSET DAEFGREQVA STSKGKHQVK 
      2010       2020       2030       2040       2050
LSMPGCPGDL GSGFRETEEM MVRAEESKPT TVDGVESIED HKRAPESGTV 
      2060       2070       2080       2090       2100
VVKSEICISM DVSKRERLQI MAERPEGGEK PELQAEDVRE IYLLNEETIE 
      2110       2120       2130       2140       2150
NGVLGGEEVV LPKTGEAEQT ERQSENFESV LQEQEEGEEV LDYESVDETS 
      2160       2170       2180       2190       2200
LPAPAEQEAE DTLEMLLTQL QSGGIIHKQT GKTLLLNEAV AHGVVPSHTA 
      2210       2220       2230       2240       2250
VKLMEKMKMF SGFFDSHTCE SLTTEDVIEE GLMDENLLQK VLASDKAISG 
      2260       2270       2280       2290       2300
VLDPGNNFVY SVKDAAAVGL LDKETAARIL EGQVVTGGIV DLKRGKKISV 
      2310       2320       2330       2340       2350
TLASNLGLIE PTSQKELVKL EKASKGKGTD EVTRQKLISL QAETSGIVDP 
      2360       2370       2380       2390       2400
KTKQPLTVAQ SVEKGLLKKE KAFQLLTKQI ADGGIIHHVS GMRLSVNNAM 
      2410       2420       2430       2440       2450
KHGLIDQDLC NELTKAESVC LQDYVHPVTK EKLPLPQAVS LGLISPAFQR 
      2460       2470       2480       2490       2500
KVQEIQAGSG SIFDPASGQR LALCQAVKEG LLPEQVMEKV LSSSEMKEGI 
      2510       2520       2530       2540       2550
VDPETCMIVP YSEFIKKCKI DIESGQRYLE VHPFRAVKDE VTGNKLTCAE 
      2560       2570       2580       2590       2600
AVRLGKVDPL PTLRLLQAQA DSGGVVEGTV SKRLSLRAAV EQGLLDEEMA 
      2610       2620       2630       2640       2650
KLIATNQMRT GGIVEASSGK RLSLKEAVEK ELISQKLAAG LREAQISEDK 
      2660       2670       2680       2690       2700
YGSEVWKVDK PHLFQKRMEK LSPKDEDVVV STSASKKSEG AEHKAESEAV 
      2710       2720       2730       2740       2750
SYNAAGGAAA ATERFPVTLT EGKSKPQETS EDGVTHQPQG RVELTPEYPS 
      2760       2770       2780       2790       2800
VLGTTSLPEE TVVVRAMERG IAKSSSQLRA AWGKESWREE VDQGTEKVKG 
      2810       2820       2830       2840       2850
LGLEKEQLLL DTEVLRSAEG SEERRRRRGF VSAEGVVAGE EGEQGERAGS 
      2860       2870       2880       2890       2900
LDGVTPAAPR ESVTAGQGKG EMGPTESGEP PEIGIPMKPA GDELAVKKTV 
      2910       2920       2930       2940       2950
KHIEEETPRL GAEGPVDQAK TSETELKATQ KQKSKKKKAK QTGIPGDSAQ 
      2960       2970       2980       2990       3000
LEKSSAEKQS LPFHGGSSRD EKEKKAISEK DKENLAGDQV FPVPPGQGEA 
      3010       3020       3030       3040       3050
QEVMKGGIRN GHGSSVALSL EERMTQEDTK VETTSDMSIA APAADELPNE 
      3060       3070       3080       3090       3100
LIIREEPRDV QETSAVLELG EKARHEQTVE ISTGEGGAPV PPKSQGEAPQ 
      3110       3120       3130       3140       3150
DRTRQLGPGD RGLLLPVIVE GELLETSRES TRPAQIMFSK KMCLEHDEKL 
      3160       3170       3180       3190       3200
VSYLSMLRDI EMRIKRVQPA EQNLAALHDL LQQAEALGAE LQELSFSVNQ 
      3210       3220       3230       3240       3250
ELDAVKWIVA NPPEEVPEQL LKALEKDAKN LQKSLSSASD VLESRLQNLR 
      3260       3270       3280       3290       3300
GAAETKKAKI LAHHETLQGK LQELLSWVSG TAESLDGSDY HHATDANSLS 
      3310       3320       3330       3340       3350
RCLQHYKELK EPLADTKSQL DATAFDIQFL ISEHAQDLTP QQSRQLLRLL 
      3360       3370       3380       3390       3400
NELQKAFRDL SERVTAQVEV LQVCLQQVEQ TDQVKTLQEQ QAARAQSLAE 
      3410       3420       3430       3440       3450
LSRWLCQAED TLAEQQRAAS EGDLSTLQQR QSDVKVKAEF IHSFFAPSPL 
      3460       3470       3480       3490       3500
PESHEVFWMS VSVSSICCGW KTVWRFSSVD FCLPPPCSSL LNMHKTGHSY 
      3510       3520       3530       3540       3550
LEPLCFQVKA AKELEENSNK IDSLLNWVAS LEQKGGLLEY RPHPIEQAPG 
      3560       3570       3580       3590       3600
VQVGTGTQDV PDGHVVGADS AAESLDEQYE RLKAQHQELL SQQQDVILAT 
      3610       3620       3630       3640       3650
QSAQAFLDKH GHSLAGEERD RLQSRLAELK DQYAASLSQS ETQLKQVQVL 
      3660       3670       3680       3690       3700
RDELQKFLRD HGEFEAWLKQ AEQDLEGMYK GDSDPTALRQ LLLRQGSFSE 
      3710       3720       3730       3740       3750
DVISHKGDLR FVTMSGQKVL DVEGAAGDAG SQPLMSGSVV KSKLEDATQR 
      3760       3770       3780       3790       3800
YTTLHSKCTK LGSHLNTLLD HYQQFQEVAE SLRTWLQESE TAVGKLLSET 
      3810       3820       3830       3840       3850
VSSDPAVLQK QLASAKQLQG DLAEHQVPVE KLQKAARSLL EVQGEPAPDH 
      3860       3870       3880       3890       3900
GHIQETTDAI VNRFQSLSQQ MAERSDLLQK SIAQSQSVQE SLESLLQSVA 
      3910       3920       3930       3940       3950
EIEKNLEREQ PAALSSASIQ DSLATSAKLK QDIARQKSCL EATREMVTQF 
      3960       3970       3980       3990       4000
MEAADSPTAS ALQGKLAEVT EHFGRLCQQQ QEREDALKGL LPKVEQYEQL 
      4010       4020       4030       4040       4050
SEKLQQFTES RARMLASGNQ PDRDIAHFSQ HIQELNSEMR QHQEDLAALE 
      4060       4070       4080       4090       4100
HLAAELGSCG FAPGASQQQE KLQSLKKDFL QLQKVAKERE KDASSCQEQL 
      4110       4120       4130       4140       4150
DEFRKLVGAV RKWLRESEGK MPSAETSLGT QELHQRRQQV QDLLEEWKGK 
      4160       4170       4180       4190       4200
GAQVEEIGRR GTLLENLIVE ITAPDTPSKA GAALPAPGGS VGSVNGYHTC 
      4210       4220       4230       4240       4250
KDLTEIQCDV SDVTQQYQGL GAALRERQQQ LSAMLEKMQD VQEEASSMLK 
      4260       4270       4280       4290       4300
WLESKERTLS ELDASSSPTK TETMRAQAEH NKAFLAELEQ NSGKIQKVKE 
      4310       4320       4330       4340       4350
ELSGLLEKYP DSPEAANWKK MQEDLNCRWE RASQATAERQ QKLEESVNQL 
      4360       4370       4380       4390       4400
ASFQAAEAQL RPWLMEKELM MSVLGPLSID PNMLNAQKQQ VQFMLKEFEA 
      4410       4420       4430       4440       4450
RRQQHEQLNQ AAQSILTGPG DVSPSTNQVR EELQGVNQKW SELMERLNSR 
      4460       4470       4480       4490       4500
SNQIDQAIVK STQYQELLQG LSEKVKAVGQ RLSSQSAIST QPDAVKQQLE 
      4510       4520       4530       4540       4550
ETSEIRSDLE QLEEEIAEAQ TLCDDLSVLI GEQYLKDELR KRLETVALPL 
      4560       4570       4580       4590       4600
KGLEDLAADR MNRLQTALAS SQQFQHMFDE LRTWLDDKLC QQAQSQPISA 
      4610       4620       4630       4640       4650
KLERLQSQIQ EQEEFQKSLN QHSGSYEMIV AEGESLLLSV QPGEEKTTLQ 
      4660       4670       4680       4690       4700
NQLVSLKTHW EELSKQAADR HSKLKDCLQK AQKYQRHTED LLPWVEDCRA 
      4710       4720       4730       4740       4750
KMSELEVTLD PVQLEATLLR SKAMLSDVEK RRSLLEMLNS AADILIDASQ 
      4760       4770       4780       4790       4800
TDEDDVRDEK AGINQKMDAI TEELQAKTGS IEEMSQRLKE FQESFKNIEK 
      4810       4820       4830       4840       4850
KLEGAKHQLE IYDALGPQAC SNKNLEKLRA QQEVLQALEP QVDYLKNFTQ 
      4860       4870       4880       4890       4900
GLVEDAPDGS DCSQLLSQAE VAQQDFKAVK QKVNDCCTLM ENKLEGIGQF 
      4910       4920       4930       4940       4950
NNRVREMFSQ LADLDDELDS MGPIGRDSDS LQSQAEDVRT FLGKLHRLKS 
      4960       4970       4980       4990       5000
DIEASESECK KMLEDEGSPD LLGLKRELET LNKQCSKLTE RGKNRQEQVE 
      5010       5020       5030       5040 
TTLSRVEDFY SRLKELTHMT TAAEENEALQ WVVGTEVETI NQQLADFKV
Length:5,049
Mass (Da):566,017
Last modified:April 7, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i708FC0DD7F52D512
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei5049Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
VXAF01000367 Genomic DNA Translation: NXJ51653.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
VXAF01000367 Genomic DNA Translation: NXJ51653.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

CDDicd00014, CH, 2 hits
cd00176, SPEC, 9 hits
Gene3Di1.10.418.10, 2 hits
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 11 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00681, Plectin, 10 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 5 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00250, PLEC, 21 hits
SM00150, SPEC, 18 hits
SUPFAMiSSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 5 hits
PROSITEiView protein in PROSITE
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7L0BVW6_9AVES
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7L0BVW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 7, 2021
Last sequence update: April 7, 2021
Last modified: May 25, 2022
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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