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Entry version 5 (25 May 2022)
Sequence version 1 (07 Apr 2021)
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Protein
Submitted name:

MACF1 factor

Gene

Macf1_1

Organism
Spizaetus tyrannus (black hawk-eagle)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MACF1 factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Macf1_1Imported
ORF Names:SPITYR_R04624Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSpizaetus tyrannus (black hawk-eagle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri252798 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAccipitriformesAccipitridaeAccipitrinaeSpizaetus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000519115 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 57Calponin-homology (CH)InterPro annotationAdd BLAST57
Domaini70 – 174Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini744 – 801SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1812 – 1839DisorderedSequence analysisAdd BLAST28
Regioni1978 – 2013DisorderedSequence analysisAdd BLAST36
Regioni2024 – 2043DisorderedSequence analysisAdd BLAST20
Regioni2115 – 2153DisorderedSequence analysisAdd BLAST39
Regioni2672 – 2699DisorderedSequence analysisAdd BLAST28
Regioni2836 – 3000DisorderedSequence analysisAdd BLAST165
Regioni3073 – 3111DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili121 – 141Sequence analysisAdd BLAST21
Coiled coili353 – 373Sequence analysisAdd BLAST21
Coiled coili378 – 405Sequence analysisAdd BLAST28
Coiled coili697 – 717Sequence analysisAdd BLAST21
Coiled coili891 – 915Sequence analysisAdd BLAST25
Coiled coili922 – 942Sequence analysisAdd BLAST21
Coiled coili970 – 990Sequence analysisAdd BLAST21
Coiled coili1279 – 1309Sequence analysisAdd BLAST31
Coiled coili1336 – 1363Sequence analysisAdd BLAST28
Coiled coili1391 – 1418Sequence analysisAdd BLAST28
Coiled coili3174 – 3194Sequence analysisAdd BLAST21
Coiled coili3221 – 3241Sequence analysisAdd BLAST21
Coiled coili3343 – 3363Sequence analysisAdd BLAST21
Coiled coili3565 – 3592Sequence analysisAdd BLAST28
Coiled coili3612 – 3639Sequence analysisAdd BLAST28
Coiled coili3885 – 3909Sequence analysisAdd BLAST25
Coiled coili4025 – 4052Sequence analysisAdd BLAST28
Coiled coili4065 – 4085Sequence analysisAdd BLAST21
Coiled coili4224 – 4244Sequence analysisAdd BLAST21
Coiled coili4288 – 4308Sequence analysisAdd BLAST21
Coiled coili4395 – 4415Sequence analysisAdd BLAST21
Coiled coili4430 – 4450Sequence analysisAdd BLAST21
Coiled coili4495 – 4529Sequence analysisAdd BLAST35
Coiled coili4602 – 4622Sequence analysisAdd BLAST21
Coiled coili4767 – 4815Sequence analysisAdd BLAST49
Coiled coili4945 – 4965Sequence analysisAdd BLAST21
Coiled coili4971 – 4998Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1812 – 1832Polar residuesSequence analysisAdd BLAST21
Compositional biasi2131 – 2145Acidic residuesSequence analysisAdd BLAST15
Compositional biasi2672 – 2696Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi2894 – 2911Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi2947 – 2962Polar residuesSequence analysisAdd BLAST16
Compositional biasi2964 – 2986Basic and acidic residuesSequence analysisAdd BLAST23

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00176, SPEC, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 11 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00681, Plectin, 10 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 5 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00250, PLEC, 21 hits
SM00150, SPEC, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A7L0BVW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PREKGRMRFH RLQNVQIALD FLKQRQVKLV NIRNDDITDG NPKLTLGLIW
60 70 80 90 100
TIILHFQISD IYISGESGDM SAKEKLLLWT QKVTAGYIGV KCTNFSSCWS
110 120 130 140 150
DGKMFNALIH RYRPDLVDME RVQIQSNREN LEQAFEIAER LGVTRLLDAE
160 170 180 190 200
DVDVPSPDEK SVITYVSSIY DAFPKVPEGG EGISAIEVDS RWLEYQSRVE
210 220 230 240 250
SLISWIKQHT ILMSDKSFPQ NPVELKALYN QYIHFKETEI PAKEQEKGRI
260 270 280 290 300
EELYKLLEVW IEFGRIKLPQ GYHPNDVEEE WGKLIIEMLE REKLLRPAVE
310 320 330 340 350
RLELLLQIAN KIQNGALSCE EKLTLAKNTL QADAAHLESG QPVQYESDVV
360 370 380 390 400
VYLQECEGLI RQLQVDVQIL RDENYYQLEE LVFRIMRLQD ELVTLRLECT
410 420 430 440 450
NLYRKGHFST LELVPSSMLS TMHLKGESLT KGLHTSSASW FRKPMTRTEL
460 470 480 490 500
VAISSSEDEG SLRFVYELLA WVEEMQMRLE RAEWGTDLPS VETQLETQRH
510 520 530 540 550
IHSSVEDLGS SVKEARMYEG KMSQNFRASY TETLGKLETQ YCKLMETSSF
560 570 580 590 600
RLRHLQSLHG FVSRATAELI WLNEKEEEEL AYDWSDNNPN IAAKKNYFLE
610 620 630 640 650
LTTELEEKQD IFRSLQDTAE LLSLENHPAK QTVEAYSAAV QTQWQWIKQL
660 670 680 690 700
CLCVEQHVKE NAAYFQFFSD ARESETYLRN LQDSIKRKYS CDHNTSLTRL
710 720 730 740 750
EDLLQDSMDE KEQLIQSKSS VASLVGRSKT IVQLRPRNPE HLVKSTIPIK
760 770 780 790 800
AVCDYRQIEI TICRNDECVL EDNSQRTKWK VISPTGNEAM VPSVCFLIPP
810 820 830 840 850
PNKEAIEMAN RVEQLYQKVM ALWHQLHMNT KSLISWNYLR KDIALVQSFS
860 870 880 890 900
MEKLRSLAQG ECQQAMKSLQ AHYEDFLQDS RDSELFSVSD RLRLEEEVES
910 920 930 940 950
SKEHIRQLLE SMENEDKDET VARTYLSELK NIRLRLEECE QRLVSQIQSP
960 970 980 990 1000
SSARADGDTI QENTIRIAEQ ERMQEDLQRL QSDLRFVSER CYSFLDKAPA
1010 1020 1030 1040 1050
GSSTPHLRSE LDLLVNKMDQ MYGLSSIYLD KLKTVDVIIR NTQGAESLVK
1060 1070 1080 1090 1100
GYEVKLSQEE AVPADLAAIQ SHRTALQQWL GEVKDKSSVF SMLEEEMAKA
1110 1120 1130 1140 1150
KAVGEQLYRL RQERSIDLER YQEKGSQLWD RWQRVCTQIE TRHAELESIQ
1160 1170 1180 1190 1200
EVLSDYRQCH SALIQWIEEI TVQQELMKPG QAEDSRVLSE QLSQQTALAA
1210 1220 1230 1240 1250
EIEKNQAKLD QCQKFSQQYS AAVKDYELQL MTYRAFVESQ QKSPMKRRRM
1260 1270 1280 1290 1300
LSSSDAITQE FMDLRTRYTA LVTLTTQHVK YISDALRRLE EEEKVVEEEK
1310 1320 1330 1340 1350
QEHVDKVKEL LGWALGLKQS VQGRTAAAGS RELGDIEKSI SEQQALNEEL
1360 1370 1380 1390 1400
AAKKEQVSEA IKTSQIFLAK HSHKLSHPEK EQISAQISAL KETYQALCSD
1410 1420 1430 1440 1450
STEQLQQLQS QLAQETEHKG SEAVAGVIDL GTVEIFPVFG AMQRGLIDQD
1460 1470 1480 1490 1500
TGLVLLEAQV ITSDLVVPET NEKLSLKKGL ARKIIDLRTF QVLQELKDAL
1510 1520 1530 1540 1550
HQVEEVSCEG RQVLPVVAAI EEGRISESIG LKILEAELIT GGFKVHKGRI
1560 1570 1580 1590 1600
SMETAVQERL LTPQLYSRLL SHLEGGKDLI DPNTAEKISL LELMHRCIIH
1610 1620 1630 1640 1650
QETGLRLLPV KQLAGGMVSL KSGRKVSIFR AVQEGLIDRQ VTVRLLEAHL
1660 1670 1680 1690 1700
FAGGIVDPRT GHRLTVDEAV RHNLIDQDLA CTLLVRQLQT GGIIDTVTGE
1710 1720 1730 1740 1750
RLTIDEALRK ELVAPRIALV VLESLWSFMG LLWPETGEIV PVADALDQGI
1760 1770 1780 1790 1800
LSTEMVYKIL SKRQLIKAVF IPETTEVLSW KKAVEHGILE RDVAKKLKST
1810 1820 1830 1840 1850
LIPDVMASVQ LAGSPNRSRH GQSNSGRSPT GHKEQSDPLL RSDDERLMFH
1860 1870 1880 1890 1900
LMTHSYINIH DGQKLLLVDG ELNNLTKALI RTQENGSCAD TLEGSEGFEE
1910 1920 1930 1940 1950
TKADAALERE PCNGLALQQL EFQFAPSKEQ REKVLPPRAL ENGEVVMGPE
1960 1970 1980 1990 2000
GLLLEDAEDI LLVEEQEQIY TKQATMKSET DAEFGREQVA STSKGKHQVK
2010 2020 2030 2040 2050
LSMPGCPGDL GSGFRETEEM MVRAEESKPT TVDGVESIED HKRAPESGTV
2060 2070 2080 2090 2100
VVKSEICISM DVSKRERLQI MAERPEGGEK PELQAEDVRE IYLLNEETIE
2110 2120 2130 2140 2150
NGVLGGEEVV LPKTGEAEQT ERQSENFESV LQEQEEGEEV LDYESVDETS
2160 2170 2180 2190 2200
LPAPAEQEAE DTLEMLLTQL QSGGIIHKQT GKTLLLNEAV AHGVVPSHTA
2210 2220 2230 2240 2250
VKLMEKMKMF SGFFDSHTCE SLTTEDVIEE GLMDENLLQK VLASDKAISG
2260 2270 2280 2290 2300
VLDPGNNFVY SVKDAAAVGL LDKETAARIL EGQVVTGGIV DLKRGKKISV
2310 2320 2330 2340 2350
TLASNLGLIE PTSQKELVKL EKASKGKGTD EVTRQKLISL QAETSGIVDP
2360 2370 2380 2390 2400
KTKQPLTVAQ SVEKGLLKKE KAFQLLTKQI ADGGIIHHVS GMRLSVNNAM
2410 2420 2430 2440 2450
KHGLIDQDLC NELTKAESVC LQDYVHPVTK EKLPLPQAVS LGLISPAFQR
2460 2470 2480 2490 2500
KVQEIQAGSG SIFDPASGQR LALCQAVKEG LLPEQVMEKV LSSSEMKEGI
2510 2520 2530 2540 2550
VDPETCMIVP YSEFIKKCKI DIESGQRYLE VHPFRAVKDE VTGNKLTCAE
2560 2570 2580 2590 2600
AVRLGKVDPL PTLRLLQAQA DSGGVVEGTV SKRLSLRAAV EQGLLDEEMA
2610 2620 2630 2640 2650
KLIATNQMRT GGIVEASSGK RLSLKEAVEK ELISQKLAAG LREAQISEDK
2660 2670 2680 2690 2700
YGSEVWKVDK PHLFQKRMEK LSPKDEDVVV STSASKKSEG AEHKAESEAV
2710 2720 2730 2740 2750
SYNAAGGAAA ATERFPVTLT EGKSKPQETS EDGVTHQPQG RVELTPEYPS
2760 2770 2780 2790 2800
VLGTTSLPEE TVVVRAMERG IAKSSSQLRA AWGKESWREE VDQGTEKVKG
2810 2820 2830 2840 2850
LGLEKEQLLL DTEVLRSAEG SEERRRRRGF VSAEGVVAGE EGEQGERAGS
2860 2870 2880 2890 2900
LDGVTPAAPR ESVTAGQGKG EMGPTESGEP PEIGIPMKPA GDELAVKKTV
2910 2920 2930 2940 2950
KHIEEETPRL GAEGPVDQAK TSETELKATQ KQKSKKKKAK QTGIPGDSAQ
2960 2970 2980 2990 3000
LEKSSAEKQS LPFHGGSSRD EKEKKAISEK DKENLAGDQV FPVPPGQGEA
3010 3020 3030 3040 3050
QEVMKGGIRN GHGSSVALSL EERMTQEDTK VETTSDMSIA APAADELPNE
3060 3070 3080 3090 3100
LIIREEPRDV QETSAVLELG EKARHEQTVE ISTGEGGAPV PPKSQGEAPQ
3110 3120 3130 3140 3150
DRTRQLGPGD RGLLLPVIVE GELLETSRES TRPAQIMFSK KMCLEHDEKL
3160 3170 3180 3190 3200
VSYLSMLRDI EMRIKRVQPA EQNLAALHDL LQQAEALGAE LQELSFSVNQ
3210 3220 3230 3240 3250
ELDAVKWIVA NPPEEVPEQL LKALEKDAKN LQKSLSSASD VLESRLQNLR
3260 3270 3280 3290 3300
GAAETKKAKI LAHHETLQGK LQELLSWVSG TAESLDGSDY HHATDANSLS
3310 3320 3330 3340 3350
RCLQHYKELK EPLADTKSQL DATAFDIQFL ISEHAQDLTP QQSRQLLRLL
3360 3370 3380 3390 3400
NELQKAFRDL SERVTAQVEV LQVCLQQVEQ TDQVKTLQEQ QAARAQSLAE
3410 3420 3430 3440 3450
LSRWLCQAED TLAEQQRAAS EGDLSTLQQR QSDVKVKAEF IHSFFAPSPL
3460 3470 3480 3490 3500
PESHEVFWMS VSVSSICCGW KTVWRFSSVD FCLPPPCSSL LNMHKTGHSY
3510 3520 3530 3540 3550
LEPLCFQVKA AKELEENSNK IDSLLNWVAS LEQKGGLLEY RPHPIEQAPG
3560 3570 3580 3590 3600
VQVGTGTQDV PDGHVVGADS AAESLDEQYE RLKAQHQELL SQQQDVILAT
3610 3620 3630 3640 3650
QSAQAFLDKH GHSLAGEERD RLQSRLAELK DQYAASLSQS ETQLKQVQVL
3660 3670 3680 3690 3700
RDELQKFLRD HGEFEAWLKQ AEQDLEGMYK GDSDPTALRQ LLLRQGSFSE
3710 3720 3730 3740 3750
DVISHKGDLR FVTMSGQKVL DVEGAAGDAG SQPLMSGSVV KSKLEDATQR
3760 3770 3780 3790 3800
YTTLHSKCTK LGSHLNTLLD HYQQFQEVAE SLRTWLQESE TAVGKLLSET
3810 3820 3830 3840 3850
VSSDPAVLQK QLASAKQLQG DLAEHQVPVE KLQKAARSLL EVQGEPAPDH
3860 3870 3880 3890 3900
GHIQETTDAI VNRFQSLSQQ MAERSDLLQK SIAQSQSVQE SLESLLQSVA
3910 3920 3930 3940 3950
EIEKNLEREQ PAALSSASIQ DSLATSAKLK QDIARQKSCL EATREMVTQF
3960 3970 3980 3990 4000
MEAADSPTAS ALQGKLAEVT EHFGRLCQQQ QEREDALKGL LPKVEQYEQL
4010 4020 4030 4040 4050
SEKLQQFTES RARMLASGNQ PDRDIAHFSQ HIQELNSEMR QHQEDLAALE
4060 4070 4080 4090 4100
HLAAELGSCG FAPGASQQQE KLQSLKKDFL QLQKVAKERE KDASSCQEQL
4110 4120 4130 4140 4150
DEFRKLVGAV RKWLRESEGK MPSAETSLGT QELHQRRQQV QDLLEEWKGK
4160 4170 4180 4190 4200
GAQVEEIGRR GTLLENLIVE ITAPDTPSKA GAALPAPGGS VGSVNGYHTC
4210 4220 4230 4240 4250
KDLTEIQCDV SDVTQQYQGL GAALRERQQQ LSAMLEKMQD VQEEASSMLK
4260 4270 4280 4290 4300
WLESKERTLS ELDASSSPTK TETMRAQAEH NKAFLAELEQ NSGKIQKVKE
4310 4320 4330 4340 4350
ELSGLLEKYP DSPEAANWKK MQEDLNCRWE RASQATAERQ QKLEESVNQL
4360 4370 4380 4390 4400
ASFQAAEAQL RPWLMEKELM MSVLGPLSID PNMLNAQKQQ VQFMLKEFEA
4410 4420 4430 4440 4450
RRQQHEQLNQ AAQSILTGPG DVSPSTNQVR EELQGVNQKW SELMERLNSR
4460 4470 4480 4490 4500
SNQIDQAIVK STQYQELLQG LSEKVKAVGQ RLSSQSAIST QPDAVKQQLE
4510 4520 4530 4540 4550
ETSEIRSDLE QLEEEIAEAQ TLCDDLSVLI GEQYLKDELR KRLETVALPL
4560 4570 4580 4590 4600
KGLEDLAADR MNRLQTALAS SQQFQHMFDE LRTWLDDKLC QQAQSQPISA
4610 4620 4630 4640 4650
KLERLQSQIQ EQEEFQKSLN QHSGSYEMIV AEGESLLLSV QPGEEKTTLQ
4660 4670 4680 4690 4700
NQLVSLKTHW EELSKQAADR HSKLKDCLQK AQKYQRHTED LLPWVEDCRA
4710 4720 4730 4740 4750
KMSELEVTLD PVQLEATLLR SKAMLSDVEK RRSLLEMLNS AADILIDASQ
4760 4770 4780 4790 4800
TDEDDVRDEK AGINQKMDAI TEELQAKTGS IEEMSQRLKE FQESFKNIEK
4810 4820 4830 4840 4850
KLEGAKHQLE IYDALGPQAC SNKNLEKLRA QQEVLQALEP QVDYLKNFTQ
4860 4870 4880 4890 4900
GLVEDAPDGS DCSQLLSQAE VAQQDFKAVK QKVNDCCTLM ENKLEGIGQF
4910 4920 4930 4940 4950
NNRVREMFSQ LADLDDELDS MGPIGRDSDS LQSQAEDVRT FLGKLHRLKS
4960 4970 4980 4990 5000
DIEASESECK KMLEDEGSPD LLGLKRELET LNKQCSKLTE RGKNRQEQVE
5010 5020 5030 5040
TTLSRVEDFY SRLKELTHMT TAAEENEALQ WVVGTEVETI NQQLADFKV
Length:5,049
Mass (Da):566,017
Last modified:April 7, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i708FC0DD7F52D512
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei5049Imported1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
VXAF01000367 Genomic DNA Translation: NXJ51653.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
VXAF01000367 Genomic DNA Translation: NXJ51653.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00014, CH, 2 hits
cd00176, SPEC, 9 hits
Gene3Di1.10.418.10, 2 hits
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 11 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00681, Plectin, 10 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 5 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00250, PLEC, 21 hits
SM00150, SPEC, 18 hits
SUPFAMiSSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 5 hits
PROSITEiView protein in PROSITE
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7L0BVW6_9AVES
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7L0BVW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 7, 2021
Last sequence update: April 7, 2021
Last modified: May 25, 2022
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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